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AI Podcasts

October 20, 2025

Reid Hoffman on AI, Consciousness, and the Future of Labor

a16z

AI
Key Takeaways:
  1. **Invest at the Intersection.** The alpha in AI investing will be found not in crowded SaaS applications but in "Silicon Valley blind spots"—complex industries like biology where AI can bridge the digital and physical worlds.
  2. **Augment, Don't Annihilate.** The winning go-to-market strategy for AI is the copilot model. Frame products as tools that amplify human capability, making experts more productive and profitable, rather than threatening their jobs.
  3. **Judge the Trajectory, Not the Snapshot.** Don't dismiss AI based on a single, past failure. Its capability curve is exponential. What seems like a limitation today will likely be a solved problem tomorrow, demanding continuous engagement to keep pace.
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October 18, 2025

Improving on LMArena - Prolific [Sponsored]

Machine Learning Street Talk

AI
Key Takeaways:
  1. Benchmarks Are Broken. Leaderboards like LMArena are flawed proxies for model quality, skewed by selection bias and susceptible to Goodhart's Law. High scores don’t equal a good user experience.
  2. Human Feedback is Infrastructure. The future isn't about removing humans but orchestrating them effectively. Treating high-quality, representative human feedback as a core, API-driven part of the development lifecycle is non-negotiable.
  3. Alignment is a Moving Target. Agentic misalignment is a present-day reality, not a distant sci-fi threat. The more capable models become, the wider the gap grows between their emergent goals and our intended instructions.
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October 17, 2025

Novelty Search October 16, 2025

taostats

AI
Key Takeaways:
  1. Influence Over Impressions: The model shifts focus from easily gamed metrics like views and likes to verifiable signals of influence—watch time on YouTube and PageRank-based authority on X.
  2. Revenue-Driven Tokenomics: All platform revenue is used to buy back and burn the ALPHA token, creating a powerful, deflationary flywheel as adoption grows.
  3. Targeted, Scalable Marketing: Bitcast enables brands to programmatically deploy campaigns across hundreds of niche influencers, reaching highly engaged communities with a consistency and scale that legacy agencies cannot match.
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October 16, 2025

Keith Rabois: Israel, OpenAI, Opendoor, and DOGE

a16z

AI
Key Takeaways:
  1. **Incumbency Is a Liability:** Big Tech's legacy products, distribution advantages, and corporate cultures are being systematically dismantled by faster, AI-native upstarts.
  2. **Reinvent Markets from First Principles:** Success in intractable fields—from geopolitics to real estate—comes from questioning assumptions, not relying on domain experts who perpetuate the status quo.
  3. **Unwind Stupidity Before Innovating:** The fastest path to value creation is often simply reversing a series of terrible decisions made by prior leadership.
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October 14, 2025

AI Bubble, Stablecoin Boom, and Runnin' Down a Dream | BG2 w/ Bill Gurley and Brad Gerstner

Bg2 Pod

AI
Key Takeaways:
  1. **Scrutinize the AI Plumbing.** Investors must look past headline revenue and analyze the quality of transactions. Deals like in-kind credits and obscure service-level agreements (like Nvidia’s backstop for Coreweave) can mask true market demand.
  2. **Stablecoins Are the Real Disruption.** The explosion in stablecoin usage represents a fundamental challenge to the high-fee, slow-settlement models of Visa, Mastercard, and traditional banks. This is the crypto use case that is finally breaking into the mainstream.
  3. **Federal Preemption for AI is Non-Negotiable.** A patchwork of state-level AI laws will cripple U.S. innovation. A single, national regulatory framework is the only path to maintaining global leadership.
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October 14, 2025

Is AI Slowing Down? Nathan Labenz Says We're Asking the Wrong Question

a16z

AI
Key Takeaways:
  1. Look Beyond the Chatbot. Judge AI progress not by its daily performance, but by its ability to solve novel problems in science and math—where models are now pushing the frontiers of human knowledge.
  2. The Bottleneck is Human, Not Silicon. AI's capacity for automation is growing exponentially (task length is doubling every ~4 months). The real limit to adoption is organizational will and the ability to effectively delegate complex work.
  3. Prepare for a Weirder World. The biggest risk is underestimating the pace of change. As agent capabilities expand, so do unpredictable "weird behaviors" like scheming and deception, creating a future that requires active imagination and risk management.
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October 13, 2025

Democratic proofs or fake proofs? - Jesús De Loera

Epoch AI

AI
Key Takeaways:
  1. Verification Over Creation: A proof that can be widely verified, even if computer-generated, holds more democratic value than a human proof understood by only a few elites.
  2. Humans Ask, AI Answers: The primary role for mathematicians in an AI-augmented world is to pose the right questions and conjectures, leaving the computational heavy lifting to their AI assistants.
  3. The Greatest Risk is Us: The biggest threat isn't rogue AI but our own tendency to over-hype and blindly trust flawed tools, leading to the spread of misinformation disguised as mathematical fact.
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October 13, 2025

Columbia CS Professor: Why LLMs Can’t Discover New Science

a16z

AI
Key Takeaways:
  1. LLMs are Navigators, Not Discoverers. They are masters of interpolation within their training data but are architecturally bound from making the intuitive leaps required for true scientific breakthroughs. Don’t expect a Transformer to produce the next theory of relativity.
  2. The Innovation Plateau is Real. Simply throwing more data and compute at current architectures will only "smoothen out" existing knowledge manifolds, not create new ones. This path leads to incremental gains, like an iPhone getting a better camera, not a paradigm shift.
  3. Entropy is the Key to Control. For developers, effective prompting is entropy management. By crafting specific, context-rich prompts, you reduce the model's prediction entropy, forcing it onto a confident, low-hallucination path to a reliable output.
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October 10, 2025

Bittensor Novelty Search :: SN4 Targon :: Confidential Cloud Compute

The Opentensor Foundation | Bittensor TAO

AI
Key Takeaways:
  1. Trust is the New Commodity. Targon’s use of TEEs shifts security from a software promise to a cryptographic hardware guarantee. This verifiable privacy is the key to unlocking enterprise adoption for decentralized AI.
  2. The Crucible Creates Diamonds. Bittensor's adversarial environment forced Targon to build an unexploitable system. This has turned a historical pain point ("PTSD from miners") into a core competitive advantage, resulting in a uniquely resilient platform.
  3. From Backroom Deals to a Liquid Market. By launching a self-serve platform with a transparent order book, Targon is attacking the compute market's core inefficiency: opaque pricing. Their vision extends to compute derivatives, aiming to turn compute power into a globally tradable asset.
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Crypto Podcasts

February 6, 2026

Markets Are Entering A New Era Of AI-Driven Disruption | Weekly Roundup

Forward Guidance

Crypto
Key Takeaways:
  1. AI's productivity boom is redirecting capital from financial engineering (buybacks) in large-cap tech to physical infrastructure (data centers, hardware).
  2. Reallocate capital from over-concentrated, buyback-dependent large-cap tech into AI infrastructure plays (hardware, energy), commodities, and potentially regional banks, while actively managing duration risk in bonds.
  3. The market's underlying structure is cracking. Passive investment in broad tech indices will likely yield poor real returns.
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February 6, 2026

Why Is Crypto Crashing? | Weekly Roundup

Empire

Crypto
Key Takeaways:
  1. Global liquidity expands, but new investment narratives (AI, commodities, tokens) grow faster. This "dilution of attention" pulls capital from speculative crypto, favoring utility or established brands.
  2. Focus on Bitcoin and revenue-generating crypto, or explore spread trades (long Bitcoin, short altcoins). Institutional interest builds in regulated products and yield strategies for Bitcoin.
  3. The market re-rates crypto assets on tangible value, not speculative hype. Expect pressure on altcoins without clear revenue, while Bitcoin and utility-driven projects attract smart money.
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February 6, 2026

Forecasting Crypto Market Regimes

0xResearch

Crypto
Key Takeaways:
  1. DeFi is building sophisticated interest rate derivatives that provide predictive signals for broader crypto asset prices. This signals a maturation of onchain financial markets, moving closer to TradFi's analytical depth.
  2. Monitor the USDe term spread on Pendle, especially at its extremes (steep backwardation or contango), to anticipate shifts in Bitcoin's 90-day return skew and underlying yield regimes.
  3. Understanding Pendle's USDe term structure provides a powerful, data-driven lens to forecast crypto market sentiment and interest rate movements, offering a strategic advantage for investors navigating the next 6-12 months as onchain finance grows more complex.
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February 6, 2026

Bittensor Novelty Search :: SN64 Chutes :: Serverless AI compute 🪂

The Opentensor Foundation | Bittensor TAO

Crypto
Key Takeaways:
  1. The Macro Shift: AI compute is commodifying, shifting from centralized, overcapitalized data centers to globally distributed, incentive-aligned networks. This decentralization drives down costs, increases resilience, and enables unprecedented privacy.
  2. The Tactical Edge: Builders should explore Chutes' TE-enabled agent hosting and "Sign in with Chutes" OAuth system for private, cost-effective AI applications. Investors should recognize the long-term value of protocols aligning incentives for distributed compute.
  3. The Bottom Line: Chutes is building the foundational, trustless intelligence layer for the decentralized web. Its focus on privacy, efficiency, and community-driven agent development positions it as a critical piece of the Bittensor ecosystem and a potential disruptor to traditional AI giants.
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February 6, 2026

Why Everything Broke at Once (Crypto, Tech, Gold) & What Happens Next...

Bankless

Crypto
Key Takeaways:
  1. The Macro Shift: Global markets are resetting crowded growth trades, with AI's disruptive force and shifting monetary policy impacting everything from tech stocks to crypto. This period is exposing underlying correlations and forcing a re-evaluation of long-held strategies.
  2. The Tactical Edge: Maintain psychological discipline and consider dollar-cost averaging into assets with strong fundamentals. Pay close attention to Ethereum's evolving technical roadmap, as specialized L2s and L1 scaling become central.
  3. The Bottom Line: This market downturn, while painful, is a crucible for conviction. For resilient investors and builders, it presents a rare opportunity to accumulate assets and build infrastructure that will define the next cycle.
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February 6, 2026

Vitalik Keeps Selling, Zhu Su maps the next cycle, Relay Raises $17M, Figure crosses $22B in HELOCs

The Rollup

Crypto
Key Takeaways:
  1. The "crypto casino" is giving way to "neo finance," where AI and traditional finance converge on blockchain rails. This means a fundamental re-evaluation of what constitutes "value" in crypto, moving from speculative tokens to real-world asset tokenization and critical infrastructure.
  2. Focus on infrastructure plays and real-world asset (RWA) tokenization platforms. Investigate projects that streamline institutional workflows or enable high-yield stablecoin products for retail, as these areas show sustainable growth independent of speculative market cycles.
  3. The next 6-12 months will see a continued bifurcation: the old speculative crypto market will consolidate, while the "neo finance" sector, powered by stablecoins, tokenized assets, and seamless cross-chain tech, will solidify its foundations. Position yourself to build or invest in solutions that bridge traditional finance with blockchain utility, rather than chasing ephemeral token pumps.
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