AI Forces a Moral Reboot. The emergence of superintelligence renders our current societal goals dangerously obsolete. Survival must become the new prime directive.
Existence is a Team Sport. The "Don't Die" philosophy is a collective mission ("we don't die") to ensure species-wide survival, not a selfish quest for individual immortality.
Prepare for the Biological Sandbox. Humanity is moving from manipulating physical atoms and digital bits to programming our own biology—a frontier with both unimaginable potential and catastrophic risk.
Stop Trying to “Steer” AGI. The control paradigm is a dead end. The goal isn’t a more obedient tool; it’s a trustworthy teammate. We must shift from engineering control to cultivating care.
Alignment is a Process, Not a Product. True alignment isn't a fixed set of rules. It’s a dynamic process of moral learning, akin to raising a child. AIs that only follow rules are brittle and dangerous.
Build for Cooperation, Not Command. The technical path forward involves training AIs in rich, multi-agent environments where they must learn cooperation and theory of mind—the foundational skills for becoming a good member of a group.
US Leads in Capital-Intensive Frontier AI; China Excels at Industrial Diffusion. The US leverages deep capital markets for its massive compute buildout and AGI research, while China uses state direction to embed AI into its vast industrial base via open-source models and hardware.
Market Structure Dictates AI Strategy. The US "efficient oligopoly" model prioritizes global dominance and profit reinvestment by a few players. China's "subjugated swarm" model creates intense domestic competition, driving down prices and accelerating adoption at the cost of profitability.
Geopolitical Tension May Be a Necessary Stabilizer. The competition between the US's freedom-oriented, frontier-pushing approach and China's stability-focused, diffusion-driven model creates a complementary tension that could be essential for navigating the "narrow corridor" between AI-driven totalitarianism and uncontrollable chaos.
Development timelines are collapsing from months to days. AI allows developers to swap entire asset libraries or generate new game concepts at unprecedented speed, turning a two-month art project into a day's work.
The lifespan of any single game is shrinking. Prepare for a world of disposable entertainment. As AI floods the market with content, the strategy will pivot from creating one long-lasting hit to deploying a rapid succession of engaging experiences.
Games are the next evolution of the attention economy. Just as memes became a core tool for community-building around tokens, easily created games will be the next engine for capturing and directing user attention in a hyper-competitive digital world.
Adopt a Stock Picker's Mentality. The crypto market is no longer a monolith where a rising tide lifts all boats. Focus on assets with real products, user growth, and cash flow, as the gap between winners and losers will only widen.
Shorting is a Tactical Assault, Not a Siege. Don't "invest" in a short. The only viable short strategies are tactical, targeting specific events like VC unlocks or news-driven spikes. Otherwise, even "total scams" can 5x against you.
Cultivate a Goldfish's Memory. The most critical trading skill is learning how to change your mind. Cut losing trades, forget the loss (but remember the lesson), and redeploy capital without emotional baggage. Stubbornness is a portfolio killer.
Word-of-mouth isn't a feature; it's the engine. Before spending a dime on marketing, obsess over the first 30 seconds of the user experience until people can't help but share it.
Being different is better than being better. Don't build incrementally better slideware. Redefine the core primitives of your category, as Gamma did by moving beyond the 16x9 slide.
Hire painfully slowly to protect your DNA. Resisting the temptation to scale headcount with user growth is a superpower. The goal isn't to hit a hiring target; it's to hire the best people.
AGI Is a Definitional Debate. Progress toward an AI that can replace a remote worker is happening fast. However, achieving "true" human-like learning efficiency may require an entirely new paradigm beyond scaling current LLMs.
The New Creator Economy Is Code. AI is turning software development into a mainstream creative pursuit, empowering a new class of solo entrepreneurs who can build what previously required entire teams.
Incumbents Learned Their Lesson. Unlike past tech shifts, today's giants are aggressively adopting AI, making it both a sustaining *and* disruptive force. The market is large enough for both incumbents and startups to create massive value.
Build the Tools, Not Just the House: CZI’s greatest leverage comes from creating open-source tools and datasets. By building the fundamental infrastructure, they empower the entire scientific community—from academic labs to startups—to accelerate discovery.
Data Is the New Microscope: The future of biology hinges on a tight feedback loop between generating novel, purpose-built datasets and training domain-specific AI models on them. This synergy is unlocking insights that were previously impossible.
Virtual Biology Is the Next Frontier: Simulating biology computationally with "virtual cells" will become the new standard for research, enabling scientists to test riskier hypotheses faster and cheaper, dramatically compressing the timeline for major breakthroughs.
The Interface is the Bottleneck. Today's chatbots are the MS-DOS of AI. The next trillion dollars of value will be unlocked not by the models themselves, but by the new "Windows/Mac OS" interface that makes AI accessible and useful for everyone.
Every Creator Will Build Software. The distinction between a content creator and a software developer is collapsing. The next platforms will empower anyone to build mini-apps, turning software into a new medium for community, expression, and monetization.
Ditch the Voice-Only Dream. The Her-inspired fantasy of a screenless, voice-only AI future is a dead end. The winning AI device will be screen-first, built around an AI-native OS that makes software deeply personal and context-aware.
**Fiscal Dominance is Here:** Government spending, not just Fed policy, is the primary driver of the current inflationary pressures and will likely lead to an 8% GDP deficit.
**Prepare for Intervention:** Expect capital controls (like remittance taxes) and yield curve control as governments grapple with the consequences of their spending.
**Store-of-Value is King:** In an environment where traditional savings (e.g., 4% on bonds) can't match 15% inflation in essential costs, assets like tech stocks and Bitcoin become non-negotiable for wealth preservation.
Fiscal Doom Loop: The US is locked in a fiscal spiral of growing deficits and debt that it seems unwilling or unable to escape, making dollar debasement a significant long-term risk.
Macro is King: Geopolitical trends, capital flows, and policy decisions (like buybacks and potential yield curve control) are now more critical drivers of asset prices than individual company fundamentals.
Bitcoin's Ascent: In a world of "Ponzi schemes," Bitcoin stands out as a rational hedge and potentially the "generational trade" against failing monetary and fiscal policies.
**Memecoin Rebound Signals Risk-On:** The sharp recovery in memecoins highlights the market's speculative appetite; treat them as high-octane, ecosystem-specific bets.
**Strategic M&A is Reshaping Access:** Companies are buying their way into regulated markets and building out institutional-grade services, with "Crypto as a Service" set to grow.
**Institutional Rails Getting Stronger:** Coinbase’s S&P 500 debut and EToro’s IPO are landmark events, cementing crypto's place in mainstream finance and improving market transparency.
ETH is Back (For Now): ETH's dramatic surge signals renewed conviction, but its long-term trajectory against Bitcoin remains a key market question.
Macro Drives All: The U.S.-China tariff pause and potential capital control strategies will significantly impact risk assets; Bitcoin and gold are positioned as key beneficiaries of dollar devaluation.
Regulation is Turning Pro-Crypto: The SEC's pivot towards clear frameworks could finally unlock institutional adoption and the tokenization of real-world assets.
ETH Rally = Fragile Foundation: ETH's recent pump is more a short-squeeze than broad institutional buy-in; treat with skepticism.
Solana's Strategic Advantages: Solana benefits from innovation, discounted token acquisitions by strategic entities, and key infrastructure developments like asset-level KYC.
Meme Meta Redux: The "Internet Capital Markets" on Solana offer high-risk, high-reward plays mirroring past speculative cycles; speed and early positioning are crucial.
ETH's Rally: A Squeeze, Not Salvation. The price pop was a function of market mechanics (short liquidations), not a fundamental shift.
Short ETH/BTC (Again) After the Fever Breaks. Wait for clear signs of weakness (2-3 red days) post-rally before considering shorts; the core bearish arguments hold.
ETH's Tech & UX Are Dated. Crippling fees and a clunky experience mean ETH is losing ground, and L2 growth doesn't inherently justify ETH's current price.
