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AI Podcasts

November 17, 2025

Hash Rate - Ep 145 - TAO Subnets Templar (3), Basilica (39), Grail (81)

Hash Rate pod - Bittensor $TAO & Subnets

AI
Key Takeaways:
  1. **A New Market is Born:** Templar isn't just cheaper; it enables something that was previously impossible for 99% of the world. Democratizing pre-training means anyone can build a truly custom, sovereign AI.
  2. **Productization is Underway:** Covenant is no longer just a research project. With enterprise sales in motion, the focus is now on revenue. The team has committed that 100% of fees from custom training will be used to buy back its tokens.
  3. **Economics are Being Rewritten:** Basilica’s incentive mechanism is a direct critique of unsustainable models on other compute subnets. Its focus on profitability and positive TAO flow sets a new standard for economic design on Bittensor.
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November 17, 2025

Bryan Johnson: Don’t Die, Beating Entropy, AI Alignment & The Two-Species Future

Bankless

AI
Key Takeaways:
  1. AI Forces a Moral Reboot. The emergence of superintelligence renders our current societal goals dangerously obsolete. Survival must become the new prime directive.
  2. Existence is a Team Sport. The "Don't Die" philosophy is a collective mission ("we don't die") to ensure species-wide survival, not a selfish quest for individual immortality.
  3. Prepare for the Biological Sandbox. Humanity is moving from manipulating physical atoms and digital bits to programming our own biology—a frontier with both unimaginable potential and catastrophic risk.
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November 17, 2025

Emmett Shear on Building AI That Actually Cares: Beyond Control and Steering

a16z

AI
Key Takeaways:
  1. Stop Trying to “Steer” AGI. The control paradigm is a dead end. The goal isn’t a more obedient tool; it’s a trustworthy teammate. We must shift from engineering control to cultivating care.
  2. Alignment is a Process, Not a Product. True alignment isn't a fixed set of rules. It’s a dynamic process of moral learning, akin to raising a child. AIs that only follow rules are brittle and dangerous.
  3. Build for Cooperation, Not Command. The technical path forward involves training AIs in rich, multi-agent environments where they must learn cooperation and theory of mind—the foundational skills for becoming a good member of a group.
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November 16, 2025

Rawson Haverty presents "US & China AI: Lessons from Across the Pacific" | dAGI Summit 2025

Delphi Digital

AI
Key Takeaways:
  1. US Leads in Capital-Intensive Frontier AI; China Excels at Industrial Diffusion. The US leverages deep capital markets for its massive compute buildout and AGI research, while China uses state direction to embed AI into its vast industrial base via open-source models and hardware.
  2. Market Structure Dictates AI Strategy. The US "efficient oligopoly" model prioritizes global dominance and profit reinvestment by a few players. China's "subjugated swarm" model creates intense domestic competition, driving down prices and accelerating adoption at the cost of profitability.
  3. Geopolitical Tension May Be a Necessary Stabilizer. The competition between the US's freedom-oriented, frontier-pushing approach and China's stability-focused, diffusion-driven model creates a complementary tension that could be essential for navigating the "narrow corridor" between AI-driven totalitarianism and uncontrollable chaos.
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November 13, 2025

How Will AI Change Gaming Development? (A Dev’s Take)

The DCo Podcast

AI
Key Takeaways:
  1. Development timelines are collapsing from months to days. AI allows developers to swap entire asset libraries or generate new game concepts at unprecedented speed, turning a two-month art project into a day's work.
  2. The lifespan of any single game is shrinking. Prepare for a world of disposable entertainment. As AI floods the market with content, the strategy will pivot from creating one long-lasting hit to deploying a rapid succession of engaging experiences.
  3. Games are the next evolution of the attention economy. Just as memes became a core tool for community-building around tokens, easily created games will be the next engine for capturing and directing user attention in a hyper-competitive digital world.
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November 11, 2025

AI Nerves, Crypto Realism, Privacy Coins, & Lessons From Trading

1000x Podcast

AI
Key Takeaways:
  1. Adopt a Stock Picker's Mentality. The crypto market is no longer a monolith where a rising tide lifts all boats. Focus on assets with real products, user growth, and cash flow, as the gap between winners and losers will only widen.
  2. Shorting is a Tactical Assault, Not a Siege. Don't "invest" in a short. The only viable short strategies are tactical, targeting specific events like VC unlocks or news-driven spikes. Otherwise, even "total scams" can 5x against you.
  3. Cultivate a Goldfish's Memory. The most critical trading skill is learning how to change your mind. Cut losing trades, forget the loss (but remember the lesson), and redeploy capital without emotional baggage. Stubbornness is a portfolio killer.
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November 11, 2025

Grant Lee: Building Gamma’s AI Presentation Company to 100 Million Users

a16z

AI
Key Takeaways:
  1. Word-of-mouth isn't a feature; it's the engine. Before spending a dime on marketing, obsess over the first 30 seconds of the user experience until people can't help but share it.
  2. Being different is better than being better. Don't build incrementally better slideware. Redefine the core primitives of your category, as Gamma did by moving beyond the 16x9 slide.
  3. Hire painfully slowly to protect your DNA. Resisting the temptation to scale headcount with user growth is a superpower. The goal isn't to hit a hiring target; it's to hire the best people.
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November 7, 2025

Amjad Masad & Adam D’Angelo: How Far Are We From AGI?

a16z

AI
Key Takeaways:
  1. AGI Is a Definitional Debate. Progress toward an AI that can replace a remote worker is happening fast. However, achieving "true" human-like learning efficiency may require an entirely new paradigm beyond scaling current LLMs.
  2. The New Creator Economy Is Code. AI is turning software development into a mainstream creative pursuit, empowering a new class of solo entrepreneurs who can build what previously required entire teams.
  3. Incumbents Learned Their Lesson. Unlike past tech shifts, today's giants are aggressively adopting AI, making it both a sustaining *and* disruptive force. The market is large enough for both incumbents and startups to create massive value.
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November 6, 2025

Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease

a16z

AI
Key Takeaways:
  1. Build the Tools, Not Just the House: CZI’s greatest leverage comes from creating open-source tools and datasets. By building the fundamental infrastructure, they empower the entire scientific community—from academic labs to startups—to accelerate discovery.
  2. Data Is the New Microscope: The future of biology hinges on a tight feedback loop between generating novel, purpose-built datasets and training domain-specific AI models on them. This synergy is unlocking insights that were previously impossible.
  3. Virtual Biology Is the Next Frontier: Simulating biology computationally with "virtual cells" will become the new standard for research, enabling scientists to test riskier hypotheses faster and cheaper, dramatically compressing the timeline for major breakthroughs.
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Crypto Podcasts

February 12, 2026

Santiago Santos: My New Crypto Investing Playbook

The Rollup

Crypto
Key Takeaways:
  1. The investment focus must shift from foundational layers to the services built on top.
  2. Prioritize investments in public equities of companies that actively use crypto infrastructure or in private equity of crypto-native applications with strong, centralized teams capable of rapid decision-making and direct value reinvestment into their token.
  3. The market is increasingly discerning between tokens that compound value and those that do not.
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February 12, 2026

Is Nic Carter Right? How Serious Is Bitcoin's Quantum Risk?

Unchained

Crypto
Key Takeaways:
  1. The quantum threat forces a re-evaluation of cryptographic foundations, pushing blockchains towards more robust, future-proof designs. This shift is not just about defense but about positioning for long-term institutional trust and capital.
  2. Prioritize chains actively researching and implementing post-quantum solutions, especially those with clear migration roadmaps and a willingness to adapt core protocols.
  3. The race to quantum-proof crypto is on. Chains that act decisively now will secure their future, attract significant capital, and potentially set new industry standards, while those that delay risk systemic failure.
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February 13, 2026

Coinbase Earnings, Bitcoin vs Tech, and Crypto’s Quantum Threat

Unchained

Crypto
Key Takeaways:
  1. AI's compute demand reshapes infrastructure, pulling Bitcoin miners into stable new business models while forcing crypto to confront an existential quantum threat.
  2. Prioritize chains and protocols investing in post-quantum cryptography, focusing on clear migration roadmaps and robust hash- or lattice-based solutions.
  3. The next 6-12 months will clarify miner AI contracts, Bitcoin's market correlation, and quantum upgrade urgency. Position your portfolio and research towards projects showing foresight and execution.
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February 12, 2026

This Is Crypto’s Biggest Bottleneck (and LI.FI Solves It)

The DCo Podcast

Crypto
Key Takeaways:
  1. The fragmentation of crypto liquidity across chains demands a unified, programmable interface for complex user strategies. LI.FI's VM and transaction rail are building this composable layer, abstracting away the underlying complexity.
  2. Investigate protocols building on LI.FI's infrastructure for streamlined multi-chain operations. For tokenized asset issuers, prioritize integration with platforms offering broad wallet distribution like LI.FI.
  3. The future of crypto involves seamless multi-chain interactions and widespread tokenized asset adoption. LI.FI's innovations position them as a core enabler, making sophisticated DeFi accessible and driving liquidity to new assets over the next 6-12 months.
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February 13, 2026

Dispersion Is Exploding While Main Street Reaccelerates | Weekly Roundup

Forward Guidance

Crypto
Key Takeaways:
  1. The era of easy, broad-market gains from passive investing is ending. Unprecedented AI capital expenditure is driving a wedge between tech and tangible assets, forcing a re-evaluation of traditional correlations and creating a bifurcated market where "real things" with fixed supply constraints are gaining favor over software-driven growth. This shift is also revealing a quiet reacceleration in Main Street economics, previously masked by top-tier spending.
  2. Adopt a long-short, beta-neutral approach to capitalize on extreme market dispersion. Identify and invest in "bottleneck" assets (e.g., metals, energy, manufacturing inputs) that are essential for AI infrastructure and have inelastic supply, while selectively shorting or avoiding overvalued software companies facing existential threats from AI.
  3. The market is undergoing a fundamental re-rating. Capital will increasingly flow from over-indexed, high-multiple digital assets to under-owned, supply-constrained physical assets. Ignoring this "flipping of the boat" means missing out on significant alpha and risking capital in sectors facing structural headwinds.
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February 12, 2026

What Does AI Mean For Your Future?

1000x Podcast

Crypto
Key Takeaways:
  1. AI is driving a rapid, unprecedented capital concentration into a select group of companies and hard assets, creating a bifurcated economic reality where skilled labor gains leverage while low-skill labor faces immediate displacement.
  2. Invest in the "picks and shovels" of the AI boom: the companies building data centers, providing energy, and offering specialized services to this infrastructure. For individuals, become an AI-fluent, indispensable contributor in your field.
  3. The next 3-4 years are a critical window. Position your finances and career now to capitalize on the AI-driven wealth transfer and avoid being left behind as economic value consolidates at an accelerating pace.
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