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AI Podcasts

August 25, 2025

Aaron Levie and Steven Sinofsky on the AI-Worker Future

a16z

AI
Key Takeaways:
  1. Embrace Specialization, Not Generalization. The most effective AI systems are emerging from a “system of many agents” approach. Instead of chasing a single AGI, the trend is toward building and orchestrating multiple deep experts, each with a narrow focus.
  2. AI Augments Experts, It Doesn't Replace Novices. The biggest productivity gains are going to those who already have domain expertise. AI is a tool whose value is unlocked by a user who can provide precise prompts and critically evaluate the output.
  3. The Next Thousand Unicorns are Agent Companies. The startup playbook is clear: go deep on a single, vertical workflow and build an agent that does it better than anyone else. Just as APIs like Twilio and Stripe unbundled services, agents will unbundle workflows, creating entire companies from what was once a feature.
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August 23, 2025

Ben Horowitz on How a16z Was Built

a16z

AI
Key Takeaways:
  1. Build a Product, Not Just a Portfolio. The dominant VC firms of the future will offer concrete services to founders, not just capital. Reputation and unwavering founder support are the ultimate competitive advantages.
  2. Size Funds to the Market Opportunity. The software market is exponentially larger than it was two decades ago. Sticking to legacy fund sizes means missing out on a dramatically expanded opportunity set.
  3. Fight for American Innovation. The biggest existential threat to technology isn't market cycles but a hostile regulatory environment. VCs must actively engage in policy to prevent the US from forfeiting leadership in foundational technologies like AI and crypto.
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August 22, 2025

ONESHOTTED

Trillion Agents

AI
Key Takeaways:
  1. Execution is a Commodity; Ideation is the Moat. The value is rapidly shifting from those who can execute a plan to those who can generate the novel plan in the first place.
  2. Your Org Chart is Now a Repo. Forward-thinking teams are treating their entire operational knowledge base as a single, AI-readable context, turning their company's history and philosophy into a prompt.
  3. Beware the Conflict Resolution Engine. A centralized AI risks becoming an echo chamber that smooths over disagreements. Actively engineer processes (like human-led PR reviews) to preserve essential conflict and challenge groupthink.
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August 22, 2025

The State of AI: Growth, Fragmentation, and the Next Wave

a16z

AI
Key Takeaways:
  1. Zero-Sum is a Losing Bet. The market isn't a monolith. Value is fragmenting across specialized applications in code, image, and vertical workflows. The "winner-take-all" thesis is dead.
  2. Moats are Made, Not Inherent. AI’s magic solves the "bootstrap problem" of user acquisition, but long-term defensibility requires building traditional software moats like brand, workflow integration, and network effects.
  3. Be on the Field, but Pick Your Spot. This is not a market to sit out, but indiscriminate investing is a death sentence. Back exceptional, proven teams, understand that conflicts can lock you out of the best deals, and never confuse market heat with genuine momentum.
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August 21, 2025

Can AI Fix Housing and Healthcare Affordability?

a16z

AI
Key Takeaways:
  1. AI is the deflationary force for stagnant sectors. While software ate the world, it skipped housing and healthcare. AI is finally tackling the operational drag that has caused costs to balloon for decades.
  2. To solve the housing crisis, make it profitable. The path to more housing supply runs through better returns. By making property operations radically more efficient, AI attracts the capital required to build.
  3. The future of work is human + AI. Automation won't eliminate jobs; it will transform them. As AI handles the administrative grind, human roles will shift to higher-value work like community engagement and complex problem-solving.
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August 19, 2025

Hash Rate - Ep 129 - Macrocosmos IOTA (sn9) and DataUniverse (sn13)

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

AI
Key Takeaways:
  1. DTO Means Business: Dynamic TAO has forced a Darwinian shift. Subnets must now achieve product-market fit and generate real revenue to survive, transforming from research projects into self-sustaining businesses.
  2. IOTA’s Grand Ambition: IOTA (SN9) isn't just another model trainer; its architecture aims to train trillion-parameter models on decentralized, consumer-grade hardware, directly challenging the dominance of centralized AI labs.
  3. Time to Garden: The protocol's long-term health hinges on active governance. A strong sentiment is emerging to prune low-effort or malicious subnets to focus emissions on projects capable of creating real, lasting value.
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August 19, 2025

Hash Rate - Ep 128 - Ridges ($TAO Subnet 62)

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

AI
Key Takeaways:
  1. AI Is Moving from Copilot to Pilot. Ridges is betting that the future isn't AI assisting humans, but AI replacing them for specific tasks. Their goal is to make hiring a software engineer as simple as subscribing to a service.
  2. Decentralized Economics Are a Moat. By leveraging Bittensor's incentive layer, Ridges outsources a $15M/year R&D budget to a global pool of competing developers, achieving a cost structure and innovation velocity that centralized players cannot match.
  3. The Breakout Subnet Is Coming. Ridges showcases how a Bittensor subnet can solve real-world business problems—privacy, cost, and quality degradation—to build a product that is not just cheaper, but fundamentally better than its centralized counterparts.
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August 18, 2025

Dylan Patel on GPT-5’s Router Moment, GPUs vs TPUs, Monetization

a16z

AI
Key Takeaways:
  1. From Performance to Profit: The AI industry is pivoting from a war of benchmarks to a game of unit economics. Features like GPT-5’s router signal that cost management and monetization are now as important as model capabilities.
  2. Hardware is a Supply Chain Game: Nvidia’s true moat is its end-to-end control of the supply chain. Competitors aren't just fighting a chip architecture; they're fighting a logistical behemoth that consistently out-executes on everything from memory procurement to time-to-market.
  3. The Grid is the Limit: The biggest check on AI’s expansion is the physical world. The speed at which new power infrastructure and data centers can be built will dictate the pace of AI deployment in the US, creating a major advantage for those who can build faster.
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August 18, 2025

Subnet 56 :: Gradients :: Bittensor End-to-end AI Model Training Suite

Opentensor Foundation

AI
Key Takeaways:
  1. Performance is Proven, Not Promised. Gradients isn't just making claims; it’s delivering benchmark-crushing results, consistently outperforming centralized incumbents and producing state-of-the-art models.
  2. Open Source Unlocks the Enterprise. The shift to verifiable, open-source training scripts is a direct solution to customer data privacy concerns, turning a critical vulnerability into a competitive advantage.
  3. The AutoML Flywheel is Spinning. The network's competitive, tournament-style mechanism creates a self-optimizing system that continuously aggregates the best training techniques, ensuring it remains at the cutting edge.
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Crypto Podcasts

April 16, 2025

How Bankless is Robinhood? - CEO Vlad Tenev #crypto #robinhood #stocks #investing #markets

Bankless

Crypto
Key Takeaways:
  1. No Charter, Still Connected: Robinhood operates without a banking charter but strategically uses bank partnerships, highlighting a hybrid approach.
  2. Fiat Bridge: Crypto's mainstream adoption currently depends heavily on traditional banks acting as the crucial fiat-to-crypto gateway.
  3. Converging Future: Expect greater integration between TradFi and crypto, spurred by regulatory clarity and the potential emergence of specialized "crypto banks."
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April 16, 2025

Guilhem Chaumont: Following the Flow Into Crypto’s Next Growth Phase

Delphi Digital

Crypto
Key Takeaways:
  1. Institutions Aren't Degens: They bring long-term capital, changing market cycles and focusing on foundational assets or tokenizing their own.
  2. Tokenize Everything: Future growth hinges on bringing RWAs on-chain, starting with liquid yield assets before tackling illiquidity.
  3. Infrastructure is the Bottleneck (and Opportunity): Building compliant, robust, and well-capitalized trading infrastructure like Flowdesk's is critical, but increasingly difficult, creating moats for established players.
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April 15, 2025

Why USDT is the Best Stablecoin | Paul & Zaheer

0xResearch

Crypto
Key Takeaways:
  1. Stability Trumps Yield: Users prioritize USDT's liquidity and reliability over potential yield from competitors.
  2. Tether as Offshore Dollars: USDT functions as a modern Eurodollar system, a role competitors and even some regulators fail to fully grasp.
  3. Consolidation is Coming: The market won't support dozens of dollar clones; expect convergence, likely favoring the most established player (USDT).
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April 15, 2025

Coinbase vs Robinhood: Who Will Win?

Empire

Crypto
Key Takeaways:
  1. Competition Kills Margins: Coinbase's high-fee model is under siege from Robinhood, TradFi giants, and the commoditization of services like staking.
  2. The ETF Hangover: Spot ETFs reduce the need for investors to use COIN as a crypto proxy, deflating its scarcity premium and potentially its multiple.
  3. Robinhood Rising: Robinhood is gaining ground, viewed by some analysts as a better-diversified and more attractive investment compared to Coinbase right now.
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April 15, 2025

Launching Crypto's Largest Tokenized Fund On Solana | Michael Sonnenshein

Lightspeed

Crypto
Key Takeaways:
  1. **BUIDL Hits $2B on Solana:** BlackRock's tokenized treasury fund expanding to Solana signifies major institutional validation and platform suitability for RWAs.
  2. **RWAs Meet DeFi:** The killer app for tokenization is bridging RWAs (like BUIDL) into DeFi ecosystems to serve as yield-bearing collateral, unlocking new capital efficiency.
  3. **Liquid Assets First:** Focus remains on tokenizing liquid, frequently priced assets (treasuries, credit funds) before tackling complex, illiquid ones like real estate.
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April 14, 2025

Bits + Bips LIVE

Unchained

Crypto
Key Takeaways:
  1. Headline Risk Reigns: Forget fundamentals for now. Market direction hinges almost entirely on White House pronouncements and tariff developments; consistency is desperately needed to restore confidence.
  2. Liquidity is King (and Scarce): Thin markets amplify moves. Watch ETF volumes (over 35% signals stress) and hedge fund positioning (currently defensive, fuel for squeezes) for tactical clues.
  3. Crypto's Macro Moment Deferred?: While geopolitics boosts crypto's *raison d'être* as a non-state asset, it needs a clearer macro picture or strong regulatory/product catalysts to break free from its current risk-asset correlation. Watch the Yuan/USD rate for capital flight signals.
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