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AI Podcasts

February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The US healthcare system is shifting from a reactive, acute care model to a proactive, preventative one.
  2. Build infrastructure that financially incentivizes preventative lifestyle interventions.
  3. The next decade will see hundreds of billions of dollars redirected towards lifestyle interventions.
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February 4, 2026

The Economic Singularity Will Make Today’s Economy Unrecognizable w/ Dr. Alexander Wissner-Gross

Milk Road AI

AI
Key Takeaways:
  1. AI-driven hyperdeflation will fundamentally alter economic structures, leading to a post-scarcity future where the primary challenge shifts from production to distribution and the integration of human and machine economies.
  2. Invest in infrastructure that bridges human and AI economies, or prepare for a future where AI agents become a significant, crypto-native economic force.
  3. The next 6-12 months will see continued acceleration of AI capabilities, pushing us closer to a future where traditional labor and intelligence are nearly free. Understanding this change is crucial for navigating the emerging economic landscape and identifying new value creation opportunities.
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February 5, 2026

Goodfire AI’s Bet: Interpretability as the Next Frontier of Model Design — Myra Deng & Mark Bissell

Latent Space

AI
Key Takeaways:
  1. The era of opaque, black-box AI is ending; the future demands intentionally designed models with human understanding and control. This shift is driven by reliability in high-stakes applications and extracting novel insights.
  2. Investigate interpretability tools (like Goodfire's platform) to gain granular control over model behavior, moving beyond basic fine-tuning for critical applications.
  3. Interpretability is not a niche; it's the missing piece for scaling AI safely into mission-critical domains. Mastering model understanding and intentional design will yield unprecedented capabilities and competitive advantage.
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February 4, 2026

Ep#61: 1x World Model

RoboPapers

AI
Key Takeaways:
  1. Robotics is moving from bespoke, data-hungry behavior cloning to generalized, human-informed learning via world models. This shift, mirroring the success of LLMs, means robots can use the vast, unstructured data of human experience to acquire new skills.
  2. Invest in platforms and data pipelines that facilitate multi-modal, multi-stage training for humanoid robots. Prioritize systems that can generate synthetic data and use world models for high-throughput, targeted policy evaluation.
  3. World models are the engine for scalable robot intelligence. They promise a future where robots learn faster, generalize wider, and self-improve through iterative simulation, making widespread humanoid deployment a near-term reality.
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February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The Macro Shift: AI is collapsing the time horizon for technological deployment and market dominance, shifting the competitive advantage from pure innovation to a combination of innovation, capital, and rapid infrastructure deployment.
  2. The Tactical Edge: Invest in companies that are not just building AI, but are fundamentally rethinking existing industries with AI-first principles, recognizing that traditional software moats are eroding.
  3. The Bottom Line: The next 12-24 months will see AI's broad impact kick in, creating unprecedented opportunities for those who understand its new "laws of physics" and the critical role of policy in shaping its trajectory.
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February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The healthcare system is moving from reactive, acute care to proactive, preventative interventions, driven by the unsustainable costs of chronic disease and a growing understanding of environmental health.
  2. Build infrastructure that financially incentivizes lifestyle interventions, such as TrueMed's HSA/FSA payment rails for health-promoting products and services.
  3. The next decade will see hundreds of billions of dollars redirected towards preventative health. Companies that bridge the gap between lifestyle choices and healthcare financing will capture significant market share.
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February 3, 2026

SpaceX Engineer Explains America's Biggest Energy Mistake | Scott Nolan, CEO of General Matter

The Generalist

AI
Key Takeaways:
  1. The Macro Shift: Global energy demand, driven by AI, forces a strategic re-evaluation of nuclear power. This creates a window for nations to re-shore critical energy infrastructure, moving from reliance on adversaries to domestic, cost-competitive solutions.
  2. The Tactical Edge: Investigate companies addressing foundational supply chain gaps in critical industries like energy. Look for teams with a "first principles" engineering approach and a track record of commercializing hard tech.
  3. The Bottom Line: America's energy independence and its ability to power future technological growth, like AI, hinge on rebuilding domestic nuclear fuel enrichment. This is not just an industrial opportunity; it is a national security imperative.
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February 4, 2026

The Economic Singularity Will Make Today’s Economy Unrecognizable w/ Dr. Alexander Wissner-Gross

Milk Road AI

AI
Key Takeaways:
  1. The Macro Shift: AI-driven hyperdeflation is colliding with the technical reality of autonomous AI agents creating their own crypto-backed economies, threatening a decoupling from human fiat systems.
  2. The Tactical Edge: Investigate and build infrastructure that bridges human and AI economies, focusing on fiat-to-crypto rails that can accommodate agent-driven transactions to prevent a complete split.
  3. The Bottom Line: The next 5-10 years will see an unprecedented economic transformation. Understanding AI's deflationary power and the emerging AI agent economy is critical for navigating a world where traditional economic models may no longer apply.
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February 3, 2026

OpenClaw Makes AI Agents and CPUs Get Real

Semi Doped

AI
Key Takeaways:
  1. The time of practical AI agents is here, moving compute demand beyond pure GPU inference to a significant reliance on CPUs for coordination, data handling, and security.
  2. Evaluate your agent deployment strategy now, prioritizing sandboxed environments (VPS, dedicated local servers) and exploring cost-optimized model routing to manage API expenses.
  3. Prepare for a future where AI agents become integral to workflows, but recognize the hidden infrastructure costs and security implications, particularly the growing importance of CPU capacity and robust access controls.
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Crypto Podcasts

June 17, 2025

How to Actually Grow on Crypto Twitter in 2025

The DCo Podcast

Crypto
Key Takeaways:
  1. Authenticity Over Algorithms: Ditch the generic social media playbook; your genuine interest in a specific crypto niche is your most potent growth tool.
  2. Niche Down to Blow Up: Become the go-to source for your specific passion (e.g., memecoins, DeFi protocols) by sharing your unique process and insights.
  3. The Audience Knows: Users can "sniff out" disingenuous content. Real interest and transparent sharing build trust and attract a loyal following.
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June 16, 2025

The State Of Crypto Derivatives

Empire

Crypto
Key Takeaways:
  1. **Risk Re-Priced**: Post-2022, understanding and mitigating counterparty and correlated risk is paramount; high returns often masked these dangers.
  2. **TradFi Rails Accelerate Crypto**: Publicly traded vehicles and ETFs are becoming key on-ramps, channeling traditional capital into crypto and reshaping market dynamics, notably compressing volatility.
  3. **Fundamental & On-Chain Focus**: Durable value (on-chain credit, strong L1s like Solana, revenue-generating protocols) and innovative on-chain derivatives platforms (like Hyperliquid) are prime areas of growth and investor interest.
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June 16, 2025

How to Value L1s?

Lightspeed

Crypto
Key Takeaways:
  1. App Revenue as a Current Yardstick: For now, L1 "GDP" (market cap / app revenue) offers a more stable cross-chain valuation tool than direct fees, providing an "apples-to-apples" comparison.
  2. The Inevitable Value Shift: Expect a future where applications, not L1s, capture the lion's share of value, as app take rates and business models mature. L1 valuations may compress as app valuations expand.
  3. L1s Must Innovate to Retain Value: Blockchains like Solana are actively strategizing (e.g., application-specific sequencing) to keep successful apps within their ecosystems, highlighting the growing pressure on L1s to prove their enduring value proposition beyond basic infrastructure.
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June 15, 2025

VCs Weigh In On Crypto Treasury Companies

Empire

Crypto
Key Takeaways:
  1. Treasury Strategies: High-Risk, Short-Term Plays: These vehicles are built for quick flips, not lasting value, with a high chance of premiums vanishing and values dropping below NAV.
  2. Beware the "Mania": The proliferation of treasury vehicles with increasingly lax terms signals a speculative fever; MicroStrategy is an outlier, not the rule.
  3. VCs Bet on Endurance: True crypto investing, from a venture perspective, demands patience and a focus on fundamental, long-term growth, distinct from chasing fleeting treasury premiums.
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June 14, 2025

The Next Crypto Companies To IPO

Empire

Crypto
Key Takeaways:
  1. **Scale is King:** Sub-$3 billion valuation companies will struggle for analyst attention and institutional investment post-IPO.
  2. **SaaS Sells:** Crypto firms with predictable, recurring revenue (like Fireblocks, Chainalysis) have a stronger IPO narrative than those riding crypto price waves.
  3. **Trust is Currency:** For select businesses like Anchorage, an IPO isn't just about capital; it’s a strategic move to bolster their fundamental value proposition—trust.
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June 14, 2025

Solana ETFs coming?

The Rollup

Crypto
Key Takeaways:
  1. Solana's ETF = Major Validation: If approved, a Solana ETF isn't just another fund; it's a significant nod to Solana's legitimacy and a big win for its community.
  2. Beyond Single Assets - Think Indices: The success of individual crypto ETFs (like a potential Solana one) could fuel demand for broader market products, such as crypto index funds on traditional stock exchanges.
  3. Staking in ETFs - Tax Clarity Coming?: Watch for regulatory updates on staking within ETFs. Positive guidance could unlock new product structures and resolve key tax concerns for investors.
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