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AI Podcasts

June 26, 2025

AI at the Edge: How Gensyn Is Building Verifiable, Decentralized Machine Learning

The People's AI

AI
Key Takeaways:
  1. Verification is AI’s Trust Bottleneck. True decentralized AI is impossible without solving verification. Without deterministic proofs, networks are vulnerable to economic exploits and malicious model poisoning, rendering them untrustworthy.
  2. The Next Frontier is Horizontal, Not Vertical. The era of simply adding more GPUs to a data center is ending. The future lies in distributing tasks across a vast network of devices, which requires a new paradigm of verifiable, deterministic algorithms.
  3. Deterministic AI Creates New Economies. A verifiable infrastructure provides the substrate for a new "machine economy" where autonomous agents transact and arbitrate disputes. This same technology can serve as a trusted, unbiased arbiter for human interactions.
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June 26, 2025

Tech Executive Answers: Can AI Solve Healthcare's Urgent Workforce Challenges? with Ankit Jain

a16z

AI
Key Takeaways:
  1. AI’s killer app in healthcare is automating administrative sludge. The most immediate ROI isn't in clinical diagnosis but in tackling the operational chaos (prior authorizations, benefit checks) that delays care and burns out staff.
  2. Expose the hidden costs of the status quo. AI’s value becomes undeniable when it reveals and corrects the existing system's deep-seated inefficiencies and error rates, like the 25% inconsistency rate in human-led payer calls.
  3. The moat is the workflow, not the model. As foundation models become commoditized, the real, defensible value for AI companies lies in deep, last-mile workflow integration and the proprietary data loops that fine-tune models for specific, high-stakes environments.
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June 25, 2025

Hash Rate - Ep 119 - The #1 Bittensor Subnet CHUTES

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

AI
Key Takeaways:
  1. Massive Utility Unlocks Adoption: Shoots' focus on simplifying AI deployment and providing access to models at low/no cost (initially) has driven user numbers to 371,000 and massive token throughput, proving real-world demand.
  2. Bridging Crypto and AI is Key: Overcoming AI developers' skepticism of crypto requires tangible benefits; Shoots aims to be that bridge, using BitTensor's incentives to power a superior, open AI platform.
  3. Privacy is the Enterprise Gateway: For decentralized AI platforms like Shoots to capture significant enterprise market share, robust, verifiable privacy solutions like Trusted Execution Environments (TEEs) are non-negotiable.
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June 25, 2025

Building Cluely: The Viral AI Startup that raised $15M in 10 Weeks

a16z

AI
Key Takeaways:
  1. Distribution is Queen: In a noisy AI world, mastering viral distribution can be a more potent advantage than a perfectly polished initial product. Eyeballs first, then iterate based on data.
  2. Embrace the Provocateur: The Gen Z approach to content—transparent, sometimes controversial, but always authentic—resonates. Leaders need demonstrable personal reach; the era of faceless corporate comms is fading.
  3. Speed Wins: In AI, "momentum as a moat" means rapid product development and distribution are critical. The ability to build the plane while it's in flight is the new founder archetype.
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June 24, 2025

Three Red Lines We're About to Cross Toward AGI

Machine Learning Street Talk

AI
Key Takeaways:
  1. Recursive Self-Improvement is a Critical Threshold: Preventing fully automated AI R&D is a key chokepoint to manage existential risks.
  2. Alignment Remains Elusive: Current methods are insufficient for robustly controlling advanced AI; "fairly reasonable" isn't safe enough.
  3. Transparency is Non-Negotiable: Governments and the public need situational awareness of frontier AI progress to inform policy and deterrence.
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June 23, 2025

Founders, Media, & Memes: a16z’s Strategy for the Future | a16z LP Summit 2025

a16z

AI
Key Takeaways:
  1. Structure Dictates Agility: a16z’s non-shared control model allows for rapid reorganization and specialization, crucial for capturing emerging tech waves like AI and crypto.
  2. Narrative is Power: In a meme-driven world, owning your narrative and media channels is paramount; a16z is actively building its presence to lead conversations.
  3. AI Needs Crypto: The burgeoning world of AI agents will create massive demand for crypto as the native transaction layer, exemplified by experiments like "Truth Terminal."
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June 21, 2025

Coatue Pt2. Open AI’s Kevin Weil Dives into All Things ChatGPT | BG2 w/ Bill Gurley & Brad Gerstner

Bg2 Pod

AI
Key Takeaways:
  1. The Current AI is Just the Beginning: Today's AI models are the "worst" we'll ever use; exponential improvements mean capabilities will dramatically expand in short timeframes.
  2. Proactive, Personalized AI is Coming: Expect AI to move from reactive answering to proactive task completion, deeply integrated into personal and professional workflows.
  3. Execution Defines the Winner: While the opportunity is immense ($100B+ revenue potential for OpenAI), success hinges on relentless execution and navigating a competitive, evolving landscape.
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June 20, 2025

Coatue’s Laffont Brothers. AI, Public & VC Mkts, Macro, US Debt, Crypto, IPO's, & more | BG2

Bg2 Pod

AI
Key Takeaways:
  1. AI is the Apex Predator: AI isn't just a feature; it's fundamentally reshaping business models, potentially leading to unprecedented productivity gains and market reallocations. Watch for AI pure-plays and established firms effectively leveraging AI for margin expansion.
  2. Crypto's Institutional Door is Creaking Open: Regulatory clarity and evolving products like interest-bearing stablecoins could unlock significant institutional capital for the digital asset class. Bitcoin's scale makes it increasingly hard to dismiss.
  3. Productivity is the New Macro Hedge: AI-fueled productivity could be the unexpected force that stabilizes the US fiscal situation, making current bond yields more rational than they appear under a "debt spiral" narrative.
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June 20, 2025

TikTok & AI Have Changed Education Forever - What it means for Teachers, Students & Parents

a16z

AI
Key Takeaways:
  1. Teacher Tools First, Student Revolution Later: AI's immediate impact is in making teachers hyper-efficient by automating administrative drudgery; direct AI-led student learning is still nascent but holds immense potential.
  2. Content is King, Delivery is Viral: AI is democratizing high-quality educational content creation and enabling novel, highly engaging delivery formats (e.g., celebrity deepfakes on TikTok), potentially bypassing traditional channels.
  3. The "Alpha" Signal is Strong: Experiments like Alpha School, though niche, prove AI's capacity to deliver superior educational outcomes, signaling a future where personalized, AI-driven learning paths become the norm if cost and accessibility barriers are overcome.
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Crypto Podcasts

February 2, 2026

Why BitGo Went Public | Mike Belshe

Empire

Crypto
Key Takeaways:
  1. Regulatory clarity and institutional demand are converging, driving a fundamental re-architecture of financial market infrastructure. This shift will see traditional finance increasingly rely on regulated crypto-native service providers.
  2. Builders and investors should prioritize infrastructure providers that offer robust regulatory compliance and fiduciary protection, as these are the non-negotiable requirements for the next wave of institutional capital.
  3. The digital asset industry is poised for massive growth, driven by Wall Street's entry. Companies like BitGo, by building transparent, regulated infrastructure, are not just participating in this growth; they are actively shaping the future of finance, making now the time to understand these foundational shifts.
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February 2, 2026

Curated Credit: How Maple and Morpho Approach DeFi Lending | Sid Powell & Merlin Egalite

0xResearch

Crypto
Key Takeaways:
  1. Institutional capital is eyeing DeFi, pushing for tokenized real-world assets like private credit and bonds to diversify yield sources beyond crypto-backed loans. This requires robust risk isolation at the smart contract level and a new generation of independent risk assessors to bridge TradFi and DeFi.
  2. Prioritize protocols that offer explicit risk profiles and transparent fee structures, especially those building towards intent-based lending. For builders, focus on creating infrastructure that supports isolated risk and attracts independent rating agencies.
  3. The future of DeFi lending hinges on transparency and sophisticated risk management. As institutions enter, the demand for clear, independently verified risk assessments will intensify, making protocols that embrace these principles the winners in the next market cycle.
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February 2, 2026

The Last Companies That Will Ever Exist

Bankless

Crypto
Key Takeaways:
  1. The global economy is transitioning from a "bits" era of digital innovation to an "atoms" era, driven by AI and robotics, where control over physical resources and their efficient deployment becomes the ultimate competitive advantage.
  2. Prioritize investments in companies demonstrating vertical integration across intelligence, energy, and labor, especially those building physical infrastructure and manufacturing capabilities at scale.
  3. The race to acquire the "Infinity Gauntlet" of capitalism is on. Companies that achieve self-sufficiency in intelligence, energy, and labor will redefine economic power, making traditional capital almost irrelevant and creating a new class of unassailable monopolies.
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February 2, 2026

Logan Jastremski: Solana vs Hyperliquid - Who Wins The Global Exchange Race?

Delphi Digital

Crypto
Key Takeaways:
  1. The global financial system demands 24/7, credibly neutral price discovery. This pushes blockchain architecture beyond raw throughput to geographically optimized, low-latency transaction inclusion, creating a truly global market.
  2. Invest in infrastructure and applications on chains pursuing multi-leader consensus and proprietary AMMs. These designs offer superior price discovery and execution for the next generation of global trading.
  3. The global exchange race is an engineering marathon, not a sprint. While Hyperliquid excels regionally, Solana's architectural bet on physics-defying global fairness aims to become the world's true price oracle, unlocking trillions in new trading volume.
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February 2, 2026

How to Fix Tokenized Securities with Olivia Olivia Vande Woude from Ava Labs

The Rollup

Crypto
Key Takeaways:
  1. Trust is moving from opaque balance sheets to verifiable, cryptographically enforced infrastructure. This means financial protocols, not just institutions, will increasingly dictate settlement, custody, and compliance.
  2. Prioritize tokenized assets and investment vehicles that offer direct legal claims and verifiable on-chain mechanics. For builders, focus on creating infrastructure that eliminates intermediaries and provides transparent, programmable utility, like vaults.
  3. The future of finance is about verifiable infrastructure and programmable ownership. Understanding the nuances of tokenized security structures and the rise of on-chain vaults will be critical for investors and builders navigating the convergence of traditional finance and DeFi over the next 6-12 months.
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February 2, 2026

The 1010 Exploit and other broken market structures

The Gwart Show

Crypto
Key Takeaways:
  1. The market is demanding verifiable, transparent, and capital-efficient trading venues that eliminate the hidden risks of centralized intermediaries. This pushes innovation towards fully onchain, unified risk engines.
  2. Explore platforms that integrate multiple DeFi primitives (spot, perp, lending) under a single, onchain risk engine. These venues offer superior capital efficiency and potentially higher risk-adjusted returns for sophisticated strategies like basis trades.
  3. The next wave of DeFi success will come from platforms that solve for capital productivity and verifiable safety, attracting institutional and sophisticated retail capital by offering returns previously unattainable in fragmented or opaque markets.
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