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AI Podcasts

May 30, 2025

SN17 - 404GEN :: Decentralized AI generated 3D assets

Opentensor Foundation

AI
Key Takeaways:
  1. Unlocking Creative Potential: 404GEN radically lowers barriers to 3D content creation, enabling faster iteration and new forms of interactive media previously unfeasible for smaller teams or individuals.
  2. Gaussian Splats are Ascendant: This representation is emerging as a powerful alternative for 3D AI, and 404GEN is at the forefront of its practical application and tooling.
  3. BitTensor's Competitive Edge Shines: The subnet's rapid quality improvement and the innovative ELO validation system highlight BitTensor's power to incentivize and coordinate decentralized intelligence towards state-of-the-art results.
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May 30, 2025

Hey Tech, Come to Healthcare

a16z

AI
Key Takeaways:
  1. **Build for Behavior Change:** The biggest wins will come from engaging consumers and enabling sustainable health behaviors, an area where tech excels.
  2. **AI is the Leapfrog:** Healthcare can jump directly to AI-driven solutions, bypassing clunky legacy software, especially for service-oriented tasks.
  3. **The Trillion-Dollar Prize is Real:** Whether through full-stack "payvider" models or horizontal platforms, the path to becoming the world's largest company runs through transforming the consumer healthcare experience.
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May 29, 2025

Building a DePIN-powered Shazam for Media with Rumi | Niko Cunningham and Mateusz Poreda

Proof of Coverage Media

AI
Key Takeaways:
  1. **Decentralized Analytics:** Rumi’s DePIN model democratizes media intelligence, offering far richer and more granular data than traditional players like Nielsen.
  2. **Context is King:** The "Shazam for media" capability will fuel a new generation of AI agents and interactive experiences, making media deeply engaging.
  3. **Investor Signal:** The $5M pre-seed (EV3, A16Z CSX) and early traction with industry players like Tivision validate Rumi's approach and market potential.
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May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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May 26, 2025

Chatbot platforms might replace social media

Machine Learning Street Talk

AI
Key Takeaways:
  1. AI Companionship is Exploding: Millions are already deeply engaged with AI for emotional connection, and this is just the beginning as technology like GPT-4o normalizes it.
  2. Lean Engineering Can Win: Chai's success with a tiny, hyper-talented team and innovative techniques like model blending proves that massive VC-backed operations aren't the only path to scale in AI.
  3. The Next Social Platform Might Be AI: As AI offers more active, personalized, and consequence-free social interaction, it could very well become the dominant way people connect, potentially supplanting traditional social media.
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Crypto Podcasts

April 1, 2025

How Zora is Redefining the Creator Economy | Jacob Horne

Bell Curve

Crypto
Key Takeaways:
  1. Zora is pioneering a shift from illiquid NFTs to fungible content coins, creating liquid markets around individual pieces of online media. This model aims to empower the long tail of creators and build a more open, composable, and value-aligned internet economy beyond ads and subscriptions.
  2. **Content is Fungible:** The market realized many NFTs were traded fungibly; coins offer a more efficient market structure for most online content.
  3. **Attention Markets Emerge:** Crypto enables open markets to price the attention and cultural relevance of content, moving beyond ad exchanges.
  4. **Simplified Creator Monetization:** Zora provides tools for creators to easily tokenize content and earn directly via integrated market mechanisms (LP fees), often surpassing earnings on traditional platforms.
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March 31, 2025

Why Stablecoins Are Crypto's Biggest Opportunity | Charlie Noyes & Bam Azizi

Empire

Crypto
Key Takeaways:
  1. Infrastructure is the Play: With issuer economics concentrated and competition fierce, the real opportunity lies in building the "picks and shovels" – APIs, UX layers, and interoperability solutions (like Mesh) – that make stablecoins usable at scale.
  2. Fragmentation is Inevitable (and an Opportunity): Expect a proliferation of stablecoins from banks, fintechs, and others. This increases complexity but creates demand for aggregators and middleware that simplify the ecosystem.
  3. Regulation Unlocks Institutions: Clearer regulations are the primary catalyst needed for risk-averse institutions to embrace stablecoins, potentially triggering a wave of adoption akin to cloud migration.
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March 30, 2025

GameStop Goes Full Saylor: Bitcoin or Bust, Lads?

blocmates.

Crypto
Key Takeaways:
  1. **Debt-Fueled Gamble:** GameStop's $1.3B Bitcoin buy using convertible bonds is a high-risk bet entirely dependent on BTC price appreciation for success and debt repayment.
  2. **Stock Price Over Operations:** The primary goal seems to be inflating the stock price via Bitcoin exposure, rather than fixing the underlying retail business.
  3. **Saylor Strategy Goes Mainstream:** This move signals the "Saylor Strategy" is spreading, potentially pushing more non-tech companies towards Bitcoin treasury reserves, amplifying both adoption and systemic risk.
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March 30, 2025

Finding Successful Investments

The Rollup

Crypto
Key Takeaways:
  1. Bet on Established Networks or Speculate on Potential: Choose Bitcoin/Ethereum for proven network effects or new L1s/L2s/Meme Coins for higher-risk, potential-driven bets.
  2. Community is the First Utility: Strong communities are the initial network effect in web3; projects building utility (games, L2s) on this base signal deepening value.
  3. Meme Coins Evolve: Watch for meme communities launching games or infrastructure (L2s/L3s) as a sign of longevity and network effect expansion.
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March 28, 2025

How to Become a Millionaire Crypto Insider (FREE 5 STEP GUIDE)

Taiki Maeda

Crypto

Key Takeaways:


1. Beware the Playbook: Recognize the cynical cycle of hype, VC validation, token launch, strategic pumping, and insider dumping.


2. Airdrops Aren't Free Lunch: Understand that airdrop campaigns primarily benefit projects via free marketing and liquidity, with insiders potentially gaming the system.


3. Demand Better: The crypto space needs greater transparency and accountability; the current incentive structure rewards manipulative behavior until it becomes unprofitable.

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March 28, 2025

Why MegaETH Trusts Ethereum’s Escape Hatch

The DCo Podcast

Crypto

Key Takeaways:


1. Trust Ethereum, Not Just the Rollup: MegaETH's security model fundamentally relies on users trusting Ethereum's liveness and escape hatch mechanism to guarantee fund safety and eventual transaction correctness, acknowledging its own lack of *real-time* censorship resistance.


2. Focus on Practical Guarantees: The emphasis shifts from the abstract ideal of "decentralization" to concrete properties like liveness and the *ability* to exit (censorship resistance), even if delayed via Ethereum settlement.


3. Modular Security is the Trend: MegaETH exemplifies the modular blockchain thesis where Layer 2 solutions inherit security from a robust base layer (Ethereum), with future developments likely deepening this integration (e.g., base/native rollups).


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