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AI Podcasts

August 25, 2025

Aaron Levie and Steven Sinofsky on the AI-Worker Future

a16z

AI
Key Takeaways:
  1. Embrace Specialization, Not Generalization. The most effective AI systems are emerging from a “system of many agents” approach. Instead of chasing a single AGI, the trend is toward building and orchestrating multiple deep experts, each with a narrow focus.
  2. AI Augments Experts, It Doesn't Replace Novices. The biggest productivity gains are going to those who already have domain expertise. AI is a tool whose value is unlocked by a user who can provide precise prompts and critically evaluate the output.
  3. The Next Thousand Unicorns are Agent Companies. The startup playbook is clear: go deep on a single, vertical workflow and build an agent that does it better than anyone else. Just as APIs like Twilio and Stripe unbundled services, agents will unbundle workflows, creating entire companies from what was once a feature.
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August 23, 2025

Ben Horowitz on How a16z Was Built

a16z

AI
Key Takeaways:
  1. Build a Product, Not Just a Portfolio. The dominant VC firms of the future will offer concrete services to founders, not just capital. Reputation and unwavering founder support are the ultimate competitive advantages.
  2. Size Funds to the Market Opportunity. The software market is exponentially larger than it was two decades ago. Sticking to legacy fund sizes means missing out on a dramatically expanded opportunity set.
  3. Fight for American Innovation. The biggest existential threat to technology isn't market cycles but a hostile regulatory environment. VCs must actively engage in policy to prevent the US from forfeiting leadership in foundational technologies like AI and crypto.
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August 22, 2025

ONESHOTTED

Trillion Agents

AI
Key Takeaways:
  1. Execution is a Commodity; Ideation is the Moat. The value is rapidly shifting from those who can execute a plan to those who can generate the novel plan in the first place.
  2. Your Org Chart is Now a Repo. Forward-thinking teams are treating their entire operational knowledge base as a single, AI-readable context, turning their company's history and philosophy into a prompt.
  3. Beware the Conflict Resolution Engine. A centralized AI risks becoming an echo chamber that smooths over disagreements. Actively engineer processes (like human-led PR reviews) to preserve essential conflict and challenge groupthink.
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August 22, 2025

The State of AI: Growth, Fragmentation, and the Next Wave

a16z

AI
Key Takeaways:
  1. Zero-Sum is a Losing Bet. The market isn't a monolith. Value is fragmenting across specialized applications in code, image, and vertical workflows. The "winner-take-all" thesis is dead.
  2. Moats are Made, Not Inherent. AI’s magic solves the "bootstrap problem" of user acquisition, but long-term defensibility requires building traditional software moats like brand, workflow integration, and network effects.
  3. Be on the Field, but Pick Your Spot. This is not a market to sit out, but indiscriminate investing is a death sentence. Back exceptional, proven teams, understand that conflicts can lock you out of the best deals, and never confuse market heat with genuine momentum.
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August 21, 2025

Can AI Fix Housing and Healthcare Affordability?

a16z

AI
Key Takeaways:
  1. AI is the deflationary force for stagnant sectors. While software ate the world, it skipped housing and healthcare. AI is finally tackling the operational drag that has caused costs to balloon for decades.
  2. To solve the housing crisis, make it profitable. The path to more housing supply runs through better returns. By making property operations radically more efficient, AI attracts the capital required to build.
  3. The future of work is human + AI. Automation won't eliminate jobs; it will transform them. As AI handles the administrative grind, human roles will shift to higher-value work like community engagement and complex problem-solving.
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August 19, 2025

Hash Rate - Ep 129 - Macrocosmos IOTA (sn9) and DataUniverse (sn13)

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

AI
Key Takeaways:
  1. DTO Means Business: Dynamic TAO has forced a Darwinian shift. Subnets must now achieve product-market fit and generate real revenue to survive, transforming from research projects into self-sustaining businesses.
  2. IOTA’s Grand Ambition: IOTA (SN9) isn't just another model trainer; its architecture aims to train trillion-parameter models on decentralized, consumer-grade hardware, directly challenging the dominance of centralized AI labs.
  3. Time to Garden: The protocol's long-term health hinges on active governance. A strong sentiment is emerging to prune low-effort or malicious subnets to focus emissions on projects capable of creating real, lasting value.
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August 19, 2025

Hash Rate - Ep 128 - Ridges ($TAO Subnet 62)

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

AI
Key Takeaways:
  1. AI Is Moving from Copilot to Pilot. Ridges is betting that the future isn't AI assisting humans, but AI replacing them for specific tasks. Their goal is to make hiring a software engineer as simple as subscribing to a service.
  2. Decentralized Economics Are a Moat. By leveraging Bittensor's incentive layer, Ridges outsources a $15M/year R&D budget to a global pool of competing developers, achieving a cost structure and innovation velocity that centralized players cannot match.
  3. The Breakout Subnet Is Coming. Ridges showcases how a Bittensor subnet can solve real-world business problems—privacy, cost, and quality degradation—to build a product that is not just cheaper, but fundamentally better than its centralized counterparts.
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August 18, 2025

Dylan Patel on GPT-5’s Router Moment, GPUs vs TPUs, Monetization

a16z

AI
Key Takeaways:
  1. From Performance to Profit: The AI industry is pivoting from a war of benchmarks to a game of unit economics. Features like GPT-5’s router signal that cost management and monetization are now as important as model capabilities.
  2. Hardware is a Supply Chain Game: Nvidia’s true moat is its end-to-end control of the supply chain. Competitors aren't just fighting a chip architecture; they're fighting a logistical behemoth that consistently out-executes on everything from memory procurement to time-to-market.
  3. The Grid is the Limit: The biggest check on AI’s expansion is the physical world. The speed at which new power infrastructure and data centers can be built will dictate the pace of AI deployment in the US, creating a major advantage for those who can build faster.
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August 18, 2025

Subnet 56 :: Gradients :: Bittensor End-to-end AI Model Training Suite

Opentensor Foundation

AI
Key Takeaways:
  1. Performance is Proven, Not Promised. Gradients isn't just making claims; it’s delivering benchmark-crushing results, consistently outperforming centralized incumbents and producing state-of-the-art models.
  2. Open Source Unlocks the Enterprise. The shift to verifiable, open-source training scripts is a direct solution to customer data privacy concerns, turning a critical vulnerability into a competitive advantage.
  3. The AutoML Flywheel is Spinning. The network's competitive, tournament-style mechanism creates a self-optimizing system that continuously aggregates the best training techniques, ensuring it remains at the cutting edge.
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Crypto Podcasts

April 10, 2025

Can Blockchain Fix AI's "IP Problem"? With Story Protocol co-founder Jason Zhao

The People's AI

Crypto
Key Takeaways:
  1. Fix IP's Plumbing: Today's IP system is archaic; Story Protocol leverages blockchain for a transparent, programmable, global alternative.
  2. Monetize AI Training: Instead of fighting AI, creators can use Story to set terms and get paid for allowing their IP to be used in AI training or outputs.
  3. Tokenize Everything: IP is a $61T+ asset class (songs, data, brands); protocols like Story unlock its value through tokenization (IPRWAs) and new licensing models.
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April 9, 2025

Are We In A Bear Market? | Carlos Gonzalez Campo

Lightspeed

Crypto
Key Takeaways:
  1. Fundamental Disconnect: Solana's network activity (DEX volume, stablecoins) is stronger now than when SOL last traded below $100, despite the recent price plunge.
  2. Diverging Narratives: Bitcoin is trading like non-sovereign money, reacting to macro news, while Solana's price is more closely tied to its Layer 1 competition with Ethereum.
  3. Leverage Alert: Near-record high Solana open interest (in SOL terms) indicates significant leverage, suggesting amplified volatility potential ahead.
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April 9, 2025

Trump Is “Kitchen Sinking” The US Economy | Darius Dale

Forward Guidance

Crypto
Key Takeaways:
  1. Expect Pain Before Gain: The transition requires near-term economic disruption and market volatility ("go down to go up") before potential long-term benefits materialize. Markets haven't fully priced this in.
  2. Fed Will Be Forced to Act: Ignore Fed rhetoric; expect QE driven by financial stability needs and the debt cycle, regardless of stated intentions about rate levels. Structural inflation near 3% makes the 2% target a source of policy error.
  3. Ditch Long Bonds, Embrace Systems: Structural inflation and fiscal risks make long-term bonds unattractive. Navigate the volatile "Fourth Turning" environment with systematic, rules-based strategies dynamically allocating across assets like stocks, gold, and Bitcoin, prioritizing risk management over prediction.
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April 8, 2025

Why Is Trump Nuking Markets? | Felix Jauvin

1000x Podcast

Crypto
Key Takeaways:
  1. Buy the Dip (Carefully): In times of extreme fear (VIX 50+, Equities -20%), layer into positions incrementally; don't try to perfectly time the bottom or get trapped holding losers.
  2. Bitcoin's Moment?: Deglobalization, capital controls, and foreign stimulus could provide short-to-medium term tailwinds for Bitcoin, potentially decoupling it from traditional risk assets.
  3. Inflation Is Likely Toast: Barring a hot war, the economic slowdown from tariffs likely outweighs direct price impacts, paving the way for eventual Fed easing, even if Powell plays coy for now.
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April 8, 2025

The State Of Solana With Carlos Gonzalez Campo

Lightspeed

Crypto
Key Takeaways:
  1. Apps Outearn the Chain: Solana apps are generating nearly twice the revenue ($1.84) per dollar compared to the network itself, proving strong economic viability on the platform.
  2. Fundamentals Over Price: Despite SOL's price drop, core network health indicators like stablecoin supply and DEX activity remain robust, suggesting the sell-off may be detached from on-chain reality.
  3. L1 Scaling is Priority: Solana is doubling down on enhancing the L1 directly via upgrades (like TPU feedback) and app-level innovation (off-chain elements), rejecting Ethereum's L2 path to keep liquidity unified.
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April 8, 2025

Grifters, Meme Coins & the Solana Comeback

The Rollup

Crypto
Key Takeaways:
  1. Grifters Follow the Heat: Speculative actors migrate to blockchains with the highest activity and potential returns, currently favouring Solana's meme coin ecosystem.
  2. Meme Coins Drive Cycles: Love them or hate them, meme coins are a powerful catalyst for user activity, price appreciation, and ecosystem attention, replicating patterns seen in Ethereum's growth.
  3. Underdog Narratives Fuel Growth: Facing adversity can forge strong, defiant communities (like Solana post-FTX) that focus inward and drive significant comebacks, echoing Ethereum's own path to dominance.
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