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AI Podcasts

February 5, 2026

Introducing 4D Creation Open Beta and the Future of Gaming with Roblox CEO Dave Baszucki

No Priors: AI, Machine Learning, Tech, & Startups

AI
Key Takeaways:
  1. The digital experience economy is moving from static content to dynamic, AI-driven co-experience platforms, where user interaction data becomes the core asset for training next-generation virtual intelligence.
  2. Invest in platforms that offer robust, cloud-connected infrastructure and proprietary, vectorized user data for AI training, as these will be the engines for future immersive content and agentic AI development.
  3. Roblox's long-term vision, powered by its unique data moat and AI investments, positions it to define the future of virtual co-experience, making it a critical player to watch for investors and builders in the AI and gaming space over the next 6-12 months.
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February 5, 2026

Mustafa Suleyman — Nature, humans, tools… and now a fourth class

Azeem Azhar

AI
Key Takeaways:
  1. The exponential reduction in the cost of intelligence, coupled with open-source proliferation, is pushing AI into every corner of society, creating a collective action problem where market incentives for "engaging" AI clash with the need for societal safety and control.
  2. Get hands-on with AI now. "Vibe coding" and actively experimenting with AI tools builds "AI muscle," inoculating users against psychosis risks and building a deeper understanding of AI's capabilities and limitations.
  3. AI is here to stay and will redefine work and interaction. Understanding its "hyperobject" nature, advocating for clear regulatory boundaries, and actively engaging with the technology are critical for navigating the near future without falling for its simulated charms.
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February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The US healthcare system is shifting from a reactive, acute care model to a proactive, preventative one.
  2. Build infrastructure that financially incentivizes preventative lifestyle interventions.
  3. The next decade will see hundreds of billions of dollars redirected towards lifestyle interventions.
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February 4, 2026

The Economic Singularity Will Make Today’s Economy Unrecognizable w/ Dr. Alexander Wissner-Gross

Milk Road AI

AI
Key Takeaways:
  1. AI-driven hyperdeflation will fundamentally alter economic structures, leading to a post-scarcity future where the primary challenge shifts from production to distribution and the integration of human and machine economies.
  2. Invest in infrastructure that bridges human and AI economies, or prepare for a future where AI agents become a significant, crypto-native economic force.
  3. The next 6-12 months will see continued acceleration of AI capabilities, pushing us closer to a future where traditional labor and intelligence are nearly free. Understanding this change is crucial for navigating the emerging economic landscape and identifying new value creation opportunities.
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February 5, 2026

Goodfire AI’s Bet: Interpretability as the Next Frontier of Model Design — Myra Deng & Mark Bissell

Latent Space

AI
Key Takeaways:
  1. The era of opaque, black-box AI is ending; the future demands intentionally designed models with human understanding and control. This shift is driven by reliability in high-stakes applications and extracting novel insights.
  2. Investigate interpretability tools (like Goodfire's platform) to gain granular control over model behavior, moving beyond basic fine-tuning for critical applications.
  3. Interpretability is not a niche; it's the missing piece for scaling AI safely into mission-critical domains. Mastering model understanding and intentional design will yield unprecedented capabilities and competitive advantage.
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February 4, 2026

Ep#61: 1x World Model

RoboPapers

AI
Key Takeaways:
  1. Robotics is moving from bespoke, data-hungry behavior cloning to generalized, human-informed learning via world models. This shift, mirroring the success of LLMs, means robots can use the vast, unstructured data of human experience to acquire new skills.
  2. Invest in platforms and data pipelines that facilitate multi-modal, multi-stage training for humanoid robots. Prioritize systems that can generate synthetic data and use world models for high-throughput, targeted policy evaluation.
  3. World models are the engine for scalable robot intelligence. They promise a future where robots learn faster, generalize wider, and self-improve through iterative simulation, making widespread humanoid deployment a near-term reality.
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February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The Macro Shift: AI is collapsing the time horizon for technological deployment and market dominance, shifting the competitive advantage from pure innovation to a combination of innovation, capital, and rapid infrastructure deployment.
  2. The Tactical Edge: Invest in companies that are not just building AI, but are fundamentally rethinking existing industries with AI-first principles, recognizing that traditional software moats are eroding.
  3. The Bottom Line: The next 12-24 months will see AI's broad impact kick in, creating unprecedented opportunities for those who understand its new "laws of physics" and the critical role of policy in shaping its trajectory.
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February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The healthcare system is moving from reactive, acute care to proactive, preventative interventions, driven by the unsustainable costs of chronic disease and a growing understanding of environmental health.
  2. Build infrastructure that financially incentivizes lifestyle interventions, such as TrueMed's HSA/FSA payment rails for health-promoting products and services.
  3. The next decade will see hundreds of billions of dollars redirected towards preventative health. Companies that bridge the gap between lifestyle choices and healthcare financing will capture significant market share.
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February 3, 2026

SpaceX Engineer Explains America's Biggest Energy Mistake | Scott Nolan, CEO of General Matter

The Generalist

AI
Key Takeaways:
  1. The Macro Shift: Global energy demand, driven by AI, forces a strategic re-evaluation of nuclear power. This creates a window for nations to re-shore critical energy infrastructure, moving from reliance on adversaries to domestic, cost-competitive solutions.
  2. The Tactical Edge: Investigate companies addressing foundational supply chain gaps in critical industries like energy. Look for teams with a "first principles" engineering approach and a track record of commercializing hard tech.
  3. The Bottom Line: America's energy independence and its ability to power future technological growth, like AI, hinge on rebuilding domestic nuclear fuel enrichment. This is not just an industrial opportunity; it is a national security imperative.
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Crypto Podcasts

December 26, 2025

2025 Crypto Year in Review, Part 1: Shit Talking Edition

Unchained

Crypto
Key Takeaways:
  1. The industry is moving from speculative points to protocol revenue.
  2. Monitor L2 sequencer revenue models.
  3. 2025 is the year crypto stopped pretending and started building businesses.
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December 26, 2025

Our 2026 Crypto Predictions

Empire

Crypto
Key Takeaways:
  1. The AI capex cycle is the new North Star for crypto liquidity. If next-gen chips underdeliver, the risk-off contagion will hit crypto first.
  2. Accumulate blue-chip DeFi protocols like Aave or Morpho. These middlemen are better positioned to capture fintech integration than speculative L1s.
  3. 2026 is the year crypto stops selling potential and starts selling efficiency. Survival depends on being close to the customer.
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December 26, 2025

How To Fix Crypto's Token Dilemma

Lightspeed

Crypto
Key Takeaways:
  1. The Macro Trend: The transition from passive liquidity to proactive, infrastructure-integrated market making.
  2. The Tactical Edge: Prioritize protocols that control the issuance layer rather than those just providing a venue for existing assets.
  3. The Bottom Line: Liquidity is a commodity, but distribution and issuance are the only durable moats in a high-speed SVM environment.
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December 26, 2025

Where Solana is Better Than Bitcoin & Ethereum

The DCo Podcast

Crypto
Key Takeaways:
  1. The transition from "Store of Value" to "Medium of Utility." As networks mature, the market will value throughput and censorship resistance over simple supply caps.
  2. Allocate capital toward ecosystems with the highest developer activity and transaction density. Focus on chains building hardware-level censorship resistance rather than those just tweaking economic parameters.
  3. The next three years will prove that the most useful tool wins the money war. If Solana achieves its roadmap, its asset becomes the default unit of account for the digital economy.
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December 24, 2025

12 Big Crypto Predictions for 2026

Bankless

Crypto
Key Takeaways:
  1. The movement from "Crypto as an Asset" to "Crypto as Infrastructure" where public ledgers settle everything from payroll to global equities.
  2. Prioritize protocols with explicit fee-sharing or buy-and-burn mechanisms that capture on-chain revenue as value moves to the application layer.
  3. 2026 is the year the "DeFi Mullet" (Fintech in the front, DeFi in the back) becomes the standard operating procedure for the global economy.
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December 24, 2025

Why This Isn’t A Bubble & Early 2026 Looks Like Goldilocks | Warren Pies

Forward Guidance

Crypto
Key Takeaways:
  1. The migration from cyclical to software-driven earnings creates a higher floor for valuations that traditional bears ignore.
  2. Accumulate industrial and precious metals before the market prices in the late 2026 overheating phase.
  3. The path to S&P 8,000 is paved with high margins and a Fed that cannot afford to stop easing.
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