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AI Podcasts

December 17, 2025

Rethinking Pre-Training for Agentic AI [Aakanksha Chowdhery] - 759

The TWIML AI Podcast with Sam Charrington

AI
Key Takeaways:
  1. Strategic Implication: The next frontier in AI is agentic, and progress hinges on fundamental pre-training innovation, not just post-training optimizations.
  2. Builder/Investor Note: Focus on teams with deep experience in scaling and debugging large models, as this is a high-capital, high-risk endeavor. Builders should prioritize developing new benchmarks for agentic capabilities.
  3. The "So What?": The industry needs to move beyond next-token prediction and static benchmarks to unlock truly capable, self-correcting AI agents in the next 6-12 months.
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December 17, 2025

Code World Model: Building World Models for Computation – Jacob Kahn, FAIR Meta

AI Engineer

AI
Key Takeaways:
  1. Shift in AI Development: The focus moves from syntax-aware code generation to execution-aware reasoning, enabling more robust and intelligent code agents.
  2. Builder/Investor Note: Prioritize tools and platforms that support explicit execution modeling and highly asynchronous, high-throughput RL training for agentic systems.
  3. The "So What?": AI that can simulate complex systems internally will drastically reduce development and testing costs, accelerating innovation in software and distributed systems over the next 6-12 months.
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December 17, 2025

AI Kernel Generation: What's working, what's not, what's next – Natalie Serrino, Gimlet Labs

AI Engineer

AI
Key Takeaways:
  1. Strategic Shift: AI-driven kernel generation is not replacing human genius but augmenting it, allowing experts to focus on novel breakthroughs while AI automates the application of known optimizations across a complex hardware landscape.
  2. Builder/Investor Note: Focus on robust validation and hardware-in-the-loop systems. Claims of "AI inventing new algorithms" in this domain are premature. The real value is in automating the "bag of tricks" for heterogeneous compute.
  3. The "So What?": This technology is critical for scaling agentic AI workloads. Expect significant investment in tools that abstract hardware complexity and enable efficient, automated optimization, driving down the cost of AI inference in the next 6-12 months.
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December 18, 2025

AI Consulting in Practice – NLW, Super ai

AI Engineer

AI
Key Takeaways:
  1. The Agent Economy is Here: Enterprises are moving past pilots with AI agents. Builders should focus on orchestration layers and human-agent interaction design.
  2. ROI Measurement is the Next Frontier: Investors should look for solutions that help organizations accurately track and attribute AI value beyond traditional metrics.
  3. Strategic AI, Not Spot Solutions: The biggest wins come from systematic, cross-organizational AI strategies that target new capabilities and revenue growth, not just incremental time savings.
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December 18, 2025

How to build an AI native company (even if your company is 50 years old) – Dan Shipper, Every

AI Engineer

AI
Key Takeaways:
  1. The 100% AI adoption threshold is a step-function change, not incremental. Companies that commit fully will outpace those with partial integration.
  2. Builders should prioritize "compounding engineering" by codifying knowledge into reusable prompts. This builds an organizational memory that accelerates future development exponentially.
  3. Re-evaluate team structures and roles. Single engineers can own complex products, and even technical managers can contribute code, shifting how organizations operate.
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December 17, 2025

“How We Can Eliminate Crime” | Ben Horowitz and Garrett Langley

a16z

AI
Key Takeaways:
  1. Effective crime reduction requires a shift from reactive punishment to proactive, intelligence-driven deterrence, making it highly probable for criminals to be caught.
  2. The market for AI-powered public safety technology, particularly solutions that integrate data for precision and accountability, presents a significant opportunity. Public-private partnerships are a key funding mechanism.
  3. Over the next 6-12 months, expect to see more cities adopt advanced surveillance and AI tools, driven by private funding, as they seek to improve safety and address staffing shortages without resorting to ineffective, broad-stroke policies.
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December 18, 2025

Two Futures | Runtime 2025

a16z

AI
Key Takeaways:
  1. Strategic Implication: The next decade will be defined by who builds the core infrastructure for intelligence. This is where the most significant value and influence will accrue.
  2. Builder/Investor Note: Direct capital and talent towards foundational AI components—chips, models, and interoperable systems. Avoid the temptation to only build at the application layer.
  3. The So What?: The window for shaping the future of intelligence is now. Engage in the deepest, most complex challenges to secure a footprint in this new era.
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December 18, 2025

The EU and the not-so-simple macroeconomics of AI – Luis Garicano

Epoch AI

AI
Key Takeaways:
  1. Strategic Implication: The global AI race is a zero-sum game for foundational models. Europe's best strategy is a "smart second mover" approach, focusing on the implementation layer by ensuring interoperability and data portability.
  2. Builder/Investor Note: Invest in AI that achieves true autonomy and enhances expert productivity. Be wary of markets stifled by over-regulation, which can impede AI adoption and growth.
  3. The "So What?": Europe faces a critical juncture. Without embracing AI-driven growth, its demographic and debt problems will worsen, leading to higher interest rates without the corresponding economic expansion.
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December 18, 2025

SAM 3: The Eyes for AI — Nikhila & Pengchuan (Meta Superintelligence), ft. Joseph Nelson (Roboflow)

Latent Space

AI
Key Takeaways:
  1. Vision AI Democratization: SAM 3 lowers the barrier for sophisticated vision tasks, making advanced segmentation and tracking accessible for a wider range of applications.
  2. Builder/Investor Note: Focus on domain-specific adaptations and tooling that enhance human-AI interaction for ambiguous visual concepts. The "last mile" of user intent is a key differentiator.
  3. The "So What?": SAM 3 accelerates the development of multimodal AI, particularly in robotics and video analysis, by providing a robust, scalable visual foundation for the next generation of intelligent systems.
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Crypto Podcasts

July 4, 2025

0xResearch Cross-Post: Crypto Regulation, Breakout Apps, and TradFi’s Impact | Jon Charbonneau

Bell Curve

Crypto
Key Takeaways:
  1. Go-to-Market > Tech Specs: In the race between new chains, attracting a single breakout app is more critical than marginal performance gains. Value accrues to whoever owns the user relationship.
  2. Bet on Improvable Niches: The biggest startup opportunities are in high-demand but clunky sectors like prediction markets and memecoin launchpads, where superior UX can create a dominant new player.
  3. Look Forward, Not Sideways: Don't get trapped by the "revenue meta." Successful investing requires a forward-looking view of a project’s potential to capture future value, a lesson exemplified by the early thesis for Solana.
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July 4, 2025

It’s A Bull Market But Not The One You Wanted With Rob Hadick & Santiago Santos | Weekly Roundup

Empire

Crypto
Key Takeaways:
  1. **The Real Bull Case is Boring.** The most significant trend isn't the next memecoin, but the "boring" migration of real-world finance onto blockchains via stablecoins. The winners will be those who solve for on-chain credit and build seamless user experiences, not just hype.
  2. **Tokenization is a Double-Edged Sword.** While providing access to new assets, current tokenized stocks are riddled with counterparty risk, thin liquidity, and opaque structures. They are a step forward but risk backfiring if not communicated with radical transparency.
  3. **The Altcoin Shakeout is Here.** Institutional interest is hyper-focused, leaving most altcoins without a bid. Protocols must now justify their existence with real revenue and utility, as the era of "liquidity-as-a-product" is over.
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July 4, 2025

Robinhood's Announcement Sets off Stock Tokens Frenzy (Weekly Crypto News)

Bankless

Crypto
Key Takeaways:
  1. Tokenized Stocks Are Here, But Imperfect. Major players are live, but the current products are IOUs, not direct equity. The real test will be liquidity, price tracking, and regulatory endurance.
  2. Tom Lee Is Creating the "MicroStrategy for ETH." He's pitching ETH to Wall Street not on decentralist ideals, but as the indispensable settlement layer for the coming stablecoin boom, front-running demand from major banks.
  3. The US Is Pumping Crypto Bags. A massive deficit bill combined with an expected dovish Fed creates a perfect storm for liquidity, positioning assets like BTC and ETH as a necessary hedge against currency debasement.
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July 4, 2025

All Roads Lead To Debasement | Weekly Roundup

Forward Guidance

Crypto
Key Takeaways:
  1. All Roads Lead to Debasement: Both political parties are now committed to a policy of fiscal dominance and financial repression. The goal is to inflate away the debt, which makes holding cash and traditional bonds a losing proposition.
  2. Get Out on the Risk Frontier: The only rational response is to move capital into assets that can benefit from currency debasement and a manufactured asset boom. This means frontier tech, crypto, and other high-growth, high-risk assets.
  3. The Social Contract is Breaking: These policies will blatantly exacerbate wealth inequality, fueling populist anger. The system is no longer a free market but a manipulated game, and the backlash will define the political landscape for the next decade.
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July 4, 2025

0xResearch - Crypto Treasury Mania, Stocks Onchain, and Crypto Venture | July 3rd, 2025

0xResearch

Crypto
Key Takeaways:
  1. **The Great Bifurcation:** Capital is rotating out of altcoins and into two main buckets: Bitcoin (channeled through treasury companies) and crypto-adjacent equities (COIN, HOOD). Don't mistake isolated pumps for a broad "alt season."
  2. **Synthetics are the New Speculation:** The next wave of on-chain gambling will be on synthetic versions of real-world assets, from private company shares to public stocks, providing exposure without the complexity of ownership.
  3. **Apps Over Chains:** The most valuable real estate in crypto is no longer the base layer but the application layer. Companies that build sticky, revenue-generating products with great UX—even if they just clip fees—are winning.
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July 3, 2025

Robinhood vs. Coinbase: The Trillion Dollar Race to Build the Financial Super App

Bankless

Crypto
Key Takeaways:
  1. **Bet on a Thesis:** Coinbase is a pure-play bet on the entire global economy moving on-chain, positioning itself as the essential B2B infrastructure provider.
  2. **Follow the Money:** Robinhood is a bet on demographics, strategically positioning itself to capture the next generation's financial life and inherit trillions in the great wealth transfer.
  3. **The Next Frontier is On-Chain:** The new battleground is Layer 2. Coinbase’s established Base ecosystem will face a formidable challenge from Robinhood Chain, with tokenized stocks as the initial prize.
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