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AI Podcasts

December 17, 2025

AI Kernel Generation: What's working, what's not, what's next – Natalie Serrino, Gimlet Labs

AI Engineer

AI
Key Takeaways:
  1. Infrastructure Shift: AI-driven kernel optimization addresses a critical bottleneck in scaling AI compute, enabling more efficient use of diverse hardware.
  2. Builder/Investor Note: Focus on solutions with robust, hardware-verified performance metrics and a clear human-in-the-loop strategy. AI is a powerful tool for automating optimization, not a magic bullet for novel algorithmic breakthroughs.
  3. The "So What?": This technology frees expert engineers from tedious optimization, allowing them to focus on higher-level research and truly innovative algorithmic design, accelerating the pace of AI development in the next 6-12 months.
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December 16, 2025

Finding The 1% of Stocks That Matter | Henry Ellenbogen Interview

Invest Like The Best

AI
Key Takeaways:
  1. Strategic Implication: The era of "free money" inflated the number of perceived compounders; a return to positive real rates demands a sharper focus on businesses demonstrating genuine financial discipline and competitive advantage.
  2. Builder/Investor Note: Seek out "Act 2" entrepreneurs and companies that can leverage AI to transform existing physical or IP-based advantages, not just create new AI products. Be prepared to buy more when market sentiment turns negative on strong businesses.
  3. The "So What?": The next 6-12 months will differentiate companies that merely adopt AI from those that strategically integrate it to build durable, uncatchable cost and distribution advantages.
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December 17, 2025

“How We Can Eliminate Crime” | Ben Horowitz and Garrett Langley

a16z

AI
Key Takeaways:
  1. The Future of Policing is Intelligent: Integrating AI, drones, and smart cameras creates a precise, accountable, and safer policing model for both officers and communities.
  2. Invest in the "How": Builders and investors should focus on technologies that enhance certainty of capture, streamline judicial processes, and support public-private partnerships to modernize urban safety infrastructure.
  3. Safety Fuels Mobility: Eliminating crime is not just about law enforcement; it's about restoring the fundamental safety required for economic mobility and a functional society.
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December 18, 2025

Two Futures | Runtime 2025

a16z

AI
Key Takeaways:
  1. Strategic Implication: The next decade's value will accrue to those building foundational AI infrastructure and the "invisible layers" that connect intelligent systems.
  2. Builder/Investor Note: Focus capital and talent on core AI models, specialized domain intelligence, and the underlying computational fabric. Superficial applications risk rapid commoditization.
  3. The So What?: This is the defining period for the architecture of global intelligence. Participation now determines future influence and relevance.
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December 16, 2025

⚡️Jailbreaking AGI: Pliny the Liberator & John V on Red Teaming, BT6, and the Future of AI Security

Latent Space

AI
Key Takeaways:
  1. Strategic Shift: AI security must move beyond superficial guardrails to a full-stack, offensive red-teaming approach that accounts for the expanding attack surface of AI agents and their tool access.
  2. Builder/Investor Note: Builders should prioritize integrating offensive security early in development. Investors should be wary of "security theater" and favor solutions that embrace open-source collaboration and address the entire AI application stack.
  3. The "So What?": The accelerating pace of AI development means static security solutions will quickly become obsolete. Proactive, community-driven, and full-stack security research is essential for navigating the next 6-12 months of AI evolution.
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December 16, 2025

Why Physical AI Needs a new Data Set | Rerun CEO

Weights & Biases

AI
Key Takeaways:
  1. Data Infrastructure is the Next Bottleneck: The physical AI sector's growth hinges on specialized data tooling that can handle multimodal, multi-rate, episodic data, moving beyond traditional tabular models.
  2. Builders, Prioritize Robustness: Focus on building systems that handle real-world variability and simplify data pipelines. Leverage open-source tools and consider combining imitation and reinforcement learning.
  3. The "So What?": The next 6-12 months will see significant improvements in robot robustness and the ability to perform longer, more complex tasks. This progress will be driven by better data management, making the gap between lab demos and deployable products narrower.
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December 16, 2025

Build reliable AI agents using W&B Training

Weights & Biases

AI
Key Takeaways:
  1. The democratization of RL for LLMs will accelerate the deployment of more reliable and sophisticated AI agents across industries.
  2. Builders should move beyond basic prompt engineering and RAG. RL fine-tuning, now accessible via W&B Serverless RL, is a critical next step for high-stakes agentic applications.
  3. For the next 6-12 months, expect a surge in production-grade AI agents, with open-source models increasingly closing the performance gap with proprietary alternatives through advanced fine-tuning.
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December 15, 2025

Coding Evals: From Code Snippets to Codebases – Naman Jain, Cursor

AI Engineer

AI
Key Takeaways:
  1. Dynamic Evaluation is Non-Negotiable: Static benchmarks are dead. Future AI development demands continuously updated, contamination-resistant evaluation sets.
  2. AI Needs AI to Judge AI: As models grow more sophisticated, LLM-driven "hack detectors" become essential for ensuring code quality and preventing adversarial exploitation of evaluation systems.
  3. User Experience Drives Adoption: For interactive AI coding tools, prioritize low latency and human-centric design; technical prowess alone will not guarantee real-world usage.
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December 15, 2025

Building in the Gemini Era – Kat Kampf & Ammaar Reshi, Google DeepMind

AI Engineer

AI
Key Takeaways:
  1. Strategic Implication: The value in software development shifts from manual coding to high-level architectural design and prompt engineering.
  2. Builder/Investor Note: Experiment with AI Studio's agentic and design capabilities. Focus on describing desired functionality rather than low-level code.
  3. The "So What?": The next 6-12 months will see a surge in AI-powered, full-stack applications built by a broader range of creators, disrupting traditional development paradigms.
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Crypto Podcasts

April 18, 2025

Is This The End of Steady Lads?

Steady Lads Podcast

Crypto
Key Takeaways:
  1. ETH Contrarian Play: Thicky eyes a deep ETH bottom ($200 target) as a long-term Proof-of-Stake bet, viewing PoW as flawed.
  2. Macro Escape: Gold's surge signals a potential flight from the USD; Bitcoin is seen as the practical digital gold alternative for individuals.
  3. Product Urgency: Crypto's long-term relevance hinges on delivering real-world products, not just speculative tokens or unsustainable pump-and-dumps like Mantra.
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April 17, 2025

Bryan Pellegrino on Building the Crypto Rails for AI Agents

The People's AI

Crypto
Key Takeaways:
  1. **Agent Volume Tsunami:** AI agents will perform vastly more blockchain operations (especially payments) than humans very soon, demanding scalable infrastructure.
  2. **Crypto is the Payment Layer:** Forget decentralized compute (for now); crypto's killer app for AI is providing seamless, low-cost global payment rails.
  3. **Build Generalizable Rails:** Success requires building adaptable, fundamental infrastructure (like Layer Zero aims to be) rather than solving fleeting, specific problems in this fast-changing landscape.
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April 17, 2025

Is Bitcoin A Safe Haven?

1000x Podcast

Crypto
Key Takeaways:
  1. **Watch IBIT/SPY:** A breakout above 0.1 in the IBIT/SPY ratio could signal Bitcoin decoupling and trigger major capital inflows.
  2. **Bitcoin > Gold (Long Term):** Bitcoin offers a superior potential upside (5-10x) compared to gold (2x) over the next decade, though its path will be far more volatile.
  3. **Diversify with Gold:** Adding gold can stabilize a portfolio (higher Sharpe), enabling investors to potentially hold larger, more volatile Bitcoin positions for long-term gains.
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April 17, 2025

Building the Future of Payments: Plasma Chain’s Global Go-To-Market Strategy

The Rollup

Crypto
Key Takeaways:
  1. Dual Strategy is Key: Plasma Chain attacks the market from both the crypto-native angle (liquidity, devs) and a targeted "ground game" (local payment integration).
  2. Targeted Regional Rollout: Specific markets like South America (El Salvador, Argentina) and Turkey are prioritized for initial real-world integration efforts.
  3. Quality Beats Quantity: Ecosystem success is measured by the value of a few core protocols, not the sheer number of deployed applications day one.
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April 16, 2025

Hash Rate - Ep 105 - SONIC $S ))) ) ) ) )

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

Crypto
Key Takeaways:
  1. **User Experience Trumps TPS:** Sonic prioritizes smooth, responsive interactions and sub-second finality over chasing headline transaction-per-second numbers.
  2. **Solving Onboarding is the Killer App:** Native account and gas abstraction aim to eliminate the wallet/gas friction that plagues crypto adoption, combined with 90% fee share making Sonic attractive for builders.
  3. **The Future is Invisible:** Sonic's 2026 goal is to make the underlying blockchain utterly seamless and invisible to the end user, enabling the next wave of Web3 applications in gaming, social, and beyond.
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April 16, 2025

Will We Bottom Soon?

1000x Podcast

Crypto
Key Takeaways:
  1. Trade the Edges, Hold the Cash: In this high-volatility chop-fest, avoid the middle ground. Take profits (20-50%) and keep powder dry for inevitable dislocations and extreme lows.
  2. Bet on Real Yield & Value Accrual: Prioritize projects like Hyperliquid that generate revenue and return value to tokens. Consider pair trades (long RWA/short ETH) to bet on promising sectors without full market exposure.
  3. Macro Shift Fuels Long-Term Bull: Geopolitical realignment (US/China, multipolarity) creates short-term chaos but potentially fuels a decade-long run for alternative reserve assets like Gold and especially Bitcoin. Brace for volatility, but position for the long game.
See full notes