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AI Podcasts

October 20, 2025

Reid Hoffman on AI, Consciousness, and the Future of Labor

a16z

AI
Key Takeaways:
  1. **Invest at the Intersection.** The alpha in AI investing will be found not in crowded SaaS applications but in "Silicon Valley blind spots"—complex industries like biology where AI can bridge the digital and physical worlds.
  2. **Augment, Don't Annihilate.** The winning go-to-market strategy for AI is the copilot model. Frame products as tools that amplify human capability, making experts more productive and profitable, rather than threatening their jobs.
  3. **Judge the Trajectory, Not the Snapshot.** Don't dismiss AI based on a single, past failure. Its capability curve is exponential. What seems like a limitation today will likely be a solved problem tomorrow, demanding continuous engagement to keep pace.
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October 18, 2025

Improving on LMArena - Prolific [Sponsored]

Machine Learning Street Talk

AI
Key Takeaways:
  1. Benchmarks Are Broken. Leaderboards like LMArena are flawed proxies for model quality, skewed by selection bias and susceptible to Goodhart's Law. High scores don’t equal a good user experience.
  2. Human Feedback is Infrastructure. The future isn't about removing humans but orchestrating them effectively. Treating high-quality, representative human feedback as a core, API-driven part of the development lifecycle is non-negotiable.
  3. Alignment is a Moving Target. Agentic misalignment is a present-day reality, not a distant sci-fi threat. The more capable models become, the wider the gap grows between their emergent goals and our intended instructions.
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October 17, 2025

Novelty Search October 16, 2025

taostats

AI
Key Takeaways:
  1. Influence Over Impressions: The model shifts focus from easily gamed metrics like views and likes to verifiable signals of influence—watch time on YouTube and PageRank-based authority on X.
  2. Revenue-Driven Tokenomics: All platform revenue is used to buy back and burn the ALPHA token, creating a powerful, deflationary flywheel as adoption grows.
  3. Targeted, Scalable Marketing: Bitcast enables brands to programmatically deploy campaigns across hundreds of niche influencers, reaching highly engaged communities with a consistency and scale that legacy agencies cannot match.
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October 16, 2025

Keith Rabois: Israel, OpenAI, Opendoor, and DOGE

a16z

AI
Key Takeaways:
  1. **Incumbency Is a Liability:** Big Tech's legacy products, distribution advantages, and corporate cultures are being systematically dismantled by faster, AI-native upstarts.
  2. **Reinvent Markets from First Principles:** Success in intractable fields—from geopolitics to real estate—comes from questioning assumptions, not relying on domain experts who perpetuate the status quo.
  3. **Unwind Stupidity Before Innovating:** The fastest path to value creation is often simply reversing a series of terrible decisions made by prior leadership.
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October 14, 2025

AI Bubble, Stablecoin Boom, and Runnin' Down a Dream | BG2 w/ Bill Gurley and Brad Gerstner

Bg2 Pod

AI
Key Takeaways:
  1. **Scrutinize the AI Plumbing.** Investors must look past headline revenue and analyze the quality of transactions. Deals like in-kind credits and obscure service-level agreements (like Nvidia’s backstop for Coreweave) can mask true market demand.
  2. **Stablecoins Are the Real Disruption.** The explosion in stablecoin usage represents a fundamental challenge to the high-fee, slow-settlement models of Visa, Mastercard, and traditional banks. This is the crypto use case that is finally breaking into the mainstream.
  3. **Federal Preemption for AI is Non-Negotiable.** A patchwork of state-level AI laws will cripple U.S. innovation. A single, national regulatory framework is the only path to maintaining global leadership.
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October 14, 2025

Is AI Slowing Down? Nathan Labenz Says We're Asking the Wrong Question

a16z

AI
Key Takeaways:
  1. Look Beyond the Chatbot. Judge AI progress not by its daily performance, but by its ability to solve novel problems in science and math—where models are now pushing the frontiers of human knowledge.
  2. The Bottleneck is Human, Not Silicon. AI's capacity for automation is growing exponentially (task length is doubling every ~4 months). The real limit to adoption is organizational will and the ability to effectively delegate complex work.
  3. Prepare for a Weirder World. The biggest risk is underestimating the pace of change. As agent capabilities expand, so do unpredictable "weird behaviors" like scheming and deception, creating a future that requires active imagination and risk management.
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October 13, 2025

Democratic proofs or fake proofs? - Jesús De Loera

Epoch AI

AI
Key Takeaways:
  1. Verification Over Creation: A proof that can be widely verified, even if computer-generated, holds more democratic value than a human proof understood by only a few elites.
  2. Humans Ask, AI Answers: The primary role for mathematicians in an AI-augmented world is to pose the right questions and conjectures, leaving the computational heavy lifting to their AI assistants.
  3. The Greatest Risk is Us: The biggest threat isn't rogue AI but our own tendency to over-hype and blindly trust flawed tools, leading to the spread of misinformation disguised as mathematical fact.
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October 13, 2025

Columbia CS Professor: Why LLMs Can’t Discover New Science

a16z

AI
Key Takeaways:
  1. LLMs are Navigators, Not Discoverers. They are masters of interpolation within their training data but are architecturally bound from making the intuitive leaps required for true scientific breakthroughs. Don’t expect a Transformer to produce the next theory of relativity.
  2. The Innovation Plateau is Real. Simply throwing more data and compute at current architectures will only "smoothen out" existing knowledge manifolds, not create new ones. This path leads to incremental gains, like an iPhone getting a better camera, not a paradigm shift.
  3. Entropy is the Key to Control. For developers, effective prompting is entropy management. By crafting specific, context-rich prompts, you reduce the model's prediction entropy, forcing it onto a confident, low-hallucination path to a reliable output.
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October 10, 2025

Bittensor Novelty Search :: SN4 Targon :: Confidential Cloud Compute

The Opentensor Foundation | Bittensor TAO

AI
Key Takeaways:
  1. Trust is the New Commodity. Targon’s use of TEEs shifts security from a software promise to a cryptographic hardware guarantee. This verifiable privacy is the key to unlocking enterprise adoption for decentralized AI.
  2. The Crucible Creates Diamonds. Bittensor's adversarial environment forced Targon to build an unexploitable system. This has turned a historical pain point ("PTSD from miners") into a core competitive advantage, resulting in a uniquely resilient platform.
  3. From Backroom Deals to a Liquid Market. By launching a self-serve platform with a transparent order book, Targon is attacking the compute market's core inefficiency: opaque pricing. Their vision extends to compute derivatives, aiming to turn compute power into a globally tradable asset.
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Crypto Podcasts

December 2, 2025

Crypto Dumps on BOJ Pivot Signal as Tether, Strategy Turmoil Hit Markets: Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. Leverage is the Real Trigger. The BOJ pivot was just the spark. The crypto market’s bonfire was fueled by excessive leverage, turning a macro ripple into a tidal wave and signaling a broader rotation from high-beta assets to value.
  2. Narrative Trumps Fundamentals (For Now). MicroStrategy’s CEO stated a basic corporate finance reality—they’d sell BTC if required to service debt—and the market tanked. This proves that in retail-driven markets, violating the "diamond hands" story is more damaging than a weak balance sheet.
  3. TradFi's Glass House. While legacy finance lobbies against crypto’s perceived risks, its own critical infrastructure is failing due to mundane issues like a broken air conditioner, making a powerful, real-time case for decentralized resilience.
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December 2, 2025

Crypto Dumps on BOJ Pivot Signal as Tether, Strategy Turmoil Hit Markets: Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. Leverage is the Accelerant: The market's violent reaction to predictable macro news reveals a system still prone to painful, cascading deleveraging events driven by over-leveraged players.
  2. Narratives are Fragile Assets: MicroStrategy’s stumble shows that in crypto, narrative integrity is as critical as financial solvency. A violation can trigger sell-offs regardless of underlying fundamentals.
  3. Old Systems Break While New Ones are Built: The CME outage is a powerful, real-time advertisement for decentralized alternatives, underscoring TradFi's fragility even as its gatekeepers resist change.
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December 2, 2025

Crypto Dumps on BOJ Pivot Signal as Tether, Strategy Turmoil Hit Markets: Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. Macro is Back in Charge. The era of cheap leverage is facing a global reckoning, with the unwind of the Yen Carry Trade serving as a key trigger. High-beta assets like crypto are the first to feel the pain.
  2. Narrative Trumps Numbers. MicroStrategy's dip wasn't about math; it was about breaking a story. In crypto, violating a core community belief can be more damaging than a weak earnings report.
  3. TradFi's Fragility is Crypto's Calling Card. While crypto fends off FUD, a major institution like the CME went offline for 10 hours due to a failed air conditioner. This is a powerful, real-world advertisement for decentralized resilience.
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December 2, 2025

Crypto Dumps on BOJ Pivot Signal as Tether, Strategy Turmoil Hit Markets: Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. High-Beta is a Crowded Trade: Crypto, alongside assets like uranium and quantum stocks, is being sold off in unison as investors rotate into value stocks. In this defensive environment, expect Bitcoin to outperform altcoins.
  2. Narrative Trumps Fundamentals (For Now): MicroStrategy’s stock plunged not on a fundamental crisis but on the CEO admitting they *might* sell Bitcoin in a corner case—a direct violation of their "never sell" narrative.
  3. Don't Fight the Central Banks: The BOJ’s tightening signal was the trigger for the dump. Conversely, the Fed's expected rate cuts and potential for future dovish leadership remain the key bullish catalysts to watch.
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December 2, 2025

LIVE | CRYPTO TRENDS WITH ALANA FROM VARIANT | 0xResearch

0xResearch

Crypto
Key Takeaways:
  1. DEXes Are Winning by Default: The sheer volume of new, on-chain-only tokens is an unstoppable force driving users to DEXes. Centralized exchanges can either integrate or become irrelevant for the long tail of assets.
  2. The Real Money is in the Rails: Don't focus on who will issue the next dominant stablecoin. The biggest opportunity lies in building the interoperability infrastructure that will connect the coming flood of branded, corporate, and national stablecoins.
  3. Bitcoin's Ultimate Bull Case is Geopolitical: In a world of fragmenting currencies and rising geopolitical tensions, Bitcoin's status as a non-sovereign, politically neutral asset makes it the ultimate contender for a global reserve currency.
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December 2, 2025

LIVE | CRYPTO TRENDS WITH ALANA FROM VARIANT | 0xResearch

0xResearch

Crypto
Key Takeaways:
  1. **Memecoins Were a Trojan Horse:** The speculative frenzy was a catalyst that massively accelerated DEX adoption and forced millions of users to finally learn how to use self-custody wallets and on-chain tools.
  2. **Prepare for Thousands of Stablecoins:** Every company with deposits will likely issue its own "branded money." The next major infrastructure battle will be building the interoperability layers—the "Visa for stablecoins"—to manage this fragmented liquidity.
  3. **The Real Stablecoin Opportunity is Global:** The next frontier isn't another USD competitor, but non-USD stablecoins tied to high-yield foreign currencies, which will unlock the creation of on-chain foreign exchange (FX) markets.
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