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AI Podcasts

May 30, 2025

SN17 - 404GEN :: Decentralized AI generated 3D assets

Opentensor Foundation

AI
Key Takeaways:
  1. Unlocking Creative Potential: 404GEN radically lowers barriers to 3D content creation, enabling faster iteration and new forms of interactive media previously unfeasible for smaller teams or individuals.
  2. Gaussian Splats are Ascendant: This representation is emerging as a powerful alternative for 3D AI, and 404GEN is at the forefront of its practical application and tooling.
  3. BitTensor's Competitive Edge Shines: The subnet's rapid quality improvement and the innovative ELO validation system highlight BitTensor's power to incentivize and coordinate decentralized intelligence towards state-of-the-art results.
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May 30, 2025

Hey Tech, Come to Healthcare

a16z

AI
Key Takeaways:
  1. **Build for Behavior Change:** The biggest wins will come from engaging consumers and enabling sustainable health behaviors, an area where tech excels.
  2. **AI is the Leapfrog:** Healthcare can jump directly to AI-driven solutions, bypassing clunky legacy software, especially for service-oriented tasks.
  3. **The Trillion-Dollar Prize is Real:** Whether through full-stack "payvider" models or horizontal platforms, the path to becoming the world's largest company runs through transforming the consumer healthcare experience.
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May 29, 2025

Building a DePIN-powered Shazam for Media with Rumi | Niko Cunningham and Mateusz Poreda

Proof of Coverage Media

AI
Key Takeaways:
  1. **Decentralized Analytics:** Rumi’s DePIN model democratizes media intelligence, offering far richer and more granular data than traditional players like Nielsen.
  2. **Context is King:** The "Shazam for media" capability will fuel a new generation of AI agents and interactive experiences, making media deeply engaging.
  3. **Investor Signal:** The $5M pre-seed (EV3, A16Z CSX) and early traction with industry players like Tivision validate Rumi's approach and market potential.
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May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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May 26, 2025

Chatbot platforms might replace social media

Machine Learning Street Talk

AI
Key Takeaways:
  1. AI Companionship is Exploding: Millions are already deeply engaged with AI for emotional connection, and this is just the beginning as technology like GPT-4o normalizes it.
  2. Lean Engineering Can Win: Chai's success with a tiny, hyper-talented team and innovative techniques like model blending proves that massive VC-backed operations aren't the only path to scale in AI.
  3. The Next Social Platform Might Be AI: As AI offers more active, personalized, and consequence-free social interaction, it could very well become the dominant way people connect, potentially supplanting traditional social media.
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Crypto Podcasts

April 29, 2025

Should VCs Benchmark Against Bitcoin? | Jon Charbonneau

0xResearch

Crypto
Key Takeaways:
  1. Don't Benchmark VCs Against Bitcoin: It's comparing different asset classes with separate goals and risk profiles.
  2. Use Altcoin Baskets Instead: A weighted average of major altcoins (ETH, SOL, etc.) offers a more relevant performance yardstick for crypto VCs.
  3. Know Your Exposure: LPs seeking Bitcoin returns should buy Bitcoin directly; VC funds offer exposure to the venture-style growth potential of crypto beyond Bitcoin.
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April 29, 2025

Why BlackRock Is Bullish On Tokenization

Empire

Crypto
Key Takeaways:
  1. Tokenization is Strategic: BlackRock sees tokenizing assets as fundamental to improving market access and efficiency, dedicating significant focus to this path.
  2. Bridging is Key: Practical solutions like ETPs and tokenized funds are crucial tools BlackRock is deploying to connect TradFi users and crypto-native institutions.
  3. Transition Takes Time: The shift to tokenized markets will be gradual, requiring careful management of legacy systems and ensuring interoperability is maintained.
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April 29, 2025

Would you take Bitcoin over 5 years or random altcoins?

The Gwart Show

Crypto
Key Takeaways:
  1. Altcoin Asymmetry: Lower-cap altcoins offer higher potential percentage gains (3-4x) with less required capital inflow compared to Bitcoin.
  2. Bitcoin's Gravity: Bitcoin's massive size makes large multiple gains (like 3x) significantly harder, requiring vast capital injections.
  3. Liquidity is King: Your bet hinges on future macro conditions; high liquidity environments tend to disproportionately benefit riskier, less liquid altcoins.
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April 29, 2025

Bits + Bips Live: Crypto, Macro, Tariffs, Stablecoins, and More

Unchained

Crypto
Key Takeaways:
  1. **The Trump Put is Real:** Market reactions demonstrably curb aggressive tariff policies; expect continued volatility but likely avoidance of worst-case tariff scenarios as Trump needs stable markets.
  2. **Bitcoin Treasury Flywheel Spins Faster:** Expect more MicroStrategy clones globally, leveraging debt and equity markets to acquire Bitcoin. Monitor NAV premiums closely – their collapse is the model's Achilles' heel.
  3. **Bitcoin's Narrative Strengthens:** Bitcoin's recent decoupling and resilience amid macro turmoil bolsters its digital gold thesis, attracting attention even from skeptics, while altcoins struggle to keep pace this cycle.
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April 28, 2025

Bitcoin’s Macro Status, Ethereum’s Cultural Reset, and Solana’s Growth Risk | Jon Charbonneau

0xResearch

Crypto
Key Takeaways:
  1. Bitcoin Stands Alone: Recognized globally, Bitcoin operates in its own macro league, detached from altcoin tech narratives.
  2. Ethereum's Redemption Arc?: A pivot to user needs and L1 scaling is underway, but Ethereum must deliver concrete performance upgrades to compete effectively.
  3. Execution is King: Solana leads the speed race but faces valuation/fee risks. The future favors chains offering the best, most sovereign execution environment, with modular plays like Celestia betting on a hyper-scaled world.
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April 28, 2025

BlackRock's Crypto Strategy In 2025 With Samara Cohen

Empire

Crypto
Key Takeaways:
  1. IBIT's Success Validates the Bridge: The Bitcoin ETP proved massive latent demand exists for accessing crypto via familiar, regulated wrappers, bringing many new investors into the fold.
  2. Tokenization Targets Infrastructure First: Forget tokenizing illiquid JPEGs (for now); the real institutional action is using blockchains to fix inefficient TradFi plumbing, starting with cash and collateral.
  3. Data & Standards are The Next Hurdle: Broader institutional adoption beyond Bitcoin requires solving the crypto data, standards, and valuation puzzle to enable reliable analysis and indexing.
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