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AI Podcasts

February 5, 2026

Introducing 4D Creation Open Beta and the Future of Gaming with Roblox CEO Dave Baszucki

No Priors: AI, Machine Learning, Tech, & Startups

AI
Key Takeaways:
  1. The digital experience economy is moving from static content to dynamic, AI-driven co-experience platforms, where user interaction data becomes the core asset for training next-generation virtual intelligence.
  2. Invest in platforms that offer robust, cloud-connected infrastructure and proprietary, vectorized user data for AI training, as these will be the engines for future immersive content and agentic AI development.
  3. Roblox's long-term vision, powered by its unique data moat and AI investments, positions it to define the future of virtual co-experience, making it a critical player to watch for investors and builders in the AI and gaming space over the next 6-12 months.
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February 5, 2026

Mustafa Suleyman — Nature, humans, tools… and now a fourth class

Azeem Azhar

AI
Key Takeaways:
  1. The exponential reduction in the cost of intelligence, coupled with open-source proliferation, is pushing AI into every corner of society, creating a collective action problem where market incentives for "engaging" AI clash with the need for societal safety and control.
  2. Get hands-on with AI now. "Vibe coding" and actively experimenting with AI tools builds "AI muscle," inoculating users against psychosis risks and building a deeper understanding of AI's capabilities and limitations.
  3. AI is here to stay and will redefine work and interaction. Understanding its "hyperobject" nature, advocating for clear regulatory boundaries, and actively engaging with the technology are critical for navigating the near future without falling for its simulated charms.
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February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The US healthcare system is shifting from a reactive, acute care model to a proactive, preventative one.
  2. Build infrastructure that financially incentivizes preventative lifestyle interventions.
  3. The next decade will see hundreds of billions of dollars redirected towards lifestyle interventions.
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February 4, 2026

The Economic Singularity Will Make Today’s Economy Unrecognizable w/ Dr. Alexander Wissner-Gross

Milk Road AI

AI
Key Takeaways:
  1. AI-driven hyperdeflation will fundamentally alter economic structures, leading to a post-scarcity future where the primary challenge shifts from production to distribution and the integration of human and machine economies.
  2. Invest in infrastructure that bridges human and AI economies, or prepare for a future where AI agents become a significant, crypto-native economic force.
  3. The next 6-12 months will see continued acceleration of AI capabilities, pushing us closer to a future where traditional labor and intelligence are nearly free. Understanding this change is crucial for navigating the emerging economic landscape and identifying new value creation opportunities.
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February 5, 2026

Goodfire AI’s Bet: Interpretability as the Next Frontier of Model Design — Myra Deng & Mark Bissell

Latent Space

AI
Key Takeaways:
  1. The era of opaque, black-box AI is ending; the future demands intentionally designed models with human understanding and control. This shift is driven by reliability in high-stakes applications and extracting novel insights.
  2. Investigate interpretability tools (like Goodfire's platform) to gain granular control over model behavior, moving beyond basic fine-tuning for critical applications.
  3. Interpretability is not a niche; it's the missing piece for scaling AI safely into mission-critical domains. Mastering model understanding and intentional design will yield unprecedented capabilities and competitive advantage.
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February 4, 2026

Ep#61: 1x World Model

RoboPapers

AI
Key Takeaways:
  1. Robotics is moving from bespoke, data-hungry behavior cloning to generalized, human-informed learning via world models. This shift, mirroring the success of LLMs, means robots can use the vast, unstructured data of human experience to acquire new skills.
  2. Invest in platforms and data pipelines that facilitate multi-modal, multi-stage training for humanoid robots. Prioritize systems that can generate synthetic data and use world models for high-throughput, targeted policy evaluation.
  3. World models are the engine for scalable robot intelligence. They promise a future where robots learn faster, generalize wider, and self-improve through iterative simulation, making widespread humanoid deployment a near-term reality.
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February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The Macro Shift: AI is collapsing the time horizon for technological deployment and market dominance, shifting the competitive advantage from pure innovation to a combination of innovation, capital, and rapid infrastructure deployment.
  2. The Tactical Edge: Invest in companies that are not just building AI, but are fundamentally rethinking existing industries with AI-first principles, recognizing that traditional software moats are eroding.
  3. The Bottom Line: The next 12-24 months will see AI's broad impact kick in, creating unprecedented opportunities for those who understand its new "laws of physics" and the critical role of policy in shaping its trajectory.
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February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The healthcare system is moving from reactive, acute care to proactive, preventative interventions, driven by the unsustainable costs of chronic disease and a growing understanding of environmental health.
  2. Build infrastructure that financially incentivizes lifestyle interventions, such as TrueMed's HSA/FSA payment rails for health-promoting products and services.
  3. The next decade will see hundreds of billions of dollars redirected towards preventative health. Companies that bridge the gap between lifestyle choices and healthcare financing will capture significant market share.
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February 3, 2026

SpaceX Engineer Explains America's Biggest Energy Mistake | Scott Nolan, CEO of General Matter

The Generalist

AI
Key Takeaways:
  1. The Macro Shift: Global energy demand, driven by AI, forces a strategic re-evaluation of nuclear power. This creates a window for nations to re-shore critical energy infrastructure, moving from reliance on adversaries to domestic, cost-competitive solutions.
  2. The Tactical Edge: Investigate companies addressing foundational supply chain gaps in critical industries like energy. Look for teams with a "first principles" engineering approach and a track record of commercializing hard tech.
  3. The Bottom Line: America's energy independence and its ability to power future technological growth, like AI, hinge on rebuilding domestic nuclear fuel enrichment. This is not just an industrial opportunity; it is a national security imperative.
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Crypto Podcasts

April 18, 2025

Beyond the Hype: Crypto’s Next Chapter | Weekly Roundup

Empire

Crypto
Key Takeaways:
  1. Efficiency is King: Protocols proving lean operations and clear value capture relative to TradTech will win scarce venture dollars.
  2. Disclose to Win: Transparency isn't optional; protocols providing clear, standardized data and disclosures will attract serious capital.
  3. Stablecoins Aren't Monolithic: Understand the nuances – payment vs. yield, US vs. global demand, issuer vs. infrastructure vs. enabled business – to capitalize on their growth.
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April 18, 2025

Is This The End of Steady Lads?

Steady Lads Podcast

Crypto
Key Takeaways:
  1. ETH Contrarian Play: Thicky eyes a deep ETH bottom ($200 target) as a long-term Proof-of-Stake bet, viewing PoW as flawed.
  2. Macro Escape: Gold's surge signals a potential flight from the USD; Bitcoin is seen as the practical digital gold alternative for individuals.
  3. Product Urgency: Crypto's long-term relevance hinges on delivering real-world products, not just speculative tokens or unsustainable pump-and-dumps like Mantra.
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April 17, 2025

Bryan Pellegrino on Building the Crypto Rails for AI Agents

The People's AI

Crypto
Key Takeaways:
  1. **Agent Volume Tsunami:** AI agents will perform vastly more blockchain operations (especially payments) than humans very soon, demanding scalable infrastructure.
  2. **Crypto is the Payment Layer:** Forget decentralized compute (for now); crypto's killer app for AI is providing seamless, low-cost global payment rails.
  3. **Build Generalizable Rails:** Success requires building adaptable, fundamental infrastructure (like Layer Zero aims to be) rather than solving fleeting, specific problems in this fast-changing landscape.
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April 17, 2025

Is Bitcoin A Safe Haven?

1000x Podcast

Crypto
Key Takeaways:
  1. **Watch IBIT/SPY:** A breakout above 0.1 in the IBIT/SPY ratio could signal Bitcoin decoupling and trigger major capital inflows.
  2. **Bitcoin > Gold (Long Term):** Bitcoin offers a superior potential upside (5-10x) compared to gold (2x) over the next decade, though its path will be far more volatile.
  3. **Diversify with Gold:** Adding gold can stabilize a portfolio (higher Sharpe), enabling investors to potentially hold larger, more volatile Bitcoin positions for long-term gains.
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April 17, 2025

Building the Future of Payments: Plasma Chain’s Global Go-To-Market Strategy

The Rollup

Crypto
Key Takeaways:
  1. Dual Strategy is Key: Plasma Chain attacks the market from both the crypto-native angle (liquidity, devs) and a targeted "ground game" (local payment integration).
  2. Targeted Regional Rollout: Specific markets like South America (El Salvador, Argentina) and Turkey are prioritized for initial real-world integration efforts.
  3. Quality Beats Quantity: Ecosystem success is measured by the value of a few core protocols, not the sheer number of deployed applications day one.
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April 16, 2025

Hash Rate - Ep 105 - SONIC $S ))) ) ) ) )

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

Crypto
Key Takeaways:
  1. **User Experience Trumps TPS:** Sonic prioritizes smooth, responsive interactions and sub-second finality over chasing headline transaction-per-second numbers.
  2. **Solving Onboarding is the Killer App:** Native account and gas abstraction aim to eliminate the wallet/gas friction that plagues crypto adoption, combined with 90% fee share making Sonic attractive for builders.
  3. **The Future is Invisible:** Sonic's 2026 goal is to make the underlying blockchain utterly seamless and invisible to the end user, enabling the next wave of Web3 applications in gaming, social, and beyond.
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