No Priors: AI, Machine Learning, Tech, & Startups
December 19, 2025

No Priors Ep. 144 | The 2026 AI Forecast with Sarah & Elad

2026 will be a year of AI's quiet, pervasive triumph, even as market sentiment oscillates. The real story isn't about hype, but about AI embedding itself deeply into the economy, transforming everything from scientific discovery to how we interact with software, all while navigating significant infrastructure and geopolitical shifts.

AI's Inexorable March: Beyond Hype to Pervasive Utility

  • "I think people will proclaim yet again that AI is not doing much and it's overhyped... the reality of the technology takes like 10 years to propagate and people are getting enormous value out of AI already and they're going to get way more out of it in the future."
  • Noise vs. Value: Expect continued "AI is overhyped" narratives. These claims will be largely irrelevant as the technology's long-term value propagation delivers substantial real-world benefits.
  • Conservative Converts: Professions historically slow to adopt new technology (doctors, lawyers, accountants) are enthusiastically embracing AI for tasks like clinical decision support and legal research. Think of it like a Luddite discovering the internet and realizing it makes their job easier; these professions find AI indispensable for processing unstructured data.
  • Vertical Consolidation: Specific industry verticals will see further consolidation of AI applications, mirroring the current state of AI coding, medical scribing, and legal tech.

The Bifurcation of AI Applications: From Scientific Breakthroughs to Consumer Agents and Robotics Reality Checks

  • "The next set of foundation models are going to come... I mean physics materials science progress by models math progress."
  • Scientific Solvers: 2026 will bring AI-driven breakthroughs in fundamental sciences (physics, materials, mathematics). Similar to AlphaFold's impact on protein folding, AI will unlock "solved" moments in other scientific domains.
  • Robotics Reality: Humanoid and semi-humanoid robots will see small-scale deployments, but initial imperfections will likely trigger a market sentiment correction. The long-term trajectory will be slow, capital-intensive, and favor incumbents (e.g., Tesla, Waymo, Chinese firms) due to hardware, manufacturing, and supply chain advantages.
  • Consumer Agent Renaissance: A new wave of "magical" consumer agent software is emerging, moving beyond basic chatbots to proactive, context-aware tools that significantly reduce user effort. Instead of you telling your AI what to do, it anticipates your needs and acts, like a personal assistant who already knows your schedule and preferences.

The Shifting AI Landscape: Capital, Geopolitics, and Core Constraints

  • "Their game theory on it was like, 'Actually, no matter what I think about it, I have to do it because retail will want it because they like want to be part of the AI revolution.'
  • IPO Dynamics: Major AI companies going public will likely attract massive retail appetite, driving strong IPO performance regardless of fundamental valuation, creating a "must-buy" scenario for institutional investors.
  • Geopolitical AI Race: The US is actively working to regain leadership in open-source AI, particularly at the frontier of large-scale open models, following a perceived shift in innovation to China.
  • Energy as a Constraint: Data center expansion and AI compute demand are increasingly constrained by energy availability and power infrastructure. "Intelligence per watt" becomes a critical metric for efficiency in the short term, though chip depreciation still dominates long-term cost.

Key Takeaways:

  • AI's real-world impact will accelerate in 2026, particularly in "conservative" professional services and fundamental sciences, despite market volatility.
  • Builders should focus on truly novel consumer agent experiences and niche robotics applications, while investors should eye AI IPOs with caution and consider energy efficiency plays.
  • The next 6-12 months will clarify the geopolitical AI race and expose the true infrastructure bottlenecks, shaping the industry's long-term trajectory.

Podcast Link: https://www.youtube.com/watch?v=TOsNrV3bXtQ

This episode dissects the 2026 AI landscape, revealing critical shifts in market sentiment, the surprising dominance of incumbents in robotics, and the emerging "age of research" that challenges pure scaling laws.

The AI Hype Cycle & Vertical Domination

  • Elad predicts a recurring pattern: AI will face both overstated bubble claims and premature declarations of failure in 2026. Despite this noise, the technology's real-world value continues to propagate, delivering substantial benefits. Sarah notes a surprising trend: professions traditionally slow to adopt technology, like physicians and lawyers, are rapidly embracing AI for tasks involving unstructured data and reasoning.
  • Elad forecasts continued market volatility, with pundits oscillating between "overhyped" and "not working" narratives, despite consistent technological progress.
  • New verticals will consolidate, mirroring the current state of AI in coding, medical scribing, and legal services.
  • Physicians, lawyers, and accountants, historically conservative adopters, show massive enthusiasm for AI tools that improve workflow and reasoning.
  • This rapid adoption in "slow-adopter" professions is a significant, under-discussed trend that will persist.
  • “The people who tended to be the slowest adopters of technology love AI. That's physicians, that's lawyers, that's certain accounting types.” — Elad

Robotics: Hype, Hardware, and Incumbents

  • Sarah anticipates a sentiment collapse around some robotics companies in 2026, not due to a lack of progress, but because initial deployments will not meet inflated timelines. Elad draws parallels to self-driving, where incumbents like Waymo (Google) and Tesla emerged as dominant players. The capital-intensive nature and hardware/manufacturing demands of robotics structurally favor large, established companies.
  • Humanoid and semi-humanoid robots will see small-scale deployments, but inevitable imperfections will trigger a market "freak out."
  • Self-driving cars, a complex single-use robot, demonstrate a long development curve, suggesting a similar trajectory for general robotics.
  • Incumbents like Tesla (Optimus) and Waymo are strong contenders due to existing expertise in models, supply chains, and sensor technology.
  • Chinese companies are also positioned as likely global winners in robotics, alongside a select few startups.
  • “Structurally when you have a lot of capital needs but also a lot of hardware and manufacturing needs that's going to favor incumbents.” — Elad

The Age of Research: Beyond Scaling Laws

  • Elad predicts breakthroughs in science and mathematics driven by new foundation models, initially appearing as "one-off" successes that will be overhyped in the short term but understated in their long-term impact. Sarah highlights Ilya Sutskever's "age of research," where compute-efficient improvements and alternative architectures (like diffusion models or State Space Models - SSMs, neural network architectures designed for processing sequential data efficiently) challenge the pure scaling paradigm.
  • Foundation models will yield anecdotal scientific breakthroughs, such as new materials or mathematical proofs, triggering a temporary hype cycle.
  • Ilya Sutskever argues for an "age of research" where novel ideas, not just infinite compute, drive rapid AI improvement.
  • Multiple architectures (e.g., diffusion, SSMs) will be scaled and tested, potentially proving relevant for large domains of usefulness.
  • The balance between inference (revenue generation) and research compute dictates the pace of exploring new directions like self-improvement or large-scale agent collaboration.
  • “If we have secret ideas around like how to get to more rapid or more compute efficient improvement then it actually isn't just a straight resource battle.” — Sarah

Market Dynamics: IPOs, M&A, and Consumer AI's Challenge

  • Elad forecasts a surge in AI IPOs in 2026, driven by immense retail appetite for pure-play AI investments beyond Nvidia. Sarah notes investor skittishness regarding demand sustainability and systemic risk in the capex cycle. Consumer AI faces a unique challenge: incumbents are formidable, and many early attempts merely iterate on old ideas, demanding highly creative and research-proximate founders for true innovation.
  • Retail investor demand for AI exposure will fuel numerous IPOs, potentially leading to significant pops for early entrants.
  • Concerns persist about whether AI demand justifies the massive capital expenditure (capex) in compute infrastructure.
  • Consumer hardware will largely fail, but "magical experiences" from stealth consumer agent software will emerge.
  • Incumbents pose a significant threat to consumer AI startups, often integrating successful ideas into their platforms, requiring startups to achieve "escape velocity" with network effects.
  • “I think you have to be like either quite close to research or pretty creatively ambitious to build like something very different that has any chance.” — Sarah

Broader Shifts: Defense, Biotech, and AI's Societal Impact

  • Elad predicts an acceleration in defense tech, particularly the shift to drone-based systems, driven by geopolitical needs and a growing density of innovative startups. Sarah highlights the underrated impact of GLP-1 drugs (Glucagon-like peptide-1 receptor agonists, a class of medications used for type 2 diabetes and weight management) and the broader peptide/biohacking trend, suggesting a future of personalized, engineered therapies. Guest predictions include AI becoming proactive, context-aware, and energy-efficient, alongside a philosophical shift from "YOLO" to "Don't Die."
  • Defense tech will accelerate, with a massive reworking of war and defense strategies towards autonomous and drone-based systems.
  • The widespread adoption of GLP-1 drugs is underrated, creating a path for other peptide and hormone therapies and fueling investment in engineered medicines.
  • Guest experts predict AI will transition from reactive prompting to proactive, deeply integrated work companions, prioritizing context and user intent.
  • The "YOLO" (You Only Live Once) philosophy will give way to a "Don't Die" ethos, emphasizing the sacredness of existence and defying self-destructive behaviors, potentially in response to AI's progress.
  • The frontier of open intelligence, which shifted to China, will see the US regain leadership through new "neolabs" focused on open models.
  • AI will become highly politicized, a major discussion point in elections, with strong proponents and opponents.
  • AI drug discovery will move from research to deployment, enabling faster development and targeting previously intractable challenges.
  • Energy efficiency in AI (intelligence per watt) will become critical in 2026 due to power constraints, though chips remain the long-term cost driver.
  • “Defense will accelerate in terms of startups and defense tech and the shift to autonomous or not autonomous but to drone based systems in general.” — Elad

Investor & Researcher Alpha

  • Capital Reallocation: Expect significant capital movement into AI IPOs, driven by retail demand, despite underlying market skittishness. Incumbents (Google, Tesla, Chinese tech giants) will continue to dominate capital-intensive sectors like robotics and foundation models.
  • Bottlenecks & Opportunities: Energy availability and compute efficiency are emerging as critical constraints. Research into alternative architectures (SSMs, diffusion) and evolutionary AI systems offers high-leverage opportunities beyond brute-force scaling.
  • Strategic Shifts: The "age of research" demands a focus on novel algorithmic breakthroughs and compute-efficient methods. Consumer AI requires founders with deep research proximity and creative ambition to overcome incumbent platform advantages. Defense tech and advanced biotech (peptides, longevity) represent high-growth, high-impact sectors.

Strategic Conclusion

2026 marks a pivotal year where AI's pervasive utility confronts market volatility and infrastructure limits. The industry must navigate a complex landscape of incumbent dominance, emerging research paradigms, and critical resource constraints to unlock the next phase of intelligent systems. The next step involves prioritizing compute efficiency and fostering truly novel, context-aware AI applications.

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