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AI Podcasts

December 17, 2025

Rethinking Pre-Training for Agentic AI [Aakanksha Chowdhery] - 759

The TWIML AI Podcast with Sam Charrington

AI
Key Takeaways:
  1. Strategic Implication: The next frontier in AI is agentic, and progress hinges on fundamental pre-training innovation, not just post-training optimizations.
  2. Builder/Investor Note: Focus on teams with deep experience in scaling and debugging large models, as this is a high-capital, high-risk endeavor. Builders should prioritize developing new benchmarks for agentic capabilities.
  3. The "So What?": The industry needs to move beyond next-token prediction and static benchmarks to unlock truly capable, self-correcting AI agents in the next 6-12 months.
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December 17, 2025

Code World Model: Building World Models for Computation – Jacob Kahn, FAIR Meta

AI Engineer

AI
Key Takeaways:
  1. Shift in AI Development: The focus moves from syntax-aware code generation to execution-aware reasoning, enabling more robust and intelligent code agents.
  2. Builder/Investor Note: Prioritize tools and platforms that support explicit execution modeling and highly asynchronous, high-throughput RL training for agentic systems.
  3. The "So What?": AI that can simulate complex systems internally will drastically reduce development and testing costs, accelerating innovation in software and distributed systems over the next 6-12 months.
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December 17, 2025

AI Kernel Generation: What's working, what's not, what's next – Natalie Serrino, Gimlet Labs

AI Engineer

AI
Key Takeaways:
  1. Strategic Shift: AI-driven kernel generation is not replacing human genius but augmenting it, allowing experts to focus on novel breakthroughs while AI automates the application of known optimizations across a complex hardware landscape.
  2. Builder/Investor Note: Focus on robust validation and hardware-in-the-loop systems. Claims of "AI inventing new algorithms" in this domain are premature. The real value is in automating the "bag of tricks" for heterogeneous compute.
  3. The "So What?": This technology is critical for scaling agentic AI workloads. Expect significant investment in tools that abstract hardware complexity and enable efficient, automated optimization, driving down the cost of AI inference in the next 6-12 months.
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December 18, 2025

AI Consulting in Practice – NLW, Super ai

AI Engineer

AI
Key Takeaways:
  1. The Agent Economy is Here: Enterprises are moving past pilots with AI agents. Builders should focus on orchestration layers and human-agent interaction design.
  2. ROI Measurement is the Next Frontier: Investors should look for solutions that help organizations accurately track and attribute AI value beyond traditional metrics.
  3. Strategic AI, Not Spot Solutions: The biggest wins come from systematic, cross-organizational AI strategies that target new capabilities and revenue growth, not just incremental time savings.
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December 18, 2025

How to build an AI native company (even if your company is 50 years old) – Dan Shipper, Every

AI Engineer

AI
Key Takeaways:
  1. The 100% AI adoption threshold is a step-function change, not incremental. Companies that commit fully will outpace those with partial integration.
  2. Builders should prioritize "compounding engineering" by codifying knowledge into reusable prompts. This builds an organizational memory that accelerates future development exponentially.
  3. Re-evaluate team structures and roles. Single engineers can own complex products, and even technical managers can contribute code, shifting how organizations operate.
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December 17, 2025

“How We Can Eliminate Crime” | Ben Horowitz and Garrett Langley

a16z

AI
Key Takeaways:
  1. Effective crime reduction requires a shift from reactive punishment to proactive, intelligence-driven deterrence, making it highly probable for criminals to be caught.
  2. The market for AI-powered public safety technology, particularly solutions that integrate data for precision and accountability, presents a significant opportunity. Public-private partnerships are a key funding mechanism.
  3. Over the next 6-12 months, expect to see more cities adopt advanced surveillance and AI tools, driven by private funding, as they seek to improve safety and address staffing shortages without resorting to ineffective, broad-stroke policies.
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December 18, 2025

Two Futures | Runtime 2025

a16z

AI
Key Takeaways:
  1. Strategic Implication: The next decade will be defined by who builds the core infrastructure for intelligence. This is where the most significant value and influence will accrue.
  2. Builder/Investor Note: Direct capital and talent towards foundational AI components—chips, models, and interoperable systems. Avoid the temptation to only build at the application layer.
  3. The So What?: The window for shaping the future of intelligence is now. Engage in the deepest, most complex challenges to secure a footprint in this new era.
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December 18, 2025

The EU and the not-so-simple macroeconomics of AI – Luis Garicano

Epoch AI

AI
Key Takeaways:
  1. Strategic Implication: The global AI race is a zero-sum game for foundational models. Europe's best strategy is a "smart second mover" approach, focusing on the implementation layer by ensuring interoperability and data portability.
  2. Builder/Investor Note: Invest in AI that achieves true autonomy and enhances expert productivity. Be wary of markets stifled by over-regulation, which can impede AI adoption and growth.
  3. The "So What?": Europe faces a critical juncture. Without embracing AI-driven growth, its demographic and debt problems will worsen, leading to higher interest rates without the corresponding economic expansion.
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December 18, 2025

SAM 3: The Eyes for AI — Nikhila & Pengchuan (Meta Superintelligence), ft. Joseph Nelson (Roboflow)

Latent Space

AI
Key Takeaways:
  1. Vision AI Democratization: SAM 3 lowers the barrier for sophisticated vision tasks, making advanced segmentation and tracking accessible for a wider range of applications.
  2. Builder/Investor Note: Focus on domain-specific adaptations and tooling that enhance human-AI interaction for ambiguous visual concepts. The "last mile" of user intent is a key differentiator.
  3. The "So What?": SAM 3 accelerates the development of multimodal AI, particularly in robotics and video analysis, by providing a robust, scalable visual foundation for the next generation of intelligent systems.
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Crypto Podcasts

June 23, 2025

The Token Transparency Framework, Worldcoin, and X’s Super App | Livestream

0xResearch

Crypto
Key Takeaways:
  1. Transparency is Non-Negotiable: The industry overwhelmingly supports standardized disclosures; projects can no longer hide in ambiguity.
  2. Apps Over Chains (Mostly): The new meta for exchanges involves building user-facing applications on existing, efficient blockchains rather than launching bespoke L1s/L2s, prioritizing speed-to-market and revenue.
  3. Proof-of-Humanity is Coming: As AI blurs online reality, solutions like Worldcoin, despite debate, are gaining traction with platforms desperate to verify real users.
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June 23, 2025

Is Tether The World's Most Valuable Company?

Bankless

Crypto
Key Takeaways:
  1. Profit Powerhouse: Tether's profitability ($13.7B+ annually) fuels its independence and aggressive investment strategy, making it a financial force comparable to nations in Treasury markets.
  2. Global First, US Second (Strategically): While pursuing US compliance for USDT, Tether’s core focus remains on emerging markets where its impact (and profitability) is higher. A new US-specific stablecoin will target different, value-added use cases.
  3. Beyond Stablecoins: Tether is diversifying heavily, aiming to become a top Bitcoin miner, expanding its tokenized gold offering (with physical redemption), and investing in AI and other tech, always with an eye on distribution.
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June 23, 2025

How To Fix Crypto's Token Problem

Lightspeed

Crypto
Key Takeaways:
  1. **Brace for "Junk":** Expect a deluge of low-quality tokens funded over the past two years to hit markets in the next 12-18 months. Extreme diligence is crucial.
  2. **Equity Rises:** The growth of crypto M&A, potential IPOs, and institutional interest will increasingly value revenue-generating companies and "real things" over purely speculative tokens.
  3. **Utility Is King (Eventually):** Projects delivering genuine products, strong user adoption, and productive tokenomics will ultimately define a more robust and trustworthy crypto ecosystem.
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June 22, 2025

Yano On What The New Token Transparency Framework Looks Like

Empire

Crypto
Key Takeaways:
  1. **Standardized Scrutiny Arrives:** The Token Transparency Framework introduces a systematic, 18-criteria evaluation, offering a clear benchmark for assessing token projects beyond hype.
  2. **Rewards & Repercussions:** By first celebrating transparent projects (like Jito and Jupiter) and then planning to rate less forthcoming ones, the framework aims to incentivize industry-wide improvements in disclosure.
  3. **Investor Toolkit Boost:** This framework provides investors with a concrete tool for due diligence, moving towards a more informed and transparent crypto investment landscape.
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June 21, 2025

0xResearch | June 20th, 2025

0xResearch

Crypto
Key Takeaways:
  1. CEXs Go Lean: Exchanges are increasingly opting for lighter on-chain footprints, prioritizing app development on existing chains over building new L1s/L2s, signaling a focus shift to direct user value.
  2. Transparency is Non-Negotiable: The 0xResearch Token Transparency Framework highlights a critical industry need for standardized disclosures, aiming to build trust and attract serious capital by demystifying token projects.
  3. Utility Drives Valuation: Projects like Kamino, despite strong fundamentals and growth, underscore that clear token utility and value accrual mechanisms are essential for market recognition and valuation.
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June 20, 2025

Macro Uncertainty, Circle’s Surge, and Prediction Market Utility | Roundup

Bell Curve

Crypto
Key Takeaways:
  1. Selective Bets Over Broad Sprees: Forget throwing darts; the crypto market now rewards surgical precision. Focus on projects with strong fundamentals and demonstrable traction, as "hyper dispersion" is the new norm.
  2. Public Equities as a Crypto Proxy: With limited direct, high-quality crypto IPOs, existing listed entities like Circle and Coinbase are soaking up institutional and retail interest, mimicking "alt season" dynamics in traditional markets.
  3. Pragmatism Pays: The industry is shedding ideological baggage. Successful projects will meet existing market needs, provide clear disclosures, and avoid outdated tokenomic "tricks." Prediction markets are an emerging utility to watch.
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