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AI Podcasts

February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The US healthcare system is shifting from a reactive, acute care model to a proactive, preventative one.
  2. Build infrastructure that financially incentivizes preventative lifestyle interventions.
  3. The next decade will see hundreds of billions of dollars redirected towards lifestyle interventions.
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February 4, 2026

The Economic Singularity Will Make Today’s Economy Unrecognizable w/ Dr. Alexander Wissner-Gross

Milk Road AI

AI
Key Takeaways:
  1. AI-driven hyperdeflation will fundamentally alter economic structures, leading to a post-scarcity future where the primary challenge shifts from production to distribution and the integration of human and machine economies.
  2. Invest in infrastructure that bridges human and AI economies, or prepare for a future where AI agents become a significant, crypto-native economic force.
  3. The next 6-12 months will see continued acceleration of AI capabilities, pushing us closer to a future where traditional labor and intelligence are nearly free. Understanding this change is crucial for navigating the emerging economic landscape and identifying new value creation opportunities.
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February 5, 2026

Goodfire AI’s Bet: Interpretability as the Next Frontier of Model Design — Myra Deng & Mark Bissell

Latent Space

AI
Key Takeaways:
  1. The era of opaque, black-box AI is ending; the future demands intentionally designed models with human understanding and control. This shift is driven by reliability in high-stakes applications and extracting novel insights.
  2. Investigate interpretability tools (like Goodfire's platform) to gain granular control over model behavior, moving beyond basic fine-tuning for critical applications.
  3. Interpretability is not a niche; it's the missing piece for scaling AI safely into mission-critical domains. Mastering model understanding and intentional design will yield unprecedented capabilities and competitive advantage.
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February 4, 2026

Ep#61: 1x World Model

RoboPapers

AI
Key Takeaways:
  1. Robotics is moving from bespoke, data-hungry behavior cloning to generalized, human-informed learning via world models. This shift, mirroring the success of LLMs, means robots can use the vast, unstructured data of human experience to acquire new skills.
  2. Invest in platforms and data pipelines that facilitate multi-modal, multi-stage training for humanoid robots. Prioritize systems that can generate synthetic data and use world models for high-throughput, targeted policy evaluation.
  3. World models are the engine for scalable robot intelligence. They promise a future where robots learn faster, generalize wider, and self-improve through iterative simulation, making widespread humanoid deployment a near-term reality.
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February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The Macro Shift: AI is collapsing the time horizon for technological deployment and market dominance, shifting the competitive advantage from pure innovation to a combination of innovation, capital, and rapid infrastructure deployment.
  2. The Tactical Edge: Invest in companies that are not just building AI, but are fundamentally rethinking existing industries with AI-first principles, recognizing that traditional software moats are eroding.
  3. The Bottom Line: The next 12-24 months will see AI's broad impact kick in, creating unprecedented opportunities for those who understand its new "laws of physics" and the critical role of policy in shaping its trajectory.
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February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The healthcare system is moving from reactive, acute care to proactive, preventative interventions, driven by the unsustainable costs of chronic disease and a growing understanding of environmental health.
  2. Build infrastructure that financially incentivizes lifestyle interventions, such as TrueMed's HSA/FSA payment rails for health-promoting products and services.
  3. The next decade will see hundreds of billions of dollars redirected towards preventative health. Companies that bridge the gap between lifestyle choices and healthcare financing will capture significant market share.
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February 3, 2026

SpaceX Engineer Explains America's Biggest Energy Mistake | Scott Nolan, CEO of General Matter

The Generalist

AI
Key Takeaways:
  1. The Macro Shift: Global energy demand, driven by AI, forces a strategic re-evaluation of nuclear power. This creates a window for nations to re-shore critical energy infrastructure, moving from reliance on adversaries to domestic, cost-competitive solutions.
  2. The Tactical Edge: Investigate companies addressing foundational supply chain gaps in critical industries like energy. Look for teams with a "first principles" engineering approach and a track record of commercializing hard tech.
  3. The Bottom Line: America's energy independence and its ability to power future technological growth, like AI, hinge on rebuilding domestic nuclear fuel enrichment. This is not just an industrial opportunity; it is a national security imperative.
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February 4, 2026

The Economic Singularity Will Make Today’s Economy Unrecognizable w/ Dr. Alexander Wissner-Gross

Milk Road AI

AI
Key Takeaways:
  1. The Macro Shift: AI-driven hyperdeflation is colliding with the technical reality of autonomous AI agents creating their own crypto-backed economies, threatening a decoupling from human fiat systems.
  2. The Tactical Edge: Investigate and build infrastructure that bridges human and AI economies, focusing on fiat-to-crypto rails that can accommodate agent-driven transactions to prevent a complete split.
  3. The Bottom Line: The next 5-10 years will see an unprecedented economic transformation. Understanding AI's deflationary power and the emerging AI agent economy is critical for navigating a world where traditional economic models may no longer apply.
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February 3, 2026

OpenClaw Makes AI Agents and CPUs Get Real

Semi Doped

AI
Key Takeaways:
  1. The time of practical AI agents is here, moving compute demand beyond pure GPU inference to a significant reliance on CPUs for coordination, data handling, and security.
  2. Evaluate your agent deployment strategy now, prioritizing sandboxed environments (VPS, dedicated local servers) and exploring cost-optimized model routing to manage API expenses.
  3. Prepare for a future where AI agents become integral to workflows, but recognize the hidden infrastructure costs and security implications, particularly the growing importance of CPU capacity and robust access controls.
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Crypto Podcasts

June 19, 2025

Crypto Options Are Broken

Forward Guidance

Crypto
Key Takeaways:
  1. Listed is Better (For Now): For functional crypto options, look to products on established, regulated exchanges with competitive market-making; on-chain options are largely unworkable due to poor liquidity and structure.
  2. US Spot Market Needs a Shake-Up: The high costs and concentration in US spot crypto trading stifle accessibility; more competition is essential.
  3. Market Structure is Destiny: The design of a market—its rules, incentives, and competitive landscape—ultimately determines execution quality and cost, far more than the underlying asset itself.
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June 19, 2025

Institutional Capital Is Reshaping Crypto | Analyst Round Table

0xResearch

Crypto
Key Takeaways:
  1. Fundamentals First: The "revenue meta" is here to stay; projects without real earnings or clear paths to profitability will struggle.
  2. Institutions are Driving: With institutional players dominating trading volumes, expect crypto valuations to increasingly align with traditional financial metrics and scrutiny.
  3. Value Accrual is King: Tokens must demonstrate how they capture and return value to holders; mechanisms like revenue share and buybacks are becoming non-negotiable.
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June 19, 2025

How The Token Transparency Framework Will Impact Prices

Empire

Crypto
Key Takeaways:
  1. **Transparency Pays:** Projects embracing transparency will likely see a long-term price premium, appealing to sophisticated, long-horizon investors.
  2. **Clarity Cuts Through Noise:** Fundamentally strong but poorly communicated projects can leverage the framework to gain visibility and investor trust.
  3. **Bad Actors Beware:** The framework is designed to punish extractive and scam projects, cleaning up the ecosystem and redirecting resources to genuine innovation.
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June 18, 2025

Introducing The Token Transparency Framework

Empire

Crypto
Key Takeaways:
  1. Shine a Light: The Framework allows legitimate projects ("peaches") to differentiate themselves from opaque or scammy ones ("lemons"), potentially reducing the 80% "lemon discount."
  2. Investor Shield: Provides investors a standardized checklist to assess a token's structural integrity beyond just its hype, looking at critical areas like equity vs. token alignment and fund use.
  3. Market Integrity Boost: Widespread adoption could significantly improve market transparency, attract institutional capital, and discourage nefarious actors, ultimately strengthening the entire crypto ecosystem.
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June 17, 2025

Analyzing Public Crypto Vehicles This Cycle

Empire

Crypto
Key Takeaways:
  1. **Public Equities Offer Familiarity:** Investors are gravitating towards public crypto vehicles for their established legal structures and operational simplicity over direct token holdings.
  2. **Leverage Looks Different Now:** Today's public crypto plays (e.g., MicroStrategy) exhibit significantly less leverage than the high-risk trades that caused meltdowns last cycle.
  3. **Securities Classification Could Be Bullish:** Regulating tokens as securities might unlock substantial institutional capital, providing clearer rules and bolstering market stability.
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June 17, 2025

Solana ETFs Are Coming With Carlos Gonzalez Campo

Lightspeed

Crypto
Key Takeaways:
  1. **Solana ETFs are knocking on the door**, potentially armed with staking yield and a clearer TradFi narrative than their Ethereum counterparts.
  2. **The DEX arena is a battlefield**: CLOBs on specialized infrastructure are rising, challenging AMMs and reshaping liquidity for everything from blue-chips to memecoins.
  3. **Stablecoins are crypto's killer app going mainstream**, with Circle's IPO firing the starting gun for broader investor participation and a new wave of competition.
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