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AI Podcasts

December 17, 2025

AI Kernel Generation: What's working, what's not, what's next – Natalie Serrino, Gimlet Labs

AI Engineer

AI
Key Takeaways:
  1. Infrastructure Shift: AI-driven kernel optimization addresses a critical bottleneck in scaling AI compute, enabling more efficient use of diverse hardware.
  2. Builder/Investor Note: Focus on solutions with robust, hardware-verified performance metrics and a clear human-in-the-loop strategy. AI is a powerful tool for automating optimization, not a magic bullet for novel algorithmic breakthroughs.
  3. The "So What?": This technology frees expert engineers from tedious optimization, allowing them to focus on higher-level research and truly innovative algorithmic design, accelerating the pace of AI development in the next 6-12 months.
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December 16, 2025

Finding The 1% of Stocks That Matter | Henry Ellenbogen Interview

Invest Like The Best

AI
Key Takeaways:
  1. Strategic Implication: The era of "free money" inflated the number of perceived compounders; a return to positive real rates demands a sharper focus on businesses demonstrating genuine financial discipline and competitive advantage.
  2. Builder/Investor Note: Seek out "Act 2" entrepreneurs and companies that can leverage AI to transform existing physical or IP-based advantages, not just create new AI products. Be prepared to buy more when market sentiment turns negative on strong businesses.
  3. The "So What?": The next 6-12 months will differentiate companies that merely adopt AI from those that strategically integrate it to build durable, uncatchable cost and distribution advantages.
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December 17, 2025

“How We Can Eliminate Crime” | Ben Horowitz and Garrett Langley

a16z

AI
Key Takeaways:
  1. The Future of Policing is Intelligent: Integrating AI, drones, and smart cameras creates a precise, accountable, and safer policing model for both officers and communities.
  2. Invest in the "How": Builders and investors should focus on technologies that enhance certainty of capture, streamline judicial processes, and support public-private partnerships to modernize urban safety infrastructure.
  3. Safety Fuels Mobility: Eliminating crime is not just about law enforcement; it's about restoring the fundamental safety required for economic mobility and a functional society.
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December 18, 2025

Two Futures | Runtime 2025

a16z

AI
Key Takeaways:
  1. Strategic Implication: The next decade's value will accrue to those building foundational AI infrastructure and the "invisible layers" that connect intelligent systems.
  2. Builder/Investor Note: Focus capital and talent on core AI models, specialized domain intelligence, and the underlying computational fabric. Superficial applications risk rapid commoditization.
  3. The So What?: This is the defining period for the architecture of global intelligence. Participation now determines future influence and relevance.
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December 16, 2025

⚡️Jailbreaking AGI: Pliny the Liberator & John V on Red Teaming, BT6, and the Future of AI Security

Latent Space

AI
Key Takeaways:
  1. Strategic Shift: AI security must move beyond superficial guardrails to a full-stack, offensive red-teaming approach that accounts for the expanding attack surface of AI agents and their tool access.
  2. Builder/Investor Note: Builders should prioritize integrating offensive security early in development. Investors should be wary of "security theater" and favor solutions that embrace open-source collaboration and address the entire AI application stack.
  3. The "So What?": The accelerating pace of AI development means static security solutions will quickly become obsolete. Proactive, community-driven, and full-stack security research is essential for navigating the next 6-12 months of AI evolution.
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December 16, 2025

Why Physical AI Needs a new Data Set | Rerun CEO

Weights & Biases

AI
Key Takeaways:
  1. Data Infrastructure is the Next Bottleneck: The physical AI sector's growth hinges on specialized data tooling that can handle multimodal, multi-rate, episodic data, moving beyond traditional tabular models.
  2. Builders, Prioritize Robustness: Focus on building systems that handle real-world variability and simplify data pipelines. Leverage open-source tools and consider combining imitation and reinforcement learning.
  3. The "So What?": The next 6-12 months will see significant improvements in robot robustness and the ability to perform longer, more complex tasks. This progress will be driven by better data management, making the gap between lab demos and deployable products narrower.
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December 16, 2025

Build reliable AI agents using W&B Training

Weights & Biases

AI
Key Takeaways:
  1. The democratization of RL for LLMs will accelerate the deployment of more reliable and sophisticated AI agents across industries.
  2. Builders should move beyond basic prompt engineering and RAG. RL fine-tuning, now accessible via W&B Serverless RL, is a critical next step for high-stakes agentic applications.
  3. For the next 6-12 months, expect a surge in production-grade AI agents, with open-source models increasingly closing the performance gap with proprietary alternatives through advanced fine-tuning.
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December 15, 2025

Coding Evals: From Code Snippets to Codebases – Naman Jain, Cursor

AI Engineer

AI
Key Takeaways:
  1. Dynamic Evaluation is Non-Negotiable: Static benchmarks are dead. Future AI development demands continuously updated, contamination-resistant evaluation sets.
  2. AI Needs AI to Judge AI: As models grow more sophisticated, LLM-driven "hack detectors" become essential for ensuring code quality and preventing adversarial exploitation of evaluation systems.
  3. User Experience Drives Adoption: For interactive AI coding tools, prioritize low latency and human-centric design; technical prowess alone will not guarantee real-world usage.
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December 15, 2025

Building in the Gemini Era – Kat Kampf & Ammaar Reshi, Google DeepMind

AI Engineer

AI
Key Takeaways:
  1. Strategic Implication: The value in software development shifts from manual coding to high-level architectural design and prompt engineering.
  2. Builder/Investor Note: Experiment with AI Studio's agentic and design capabilities. Focus on describing desired functionality rather than low-level code.
  3. The "So What?": The next 6-12 months will see a surge in AI-powered, full-stack applications built by a broader range of creators, disrupting traditional development paradigms.
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Crypto Podcasts

April 14, 2025

Bringing the World’s Vehicles Onchain with DIMO | Rob Solomon

Proof of Coverage Media

Crypto
Key Takeaways:
  1. Real Utility Drives Adoption: DIMO focuses on tangible benefits (cashback for data, vehicle tracking) beyond token speculation, making the platform sticky for everyday users.
  2. Tokenomics Power the Ecosystem: The $DIMO token is integral, used by developers for data access, with a burn mechanism creating deflationary pressure tied directly to network usage and revenue growth.
  3. Decentralization is the Moat: Building onchain provides a crucial advantage over closed ecosystems, ensuring user control, preventing platform risk, and attracting developers wary of centralized gatekeepers.
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April 14, 2025

The Biggest Market Crash Since 2020, What Next?

Forward Guidance

Crypto
Key Takeaways:
  1. Volatility is the New Normal: Brace for sustained higher volatility; cash and defensive positioning (energy, industrials) are prudent.
  2. Bitcoin's Moment? BTC is increasingly viewed as a macro hedge against instability and potential Fed easing, likely outperforming most alts.
  3. Policy Matters: Deficit reduction, trade wars, and Fed reactions are driving markets; understanding the administration's long-term goals (per Bessent) is crucial.
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April 14, 2025

Building the Future of Global Payments | Paul & Zaheer

0xResearch

Crypto
Key Takeaways:
  1. Specialization Wins: General-purpose blockchains struggle to optimally serve the massive, specific needs of stablecoin transfers; dedicated infrastructure like Plasma is required to unlock the next phase of growth.
  2. USDT is the Global Standard: Tether's dominance, especially outside the US, mirrors the Eurodollar system. It's the Schelling point for international digital dollars, unlikely to be displaced by domestic-focused or bank-issued alternatives.
  3. Focus on Fundamentals: Plasma bets on core utility (cheap/free, fast, secure transfers) and deep integrations over complex tokenomics, aiming to capture trillions in real-world commerce settlement.
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April 14, 2025

The Biggest Market Crash Since 2020, What Next? | Felix Jauvin & Quinn Thompson

Empire

Crypto
Key Takeaways:
  1. Valuations & Policy Collide: Overly optimistic markets hit a wall of peak valuations, expiring liquidity, and initially growth-negative policies.
  2. Bitcoin vs. The World: Bitcoin's near-term strength is tied to potential forced central bank liquidity, while major upside requires a breakdown in traditional fiscal/monetary stability. Prioritize BTC over most alts.
  3. Cash & Caution: Elevated volatility persists. Holding cash and focusing on resilient sectors (e.g., critical resources, energy) is prudent while navigating potential deleveraging events and geopolitical risks.
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April 11, 2025

Crypto Meets Chemistry :: Bittensor SN68 NOVA, Decentralized AI Drug Discovery

Opentensor Foundation

Crypto
Key Takeaways:
  1. Adversarial Advantage: Bittensor's miners are exceptionally efficient at finding flaws in AI models, turning a potential vulnerability into a powerful, real-time stress-testing mechanism crucial for robust drug discovery AI.
  2. Incentivizing Innovation: Token emissions provide funding and incentives for tackling high-risk, high-reward drug discovery challenges that traditional models struggle to support, fostering novelty over incrementalism.
  3. Digital-to-Physical Bridge: Nova plans to translate computational discoveries into real-world value through synthesis, lab validation, and strategic partnerships, aiming to become a pioneering crypto-native biotech entity.
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April 11, 2025

Trump Tariff Madness! w/ Ben Hunt & Jonah Van Bourg

Steady Lads Podcast

Crypto
Key Takeaways:
  1. Dollar Under Pressure: Aggressive US trade policies risk eroding the dollar's reserve status, making diversification into assets like gold and Bitcoin increasingly rational.
  2. Bitcoin's Moment: Bitcoin showed relative strength during market panic, bolstering its narrative as a non-sovereign hedge against policy error; it could be the "fastest horse" in a dollar diversification race.
  3. Navigating Volatility: For traders, volatility is opportunity (buy dips, anticipate intervention); for investors, it requires a long-term view, potentially adjusting allocations (e.g., less equities/bonds, more gold/BTC) and using dips strategically.
See full notes