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AI Podcasts

June 26, 2025

AI at the Edge: How Gensyn Is Building Verifiable, Decentralized Machine Learning

The People's AI

AI
Key Takeaways:
  1. Verification is AI’s Trust Bottleneck. True decentralized AI is impossible without solving verification. Without deterministic proofs, networks are vulnerable to economic exploits and malicious model poisoning, rendering them untrustworthy.
  2. The Next Frontier is Horizontal, Not Vertical. The era of simply adding more GPUs to a data center is ending. The future lies in distributing tasks across a vast network of devices, which requires a new paradigm of verifiable, deterministic algorithms.
  3. Deterministic AI Creates New Economies. A verifiable infrastructure provides the substrate for a new "machine economy" where autonomous agents transact and arbitrate disputes. This same technology can serve as a trusted, unbiased arbiter for human interactions.
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June 26, 2025

Tech Executive Answers: Can AI Solve Healthcare's Urgent Workforce Challenges? with Ankit Jain

a16z

AI
Key Takeaways:
  1. AI’s killer app in healthcare is automating administrative sludge. The most immediate ROI isn't in clinical diagnosis but in tackling the operational chaos (prior authorizations, benefit checks) that delays care and burns out staff.
  2. Expose the hidden costs of the status quo. AI’s value becomes undeniable when it reveals and corrects the existing system's deep-seated inefficiencies and error rates, like the 25% inconsistency rate in human-led payer calls.
  3. The moat is the workflow, not the model. As foundation models become commoditized, the real, defensible value for AI companies lies in deep, last-mile workflow integration and the proprietary data loops that fine-tune models for specific, high-stakes environments.
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June 25, 2025

Hash Rate - Ep 119 - The #1 Bittensor Subnet CHUTES

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

AI
Key Takeaways:
  1. Massive Utility Unlocks Adoption: Shoots' focus on simplifying AI deployment and providing access to models at low/no cost (initially) has driven user numbers to 371,000 and massive token throughput, proving real-world demand.
  2. Bridging Crypto and AI is Key: Overcoming AI developers' skepticism of crypto requires tangible benefits; Shoots aims to be that bridge, using BitTensor's incentives to power a superior, open AI platform.
  3. Privacy is the Enterprise Gateway: For decentralized AI platforms like Shoots to capture significant enterprise market share, robust, verifiable privacy solutions like Trusted Execution Environments (TEEs) are non-negotiable.
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June 25, 2025

Building Cluely: The Viral AI Startup that raised $15M in 10 Weeks

a16z

AI
Key Takeaways:
  1. Distribution is Queen: In a noisy AI world, mastering viral distribution can be a more potent advantage than a perfectly polished initial product. Eyeballs first, then iterate based on data.
  2. Embrace the Provocateur: The Gen Z approach to content—transparent, sometimes controversial, but always authentic—resonates. Leaders need demonstrable personal reach; the era of faceless corporate comms is fading.
  3. Speed Wins: In AI, "momentum as a moat" means rapid product development and distribution are critical. The ability to build the plane while it's in flight is the new founder archetype.
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June 24, 2025

Three Red Lines We're About to Cross Toward AGI

Machine Learning Street Talk

AI
Key Takeaways:
  1. Recursive Self-Improvement is a Critical Threshold: Preventing fully automated AI R&D is a key chokepoint to manage existential risks.
  2. Alignment Remains Elusive: Current methods are insufficient for robustly controlling advanced AI; "fairly reasonable" isn't safe enough.
  3. Transparency is Non-Negotiable: Governments and the public need situational awareness of frontier AI progress to inform policy and deterrence.
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June 23, 2025

Founders, Media, & Memes: a16z’s Strategy for the Future | a16z LP Summit 2025

a16z

AI
Key Takeaways:
  1. Structure Dictates Agility: a16z’s non-shared control model allows for rapid reorganization and specialization, crucial for capturing emerging tech waves like AI and crypto.
  2. Narrative is Power: In a meme-driven world, owning your narrative and media channels is paramount; a16z is actively building its presence to lead conversations.
  3. AI Needs Crypto: The burgeoning world of AI agents will create massive demand for crypto as the native transaction layer, exemplified by experiments like "Truth Terminal."
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June 21, 2025

Coatue Pt2. Open AI’s Kevin Weil Dives into All Things ChatGPT | BG2 w/ Bill Gurley & Brad Gerstner

Bg2 Pod

AI
Key Takeaways:
  1. The Current AI is Just the Beginning: Today's AI models are the "worst" we'll ever use; exponential improvements mean capabilities will dramatically expand in short timeframes.
  2. Proactive, Personalized AI is Coming: Expect AI to move from reactive answering to proactive task completion, deeply integrated into personal and professional workflows.
  3. Execution Defines the Winner: While the opportunity is immense ($100B+ revenue potential for OpenAI), success hinges on relentless execution and navigating a competitive, evolving landscape.
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June 20, 2025

Coatue’s Laffont Brothers. AI, Public & VC Mkts, Macro, US Debt, Crypto, IPO's, & more | BG2

Bg2 Pod

AI
Key Takeaways:
  1. AI is the Apex Predator: AI isn't just a feature; it's fundamentally reshaping business models, potentially leading to unprecedented productivity gains and market reallocations. Watch for AI pure-plays and established firms effectively leveraging AI for margin expansion.
  2. Crypto's Institutional Door is Creaking Open: Regulatory clarity and evolving products like interest-bearing stablecoins could unlock significant institutional capital for the digital asset class. Bitcoin's scale makes it increasingly hard to dismiss.
  3. Productivity is the New Macro Hedge: AI-fueled productivity could be the unexpected force that stabilizes the US fiscal situation, making current bond yields more rational than they appear under a "debt spiral" narrative.
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June 20, 2025

TikTok & AI Have Changed Education Forever - What it means for Teachers, Students & Parents

a16z

AI
Key Takeaways:
  1. Teacher Tools First, Student Revolution Later: AI's immediate impact is in making teachers hyper-efficient by automating administrative drudgery; direct AI-led student learning is still nascent but holds immense potential.
  2. Content is King, Delivery is Viral: AI is democratizing high-quality educational content creation and enabling novel, highly engaging delivery formats (e.g., celebrity deepfakes on TikTok), potentially bypassing traditional channels.
  3. The "Alpha" Signal is Strong: Experiments like Alpha School, though niche, prove AI's capacity to deliver superior educational outcomes, signaling a future where personalized, AI-driven learning paths become the norm if cost and accessibility barriers are overcome.
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Crypto Podcasts

May 27, 2025

Empire Cross-Post: The Bull Case For Ethereum | Tom Dunleavy & Ryan Berckmans

Bell Curve

Crypto
Key Takeaways:
  1. L1 is HQ: Ethereum's "pivot" reasserts the L1's central role, supported by L2s that offer crucial business model diversity and customization for the world coming on-chain.
  2. Value Accrual via Security & Confidence: ETH's valuation is increasingly tied to the total economic value it secures and the market's confidence in its future, not just direct fee revenue.
  3. Business Development is Crucial: To compete and grow, Ethereum requires a significantly more robust and proactive go-to-market strategy to attract users, institutions, and developers.
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May 27, 2025

The Altseason Rotation Has Begun! Here's The Data Behind the Next Rotation

Bankless

Crypto
Key Takeaways:
  1. Rotation Imminent: Data suggests Bitcoin's strength is setting the stage for capital to flow into altcoins, particularly Ether, which is seen as "hated" and due for a rebound against Bitcoin.
  2. Macro is Bullish (For Now): Continued fiscal spending and an anticipated stablecoin bill are significant tailwinds, though summer may bring some turbulence.
  3. Strategic Allocation is Key: Focus on assets with strong fundamentals or high attention. Consider beta plays like "blue-chip" meme coins (Pepe for ETH, Bonk for SOL) for higher-risk, higher-reward exposure, but plan exits for speculative positions.
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May 27, 2025

Travis Millott: Tao Templar, Bittensor Subnets, Dynamic Tao, Mining, Crypto Education | Ep. 44

Ventura Labs

Crypto
Key Takeaways:
  1. Dynamic Tao is High-Risk: Approach investments with extreme caution; the market is volatile, and significant capital loss is a tangible risk.
  2. Embrace Unpredictable Innovation: Bittensor's core value lies in its capacity to generate unforeseen, groundbreaking solutions from a global, permissionless, and competitive talent pool.
  3. Substrate Chain Decentralization is Critical: The successful decentralization of Bittensor's foundational layer is a paramount upcoming milestone for its long-term viability, security, and censorship resistance.
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May 26, 2025

The Bitcoin Treasury Playbook With Tyler Evans & Josh Solesbury

Empire

Crypto
Key Takeaways:
  1. Global Takeover: Bitcoin treasury strategies are rapidly globalizing, creating new Bitcoin-proxy investment vehicles in numerous capital markets.
  2. Investor Vigilance: While "Bitcoin plus" returns are alluring, investors must critically assess MNAV multiples and beware of highly leveraged companies lacking strong, transparent leadership.
  3. Reverse Tokenization is Real: Crypto assets are increasingly entering traditional finance via these public companies, fundamentally changing institutional access and perception.
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May 26, 2025

Why Analysts Are Valuing ETH All Wrong

Bankless

Crypto
Key Takeaways:
  1. **L1s are Money, Not Stocks:** Stop trying to fit square pegs (L1s) into round holes (DCF models for companies). Their value accrues like money, through network effects and demand for their monetary properties.
  2. **RSOV is Your New Lens:** Use RSOV to gauge the "stickiness" of capital in an L1 ecosystem. A growing RSOV suggests a strengthening monetary base and potentially a rising valuation floor.
  3. **ETH's RSOV Story:** ETH, when viewed through the RSOV lens, appears undervalued relative to assets like Bitcoin, especially considering catalysts like EIP-4844 ("proto-danksharding") and the growth of its L2 ecosystem, which drives ETH's use as a store of value.
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May 23, 2025

Entering Ethereum’s New Era | Tomasz Stańczak

Bell Curve

Crypto
Key Takeaways:
  1. Aggressive Scaling is Non-Negotiable: The EF is committed to exponential L1 scaling to support a vastly larger on-chain economy.
  2. TradFi Integration is Here: Ethereum is the prime venue for tokenizing real-world assets, bridging traditional finance with decentralized systems.
  3. A Renewed "Winning" Culture: The EF is adopting a more proactive, delivery-focused approach to ensure Ethereum's continued leadership and impact.
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