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AI Podcasts

December 17, 2025

Rethinking Pre-Training for Agentic AI [Aakanksha Chowdhery] - 759

The TWIML AI Podcast with Sam Charrington

AI
Key Takeaways:
  1. Strategic Implication: The next frontier in AI is agentic, and progress hinges on fundamental pre-training innovation, not just post-training optimizations.
  2. Builder/Investor Note: Focus on teams with deep experience in scaling and debugging large models, as this is a high-capital, high-risk endeavor. Builders should prioritize developing new benchmarks for agentic capabilities.
  3. The "So What?": The industry needs to move beyond next-token prediction and static benchmarks to unlock truly capable, self-correcting AI agents in the next 6-12 months.
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December 17, 2025

Code World Model: Building World Models for Computation – Jacob Kahn, FAIR Meta

AI Engineer

AI
Key Takeaways:
  1. Shift in AI Development: The focus moves from syntax-aware code generation to execution-aware reasoning, enabling more robust and intelligent code agents.
  2. Builder/Investor Note: Prioritize tools and platforms that support explicit execution modeling and highly asynchronous, high-throughput RL training for agentic systems.
  3. The "So What?": AI that can simulate complex systems internally will drastically reduce development and testing costs, accelerating innovation in software and distributed systems over the next 6-12 months.
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December 17, 2025

AI Kernel Generation: What's working, what's not, what's next – Natalie Serrino, Gimlet Labs

AI Engineer

AI
Key Takeaways:
  1. Strategic Shift: AI-driven kernel generation is not replacing human genius but augmenting it, allowing experts to focus on novel breakthroughs while AI automates the application of known optimizations across a complex hardware landscape.
  2. Builder/Investor Note: Focus on robust validation and hardware-in-the-loop systems. Claims of "AI inventing new algorithms" in this domain are premature. The real value is in automating the "bag of tricks" for heterogeneous compute.
  3. The "So What?": This technology is critical for scaling agentic AI workloads. Expect significant investment in tools that abstract hardware complexity and enable efficient, automated optimization, driving down the cost of AI inference in the next 6-12 months.
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December 18, 2025

AI Consulting in Practice – NLW, Super ai

AI Engineer

AI
Key Takeaways:
  1. The Agent Economy is Here: Enterprises are moving past pilots with AI agents. Builders should focus on orchestration layers and human-agent interaction design.
  2. ROI Measurement is the Next Frontier: Investors should look for solutions that help organizations accurately track and attribute AI value beyond traditional metrics.
  3. Strategic AI, Not Spot Solutions: The biggest wins come from systematic, cross-organizational AI strategies that target new capabilities and revenue growth, not just incremental time savings.
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December 18, 2025

How to build an AI native company (even if your company is 50 years old) – Dan Shipper, Every

AI Engineer

AI
Key Takeaways:
  1. The 100% AI adoption threshold is a step-function change, not incremental. Companies that commit fully will outpace those with partial integration.
  2. Builders should prioritize "compounding engineering" by codifying knowledge into reusable prompts. This builds an organizational memory that accelerates future development exponentially.
  3. Re-evaluate team structures and roles. Single engineers can own complex products, and even technical managers can contribute code, shifting how organizations operate.
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December 17, 2025

“How We Can Eliminate Crime” | Ben Horowitz and Garrett Langley

a16z

AI
Key Takeaways:
  1. Effective crime reduction requires a shift from reactive punishment to proactive, intelligence-driven deterrence, making it highly probable for criminals to be caught.
  2. The market for AI-powered public safety technology, particularly solutions that integrate data for precision and accountability, presents a significant opportunity. Public-private partnerships are a key funding mechanism.
  3. Over the next 6-12 months, expect to see more cities adopt advanced surveillance and AI tools, driven by private funding, as they seek to improve safety and address staffing shortages without resorting to ineffective, broad-stroke policies.
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December 18, 2025

Two Futures | Runtime 2025

a16z

AI
Key Takeaways:
  1. Strategic Implication: The next decade will be defined by who builds the core infrastructure for intelligence. This is where the most significant value and influence will accrue.
  2. Builder/Investor Note: Direct capital and talent towards foundational AI components—chips, models, and interoperable systems. Avoid the temptation to only build at the application layer.
  3. The So What?: The window for shaping the future of intelligence is now. Engage in the deepest, most complex challenges to secure a footprint in this new era.
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December 18, 2025

The EU and the not-so-simple macroeconomics of AI – Luis Garicano

Epoch AI

AI
Key Takeaways:
  1. Strategic Implication: The global AI race is a zero-sum game for foundational models. Europe's best strategy is a "smart second mover" approach, focusing on the implementation layer by ensuring interoperability and data portability.
  2. Builder/Investor Note: Invest in AI that achieves true autonomy and enhances expert productivity. Be wary of markets stifled by over-regulation, which can impede AI adoption and growth.
  3. The "So What?": Europe faces a critical juncture. Without embracing AI-driven growth, its demographic and debt problems will worsen, leading to higher interest rates without the corresponding economic expansion.
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December 18, 2025

SAM 3: The Eyes for AI — Nikhila & Pengchuan (Meta Superintelligence), ft. Joseph Nelson (Roboflow)

Latent Space

AI
Key Takeaways:
  1. Vision AI Democratization: SAM 3 lowers the barrier for sophisticated vision tasks, making advanced segmentation and tracking accessible for a wider range of applications.
  2. Builder/Investor Note: Focus on domain-specific adaptations and tooling that enhance human-AI interaction for ambiguous visual concepts. The "last mile" of user intent is a key differentiator.
  3. The "So What?": SAM 3 accelerates the development of multimodal AI, particularly in robotics and video analysis, by providing a robust, scalable visual foundation for the next generation of intelligent systems.
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Crypto Podcasts

September 8, 2025

pump.fun's Sapijiju: First-Ever Discussion on Building the Future of Social Trading

Delphi Digital

Crypto
Key Takeaways:
  1. Weaponized Capital: With nearly $2 billion on its balance sheet, pump.fun sees capital as a "weapon" for strategic acquisitions and user incentives to methodically capture market share from both crypto and Web2 incumbents.
  2. Creators Are the New Go-To-Market: The entire growth strategy hinges on a simple, powerful premise: pay creators exponentially more than anyone else. This is their path to onboarding millions of mainstream users who have never touched crypto.
  3. The Anti-VC Play: The platform’s raw, unfiltered nature is a direct response to a crypto industry viewed as rife with opaque, VC-backed projects. Its honesty and fun resonate with a generation tired of being retail exit liquidity.
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September 3, 2025

Gold Is Breaking Out, BTC Next?

1000x Podcast

Crypto
Key Takeaways:
  1. **Gold's rally is fundamentally driven.** Falling rates and central bank de-dollarization are creating a powerful tailwind for the precious metal, signaling a major shift in global asset allocation.
  2. **Bitcoin is riding gold's coattails.** As the "digital gold" narrative strengthens, a rising gold price is perceived as a bullish leading indicator for BTC, with investors watching the BTC/Gold market cap ratio as a key metric.
  3. **Your past market experiences are blinding you.** Investors must actively identify and challenge their "childhood curses"—biases formed during previous market cycles—to capitalize on new trends.
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September 3, 2025

How Crypto Insiders Are Sidestepping the Law to Dump on Retail

Unchained

Crypto
Key Takeaways:
  1. **The 10-Minute Rule:** If you’re not in a memecoin launch within the first 10 minutes, you are the exit liquidity. The game is rigged by snipers with privileged information.
  2. **Deception is the Default:** Insiders use sophisticated tactics like one-sided LPs to hide their selling, making it crucial for investors to look beyond simple price charts.
  3. **Self-Policing is the Only Way:** Don't wait for regulators. The crypto community must build its own systems of accountability to expose and sideline repeat offenders.
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September 3, 2025

Why Everyone Keeps Misreading The New Macro Regime | Ben Kizemchuk

Forward Guidance

Crypto
Key Takeaways:
  1. **Fiscal Is King.** The government, not the Fed, is in the driver's seat. Higher interest rates are now stimulative, as higher interest payments on government debt inject more cash directly into the private sector.
  2. **The Market Is The Economy.** Passive flows have rewired capital allocation, turning the stock market into an automated utility that concentrates wealth in mega-cap companies, making traditional valuation metrics less relevant.
  3. **Invest in Scarcity.** In a world of unlimited fiat currency and financially repressed bond yields, assets with a fixed supply, such as gold and crypto, become critical portfolio components, while traditional fixed income loses its appeal.
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September 2, 2025

Why Is Everyone So Bearish?

1000x Podcast

Crypto
Key Takeaways:
  1. Fade the Crowd. Widespread retail despair is a signal of an underexposed market, creating a powerful contrarian buying opportunity.
  2. Macro Is the Driver. Pro-crypto deregulation and future rate cuts are the real forces to watch, not short-term price action.
  3. Alpha Demands Work. The era of easy altcoin gains is over. The new "wealth hack" is to develop deep expertise by embedding yourself in a project's ecosystem.
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September 1, 2025

Kraken’s 10 Year Plan | Arjun Sethi

Empire

Crypto
Key Takeaways:
  1. **Incentives Define the Game:** Arjun’s 10-year compensation plan isn't just a detail; it’s a strategy. It forces long-term thinking and aligns the entire organization around monumental growth targets, a stark contrast to the short-term focus of many public companies.
  2. **Win the "Meaty Middle":** While competitors fight over retail users or institutional whales, Kraken is cornering the market of professional traders. This overlooked segment is the engine of global liquidity and the key to building a durable, high-volume exchange.
  3. **On-Chain IPOs Are Coming:** The future of capital markets is global, on-chain, and permissionless. Traditional companies are already looking to bypass Wall Street for venues like Kraken, signaling a fundamental shift in how businesses access capital.
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