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AI Podcasts

December 17, 2025

Rethinking Pre-Training for Agentic AI [Aakanksha Chowdhery] - 759

The TWIML AI Podcast with Sam Charrington

AI
Key Takeaways:
  1. Strategic Implication: The next frontier in AI is agentic, and progress hinges on fundamental pre-training innovation, not just post-training optimizations.
  2. Builder/Investor Note: Focus on teams with deep experience in scaling and debugging large models, as this is a high-capital, high-risk endeavor. Builders should prioritize developing new benchmarks for agentic capabilities.
  3. The "So What?": The industry needs to move beyond next-token prediction and static benchmarks to unlock truly capable, self-correcting AI agents in the next 6-12 months.
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December 17, 2025

Code World Model: Building World Models for Computation – Jacob Kahn, FAIR Meta

AI Engineer

AI
Key Takeaways:
  1. Shift in AI Development: The focus moves from syntax-aware code generation to execution-aware reasoning, enabling more robust and intelligent code agents.
  2. Builder/Investor Note: Prioritize tools and platforms that support explicit execution modeling and highly asynchronous, high-throughput RL training for agentic systems.
  3. The "So What?": AI that can simulate complex systems internally will drastically reduce development and testing costs, accelerating innovation in software and distributed systems over the next 6-12 months.
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December 17, 2025

AI Kernel Generation: What's working, what's not, what's next – Natalie Serrino, Gimlet Labs

AI Engineer

AI
Key Takeaways:
  1. Strategic Shift: AI-driven kernel generation is not replacing human genius but augmenting it, allowing experts to focus on novel breakthroughs while AI automates the application of known optimizations across a complex hardware landscape.
  2. Builder/Investor Note: Focus on robust validation and hardware-in-the-loop systems. Claims of "AI inventing new algorithms" in this domain are premature. The real value is in automating the "bag of tricks" for heterogeneous compute.
  3. The "So What?": This technology is critical for scaling agentic AI workloads. Expect significant investment in tools that abstract hardware complexity and enable efficient, automated optimization, driving down the cost of AI inference in the next 6-12 months.
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December 18, 2025

AI Consulting in Practice – NLW, Super ai

AI Engineer

AI
Key Takeaways:
  1. The Agent Economy is Here: Enterprises are moving past pilots with AI agents. Builders should focus on orchestration layers and human-agent interaction design.
  2. ROI Measurement is the Next Frontier: Investors should look for solutions that help organizations accurately track and attribute AI value beyond traditional metrics.
  3. Strategic AI, Not Spot Solutions: The biggest wins come from systematic, cross-organizational AI strategies that target new capabilities and revenue growth, not just incremental time savings.
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December 18, 2025

How to build an AI native company (even if your company is 50 years old) – Dan Shipper, Every

AI Engineer

AI
Key Takeaways:
  1. The 100% AI adoption threshold is a step-function change, not incremental. Companies that commit fully will outpace those with partial integration.
  2. Builders should prioritize "compounding engineering" by codifying knowledge into reusable prompts. This builds an organizational memory that accelerates future development exponentially.
  3. Re-evaluate team structures and roles. Single engineers can own complex products, and even technical managers can contribute code, shifting how organizations operate.
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December 17, 2025

“How We Can Eliminate Crime” | Ben Horowitz and Garrett Langley

a16z

AI
Key Takeaways:
  1. Effective crime reduction requires a shift from reactive punishment to proactive, intelligence-driven deterrence, making it highly probable for criminals to be caught.
  2. The market for AI-powered public safety technology, particularly solutions that integrate data for precision and accountability, presents a significant opportunity. Public-private partnerships are a key funding mechanism.
  3. Over the next 6-12 months, expect to see more cities adopt advanced surveillance and AI tools, driven by private funding, as they seek to improve safety and address staffing shortages without resorting to ineffective, broad-stroke policies.
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December 18, 2025

Two Futures | Runtime 2025

a16z

AI
Key Takeaways:
  1. Strategic Implication: The next decade will be defined by who builds the core infrastructure for intelligence. This is where the most significant value and influence will accrue.
  2. Builder/Investor Note: Direct capital and talent towards foundational AI components—chips, models, and interoperable systems. Avoid the temptation to only build at the application layer.
  3. The So What?: The window for shaping the future of intelligence is now. Engage in the deepest, most complex challenges to secure a footprint in this new era.
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December 18, 2025

The EU and the not-so-simple macroeconomics of AI – Luis Garicano

Epoch AI

AI
Key Takeaways:
  1. Strategic Implication: The global AI race is a zero-sum game for foundational models. Europe's best strategy is a "smart second mover" approach, focusing on the implementation layer by ensuring interoperability and data portability.
  2. Builder/Investor Note: Invest in AI that achieves true autonomy and enhances expert productivity. Be wary of markets stifled by over-regulation, which can impede AI adoption and growth.
  3. The "So What?": Europe faces a critical juncture. Without embracing AI-driven growth, its demographic and debt problems will worsen, leading to higher interest rates without the corresponding economic expansion.
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December 18, 2025

SAM 3: The Eyes for AI — Nikhila & Pengchuan (Meta Superintelligence), ft. Joseph Nelson (Roboflow)

Latent Space

AI
Key Takeaways:
  1. Vision AI Democratization: SAM 3 lowers the barrier for sophisticated vision tasks, making advanced segmentation and tracking accessible for a wider range of applications.
  2. Builder/Investor Note: Focus on domain-specific adaptations and tooling that enhance human-AI interaction for ambiguous visual concepts. The "last mile" of user intent is a key differentiator.
  3. The "So What?": SAM 3 accelerates the development of multimodal AI, particularly in robotics and video analysis, by providing a robust, scalable visual foundation for the next generation of intelligent systems.
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Crypto Podcasts

June 10, 2025

Crypto's Fastest Payments App, Only Possible On Solana | Ted Livingston

Lightspeed

Crypto
Key Takeaways:
  1. Flipcash is betting that a hyper-fast, intuitive "digital cash" experience, leveraging Solana's speed and a novel L2, can carve out a unique niche in the crowded payments landscape.
  2. The shift to USDC and a clever onboarding mechanism (pay for account, get instant credit) aims to overcome common crypto adoption hurdles related to volatility and empty wallets.
  3. Solana's Speed is a Moat: Flipcash's core "instant cash" UX is explicitly tied to Solana's performance, highlighting the chain's capability for consumer-facing applications demanding high speed.
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June 10, 2025

Bits + Bips LIVE - June 9th, 2025

Unchained

Crypto
Key Takeaways:
  1. Political Winds Shift Crypto Sails: The Trump-Musk fallout underscores the urgency for clear crypto legislation, as policy can be derailed by high-level discord.
  2. Stablecoin Showdown Looms: Circle's hot IPO masks a fiercely competitive future where big banks could disrupt incumbents by leveraging distribution and offering yield.
  3. Q4 Top Signal? The flurry of crypto IPOs (Circle, potentially Gemini, Kraken) and soaring Bitcoin treasury adoption might signal a market peak approaching in Q4 2025 or Q1 2026.
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June 9, 2025

Why We Are Bullish

1000x Podcast

Crypto
Key Takeaways:
  1. Bitcoin is king: Expect Bitcoin to outperform traditional assets significantly; avoid fumbling this generational chance through common investor errors.
  2. Evolve your strategy: The game has shifted from infrastructure hype and rapid trading to identifying and holding quality applications and tokens like Hyperliquid or Syrup with longer horizons.
  3. Appetite meets fundamentals: While hype can drive initial pumps (e.g., Circle IPO), sustainable value lies in strong business models (Tether's organic growth) and clear token utility.
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June 9, 2025

How Venture Is Navigating Crypto IPOs

Empire

Crypto
Key Takeaways:
  1. **IPO Appetite is Real (for Some):** Public markets are hungry for crypto, but primarily for clear narratives like stablecoins (see: Circle); broader adoption requires substantial revenue.
  2. **VCs Get Flexible:** The smart money is adapting, ready to pounce on equity or tokens, depending on where the value (and exit) lies.
  3. **On-Chain IPOs - The Next Speculative Playground?:** Imagine a world where early-stage crypto companies list on-chain, offering a more productive outlet for speculative capital than today's memecoin casino.
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June 9, 2025

Is Joe Lubin the Michael Saylor of Ethereum?

Bankless

Crypto
Key Takeaways:
  1. Regulatory Renaissance: The SEC's stance has softened, creating a more favorable U.S. environment for crypto; Ether's non-security status (for the scope of the past investigation) is a major win.
  2. Ether as a Productive Treasury Asset: ESBET's strategy of acquiring and actively yielding Ether could set a new standard for corporate treasuries, showcasing Ether's utility beyond just holding.
  3. The "Trust Commodity" Narrative: Expect a strong push to frame Ether's value around its ability to provide programmable trust and facilitate economic activity, with Lubin championing this.
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June 6, 2025

Could Crypto Treasury Companies Create Systemic Risk for the Industry?

Unchained

Crypto
Key Takeaways:
  1. High Premiums are a Red Flag: The massive premiums (some at 80x NAV) on many new crypto treasury stocks are likely unsustainable and warrant extreme investor caution.
  2. Collateralization is the Catalyst: The primary systemic risk emerges if these shares become widely accepted as collateral, creating a leveraged ecosystem vulnerable to market shocks.
  3. History as a Guide: The industry must heed the lessons from GBTC's collapse to prevent irresponsible risk-taking and a potential repeat of cascading failures.
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