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AI Podcasts

May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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May 26, 2025

Chatbot platforms might replace social media

Machine Learning Street Talk

AI
Key Takeaways:
  1. AI Companionship is Exploding: Millions are already deeply engaged with AI for emotional connection, and this is just the beginning as technology like GPT-4o normalizes it.
  2. Lean Engineering Can Win: Chai's success with a tiny, hyper-talented team and innovative techniques like model blending proves that massive VC-backed operations aren't the only path to scale in AI.
  3. The Next Social Platform Might Be AI: As AI offers more active, personalized, and consequence-free social interaction, it could very well become the dominant way people connect, potentially supplanting traditional social media.
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May 25, 2025

How Endless Debt Became America's Culture

Forward Guidance

AI
Key Takeaways:
  1. **Debt is Destiny:** America's fiscal irresponsibility and cultural embrace of debt ensure ongoing money printing and inflation, making currency debasement a near certainty.
  2. **The One True Trade:** Forget complex analytics; the primary goal is preserving purchasing power. This means owning store-of-value assets like Bitcoin and gold, which are positioned to thrive.
  3. **AI Accelerates the Crisis:** Artificial intelligence will not only disrupt labor markets but also intensify the debt crisis by devaluing traditional education and fueling calls for more government relief.
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May 24, 2025

SN85 :: VIDAIO :: Decentralized AI Video Upscaling & Compression ++ Roadmap & Enterprise Utility

Opentensor Foundation

AI
Key Takeaways:
  1. Decentralized AI is Production-Ready: VIDAIO demonstrates that complex AI tasks like video processing can be effectively decentralized and optimized through BitTensor's subnet model, with miners already outperforming base models.
  2. Perceptual Quality Wins: Focusing on human-perceived video quality, rather than just raw specs, is key for AI video tools, leading to more efficient and visually appealing results.
  3. Subnets Must Aim for Self-Sufficiency: The long-term viability of BitTensor subnets hinges on generating real-world revenue and solving actual customer problems, moving beyond reliance on token emissions.
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May 24, 2025

Sovereign AI: Why Nations Are Building Their Own Models

a16z

AI
Key Takeaways:
  1. National AI is Non-Negotiable: Countries are investing heavily in "AI factories" to control their digital destiny and cultural narratives.
  2. Models are Culture: AI outputs reflect embedded values, making local control over AI development and deployment a geopolitical imperative.
  3. Lead by Building Better: The US can maintain AI leadership by out-innovating competitors and enabling allies, pursuing "foundation model diplomacy" to ensure its technology underpins global progress.
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Crypto Podcasts

July 29, 2025

Why Charles Hoskinson Is Still Actively Involved In Crypto

Empire

Crypto
Key Takeaways:
  1. Crypto as a Political Countermeasure: For Hoskinson, blockchain is the practical tool to enforce the sound money and transparent governance that the US government has abandoned.
  2. The Federal Reserve Is a Core Target: He identifies the Federal Reserve's unchecked power over the monetary supply as a central flaw in the current system, positioning decentralized currencies as a direct challenge to its authority.
  3. A Mission, Not a Job: His daily engagement isn't for financial gain but is driven by the conviction that the fight for a more honest and accountable system is far from over.
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July 29, 2025

The State Of Solana With Carlos Gonzalez Campo

Lightspeed

Crypto
Key Takeaways:
  1. Tech Over Hype: Solana’s long-term bet is on fundamental technology. Upgrades like Jito’s BAM are designed to create a superior on-chain environment for sophisticated finance, even if it means losing short-term narrative battles to ETH.
  2. The Institutional Gap: Ethereum is currently winning the institutional game with simple, powerful stories around stablecoins and treasury assets. Solana needs a clearer, more accessible pitch beyond raw performance to compete for this capital.
  3. Performance is Non-Negotiable: The Solana ecosystem is doubling down on its high-throughput thesis. Expect a continued push for more blockspace and faster finality, even if it makes running a validator more exclusive. The trade-off is deemed worth it to bring global-scale finance on-chain.
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July 28, 2025

The Rise Of Crypto Treasury Companies

1000x Podcast

Crypto
Key Takeaways:
  1. **Treasury Companies Are A Double-Edged Sword.** They are creating massive buy-side pressure now but pose a systemic risk. Their weak debt covenants could turn a market dip into a liquidation cascade.
  2. **Market Structure Over Fundamentals (For Now).** ETH’s surge exemplifies this trend. Despite weak fundamentals, its powerful technical breakout and role as the next asset for treasury buyers are driving its outperformance.
  3. **Watch the NAV Premium.** The key health metric is the premium-to-NAV on these treasury companies. As long as investors pay $2 for $1 of crypto, the mania continues. A flip to a discount is the canary in the coal mine.
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July 28, 2025

Charles Hoskinson: ADA Is A Better Investment Than BTC

Empire

Crypto
Key Takeaways:
  1. The Cycle is Dead, Long Live the Cycle: The old four-year, retail-driven crypto cycle is over. We're in an institutionally-led "gigachad bull run" that will last through 2026 and push the market cap above $10 trillion, pending regulatory clarity.
  2. Narrative is the Ultimate Metric: Chains that focus on philosophical purity and solving real-world problems (Bitcoin, Cardano) build more resilient communities and long-term value than those chasing fleeting metrics like TPS and TVL.
  3. Bitcoin's Next Chapter will be Written on Cardano: As Bitcoin matures into a yield-bearing asset, its massive capital base will seek returns elsewhere. Cardano’s UTXO model and upcoming interoperability features are designed to capture this flow, positioning it as Bitcoin’s de facto yield layer.
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July 27, 2025

Liberation Day Broke The Dollar

Forward Guidance

Crypto
Key Takeaways:
  1. The Dollar's "Gold Moment" is Here. The dollar is decoupling from its traditional anchor (rate differentials) just as gold decoupled from real yields, signaling a permanent regime shift driven by geopolitics, not just economics.
  2. The "Dollar Smile" Has Inverted. The dollar is no longer a reliable risk-off hedge. Its positive correlation with equities means it now falls during market stress—a fundamental rewiring for asset allocators.
  3. The Devaluation Trade is a Trap (For Now). While the long-term bearish case for the dollar is clear, the trade is dangerously crowded. Expect markets to test this one-sided positioning with a painful bounce before the ultimate decline resumes.
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July 26, 2025

Hivemind: Ethena Founder, the GENIUS Act & Overvalued L1s

Empire

Crypto
Key Takeaways:
  1. **The Real Cycle Indicator:** Forget price targets. The bull market's health is directly tied to the premium-to-NAV on crypto treasury vehicles. When those premiums collapse, the party is over.
  2. **L1s Are Dead Money:** The dominant thesis is a massive market re-rating where capital flees overvalued L1 infrastructure and concentrates into Bitcoin and a handful of cash-flow-positive applications.
  3. **Stablecoins Aren't a Commodity:** The moats are deep. New issuers will struggle to compete with Tether's liquidity network effects and Ethena's structural yield advantage, making it a bear market for new stablecoin startups.
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