AI Forces a Moral Reboot. The emergence of superintelligence renders our current societal goals dangerously obsolete. Survival must become the new prime directive.
Existence is a Team Sport. The "Don't Die" philosophy is a collective mission ("we don't die") to ensure species-wide survival, not a selfish quest for individual immortality.
Prepare for the Biological Sandbox. Humanity is moving from manipulating physical atoms and digital bits to programming our own biology—a frontier with both unimaginable potential and catastrophic risk.
Stop Trying to “Steer” AGI. The control paradigm is a dead end. The goal isn’t a more obedient tool; it’s a trustworthy teammate. We must shift from engineering control to cultivating care.
Alignment is a Process, Not a Product. True alignment isn't a fixed set of rules. It’s a dynamic process of moral learning, akin to raising a child. AIs that only follow rules are brittle and dangerous.
Build for Cooperation, Not Command. The technical path forward involves training AIs in rich, multi-agent environments where they must learn cooperation and theory of mind—the foundational skills for becoming a good member of a group.
US Leads in Capital-Intensive Frontier AI; China Excels at Industrial Diffusion. The US leverages deep capital markets for its massive compute buildout and AGI research, while China uses state direction to embed AI into its vast industrial base via open-source models and hardware.
Market Structure Dictates AI Strategy. The US "efficient oligopoly" model prioritizes global dominance and profit reinvestment by a few players. China's "subjugated swarm" model creates intense domestic competition, driving down prices and accelerating adoption at the cost of profitability.
Geopolitical Tension May Be a Necessary Stabilizer. The competition between the US's freedom-oriented, frontier-pushing approach and China's stability-focused, diffusion-driven model creates a complementary tension that could be essential for navigating the "narrow corridor" between AI-driven totalitarianism and uncontrollable chaos.
Development timelines are collapsing from months to days. AI allows developers to swap entire asset libraries or generate new game concepts at unprecedented speed, turning a two-month art project into a day's work.
The lifespan of any single game is shrinking. Prepare for a world of disposable entertainment. As AI floods the market with content, the strategy will pivot from creating one long-lasting hit to deploying a rapid succession of engaging experiences.
Games are the next evolution of the attention economy. Just as memes became a core tool for community-building around tokens, easily created games will be the next engine for capturing and directing user attention in a hyper-competitive digital world.
Adopt a Stock Picker's Mentality. The crypto market is no longer a monolith where a rising tide lifts all boats. Focus on assets with real products, user growth, and cash flow, as the gap between winners and losers will only widen.
Shorting is a Tactical Assault, Not a Siege. Don't "invest" in a short. The only viable short strategies are tactical, targeting specific events like VC unlocks or news-driven spikes. Otherwise, even "total scams" can 5x against you.
Cultivate a Goldfish's Memory. The most critical trading skill is learning how to change your mind. Cut losing trades, forget the loss (but remember the lesson), and redeploy capital without emotional baggage. Stubbornness is a portfolio killer.
Word-of-mouth isn't a feature; it's the engine. Before spending a dime on marketing, obsess over the first 30 seconds of the user experience until people can't help but share it.
Being different is better than being better. Don't build incrementally better slideware. Redefine the core primitives of your category, as Gamma did by moving beyond the 16x9 slide.
Hire painfully slowly to protect your DNA. Resisting the temptation to scale headcount with user growth is a superpower. The goal isn't to hit a hiring target; it's to hire the best people.
AGI Is a Definitional Debate. Progress toward an AI that can replace a remote worker is happening fast. However, achieving "true" human-like learning efficiency may require an entirely new paradigm beyond scaling current LLMs.
The New Creator Economy Is Code. AI is turning software development into a mainstream creative pursuit, empowering a new class of solo entrepreneurs who can build what previously required entire teams.
Incumbents Learned Their Lesson. Unlike past tech shifts, today's giants are aggressively adopting AI, making it both a sustaining *and* disruptive force. The market is large enough for both incumbents and startups to create massive value.
Build the Tools, Not Just the House: CZI’s greatest leverage comes from creating open-source tools and datasets. By building the fundamental infrastructure, they empower the entire scientific community—from academic labs to startups—to accelerate discovery.
Data Is the New Microscope: The future of biology hinges on a tight feedback loop between generating novel, purpose-built datasets and training domain-specific AI models on them. This synergy is unlocking insights that were previously impossible.
Virtual Biology Is the Next Frontier: Simulating biology computationally with "virtual cells" will become the new standard for research, enabling scientists to test riskier hypotheses faster and cheaper, dramatically compressing the timeline for major breakthroughs.
The Interface is the Bottleneck. Today's chatbots are the MS-DOS of AI. The next trillion dollars of value will be unlocked not by the models themselves, but by the new "Windows/Mac OS" interface that makes AI accessible and useful for everyone.
Every Creator Will Build Software. The distinction between a content creator and a software developer is collapsing. The next platforms will empower anyone to build mini-apps, turning software into a new medium for community, expression, and monetization.
Ditch the Voice-Only Dream. The Her-inspired fantasy of a screenless, voice-only AI future is a dead end. The winning AI device will be screen-first, built around an AI-native OS that makes software deeply personal and context-aware.
PMF is the Real Boss: Forget the regulatory FUD; crypto's primary challenge now is the age-old startup struggle – building things people actually need and use.
Solana's Pragmatic Pull: The ecosystem's intense focus on PMF over ideological purity is attracting founders eager to build real markets and applications.
Show Me the Revenue (or Sticky Users): True PMF often translates to tangible results like revenue (Pump.fun, Jito) or deeply embedded usage (Bitcoin, potentially Aave), separating signal from noise.
**Trust, But Verify Rigorously:** Assume data discrepancies exist; stated figures and dashboard metrics demand independent on-chain verification.
**Standardize or Suffer:** The lack of "Crypto GAAP" hinders meaningful comparison and valuation; clear definitions and reporting cadence are essential.
**Make On-Chain Data Truly Accessible:** Transparency requires more than just public ledgers; it needs standardized, verifiable, and easily accessible reporting directly from protocols.
Stablecoins exploit bank inefficiency: They offer a direct route to bypass ~10% cross-border banking fees, meeting real demand.
Dollar desire drives adoption: In high-inflation countries, stablecoins provide crucial access to the US dollar and dollar-priced goods.
Currency consolidation favors majors: Geopolitical shifts may shrink the currency landscape, potentially strengthening the role of major currencies and their stablecoin counterparts (USD, EUR, RMB).
Brace for Trade War Impact: The economic fallout from tariffs and uncertainty is likely underestimated and poses significant downside risk to US equities and global growth.
Demand Crypto Transparency: The lack of clear disclosure rules around token holdings and sales remains a critical vulnerability; solutions are needed, potentially driven by major exchanges or self-regulatory efforts.
AI Value Shifts to Apps: Foundational models risk commoditization; long-term defensibility for AI startups hinges on building strong distribution and network effects on the application layer, potentially by remaining model-agnostic.
**Market Bifurcation:** Expect continued divergence – select assets might surge on squeezed supply, but most face headwinds without new buyers. Stay nimble.
**Efficiency is King:** Capital is scarcer. Projects must prove lean operations and clear value accrual compared to TradFi alternatives to win funding.
**Transparency Unlocks Capital:** Don't wait for regulation. Proactive, standardized disclosure of financials, token flows, and operations will attract sophisticated investors and build desperately needed trust.
Efficiency is King: Protocols proving lean operations and clear value capture relative to TradTech will win scarce venture dollars.
Disclose to Win: Transparency isn't optional; protocols providing clear, standardized data and disclosures will attract serious capital.
Stablecoins Aren't Monolithic: Understand the nuances – payment vs. yield, US vs. global demand, issuer vs. infrastructure vs. enabled business – to capitalize on their growth.
