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AI Podcasts

December 17, 2025

Rethinking Pre-Training for Agentic AI [Aakanksha Chowdhery] - 759

The TWIML AI Podcast with Sam Charrington

AI
Key Takeaways:
  1. Strategic Implication: The next frontier in AI is agentic, and progress hinges on fundamental pre-training innovation, not just post-training optimizations.
  2. Builder/Investor Note: Focus on teams with deep experience in scaling and debugging large models, as this is a high-capital, high-risk endeavor. Builders should prioritize developing new benchmarks for agentic capabilities.
  3. The "So What?": The industry needs to move beyond next-token prediction and static benchmarks to unlock truly capable, self-correcting AI agents in the next 6-12 months.
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December 17, 2025

Code World Model: Building World Models for Computation – Jacob Kahn, FAIR Meta

AI Engineer

AI
Key Takeaways:
  1. Shift in AI Development: The focus moves from syntax-aware code generation to execution-aware reasoning, enabling more robust and intelligent code agents.
  2. Builder/Investor Note: Prioritize tools and platforms that support explicit execution modeling and highly asynchronous, high-throughput RL training for agentic systems.
  3. The "So What?": AI that can simulate complex systems internally will drastically reduce development and testing costs, accelerating innovation in software and distributed systems over the next 6-12 months.
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December 17, 2025

AI Kernel Generation: What's working, what's not, what's next – Natalie Serrino, Gimlet Labs

AI Engineer

AI
Key Takeaways:
  1. Strategic Shift: AI-driven kernel generation is not replacing human genius but augmenting it, allowing experts to focus on novel breakthroughs while AI automates the application of known optimizations across a complex hardware landscape.
  2. Builder/Investor Note: Focus on robust validation and hardware-in-the-loop systems. Claims of "AI inventing new algorithms" in this domain are premature. The real value is in automating the "bag of tricks" for heterogeneous compute.
  3. The "So What?": This technology is critical for scaling agentic AI workloads. Expect significant investment in tools that abstract hardware complexity and enable efficient, automated optimization, driving down the cost of AI inference in the next 6-12 months.
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December 18, 2025

AI Consulting in Practice – NLW, Super ai

AI Engineer

AI
Key Takeaways:
  1. The Agent Economy is Here: Enterprises are moving past pilots with AI agents. Builders should focus on orchestration layers and human-agent interaction design.
  2. ROI Measurement is the Next Frontier: Investors should look for solutions that help organizations accurately track and attribute AI value beyond traditional metrics.
  3. Strategic AI, Not Spot Solutions: The biggest wins come from systematic, cross-organizational AI strategies that target new capabilities and revenue growth, not just incremental time savings.
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December 18, 2025

How to build an AI native company (even if your company is 50 years old) – Dan Shipper, Every

AI Engineer

AI
Key Takeaways:
  1. The 100% AI adoption threshold is a step-function change, not incremental. Companies that commit fully will outpace those with partial integration.
  2. Builders should prioritize "compounding engineering" by codifying knowledge into reusable prompts. This builds an organizational memory that accelerates future development exponentially.
  3. Re-evaluate team structures and roles. Single engineers can own complex products, and even technical managers can contribute code, shifting how organizations operate.
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December 17, 2025

“How We Can Eliminate Crime” | Ben Horowitz and Garrett Langley

a16z

AI
Key Takeaways:
  1. Effective crime reduction requires a shift from reactive punishment to proactive, intelligence-driven deterrence, making it highly probable for criminals to be caught.
  2. The market for AI-powered public safety technology, particularly solutions that integrate data for precision and accountability, presents a significant opportunity. Public-private partnerships are a key funding mechanism.
  3. Over the next 6-12 months, expect to see more cities adopt advanced surveillance and AI tools, driven by private funding, as they seek to improve safety and address staffing shortages without resorting to ineffective, broad-stroke policies.
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December 18, 2025

Two Futures | Runtime 2025

a16z

AI
Key Takeaways:
  1. Strategic Implication: The next decade will be defined by who builds the core infrastructure for intelligence. This is where the most significant value and influence will accrue.
  2. Builder/Investor Note: Direct capital and talent towards foundational AI components—chips, models, and interoperable systems. Avoid the temptation to only build at the application layer.
  3. The So What?: The window for shaping the future of intelligence is now. Engage in the deepest, most complex challenges to secure a footprint in this new era.
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December 18, 2025

The EU and the not-so-simple macroeconomics of AI – Luis Garicano

Epoch AI

AI
Key Takeaways:
  1. Strategic Implication: The global AI race is a zero-sum game for foundational models. Europe's best strategy is a "smart second mover" approach, focusing on the implementation layer by ensuring interoperability and data portability.
  2. Builder/Investor Note: Invest in AI that achieves true autonomy and enhances expert productivity. Be wary of markets stifled by over-regulation, which can impede AI adoption and growth.
  3. The "So What?": Europe faces a critical juncture. Without embracing AI-driven growth, its demographic and debt problems will worsen, leading to higher interest rates without the corresponding economic expansion.
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December 18, 2025

SAM 3: The Eyes for AI — Nikhila & Pengchuan (Meta Superintelligence), ft. Joseph Nelson (Roboflow)

Latent Space

AI
Key Takeaways:
  1. Vision AI Democratization: SAM 3 lowers the barrier for sophisticated vision tasks, making advanced segmentation and tracking accessible for a wider range of applications.
  2. Builder/Investor Note: Focus on domain-specific adaptations and tooling that enhance human-AI interaction for ambiguous visual concepts. The "last mile" of user intent is a key differentiator.
  3. The "So What?": SAM 3 accelerates the development of multimodal AI, particularly in robotics and video analysis, by providing a robust, scalable visual foundation for the next generation of intelligent systems.
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Crypto Podcasts

June 13, 2025

Takeaways from the SEC Roundtable and Privy Acquisition | Weekly Roundup

Empire

Crypto
Key Takeaways:
  1. Regulatory Thaw: The SEC’s new leadership signals a more accommodating stance on crypto, potentially unlocking significant growth for DeFi in the US.
  2. Market Structure Evolution: Tokenization is increasingly viewed as the key to modernizing capital markets, with on-chain IPOs and improved secondary market liquidity on the horizon.
  3. Infrastructure is King: Acquisitions like Privy by Stripe highlight the race to build and control the foundational layers of the crypto economy, especially around wallets and stablecoins.
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June 13, 2025

Institutions Pour Billions into Crypto! Stripe’s Bold Move & Genius Act Explained

Bankless

Crypto
Key Takeaways:
  1. Institutional FOMO is Real: Bitcoin and Ethereum ETFs are magnets for capital, and Circle's IPO success signals massive pent-up demand.
  2. Regulation is Maturing: The Genius Act is poised to legitimize stablecoins, while the Clarity Act could reshape token classifications.
  3. Adoption Accelerates: Stripe's crypto acquisitions and Poly Market's X integration show crypto moving beyond niche use cases.
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June 13, 2025

Standard Chartered: The Bull Case For Solana | Geoff Kendrick

Lightspeed

Crypto
Key Takeaways:
  1. Solana's Next Act is Crucial: Current memecoin activity, while impressive, is viewed by institutions like Standard Chartered as less sustainable than diversified utility; a pivot to tokenized equities or social is key for long-term valuation.
  2. Perception Battles Performance: Ethereum's established "trustworthiness" gives it an institutional edge, even if Solana offers superior tech for certain applications. Solana must overcome its "memecoin" image to attract serious TradFi.
  3. Near-Term Headwinds for Solana Relative to Ethereum: Kendrick suggests Ethereum might outperform Solana in the near term (though both underperform Bitcoin) as Solana navigates its transition phase, while Ethereum benefits from incumbency in stablecoins and tokenized RWAs.
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June 12, 2025

The Digital Payment Race That Will Reshape the World

Forward Guidance

Crypto
Key Takeaways:
  1. **Currency Cold War:** A "currency conflict" is unfolding, with the winner set to define the financial backbone of the next-gen internet and global commerce.
  2. **Stablecoins vs. The State:** USD stablecoins are pitched as the West's best bet for the internet's future currency, directly competing with state-backed digital currencies like China's e-CNY.
  3. **Agent-Powered Internet:** The dream is an internet where AI agents, fueled by ultra-low-cost stablecoin transactions, manage our digital lives, moving incentives away from human attention.
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June 12, 2025

The Last Mile Problem For Stablecoins | Analyst Round Table

0xResearch

Crypto
Key Takeaways:
  1. **Solve Real Friction:** The "last-mile" challenge—seamlessly converting stablecoins to local cash in emerging markets—remains the critical bottleneck and prime opportunity for stablecoin protocols.
  2. **Moats are Real:** Overcoming established players like Tron requires more than just better tech or lower fees; it demands superior distribution and user migration strategies.
  3. **Align Incentives:** Morpho's structural changes offer a compelling model for aligning team, investor, and token holder interests, potentially setting a new standard for Web3 projects.
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June 12, 2025

Hivemind: Circle Valuation, Pump.Fun Token & What We’re Bullish

Empire

Crypto
Key Takeaways:
  1. Deficit Tailwinds: Persistent global fiscal deficits are expected to continue fueling appreciation in risk assets, including cryptocurrencies.
  2. Stablecoin Tsunami: Stablecoins are not just a crypto niche but a fundamental disruptor to the traditional banking system, with significant investment flowing into leaders like Circle, despite valuation concerns.
  3. App-Layer Alpha: Value is increasingly found in specific applications (like Pump.Fun) and companies leveraging crypto (like Galaxy Digital's AI/crypto blend), sometimes even diverting attention from base-layer L1 tokens.
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