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AI Podcasts

May 30, 2025

SN17 - 404GEN :: Decentralized AI generated 3D assets

Opentensor Foundation

AI
Key Takeaways:
  1. Unlocking Creative Potential: 404GEN radically lowers barriers to 3D content creation, enabling faster iteration and new forms of interactive media previously unfeasible for smaller teams or individuals.
  2. Gaussian Splats are Ascendant: This representation is emerging as a powerful alternative for 3D AI, and 404GEN is at the forefront of its practical application and tooling.
  3. BitTensor's Competitive Edge Shines: The subnet's rapid quality improvement and the innovative ELO validation system highlight BitTensor's power to incentivize and coordinate decentralized intelligence towards state-of-the-art results.
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May 30, 2025

Hey Tech, Come to Healthcare

a16z

AI
Key Takeaways:
  1. **Build for Behavior Change:** The biggest wins will come from engaging consumers and enabling sustainable health behaviors, an area where tech excels.
  2. **AI is the Leapfrog:** Healthcare can jump directly to AI-driven solutions, bypassing clunky legacy software, especially for service-oriented tasks.
  3. **The Trillion-Dollar Prize is Real:** Whether through full-stack "payvider" models or horizontal platforms, the path to becoming the world's largest company runs through transforming the consumer healthcare experience.
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May 29, 2025

Building a DePIN-powered Shazam for Media with Rumi | Niko Cunningham and Mateusz Poreda

Proof of Coverage Media

AI
Key Takeaways:
  1. **Decentralized Analytics:** Rumi’s DePIN model democratizes media intelligence, offering far richer and more granular data than traditional players like Nielsen.
  2. **Context is King:** The "Shazam for media" capability will fuel a new generation of AI agents and interactive experiences, making media deeply engaging.
  3. **Investor Signal:** The $5M pre-seed (EV3, A16Z CSX) and early traction with industry players like Tivision validate Rumi's approach and market potential.
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May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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May 26, 2025

Chatbot platforms might replace social media

Machine Learning Street Talk

AI
Key Takeaways:
  1. AI Companionship is Exploding: Millions are already deeply engaged with AI for emotional connection, and this is just the beginning as technology like GPT-4o normalizes it.
  2. Lean Engineering Can Win: Chai's success with a tiny, hyper-talented team and innovative techniques like model blending proves that massive VC-backed operations aren't the only path to scale in AI.
  3. The Next Social Platform Might Be AI: As AI offers more active, personalized, and consequence-free social interaction, it could very well become the dominant way people connect, potentially supplanting traditional social media.
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Crypto Podcasts

March 11, 2025

Rich Rines on Bitcoin's Path to $1,000,000

The Rollup

Crypto

Key Takeaways:

  • 1. Institutional interest is driving the development of structured financial products for Bitcoin, enhancing its legitimacy and adoption.
  • 2. Bitcoin's design as a secure, slow asset is a strategic advantage, positioning it as a leading collateral asset in the global financial system.
  • 3. The future of Bitcoin lies in horizontal scaling and innovative financial products, with the potential to significantly impact the broader crypto ecosystem.
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March 10, 2025

Can Frontends Act as a Moat? | Josh Litchman & Tolks

0xResearch

Crypto

Key Takeaways:

  • 1. The crypto market is maturing, with a shift towards fundamentals and defensive tokens gaining prominence.
  • 2. Frontends are crucial in capturing and retaining users, acting as a strategic moat in the competitive crypto landscape.
  • 3. Crypto gaming is evolving, with casual games offering new opportunities for user engagement and economic experimentation.
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March 9, 2025

Is The Bottom In?

Steady Lads Podcast

Crypto

Key Takeaways:

  • 1. The crypto market is undergoing a correction, with significant volatility and mixed sentiment about future directions.
  • 2. Political figures are influencing crypto markets, but their involvement is often seen as unpredictable and potentially destabilizing.
  • 3. Binance's actions against market manipulation may signal a shift towards more stable and fundamental-driven market conditions.
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March 26, 2025

Why Institutions Are Bullish With Eric Peters

Empire

Crypto

Key Takeaways:

  1. The politicization of markets will continue to drive volatility and uncertainty, making crypto an attractive alternative asset class.
  2. Institutional adoption is gaining momentum, with sovereign wealth funds, pensions, and endowments poised to increase their allocations to crypto.
  3. The tokenization of everything is coming, creating massive opportunities within the crypto ecosystem.
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March 26, 2025

Will We See A Solana ETF In 2025? | Matthew Sigel

Lightspeed

Crypto

Key Takeaways:

  1. Institutional interest in Bitcoin is growing, but Solana and other altcoins face headwinds from low institutional adoption, regulatory uncertainty, and a challenging macroeconomic environment.
  2. A Solana ETF is highly probable by late 2025, pending regulatory approvals and assuming the SEC addresses outstanding questions.
  3. Growth in stablecoin usage and its impact on fee revenue for SOL holders is crucial for driving future institutional adoption of Solana.
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March 25, 2025

Live From DAS: Building Empirical Valuation Frameworks For Digital Assets

0xResearch

Crypto

Key Takeaways:

  1. While traditional valuation methods offer a starting point, crypto valuations are heavily influenced by market sentiment and flow. Focus on a token's potential to generate future cash flows.
  2. Tokenomics, specifically inflation and its interaction with staking rates, play a critical role in determining a token's value. Analyze these dynamics carefully.
  3. Prudent portfolio construction with diversified position sizing is essential for navigating the volatile crypto market and capturing potential upside while mitigating risk.
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