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AI Podcasts

February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The Macro Shift: AI is collapsing the time horizon for technological deployment and market dominance, shifting the competitive advantage from pure innovation to a combination of innovation, capital, and rapid infrastructure deployment.
  2. The Tactical Edge: Invest in companies that are not just building AI, but are fundamentally rethinking existing industries with AI-first principles, recognizing that traditional software moats are eroding.
  3. The Bottom Line: The next 12-24 months will see AI's broad impact kick in, creating unprecedented opportunities for those who understand its new "laws of physics" and the critical role of policy in shaping its trajectory.
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February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The healthcare system is moving from reactive, acute care to proactive, preventative interventions, driven by the unsustainable costs of chronic disease and a growing understanding of environmental health.
  2. Build infrastructure that financially incentivizes lifestyle interventions, such as TrueMed's HSA/FSA payment rails for health-promoting products and services.
  3. The next decade will see hundreds of billions of dollars redirected towards preventative health. Companies that bridge the gap between lifestyle choices and healthcare financing will capture significant market share.
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February 3, 2026

SpaceX Engineer Explains America's Biggest Energy Mistake | Scott Nolan, CEO of General Matter

The Generalist

AI
Key Takeaways:
  1. The Macro Shift: Global energy demand, driven by AI, forces a strategic re-evaluation of nuclear power. This creates a window for nations to re-shore critical energy infrastructure, moving from reliance on adversaries to domestic, cost-competitive solutions.
  2. The Tactical Edge: Investigate companies addressing foundational supply chain gaps in critical industries like energy. Look for teams with a "first principles" engineering approach and a track record of commercializing hard tech.
  3. The Bottom Line: America's energy independence and its ability to power future technological growth, like AI, hinge on rebuilding domestic nuclear fuel enrichment. This is not just an industrial opportunity; it is a national security imperative.
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February 4, 2026

The Economic Singularity Will Make Today’s Economy Unrecognizable w/ Dr. Alexander Wissner-Gross

Milk Road AI

AI
Key Takeaways:
  1. The Macro Shift: AI-driven hyperdeflation is colliding with the technical reality of autonomous AI agents creating their own crypto-backed economies, threatening a decoupling from human fiat systems.
  2. The Tactical Edge: Investigate and build infrastructure that bridges human and AI economies, focusing on fiat-to-crypto rails that can accommodate agent-driven transactions to prevent a complete split.
  3. The Bottom Line: The next 5-10 years will see an unprecedented economic transformation. Understanding AI's deflationary power and the emerging AI agent economy is critical for navigating a world where traditional economic models may no longer apply.
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February 3, 2026

OpenClaw Makes AI Agents and CPUs Get Real

Semi Doped

AI
Key Takeaways:
  1. The time of practical AI agents is here, moving compute demand beyond pure GPU inference to a significant reliance on CPUs for coordination, data handling, and security.
  2. Evaluate your agent deployment strategy now, prioritizing sandboxed environments (VPS, dedicated local servers) and exploring cost-optimized model routing to manage API expenses.
  3. Prepare for a future where AI agents become integral to workflows, but recognize the hidden infrastructure costs and security implications, particularly the growing importance of CPU capacity and robust access controls.
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February 4, 2026

⚡️ Context graphs: AI’s trillion-dollar opportunity — Jaya Gupta, Ashu Garg, Foundation Capital

Latent Space

AI
Key Takeaways:
  1. The shift from "how" to "why" in AI agent capabilities creates a new, multi-trillion-dollar market for companies that can capture institutional decision logic.
  2. Invest in or build agentic systems that are in the "right path" of business processes, actively capturing decision traces from unstructured data.
  3. Hundreds of context graphs will be in production at scale within a year, defining a new "context graph stack." The winning companies will be those that master this flywheel, extracting value to accelerate automation and build deep, defensible moats.
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February 2, 2026

We Entered an Era Where No One Knows What Comes Next

Turing Post

AI
Key Takeaways:
  1. The shift from linear, bottleneck-driven technological progress to a multi-layered, interconnected advancement model in AI has rendered traditional forecasting obsolete, forcing a re-evaluation of what "singularity" truly represents.
  2. Prioritize adaptability: Invest in modular, composable AI infrastructure and tools that thrive in multi-layered, unpredictable environments, rather than betting on single-bottleneck solutions.
  3. The inability to narrate AI's future means traditional roadmaps are obsolete; success hinges on navigating simultaneous, interconnected advancements and embracing the emergent.
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February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The era of infrastructure-heavy tech deployment is over; AI's internet-native nature means immediate, widespread application. This shifts the competitive advantage from capital-intensive builds to rapid iteration and data leverage.
  2. Invest in companies that are not just using AI, but are fundamentally rethinking their business models around AI's ability to collapse traditional cost structures and accelerate product development.
  3. AI is a force multiplier for both individual opportunity and national power. Understanding its immediate deployability and the new rules of company building is crucial for investors and builders aiming to lead in the next wave of innovation over the next 12-24 months.
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February 2, 2026

Ben Horowitz and David Solomon: The Sweetest Macro Spot in 40 Years

a16z

AI
Key Takeaways:
  1. Unprecedented fiscal and monetary stimulus, coupled with a deregulatory environment, creates a powerful tailwind for financial assets and tech, driving a capital investment super cycle.
  2. Investors should prioritize companies with proprietary data and GPU access, as these are the new moats in an AI-driven world where traditional software leads are eroding.
  3. The convergence of a stimulative macro environment and AI's disruptive force means capital will flow to those who can scale, innovate, and navigate complex policy landscapes, making strategic positioning now critical for future relevance.
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Crypto Podcasts

February 7, 2026

Crypto’s Reality Check | Roundup

Bell Curve

Crypto
Key Takeaways:
  1. AI's gravitational pull on talent and capital is forcing crypto to mature beyond speculative tokenomics, transitioning focus from "meme value" to demonstrable product-market fit and real-world utility.
  2. Identify and invest in projects building at the intersection of crypto and AI, or those creating "net new" applications that abstract away crypto complexity for mainstream users, especially in areas like identity or fintech.
  3. This bear market is a necessary, albeit painful, reset. It's a time for builders to focus on creating tangible value and for investors to seek out projects with genuine utility, as the era of easy speculative gains is over.
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February 7, 2026

How Chutes Hit 160B Tokens/Day (Without Centralized Infrastructure)

The Opentensor Foundation | Bittensor TAO

Crypto
Key Takeaways:
  1. The commodification of AI compute, driven by decentralized networks, is shifting power from centralized data centers to globally distributed, incentive-aligned miners. This creates a more efficient, resilient, and cost-effective foundation for intelligence.
  2. Explore building AI agents and applications on Shoots' expanding platform, leveraging their TEEs and end-to-end encryption for privacy-sensitive use cases. The "Sign in with Shoots" OAuth system offers a compelling way to integrate AI capabilities without upfront compute costs.
  3. Shoots is not just an inference provider; it's building the foundational infrastructure for a truly decentralized, private, and intelligent internet. Over the next 6-12 months, expect to see a proliferation of sophisticated AI agents and applications built on Shoots, driven by its unique blend of incentives, security, and global compute.
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February 7, 2026

Vitalik Signals the End of the Rollup-Centric Roadmap: What's Next?

Bankless

Crypto
Key Takeaways:
  1. The Macro Shift: Ethereum pivots from a "rollup-centric" vision to a multi-faceted approach: a powerful, ZKVM-scaled L1 coexists with a diverse "alliance" of specialized L2s. This adapts to technical realities and renews L1's core focus.
  2. The Tactical Edge: Builders should prioritize differentiated L2 solutions or contribute to L1's ZKVM scaling. Investors should evaluate L2s based on distinct utility and symbiotic relationship with Ethereum.
  3. The Bottom Line: Ethereum's market leadership remains, but this pivot signals a pragmatic roadmap. The next 6-12 months will see rallying around L1 ZKVM scaling and clearer L2 roles, demanding sharper focus on where value accrual and innovation occur.
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February 6, 2026

'No More Dry Powder to Come Into Tokens': Why Crypto Is Down

Unchained

Crypto
Key Takeaways:
  1. Global liquidity is high, but capital is reallocating from speculative crypto to traditional stores of value and, paradoxically, to DeFi platforms offering RWA exposure. This signals a maturation where utility and transparency are gaining ground over pure hype.
  2. Identify protocols with demonstrable revenue generation from real-world use cases, like Hyperliquid, as potential outperformers. Focus on platforms that offer transparency and accountability, as market structure shifts towards more regulated and predictable venues.
  3. The crypto market is undergoing a structural reset, moving away from a retail-driven, speculative cycle. Investors must adapt to a landscape where fresh capital is scarce, institutional flows favor gold, and DeFi's next frontier involves real-world assets.
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February 6, 2026

Is Crypto Focusing on the Wrong Regulatory Fight? DEX in the City

Unchained

Crypto
Key Takeaways:
  1. The convergence of AI agents and programmable money is creating a new frontier for digital commerce and liability. This shift demands a proactive re-evaluation of regulatory frameworks, moving beyond human-centric definitions of accountability and transaction.
  2. Builders should design AI agent systems with cryptographically embedded controls, allowing for granular policy enforcement (e.g., spending limits triggering human review) and leveraging stablecoins for microtransactions in decentralized agent-to-agent economies.
  3. The next 6-12 months will see increasing pressure to define AI agent liability and payment rails. Investors should prioritize projects building infrastructure for secure, auditable agent commerce, while builders must integrate compliance and control mechanisms from day one to navigate this evolving landscape.
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February 7, 2026

What Do Jobs and Money Look Like in a Post-Human Economy?

Unchained

Crypto
Key Takeaways:
  1. The economy is shifting from human-centric labor and scarcity to AI-driven abundance, where machine intelligence itself becomes the primary unit of economic exchange, challenging traditional monetary and employment structures.
  2. Investigate and build "proof of control" solutions using crypto primitives (like ZKPs, TEEs, decentralized compute/storage) to secure AI agents and data.
  3. The next 6-12 months will see increased demand for verifiable control over AI systems. Understanding how crypto enables this, and how human value shifts from transactional jobs to unique human interaction, is crucial for navigating this new economic reality.
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