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AI Podcasts

February 12, 2026

🔬Generating Molecules, Not Just Models

Latent Space

AI
Key Takeaways:
  1. The field is moving from predicting existing biological structures to generating novel ones, driven by open-source AI models. This transforms biology from an observational science into a design-first engineering discipline, where computational power and accessible tools dictate the pace of innovation.
  2. Invest in platforms that abstract away the computational complexity of molecular design, offering robust, validated generative AI tools and scalable infrastructure. This allows scientists to focus on therapeutic hypotheses, not GPU management, accelerating time to experimental validation.
  3. The next wave of biological breakthroughs will come from those who can rapidly iterate on designed molecules, not just discovered ones. Access to powerful, user-friendly generative AI platforms like Boltz Lab will be a critical differentiator for biotech and pharma in the near future.
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February 12, 2026

Owning the AI Pareto Frontier — Jeff Dean

Latent Space

AI
Key Takeaways:
  1. Prioritize low-latency, multi-turn interaction models for agentic workflows. Invest in prompt engineering as a core skill, treating it as advanced executive communication to precisely guide AI agents.
  2. The AI industry is moving beyond raw model size as the sole metric of progress. The true frontier is now defined by the efficiency of capability delivery—how quickly, affordably, and contextually a model can perform complex tasks for a user, driven by hardware-software co-design and intelligent data management.
  3. The next 6-12 months will see a bifurcation in AI development: hyper-specialized, low-latency "flash" models for ubiquitous, agent-driven tasks, and ultra-capable "pro" models for deep reasoning, with hardware co-design and multimodal data integration being the key differentiators for sustained competitive advantage.
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February 11, 2026

Inside The Life of Silicon Valley's First Athlete Investor | Magic Johnson

a16z

AI
Key Takeaways:
  1. The shift from transactional endorsements to equity-driven ownership for public figures is accelerating, driven by soaring asset valuations in sports and entertainment, and amplified by new tech that allows for more direct brand building and value creation. This means the "celebrity investor" is no longer a novelty but a strategic force, demanding a different approach to deal flow and value add.
  2. Cultivate a diverse, expert team that can challenge your assumptions and vet opportunities, especially in unfamiliar sectors. Prioritize long-term equity plays over short-term cash, and actively seek out "boring" businesses with consistent growth potential, as these often hide outsized returns.
  3. The future of wealth creation for founders and investors lies in understanding that relationships are capital, equity is king, and a "win-at-all-costs" mentality must extend beyond your core expertise into every business venture. Position yourself to identify and participate in deals that leverage both established industries (like sports) and emerging tech (like AI), recognizing that early entry and strategic partnerships are paramount for exponential growth.
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February 11, 2026

Inside The Life of Silicon Valley's First Athlete Investor | Magic Johnson

a16z

AI
Key Takeaways:
  1. The athlete-investor archetype, pioneered by Magic Johnson, signals a broader trend where personal brand and strategic capital disrupt traditional investment. This shift is accelerated by AI and blockchain, enabling individuals to build billion-dollar enterprises.
  2. Cultivate a "give-first" network by consistently adding value to relationships. Attend industry events early to maximize quality time with key decision-makers.
  3. Long-term wealth creation hinges on disciplined equity ownership, investing in "boring" but essential sectors, and assembling an expert team. This framework is crucial for navigating tech opportunities over the next 6-12 months.
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February 11, 2026

Inside The Life of Silicon Valley's First Athlete Investor | Magic Johnson

a16z

AI
Key Takeaways:
  1. The era of celebrity endorsements is giving way to direct equity ownership and entrepreneurial ventures, as high-profile individuals increasingly seek to build lasting business empires rather than just collect checks. This trend is amplified by new technologies like AI, which lower the barrier to entry for creating and scaling businesses.
  2. Cultivate a powerful network by consistently showing up early to meetings and prioritizing long-term relationships over immediate transactions. Actively seek out "boring" businesses or underserved markets with high demand, as these often yield consistent, outsized returns.
  3. Success in the next 6-12 months hinges on a "win-first" mentality, strategic team building, and a willingness to invest capital into core value drivers. Embrace partnerships and leverage your unique "added value" beyond just capital to secure the best deals and accelerate growth in a rapidly evolving tech and business landscape.
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February 11, 2026

Inside The Life of Silicon Valley's First Athlete Investor | Magic Johnson

a16z

AI
Key Takeaways:
  1. The Macro Shift: Celebrity capital is moving from transactional endorsements to strategic equity ownership, mirroring a broader trend where individuals, powered by AI and blockchain tools, can build high-value companies with leaner teams, making strategic capital more impactful than ever.
  2. The Tactical Edge: Cultivate a network of mentors and partners, prioritize equity in "boring" but high-demand sectors, and be prepared to invest significant capital into improving core product and customer experience.
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February 11, 2026

Inside The Life of Silicon Valley's First Athlete Investor | Magic Johnson

a16z

AI
Key Takeaways:
  1. The era of celebrity endorsements is giving way to a new reality where personal brand power is directly converted into equity ownership and enterprise building, accelerated by accessible tech like AI for rapid business creation.
  2. Cultivate a diverse network through consistent, intentional engagement, and prioritize investments in demand-driven, "boring" businesses that offer long-term growth and opportunities for strategic value addition.
  3. Success in the next decade demands a "win-at-all-costs" mindset, a willingness to invest in operational excellence (including AI and analytics), and a strategic shift from short-term gains to long-term equity and partnership.
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February 11, 2026

Inside The Life of Silicon Valley's First Athlete Investor | Magic Johnson

a16z

AI
Key Takeaways:
  1. Cultivate a diverse, long-term network, prioritizing relationships.
  2. Seek "boring" businesses in high-demand, underserved markets, and invest in customer experience and product quality.
  3. Future wealth creation for builders and investors demands a long-term, value-add mindset, leveraging partnerships and foundational improvements, not fleeting trends.
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February 11, 2026

The Autonomous Driving Race Is Already Over w/ Kyle Reidhead

Milk Road AI

AI
Key Takeaways:
  1. AI-driven automation and deflationary economics are converging with Tesla's proprietary neural networks and vast real-world data. This creates an unassailable moat in autonomous transportation and labor.
  2. Monitor upcoming regulatory approvals for unsupervised FSD in key US states. This event will trigger the rollout of Tesla's robo-taxi network, fundamentally altering vehicle economics.
  3. Tesla is not just a car company; it is a foundational AI and robotics platform. Its FSD and robo-taxi network, combined with the broader Musk ecosystem, position it to capture a multi-trillion dollar market in autonomous services and labor, driving massive deflation and investor upside over the next decade.
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Crypto Podcasts

May 27, 2025

Is Bitcoin Heading To $150k?

1000x Podcast

Crypto
Key Takeaways:
  1. Bitcoin's Bullish Trajectory: Bitcoin is on a path to potentially reach $150k-$200k, supported by a low-hype, strong-setup environment and a more sophisticated investor base.
  2. Strategic Altcoin Hunting: Focus on revenue-generating altcoins with solid fundamentals (check DeFiLlama) and consider measured exposure to the burgeoning AI crypto sector.
  3. Prioritize Self-Custody: Given exchange vulnerabilities, holding your assets offline in cold storage is more critical than ever.
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May 27, 2025

Empire Cross-Post: The Bull Case For Ethereum | Tom Dunleavy & Ryan Berckmans

Bell Curve

Crypto
Key Takeaways:
  1. L1 is HQ: Ethereum's "pivot" reasserts the L1's central role, supported by L2s that offer crucial business model diversity and customization for the world coming on-chain.
  2. Value Accrual via Security & Confidence: ETH's valuation is increasingly tied to the total economic value it secures and the market's confidence in its future, not just direct fee revenue.
  3. Business Development is Crucial: To compete and grow, Ethereum requires a significantly more robust and proactive go-to-market strategy to attract users, institutions, and developers.
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May 27, 2025

The Altseason Rotation Has Begun! Here's The Data Behind the Next Rotation

Bankless

Crypto
Key Takeaways:
  1. Rotation Imminent: Data suggests Bitcoin's strength is setting the stage for capital to flow into altcoins, particularly Ether, which is seen as "hated" and due for a rebound against Bitcoin.
  2. Macro is Bullish (For Now): Continued fiscal spending and an anticipated stablecoin bill are significant tailwinds, though summer may bring some turbulence.
  3. Strategic Allocation is Key: Focus on assets with strong fundamentals or high attention. Consider beta plays like "blue-chip" meme coins (Pepe for ETH, Bonk for SOL) for higher-risk, higher-reward exposure, but plan exits for speculative positions.
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May 27, 2025

Travis Millott: Tao Templar, Bittensor Subnets, Dynamic Tao, Mining, Crypto Education | Ep. 44

Ventura Labs

Crypto
Key Takeaways:
  1. Dynamic Tao is High-Risk: Approach investments with extreme caution; the market is volatile, and significant capital loss is a tangible risk.
  2. Embrace Unpredictable Innovation: Bittensor's core value lies in its capacity to generate unforeseen, groundbreaking solutions from a global, permissionless, and competitive talent pool.
  3. Substrate Chain Decentralization is Critical: The successful decentralization of Bittensor's foundational layer is a paramount upcoming milestone for its long-term viability, security, and censorship resistance.
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May 26, 2025

The Bitcoin Treasury Playbook With Tyler Evans & Josh Solesbury

Empire

Crypto
Key Takeaways:
  1. Global Takeover: Bitcoin treasury strategies are rapidly globalizing, creating new Bitcoin-proxy investment vehicles in numerous capital markets.
  2. Investor Vigilance: While "Bitcoin plus" returns are alluring, investors must critically assess MNAV multiples and beware of highly leveraged companies lacking strong, transparent leadership.
  3. Reverse Tokenization is Real: Crypto assets are increasingly entering traditional finance via these public companies, fundamentally changing institutional access and perception.
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May 26, 2025

Why Analysts Are Valuing ETH All Wrong

Bankless

Crypto
Key Takeaways:
  1. **L1s are Money, Not Stocks:** Stop trying to fit square pegs (L1s) into round holes (DCF models for companies). Their value accrues like money, through network effects and demand for their monetary properties.
  2. **RSOV is Your New Lens:** Use RSOV to gauge the "stickiness" of capital in an L1 ecosystem. A growing RSOV suggests a strengthening monetary base and potentially a rising valuation floor.
  3. **ETH's RSOV Story:** ETH, when viewed through the RSOV lens, appears undervalued relative to assets like Bitcoin, especially considering catalysts like EIP-4844 ("proto-danksharding") and the growth of its L2 ecosystem, which drives ETH's use as a store of value.
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