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AI Podcasts

May 30, 2025

SN17 - 404GEN :: Decentralized AI generated 3D assets

Opentensor Foundation

AI
Key Takeaways:
  1. Unlocking Creative Potential: 404GEN radically lowers barriers to 3D content creation, enabling faster iteration and new forms of interactive media previously unfeasible for smaller teams or individuals.
  2. Gaussian Splats are Ascendant: This representation is emerging as a powerful alternative for 3D AI, and 404GEN is at the forefront of its practical application and tooling.
  3. BitTensor's Competitive Edge Shines: The subnet's rapid quality improvement and the innovative ELO validation system highlight BitTensor's power to incentivize and coordinate decentralized intelligence towards state-of-the-art results.
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May 30, 2025

Hey Tech, Come to Healthcare

a16z

AI
Key Takeaways:
  1. **Build for Behavior Change:** The biggest wins will come from engaging consumers and enabling sustainable health behaviors, an area where tech excels.
  2. **AI is the Leapfrog:** Healthcare can jump directly to AI-driven solutions, bypassing clunky legacy software, especially for service-oriented tasks.
  3. **The Trillion-Dollar Prize is Real:** Whether through full-stack "payvider" models or horizontal platforms, the path to becoming the world's largest company runs through transforming the consumer healthcare experience.
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May 29, 2025

Building a DePIN-powered Shazam for Media with Rumi | Niko Cunningham and Mateusz Poreda

Proof of Coverage Media

AI
Key Takeaways:
  1. **Decentralized Analytics:** Rumi’s DePIN model democratizes media intelligence, offering far richer and more granular data than traditional players like Nielsen.
  2. **Context is King:** The "Shazam for media" capability will fuel a new generation of AI agents and interactive experiences, making media deeply engaging.
  3. **Investor Signal:** The $5M pre-seed (EV3, A16Z CSX) and early traction with industry players like Tivision validate Rumi's approach and market potential.
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May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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May 26, 2025

Chatbot platforms might replace social media

Machine Learning Street Talk

AI
Key Takeaways:
  1. AI Companionship is Exploding: Millions are already deeply engaged with AI for emotional connection, and this is just the beginning as technology like GPT-4o normalizes it.
  2. Lean Engineering Can Win: Chai's success with a tiny, hyper-talented team and innovative techniques like model blending proves that massive VC-backed operations aren't the only path to scale in AI.
  3. The Next Social Platform Might Be AI: As AI offers more active, personalized, and consequence-free social interaction, it could very well become the dominant way people connect, potentially supplanting traditional social media.
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Crypto Podcasts

January 10, 2026

LIVE: Aerodrome and Metadex03 | 0xResearch

0xResearch

Crypto
Key Takeaways:
  1. The Macro Trend: The transition from fragmented L2 liquidity to unified cross-chain execution.
  2. The Tactical Edge: Monitor Arrow’s Q2 launch on Mainnet to capitalize on the initial liquidity migration.
  3. The Bottom Line: Arrow is building the operating system for Ethereum liquidity. If they capture even a fraction of Mainnet the economic model moves from inflationary to net-positive.
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January 10, 2026

Jordi Alexander on Market Outlook, Token Buybacks, and Neo Finance

The Rollup

Crypto
Key Takeaways:
  1. The move from "fugazi decentralization" to "Neo Finance" means capital will flee empty L1s for protocols with verifiable revenue.
  2. Accumulate Bitcoin as a macro hedge while building a basket of revenue-generating alts like Meteora or Hyperliquid during price dips.
  3. Survival in 2026 requires moving past the "infra thesis" to find projects that treat their token as a real financial instrument.
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January 10, 2026

Zcash drama, stablecoin adoption, reinsurance markets & onchain reputation with Iron, Re, and Fluent

The Rollup

Crypto
Key Takeaways:
  1. The Macro Shift: The Unification. Legacy finance is unbundling into onchain modules where yield is derived from real-world economic activity rather than token emissions.
  2. The Tactical Edge: Audit your yield. Move capital toward protocols like RE that bridge to non-self-referential markets.
  3. The Bottom Line: The next 12 months belong to "Neo-Finance" players who dominate the boring work of regulatory compliance and fiat integration.
See full notes
January 9, 2026

Lighter’s Token Launch, Erebor Raises $350M & Walmart's Crypto Strategy

Empire

Crypto
Key Takeaways:
  1. The market is bifurcating into protocols with real product market fit and a long tail of zombie assets.
  2. Monitor the "One Pay" app ecosystem for integration opportunities.
  3. 2026 is the year stablecoins move from treasury management to domestic retail reality.
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January 9, 2026

Aerodrome’s Big Upgrade | Alexander Cutler

0xResearch

Crypto
Key Takeaways:
  1. The Macro Transition: Vertical Liquidity. Exchanges are evolving from passive pools into active revenue collectors that capture MEV and launch fees to subsidize liquidity.
  2. The Tactical Edge: Monitor Aero. Watch the Metadex03 launch in Q2 to see if liquidity migrates from Uniswap to the higher-yield Aero pools on Ethereum Mainnet.
  3. The Bottom Line: Aero is betting that better economics for liquidity providers will always win the war for volume. If they successfully export their Base dominance to Mainnet, the decentralized exchange hierarchy will be permanently altered over the next 12 months.
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January 9, 2026

Nic Carter: Quantum Threatens $600B of Bitcoin

Delphi Digital

Crypto
Key Takeaways:
  1. The transition from classical to quantum computing turns static digital gold into a melting ice cube.
  2. Audit your cold storage to ensure you aren't reusing addresses or holding funds in P2PK formats.
  3. Bitcoin’s survival depends on the community’s ability to prioritize insurance over ideological purity before 2030.
See full notes