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AI Podcasts

February 12, 2026

🔬Generating Molecules, Not Just Models

Latent Space

AI
Key Takeaways:
  1. The field is moving from predicting existing biological structures to generating novel ones, driven by open-source AI models. This transforms biology from an observational science into a design-first engineering discipline, where computational power and accessible tools dictate the pace of innovation.
  2. Invest in platforms that abstract away the computational complexity of molecular design, offering robust, validated generative AI tools and scalable infrastructure. This allows scientists to focus on therapeutic hypotheses, not GPU management, accelerating time to experimental validation.
  3. The next wave of biological breakthroughs will come from those who can rapidly iterate on designed molecules, not just discovered ones. Access to powerful, user-friendly generative AI platforms like Boltz Lab will be a critical differentiator for biotech and pharma in the near future.
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February 12, 2026

Owning the AI Pareto Frontier — Jeff Dean

Latent Space

AI
Key Takeaways:
  1. Prioritize low-latency, multi-turn interaction models for agentic workflows. Invest in prompt engineering as a core skill, treating it as advanced executive communication to precisely guide AI agents.
  2. The AI industry is moving beyond raw model size as the sole metric of progress. The true frontier is now defined by the efficiency of capability delivery—how quickly, affordably, and contextually a model can perform complex tasks for a user, driven by hardware-software co-design and intelligent data management.
  3. The next 6-12 months will see a bifurcation in AI development: hyper-specialized, low-latency "flash" models for ubiquitous, agent-driven tasks, and ultra-capable "pro" models for deep reasoning, with hardware co-design and multimodal data integration being the key differentiators for sustained competitive advantage.
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February 11, 2026

Inside The Life of Silicon Valley's First Athlete Investor | Magic Johnson

a16z

AI
Key Takeaways:
  1. The shift from transactional endorsements to equity-driven ownership for public figures is accelerating, driven by soaring asset valuations in sports and entertainment, and amplified by new tech that allows for more direct brand building and value creation. This means the "celebrity investor" is no longer a novelty but a strategic force, demanding a different approach to deal flow and value add.
  2. Cultivate a diverse, expert team that can challenge your assumptions and vet opportunities, especially in unfamiliar sectors. Prioritize long-term equity plays over short-term cash, and actively seek out "boring" businesses with consistent growth potential, as these often hide outsized returns.
  3. The future of wealth creation for founders and investors lies in understanding that relationships are capital, equity is king, and a "win-at-all-costs" mentality must extend beyond your core expertise into every business venture. Position yourself to identify and participate in deals that leverage both established industries (like sports) and emerging tech (like AI), recognizing that early entry and strategic partnerships are paramount for exponential growth.
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February 11, 2026

Inside The Life of Silicon Valley's First Athlete Investor | Magic Johnson

a16z

AI
Key Takeaways:
  1. The athlete-investor archetype, pioneered by Magic Johnson, signals a broader trend where personal brand and strategic capital disrupt traditional investment. This shift is accelerated by AI and blockchain, enabling individuals to build billion-dollar enterprises.
  2. Cultivate a "give-first" network by consistently adding value to relationships. Attend industry events early to maximize quality time with key decision-makers.
  3. Long-term wealth creation hinges on disciplined equity ownership, investing in "boring" but essential sectors, and assembling an expert team. This framework is crucial for navigating tech opportunities over the next 6-12 months.
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February 11, 2026

Inside The Life of Silicon Valley's First Athlete Investor | Magic Johnson

a16z

AI
Key Takeaways:
  1. The era of celebrity endorsements is giving way to direct equity ownership and entrepreneurial ventures, as high-profile individuals increasingly seek to build lasting business empires rather than just collect checks. This trend is amplified by new technologies like AI, which lower the barrier to entry for creating and scaling businesses.
  2. Cultivate a powerful network by consistently showing up early to meetings and prioritizing long-term relationships over immediate transactions. Actively seek out "boring" businesses or underserved markets with high demand, as these often yield consistent, outsized returns.
  3. Success in the next 6-12 months hinges on a "win-first" mentality, strategic team building, and a willingness to invest capital into core value drivers. Embrace partnerships and leverage your unique "added value" beyond just capital to secure the best deals and accelerate growth in a rapidly evolving tech and business landscape.
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February 11, 2026

Inside The Life of Silicon Valley's First Athlete Investor | Magic Johnson

a16z

AI
Key Takeaways:
  1. The Macro Shift: Celebrity capital is moving from transactional endorsements to strategic equity ownership, mirroring a broader trend where individuals, powered by AI and blockchain tools, can build high-value companies with leaner teams, making strategic capital more impactful than ever.
  2. The Tactical Edge: Cultivate a network of mentors and partners, prioritize equity in "boring" but high-demand sectors, and be prepared to invest significant capital into improving core product and customer experience.
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February 11, 2026

Inside The Life of Silicon Valley's First Athlete Investor | Magic Johnson

a16z

AI
Key Takeaways:
  1. The era of celebrity endorsements is giving way to a new reality where personal brand power is directly converted into equity ownership and enterprise building, accelerated by accessible tech like AI for rapid business creation.
  2. Cultivate a diverse network through consistent, intentional engagement, and prioritize investments in demand-driven, "boring" businesses that offer long-term growth and opportunities for strategic value addition.
  3. Success in the next decade demands a "win-at-all-costs" mindset, a willingness to invest in operational excellence (including AI and analytics), and a strategic shift from short-term gains to long-term equity and partnership.
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February 11, 2026

Inside The Life of Silicon Valley's First Athlete Investor | Magic Johnson

a16z

AI
Key Takeaways:
  1. Cultivate a diverse, long-term network, prioritizing relationships.
  2. Seek "boring" businesses in high-demand, underserved markets, and invest in customer experience and product quality.
  3. Future wealth creation for builders and investors demands a long-term, value-add mindset, leveraging partnerships and foundational improvements, not fleeting trends.
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February 11, 2026

The Autonomous Driving Race Is Already Over w/ Kyle Reidhead

Milk Road AI

AI
Key Takeaways:
  1. AI-driven automation and deflationary economics are converging with Tesla's proprietary neural networks and vast real-world data. This creates an unassailable moat in autonomous transportation and labor.
  2. Monitor upcoming regulatory approvals for unsupervised FSD in key US states. This event will trigger the rollout of Tesla's robo-taxi network, fundamentally altering vehicle economics.
  3. Tesla is not just a car company; it is a foundational AI and robotics platform. Its FSD and robo-taxi network, combined with the broader Musk ecosystem, position it to capture a multi-trillion dollar market in autonomous services and labor, driving massive deflation and investor upside over the next decade.
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Crypto Podcasts

May 19, 2025

Logan Allen: Nockchain's Global Competition for Useful ZK Proof of Work Miners Kicks Off

Delphi Digital

Crypto
Key Takeaways:
  1. ZKPoW is a Novel Force: Nockchain's ZK Proof of Work directly builds valuable ZK proving capacity, turning mining into a productive, network-enhancing activity.
  2. Hardware Revolution Looms: The mining competition will drive innovation in ZK-specific hardware (FPGAs, ASICs for polynomial math), creating a new hardware market distinct from Bitcoin's.
  3. Intent-Driven Future: Nockchain's architecture points towards a future of composable "micro-apps" and verifiable services, where on-chain logic focuses on proof verification, potentially enabling new decentralized AI/ML applications and "computational commodities."
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May 18, 2025

Weimar America: The Inflation Spiral Has Begun

Forward Guidance

Crypto
Key Takeaways:
  1. **Fiscal Dominance is Here:** Government spending, not just Fed policy, is the primary driver of the current inflationary pressures and will likely lead to an 8% GDP deficit.
  2. **Prepare for Intervention:** Expect capital controls (like remittance taxes) and yield curve control as governments grapple with the consequences of their spending.
  3. **Store-of-Value is King:** In an environment where traditional savings (e.g., 4% on bonds) can't match 15% inflation in essential costs, assets like tech stocks and Bitcoin become non-negotiable for wealth preservation.
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May 17, 2025

The Fiscal Spiral Has No Off Switch | Weekly Roundup

Forward Guidance

Crypto
Key Takeaways:
  1. Fiscal Doom Loop: The US is locked in a fiscal spiral of growing deficits and debt that it seems unwilling or unable to escape, making dollar debasement a significant long-term risk.
  2. Macro is King: Geopolitical trends, capital flows, and policy decisions (like buybacks and potential yield curve control) are now more critical drivers of asset prices than individual company fundamentals.
  3. Bitcoin's Ascent: In a world of "Ponzi schemes," Bitcoin stands out as a rational hedge and potentially the "generational trade" against failing monetary and fiscal policies.
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May 16, 2025

The Next Phase of the Bull Market | Weekly Roundup

Empire

Crypto
Key Takeaways:
  1. **Memecoin Rebound Signals Risk-On:** The sharp recovery in memecoins highlights the market's speculative appetite; treat them as high-octane, ecosystem-specific bets.
  2. **Strategic M&A is Reshaping Access:** Companies are buying their way into regulated markets and building out institutional-grade services, with "Crypto as a Service" set to grow.
  3. **Institutional Rails Getting Stronger:** Coinbase’s S&P 500 debut and EToro’s IPO are landmark events, cementing crypto's place in mainstream finance and improving market transparency.
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May 16, 2025

Markets Are EXPLODING - Here’s Why! ETH Surge, U.S. China Deal & What’s Next

Bankless

Crypto
Key Takeaways:
  1. ETH is Back (For Now): ETH's dramatic surge signals renewed conviction, but its long-term trajectory against Bitcoin remains a key market question.
  2. Macro Drives All: The U.S.-China tariff pause and potential capital control strategies will significantly impact risk assets; Bitcoin and gold are positioned as key beneficiaries of dollar devaluation.
  3. Regulation is Turning Pro-Crypto: The SEC's pivot towards clear frameworks could finally unlock institutional adoption and the tokenization of real-world assets.
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May 15, 2025

Hivemind: ETH Pump, Solana’s Edge & the New Meme Meta

Empire

Crypto
Key Takeaways:
  1. ETH Rally = Fragile Foundation: ETH's recent pump is more a short-squeeze than broad institutional buy-in; treat with skepticism.
  2. Solana's Strategic Advantages: Solana benefits from innovation, discounted token acquisitions by strategic entities, and key infrastructure developments like asset-level KYC.
  3. Meme Meta Redux: The "Internet Capital Markets" on Solana offer high-risk, high-reward plays mirroring past speculative cycles; speed and early positioning are crucial.
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