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AI Podcasts

November 17, 2025

Hash Rate - Ep 145 - TAO Subnets Templar (3), Basilica (39), Grail (81)

Hash Rate pod - Bittensor $TAO & Subnets

AI
Key Takeaways:
  1. **A New Market is Born:** Templar isn't just cheaper; it enables something that was previously impossible for 99% of the world. Democratizing pre-training means anyone can build a truly custom, sovereign AI.
  2. **Productization is Underway:** Covenant is no longer just a research project. With enterprise sales in motion, the focus is now on revenue. The team has committed that 100% of fees from custom training will be used to buy back its tokens.
  3. **Economics are Being Rewritten:** Basilica’s incentive mechanism is a direct critique of unsustainable models on other compute subnets. Its focus on profitability and positive TAO flow sets a new standard for economic design on Bittensor.
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November 17, 2025

Bryan Johnson: Don’t Die, Beating Entropy, AI Alignment & The Two-Species Future

Bankless

AI
Key Takeaways:
  1. AI Forces a Moral Reboot. The emergence of superintelligence renders our current societal goals dangerously obsolete. Survival must become the new prime directive.
  2. Existence is a Team Sport. The "Don't Die" philosophy is a collective mission ("we don't die") to ensure species-wide survival, not a selfish quest for individual immortality.
  3. Prepare for the Biological Sandbox. Humanity is moving from manipulating physical atoms and digital bits to programming our own biology—a frontier with both unimaginable potential and catastrophic risk.
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November 17, 2025

Emmett Shear on Building AI That Actually Cares: Beyond Control and Steering

a16z

AI
Key Takeaways:
  1. Stop Trying to “Steer” AGI. The control paradigm is a dead end. The goal isn’t a more obedient tool; it’s a trustworthy teammate. We must shift from engineering control to cultivating care.
  2. Alignment is a Process, Not a Product. True alignment isn't a fixed set of rules. It’s a dynamic process of moral learning, akin to raising a child. AIs that only follow rules are brittle and dangerous.
  3. Build for Cooperation, Not Command. The technical path forward involves training AIs in rich, multi-agent environments where they must learn cooperation and theory of mind—the foundational skills for becoming a good member of a group.
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November 16, 2025

Rawson Haverty presents "US & China AI: Lessons from Across the Pacific" | dAGI Summit 2025

Delphi Digital

AI
Key Takeaways:
  1. US Leads in Capital-Intensive Frontier AI; China Excels at Industrial Diffusion. The US leverages deep capital markets for its massive compute buildout and AGI research, while China uses state direction to embed AI into its vast industrial base via open-source models and hardware.
  2. Market Structure Dictates AI Strategy. The US "efficient oligopoly" model prioritizes global dominance and profit reinvestment by a few players. China's "subjugated swarm" model creates intense domestic competition, driving down prices and accelerating adoption at the cost of profitability.
  3. Geopolitical Tension May Be a Necessary Stabilizer. The competition between the US's freedom-oriented, frontier-pushing approach and China's stability-focused, diffusion-driven model creates a complementary tension that could be essential for navigating the "narrow corridor" between AI-driven totalitarianism and uncontrollable chaos.
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November 13, 2025

How Will AI Change Gaming Development? (A Dev’s Take)

The DCo Podcast

AI
Key Takeaways:
  1. Development timelines are collapsing from months to days. AI allows developers to swap entire asset libraries or generate new game concepts at unprecedented speed, turning a two-month art project into a day's work.
  2. The lifespan of any single game is shrinking. Prepare for a world of disposable entertainment. As AI floods the market with content, the strategy will pivot from creating one long-lasting hit to deploying a rapid succession of engaging experiences.
  3. Games are the next evolution of the attention economy. Just as memes became a core tool for community-building around tokens, easily created games will be the next engine for capturing and directing user attention in a hyper-competitive digital world.
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November 11, 2025

AI Nerves, Crypto Realism, Privacy Coins, & Lessons From Trading

1000x Podcast

AI
Key Takeaways:
  1. Adopt a Stock Picker's Mentality. The crypto market is no longer a monolith where a rising tide lifts all boats. Focus on assets with real products, user growth, and cash flow, as the gap between winners and losers will only widen.
  2. Shorting is a Tactical Assault, Not a Siege. Don't "invest" in a short. The only viable short strategies are tactical, targeting specific events like VC unlocks or news-driven spikes. Otherwise, even "total scams" can 5x against you.
  3. Cultivate a Goldfish's Memory. The most critical trading skill is learning how to change your mind. Cut losing trades, forget the loss (but remember the lesson), and redeploy capital without emotional baggage. Stubbornness is a portfolio killer.
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November 11, 2025

Grant Lee: Building Gamma’s AI Presentation Company to 100 Million Users

a16z

AI
Key Takeaways:
  1. Word-of-mouth isn't a feature; it's the engine. Before spending a dime on marketing, obsess over the first 30 seconds of the user experience until people can't help but share it.
  2. Being different is better than being better. Don't build incrementally better slideware. Redefine the core primitives of your category, as Gamma did by moving beyond the 16x9 slide.
  3. Hire painfully slowly to protect your DNA. Resisting the temptation to scale headcount with user growth is a superpower. The goal isn't to hit a hiring target; it's to hire the best people.
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November 7, 2025

Amjad Masad & Adam D’Angelo: How Far Are We From AGI?

a16z

AI
Key Takeaways:
  1. AGI Is a Definitional Debate. Progress toward an AI that can replace a remote worker is happening fast. However, achieving "true" human-like learning efficiency may require an entirely new paradigm beyond scaling current LLMs.
  2. The New Creator Economy Is Code. AI is turning software development into a mainstream creative pursuit, empowering a new class of solo entrepreneurs who can build what previously required entire teams.
  3. Incumbents Learned Their Lesson. Unlike past tech shifts, today's giants are aggressively adopting AI, making it both a sustaining *and* disruptive force. The market is large enough for both incumbents and startups to create massive value.
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November 6, 2025

Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease

a16z

AI
Key Takeaways:
  1. Build the Tools, Not Just the House: CZI’s greatest leverage comes from creating open-source tools and datasets. By building the fundamental infrastructure, they empower the entire scientific community—from academic labs to startups—to accelerate discovery.
  2. Data Is the New Microscope: The future of biology hinges on a tight feedback loop between generating novel, purpose-built datasets and training domain-specific AI models on them. This synergy is unlocking insights that were previously impossible.
  3. Virtual Biology Is the Next Frontier: Simulating biology computationally with "virtual cells" will become the new standard for research, enabling scientists to test riskier hypotheses faster and cheaper, dramatically compressing the timeline for major breakthroughs.
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Crypto Podcasts

June 17, 2025

How to Actually Grow on Crypto Twitter in 2025

The DCo Podcast

Crypto
Key Takeaways:
  1. Authenticity Over Algorithms: Ditch the generic social media playbook; your genuine interest in a specific crypto niche is your most potent growth tool.
  2. Niche Down to Blow Up: Become the go-to source for your specific passion (e.g., memecoins, DeFi protocols) by sharing your unique process and insights.
  3. The Audience Knows: Users can "sniff out" disingenuous content. Real interest and transparent sharing build trust and attract a loyal following.
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June 16, 2025

The State Of Crypto Derivatives

Empire

Crypto
Key Takeaways:
  1. **Risk Re-Priced**: Post-2022, understanding and mitigating counterparty and correlated risk is paramount; high returns often masked these dangers.
  2. **TradFi Rails Accelerate Crypto**: Publicly traded vehicles and ETFs are becoming key on-ramps, channeling traditional capital into crypto and reshaping market dynamics, notably compressing volatility.
  3. **Fundamental & On-Chain Focus**: Durable value (on-chain credit, strong L1s like Solana, revenue-generating protocols) and innovative on-chain derivatives platforms (like Hyperliquid) are prime areas of growth and investor interest.
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June 16, 2025

How to Value L1s?

Lightspeed

Crypto
Key Takeaways:
  1. App Revenue as a Current Yardstick: For now, L1 "GDP" (market cap / app revenue) offers a more stable cross-chain valuation tool than direct fees, providing an "apples-to-apples" comparison.
  2. The Inevitable Value Shift: Expect a future where applications, not L1s, capture the lion's share of value, as app take rates and business models mature. L1 valuations may compress as app valuations expand.
  3. L1s Must Innovate to Retain Value: Blockchains like Solana are actively strategizing (e.g., application-specific sequencing) to keep successful apps within their ecosystems, highlighting the growing pressure on L1s to prove their enduring value proposition beyond basic infrastructure.
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June 15, 2025

VCs Weigh In On Crypto Treasury Companies

Empire

Crypto
Key Takeaways:
  1. Treasury Strategies: High-Risk, Short-Term Plays: These vehicles are built for quick flips, not lasting value, with a high chance of premiums vanishing and values dropping below NAV.
  2. Beware the "Mania": The proliferation of treasury vehicles with increasingly lax terms signals a speculative fever; MicroStrategy is an outlier, not the rule.
  3. VCs Bet on Endurance: True crypto investing, from a venture perspective, demands patience and a focus on fundamental, long-term growth, distinct from chasing fleeting treasury premiums.
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June 14, 2025

The Next Crypto Companies To IPO

Empire

Crypto
Key Takeaways:
  1. **Scale is King:** Sub-$3 billion valuation companies will struggle for analyst attention and institutional investment post-IPO.
  2. **SaaS Sells:** Crypto firms with predictable, recurring revenue (like Fireblocks, Chainalysis) have a stronger IPO narrative than those riding crypto price waves.
  3. **Trust is Currency:** For select businesses like Anchorage, an IPO isn't just about capital; it’s a strategic move to bolster their fundamental value proposition—trust.
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June 14, 2025

Solana ETFs coming?

The Rollup

Crypto
Key Takeaways:
  1. Solana's ETF = Major Validation: If approved, a Solana ETF isn't just another fund; it's a significant nod to Solana's legitimacy and a big win for its community.
  2. Beyond Single Assets - Think Indices: The success of individual crypto ETFs (like a potential Solana one) could fuel demand for broader market products, such as crypto index funds on traditional stock exchanges.
  3. Staking in ETFs - Tax Clarity Coming?: Watch for regulatory updates on staking within ETFs. Positive guidance could unlock new product structures and resolve key tax concerns for investors.
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