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AI Podcasts

June 26, 2025

AI at the Edge: How Gensyn Is Building Verifiable, Decentralized Machine Learning

The People's AI

AI
Key Takeaways:
  1. Verification is AI’s Trust Bottleneck. True decentralized AI is impossible without solving verification. Without deterministic proofs, networks are vulnerable to economic exploits and malicious model poisoning, rendering them untrustworthy.
  2. The Next Frontier is Horizontal, Not Vertical. The era of simply adding more GPUs to a data center is ending. The future lies in distributing tasks across a vast network of devices, which requires a new paradigm of verifiable, deterministic algorithms.
  3. Deterministic AI Creates New Economies. A verifiable infrastructure provides the substrate for a new "machine economy" where autonomous agents transact and arbitrate disputes. This same technology can serve as a trusted, unbiased arbiter for human interactions.
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June 26, 2025

Tech Executive Answers: Can AI Solve Healthcare's Urgent Workforce Challenges? with Ankit Jain

a16z

AI
Key Takeaways:
  1. AI’s killer app in healthcare is automating administrative sludge. The most immediate ROI isn't in clinical diagnosis but in tackling the operational chaos (prior authorizations, benefit checks) that delays care and burns out staff.
  2. Expose the hidden costs of the status quo. AI’s value becomes undeniable when it reveals and corrects the existing system's deep-seated inefficiencies and error rates, like the 25% inconsistency rate in human-led payer calls.
  3. The moat is the workflow, not the model. As foundation models become commoditized, the real, defensible value for AI companies lies in deep, last-mile workflow integration and the proprietary data loops that fine-tune models for specific, high-stakes environments.
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June 25, 2025

Hash Rate - Ep 119 - The #1 Bittensor Subnet CHUTES

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

AI
Key Takeaways:
  1. Massive Utility Unlocks Adoption: Shoots' focus on simplifying AI deployment and providing access to models at low/no cost (initially) has driven user numbers to 371,000 and massive token throughput, proving real-world demand.
  2. Bridging Crypto and AI is Key: Overcoming AI developers' skepticism of crypto requires tangible benefits; Shoots aims to be that bridge, using BitTensor's incentives to power a superior, open AI platform.
  3. Privacy is the Enterprise Gateway: For decentralized AI platforms like Shoots to capture significant enterprise market share, robust, verifiable privacy solutions like Trusted Execution Environments (TEEs) are non-negotiable.
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June 25, 2025

Building Cluely: The Viral AI Startup that raised $15M in 10 Weeks

a16z

AI
Key Takeaways:
  1. Distribution is Queen: In a noisy AI world, mastering viral distribution can be a more potent advantage than a perfectly polished initial product. Eyeballs first, then iterate based on data.
  2. Embrace the Provocateur: The Gen Z approach to content—transparent, sometimes controversial, but always authentic—resonates. Leaders need demonstrable personal reach; the era of faceless corporate comms is fading.
  3. Speed Wins: In AI, "momentum as a moat" means rapid product development and distribution are critical. The ability to build the plane while it's in flight is the new founder archetype.
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June 24, 2025

Three Red Lines We're About to Cross Toward AGI

Machine Learning Street Talk

AI
Key Takeaways:
  1. Recursive Self-Improvement is a Critical Threshold: Preventing fully automated AI R&D is a key chokepoint to manage existential risks.
  2. Alignment Remains Elusive: Current methods are insufficient for robustly controlling advanced AI; "fairly reasonable" isn't safe enough.
  3. Transparency is Non-Negotiable: Governments and the public need situational awareness of frontier AI progress to inform policy and deterrence.
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June 23, 2025

Founders, Media, & Memes: a16z’s Strategy for the Future | a16z LP Summit 2025

a16z

AI
Key Takeaways:
  1. Structure Dictates Agility: a16z’s non-shared control model allows for rapid reorganization and specialization, crucial for capturing emerging tech waves like AI and crypto.
  2. Narrative is Power: In a meme-driven world, owning your narrative and media channels is paramount; a16z is actively building its presence to lead conversations.
  3. AI Needs Crypto: The burgeoning world of AI agents will create massive demand for crypto as the native transaction layer, exemplified by experiments like "Truth Terminal."
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June 21, 2025

Coatue Pt2. Open AI’s Kevin Weil Dives into All Things ChatGPT | BG2 w/ Bill Gurley & Brad Gerstner

Bg2 Pod

AI
Key Takeaways:
  1. The Current AI is Just the Beginning: Today's AI models are the "worst" we'll ever use; exponential improvements mean capabilities will dramatically expand in short timeframes.
  2. Proactive, Personalized AI is Coming: Expect AI to move from reactive answering to proactive task completion, deeply integrated into personal and professional workflows.
  3. Execution Defines the Winner: While the opportunity is immense ($100B+ revenue potential for OpenAI), success hinges on relentless execution and navigating a competitive, evolving landscape.
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June 20, 2025

Coatue’s Laffont Brothers. AI, Public & VC Mkts, Macro, US Debt, Crypto, IPO's, & more | BG2

Bg2 Pod

AI
Key Takeaways:
  1. AI is the Apex Predator: AI isn't just a feature; it's fundamentally reshaping business models, potentially leading to unprecedented productivity gains and market reallocations. Watch for AI pure-plays and established firms effectively leveraging AI for margin expansion.
  2. Crypto's Institutional Door is Creaking Open: Regulatory clarity and evolving products like interest-bearing stablecoins could unlock significant institutional capital for the digital asset class. Bitcoin's scale makes it increasingly hard to dismiss.
  3. Productivity is the New Macro Hedge: AI-fueled productivity could be the unexpected force that stabilizes the US fiscal situation, making current bond yields more rational than they appear under a "debt spiral" narrative.
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June 20, 2025

TikTok & AI Have Changed Education Forever - What it means for Teachers, Students & Parents

a16z

AI
Key Takeaways:
  1. Teacher Tools First, Student Revolution Later: AI's immediate impact is in making teachers hyper-efficient by automating administrative drudgery; direct AI-led student learning is still nascent but holds immense potential.
  2. Content is King, Delivery is Viral: AI is democratizing high-quality educational content creation and enabling novel, highly engaging delivery formats (e.g., celebrity deepfakes on TikTok), potentially bypassing traditional channels.
  3. The "Alpha" Signal is Strong: Experiments like Alpha School, though niche, prove AI's capacity to deliver superior educational outcomes, signaling a future where personalized, AI-driven learning paths become the norm if cost and accessibility barriers are overcome.
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Crypto Podcasts

December 30, 2025

What's Next For Crypto In 2026 | Kairos Research

Lightspeed

Crypto
Key Takeaways:
  1. The migration from subsidized security to fee-based sustainability. Capital is fleeing "fake money" inflation for real yield.
  2. Monitor Solana's BAM plugins for maker prioritization. This allows perps to offer tighter spreads than centralized exchanges.
  3. 2026 is the year of the "Real" app. The winners will be those who stop hoarding interest and start sharing it with their users.
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December 30, 2025

Landmark Regulation, ICOs, Downtober & Privacy: 2025 Crypto Year in Review (Part 2)

Unchained

Crypto
Key Takeaways:
  1. The Macro Shift: Regulatory moats are being built around stablecoins to protect bank deposits. This forces a migration toward "consortium" models like Stripe’s Tempo.
  2. The Tactical Edge: Audit market maker agreements to ensure protection against exchange API failures. Reliability is now a competitive advantage.
  3. 2026 looks like a liquidity-driven recovery. The "easy road" is over, but the infrastructure for the next cycle is finally being built by adults.
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December 29, 2025

HIP-3 and Markets by Kinetiq with Omnia | Livestream

0xResearch

Crypto
Key Takeaways:
  1. The Macro Trend: Vertical Integration. Protocols are moving from single-utility tools to full-stack financial ecosystems that own both the liquidity and the application layer.
  2. The Tactical Edge: Monitor HIP-3 auctions. Watch how new exchanges utilize Kinetic's infrastructure to bootstrap liquidity without issuing predatory new tokens.
  3. The Bottom Line: Kinetic is building the infrastructure for a post-Binance world where users own the venues they trade on. This matters for your roadmap because user-owned liquidity is the next major phase of DeFi growth.
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December 29, 2025

Investing Trends for 2026: DeFi, Tokenization, Capital Formation, Speculation & AI

Bankless

Crypto
Key Takeaways:
  1. The move from human-centric trading to an agent-led economy where programmable money is the native substrate.
  2. Prioritize startups building verticalized tokenization for high-yield exogenous assets rather than generalized service providers.
  3. Crypto is becoming the invisible backend for global finance. Over the next year, the winners will be those who hide the blockchain while using its efficiency to crush traditional margins.
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December 28, 2025

Getting To The Bottom Of Quantum w/ Rearden

The Gwart Show

Crypto
Key Takeaways:
  1. The Macro Transition: Cryptographic security is moving from static models to active systems that must anticipate both classical and quantum breakthroughs.
  2. The Tactical Edge: Audit your UTXOs to ensure no address reuse and keep your Xpubs strictly offline.
  3. The Bottom Line: Quantum risk is a long tail event that serves as a catalyst for necessary Bitcoin upgrades like OP_CAT and BIP 360.
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December 28, 2025

Getting To The Bottom Of Quantum w/ Rearden

The Gwart Show

Crypto
Key Takeaways:
  1. The Macro Shift: Technical reality is decoupled from venture capital hype.
  2. The Tactical Edge: Use hashed addresses and run a node.
  3. The Bottom Line: Quantum is an engineering hurdle rather than an existential crisis for the next decade.
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