a16z
September 3, 2025

Jack Altman & Martin Casado on the Future of Venture Capital

Jack Altman, CEO of Lattice, and Martin Casado, a General Partner at a16z with deep roots in enterprise infrastructure, dissect the tectonic shifts reshaping venture capital. They cover everything from the specialization of VC firms to the inverted laws of competition in the AI gold rush, offering a masterclass in modern venture strategy.

The Evolution of the VC Playbook

  • “As the market grows, you have to specialize. In 1980, if you did enterprise infrastructure software, how many companies could you invest in? Now, someone can have an entire career investing in databases alone.”
  • “The traditional media just turned on tech and it hates tech... if you want to help a portfolio, you do want to build a bit of a platform; you have to go direct.”
  • Venture capital is shifting from small, generalist partnerships to scaled, specialized platforms. This evolution is a direct response to the massive growth of the tech market, which now contains sub-sectors large enough to support entire investment careers.
  • Firms are becoming media companies out of necessity. With traditional media increasingly hostile to tech, VCs must build their own platforms to control their narrative and provide an essential distribution channel for their portfolio companies.
  • Scaling a firm with a generalist, consensus-driven model is impossible. Specialization allows for structured market coverage and prevents decision-making gridlock as Assets Under Management (AUM) grows.

Investing in AI Infrastructure

  • “The companies that provide infrastructure, I think ultimately they are the source of value and differentiation... They just have better multiples and they're more durable because they service everything above it.”
  • Infrastructure is where the real value accrues. In any software stack, the infrastructure layer provides the core technical differentiation, leading to more durable companies with higher multiples compared to the apps built on top.
  • Don't fear the incumbents. Despite the "shadow" cast by giants like AWS, it's exceedingly rare for them to kill a focused startup. Big companies struggle to execute with the agility and focus of a dedicated team, especially in a rapidly expanding market.
  • Platform shifts create new infrastructure layers. As AI matures, it will create a new wave of essential infrastructure companies, mirroring the cycles seen with the internet and cloud.

Competition & Conflicts in the AI Gold Rush

  • “The market is so big and it's growing so fast, even companies that seem like they're competing end up in totally different places... This is the first time I can remember where the actual talent competition is way more fierce than the market competition.”
  • In AI, the real scarcity is talent, not customers. The market is expanding so quickly that startups are competing more intensely for the handful of engineers who have trained large models at scale than they are for market share.
  • Navigating portfolio conflict requires clear frameworks. One of the toughest new conflicts is choosing between an existing portfolio company pivoting clumsily into AI and a new, "AI-native" startup. To manage direct competition, a16z uses a "mortal enemy" rule: a founder can name one competitor the firm will never back.
  • The AI markets that are definitively working are those driving the marginal cost of content creation to zero (e.g., images, music, speech). Enterprise agentic workflows show promise but have less certain unit economics.

Key Takeaways:

  • Venture capital's structure is fundamentally adapting to a tech landscape orders of magnitude larger than the one it was designed for. In the AI era, the fiercest battles are not for customers but for elite talent, forcing a re-evaluation of where competitive advantage truly lies.
  • Bet on Infrastructure. In new technology waves, infrastructure companies capture the most durable value and command the highest multiples. Focus on the picks and shovels.
  • Talent is the New Moat. The primary constraint on AI's growth is the scarcity of elite technical talent. Winning in this market means backing the teams that can attract and cluster these individuals.
  • Forget the TAM Handbook. In an explosive market like AI, traditional analysis of Total Addressable Market (TAM) is less important than identifying the best team. Back the category leader, because the market is the market.

For further insights and detailed discussions, watch the full podcast: Link

This episode reveals how venture capital is fundamentally restructuring to capitalize on the AI gold rush, shifting from generalist models to specialized platforms and prioritizing talent acquisition over traditional market analysis.

The Evolving Role of Media in Venture Capital

  • Martin Casado, a General Partner at Andreessen Horowitz, opens by dissecting the shifting role of media in venture capital. He notes that historically, top investors like those at Sequoia Capital were not public figures. However, two key changes have made a direct media presence essential.
    • First, traditional media has become increasingly hostile towards the tech industry, making it a "dangerous" channel for founders. VCs now need their own platforms to control the narrative and support their portfolio companies.
    • Second, the media landscape has become highly "episodic," driven by major events like a GPT-5 launch. Martin argues that VCs must build in-house media capabilities to help their companies navigate this fast-moving environment and capture attention. He states, "If you want to help a portfolio, you do want to build a bit of a platform, you do have to go straight."

The Shift from Generalist to Specialist VC

  • The conversation explores Andreessen Horowitz's evolution from a firm of generalist partners to a specialized platform model. When Martin joined in 2016, the firm was small, and partners were generalists who often invested outside their operational expertise.
    • Martin explains this shift is a necessary response to the massive growth of the tech market. In the past, tech was a niche market, but now an investor can build an entire career focusing solely on a sub-sector like databases.
    • Specialization is driven by both market growth and the need to scale a firm's assets under management (AUM). A generalist, consensus-driven partnership model cannot scale effectively, as it lacks a structured approach to market coverage and talent acquisition.
    • This specialization allows the firm to offer a competitive suite of products (seed, venture, growth funds) without creating internal weaknesses that rivals could exploit.

Defining and Investing in AI Infrastructure

  • Jack Altman and Martin pivot to AI infrastructure, which Martin defines as the foundational technology sold to technical buyers—developers, database administrators, and network engineers. This includes compute, storage, networking, models, and developer tools.
    • Martin presents a strong, albeit self-admittedly "inflammatory," opinion: true, durable value and differentiation in software accrue to the infrastructure layer. Application-level features are often superficial, while performance and reliability are foundational.
    • He cites a public market analysis showing that infrastructure companies consistently command higher multiples than application companies. Martin believes this is because they are "the source of value" for everything built on top.
    • Strategic Implication: For investors, this suggests that during platform shifts like the current AI boom, the most durable, high-value investments will be in the new infrastructure companies that emerge, rather than the applications built upon them.

Navigating Competitive Conflicts in a Crowded AI Market

  • The discussion addresses the growing challenge of portfolio conflicts, where two firm-backed companies begin to compete. Martin categorizes these conflicts and outlines his approach.
    • Pivots: The most common conflict arises when one company pivots into another's space. This is largely uncontrollable from an investor's perspective.
    • AI-Native vs. Legacy: A newer, more complex conflict involves legacy portfolio companies trying to adopt AI versus new, AI-native startups. Martin notes the difficulty in backing a new AI-native company when a legacy one claims to be moving into that space, even if its chances of success are low.
    • To manage direct competition, Martin uses a strategy borrowed from Chris Dixon: "Is this your mortal enemy? You only get one... if this is your mortal enemy, we'll do everything together to kill it, and we won't invest in that." This empowers founders while preventing them from hamstringing the firm's investment efforts.

The Fierce Competition for AI Talent

  • A key insight from the conversation is that in the current AI landscape, the competition for talent is far more intense than the competition for market share.
    • Martin observes that the AI market is expanding so rapidly that even companies that appear to be direct competitors often end up in different market segments.
    • However, these same companies are all competing for an extremely limited pool of specialized talent, such as researchers who have experience training large-scale models. He notes, "This is the first time I can remember where the actual talent competition is like way more fierce than the market."
    • This talent scarcity is driving phenomena like "mega aqua-hires," where entire teams are acquired for their unique experience. This mirrors historical patterns seen during previous tech booms, like the early internet era with specialized skills such as writing a BGP stack (Border Gateway Protocol, the routing protocol that makes the internet work).

Identifying Working and Emerging AI Markets

  • Martin provides a clear breakdown of which AI markets are currently working, which are emerging, and which face economic uncertainty.
    • Clearly Working: Diffusion models for content creation (images, music, speech) are thriving. The economics are simple and powerful, as they bring the marginal cost of content creation to near zero. Companies like 11 Labs are prime examples.
    • Emerging & Viable: The "loneliness and companionship" market is a functional use case with strong user engagement and willingness to pay. However, from an investor's perspective, it appears to be a fragmented, long-tail market.
    • Economically Uncertain: Enterprise use cases focused on agentic, automated workflows (e.g., advanced chatbots) are functional but face unclear economics. These often require significant bespoke work, making their financial model less straightforward than pure content creation.

The State of AI in Code Generation

  • The conversation delves into the productivity impact of AI in software development, a field Martin knows well from his background and investment in Cursor.
    • Martin acknowledges the "dazzling" nature of AI tools can make it hard to assess their true utility. He points to studies showing a discrepancy between programmers' perceived productivity gains and observed results.
    • He argues that AI is already highly effective for routine tasks programmers dislike, such as writing documentation, generating boilerplate code, and navigating complex frameworks.
    • While the core task of writing novel code is still in its early days, he is confident that best practices will emerge, leading to a 10x productivity increase over time. He concludes, "This is the first time I would say that we're probably getting legitimately disrupted as a discipline."

The Critical Debate: Open Source vs. Closed Source AI

  • Martin expresses strong concern over the anti-open-source sentiment that emerged last year, particularly from VCs, academics, and founders who should have been its biggest champions.
    • He views open source as a vital mechanism for a healthy, competitive ecosystem, preventing monopolies and fostering innovation.
    • He attributes the fear-driven, anti-open-source narrative to the intellectual legacy of Nick Bostrom's 2014 book Superintelligence, which primed influential figures to view AI through a lens of existential risk.
    • While acknowledging real risks exist, Martin felt the debate became dangerously lopsided. He is relieved that the discourse has now become more "even-handed," with the right voices re-entering the conversation to advocate for the benefits of open innovation.

Firm Strategy in an AI Gold Rush

  • Jack asks about Andreessen Horowitz's investment strategy in a high-velocity market. Martin explains their core principle is avoiding a specific type of error.
    • "The only sin is picking the wrong company in a certain space because that conflict thing... you're conflicted out of the winner." Investing in a space that fails is acceptable, but picking the second-best company in a winning space is the critical mistake.
    • In a rapidly expanding market like AI, traditional metrics like Total Addressable Market (TAM) and valuation become less relevant. The market is growing too fast to predict accurately.
    • Actionable Insight: The primary focus must be on identifying and backing the absolute best team. The strategy is to wait until you can confidently identify the winner in a given space and then invest, even if it means waiting for a later round.

Rethinking the Role of a VC Board Member

  • In the final segment, Martin deconstructs the conventional wisdom around board roles and responsibilities.
    • He argues that the primary, formal role of a board is fiduciary governance—keeping everyone out of jail and protecting shareholders. This work, he claims, is not time-intensive.
    • The real work, often conflated with board duties, is being helpful to the company through advising, hiring, and providing resources. This is where a firm's platform becomes critical.
    • Martin's ability to manage numerous board seats stems from separating these two functions and leveraging his firm's extensive platform to provide value, a task not limited to board members. He notes, "A lot of the companies I spend the most with I'm not even on the board."

Conclusion

This discussion highlights that success in the AI era requires VCs to abandon outdated models. Investors and researchers must focus on backing elite, specialized talent and foundational infrastructure, as traditional market sizing and valuation metrics are becoming obsolete in this rapidly expanding, winner-take-all environment.

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