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AI Podcasts

February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The healthcare system is moving from reactive, acute care to proactive, preventative interventions, driven by the unsustainable costs of chronic disease and a growing understanding of environmental health.
  2. Build infrastructure that financially incentivizes lifestyle interventions, such as TrueMed's HSA/FSA payment rails for health-promoting products and services.
  3. The next decade will see hundreds of billions of dollars redirected towards preventative health. Companies that bridge the gap between lifestyle choices and healthcare financing will capture significant market share.
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February 3, 2026

SpaceX Engineer Explains America's Biggest Energy Mistake | Scott Nolan, CEO of General Matter

The Generalist

AI
Key Takeaways:
  1. The Macro Shift: Global energy demand, driven by AI, forces a strategic re-evaluation of nuclear power. This creates a window for nations to re-shore critical energy infrastructure, moving from reliance on adversaries to domestic, cost-competitive solutions.
  2. The Tactical Edge: Investigate companies addressing foundational supply chain gaps in critical industries like energy. Look for teams with a "first principles" engineering approach and a track record of commercializing hard tech.
  3. The Bottom Line: America's energy independence and its ability to power future technological growth, like AI, hinge on rebuilding domestic nuclear fuel enrichment. This is not just an industrial opportunity; it is a national security imperative.
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February 4, 2026

The Economic Singularity Will Make Today’s Economy Unrecognizable w/ Dr. Alexander Wissner-Gross

Milk Road AI

AI
Key Takeaways:
  1. The Macro Shift: AI-driven hyperdeflation is colliding with the technical reality of autonomous AI agents creating their own crypto-backed economies, threatening a decoupling from human fiat systems.
  2. The Tactical Edge: Investigate and build infrastructure that bridges human and AI economies, focusing on fiat-to-crypto rails that can accommodate agent-driven transactions to prevent a complete split.
  3. The Bottom Line: The next 5-10 years will see an unprecedented economic transformation. Understanding AI's deflationary power and the emerging AI agent economy is critical for navigating a world where traditional economic models may no longer apply.
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February 3, 2026

OpenClaw Makes AI Agents and CPUs Get Real

Semi Doped

AI
Key Takeaways:
  1. The time of practical AI agents is here, moving compute demand beyond pure GPU inference to a significant reliance on CPUs for coordination, data handling, and security.
  2. Evaluate your agent deployment strategy now, prioritizing sandboxed environments (VPS, dedicated local servers) and exploring cost-optimized model routing to manage API expenses.
  3. Prepare for a future where AI agents become integral to workflows, but recognize the hidden infrastructure costs and security implications, particularly the growing importance of CPU capacity and robust access controls.
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February 4, 2026

⚡️ Context graphs: AI’s trillion-dollar opportunity — Jaya Gupta, Ashu Garg, Foundation Capital

Latent Space

AI
Key Takeaways:
  1. The shift from "how" to "why" in AI agent capabilities creates a new, multi-trillion-dollar market for companies that can capture institutional decision logic.
  2. Invest in or build agentic systems that are in the "right path" of business processes, actively capturing decision traces from unstructured data.
  3. Hundreds of context graphs will be in production at scale within a year, defining a new "context graph stack." The winning companies will be those that master this flywheel, extracting value to accelerate automation and build deep, defensible moats.
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February 2, 2026

We Entered an Era Where No One Knows What Comes Next

Turing Post

AI
Key Takeaways:
  1. The shift from linear, bottleneck-driven technological progress to a multi-layered, interconnected advancement model in AI has rendered traditional forecasting obsolete, forcing a re-evaluation of what "singularity" truly represents.
  2. Prioritize adaptability: Invest in modular, composable AI infrastructure and tools that thrive in multi-layered, unpredictable environments, rather than betting on single-bottleneck solutions.
  3. The inability to narrate AI's future means traditional roadmaps are obsolete; success hinges on navigating simultaneous, interconnected advancements and embracing the emergent.
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February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The era of infrastructure-heavy tech deployment is over; AI's internet-native nature means immediate, widespread application. This shifts the competitive advantage from capital-intensive builds to rapid iteration and data leverage.
  2. Invest in companies that are not just using AI, but are fundamentally rethinking their business models around AI's ability to collapse traditional cost structures and accelerate product development.
  3. AI is a force multiplier for both individual opportunity and national power. Understanding its immediate deployability and the new rules of company building is crucial for investors and builders aiming to lead in the next wave of innovation over the next 12-24 months.
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February 2, 2026

Ben Horowitz and David Solomon: The Sweetest Macro Spot in 40 Years

a16z

AI
Key Takeaways:
  1. Unprecedented fiscal and monetary stimulus, coupled with a deregulatory environment, creates a powerful tailwind for financial assets and tech, driving a capital investment super cycle.
  2. Investors should prioritize companies with proprietary data and GPU access, as these are the new moats in an AI-driven world where traditional software leads are eroding.
  3. The convergence of a stimulative macro environment and AI's disruptive force means capital will flow to those who can scale, innovate, and navigate complex policy landscapes, making strategic positioning now critical for future relevance.
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February 3, 2026

Inside The Biggest Uranium Deal In 50 Years | Scott Nolan, CEO of General Matter

The Generalist

AI
Key Takeaways:
  1. Geopolitical tensions and the insatiable energy demands of the AI revolution are forcing a re-evaluation of national energy security.
  2. Invest in companies applying "first principles" engineering and a commercial cost-reduction mindset to foundational, capital-intensive industries.
  3. The US nuclear fuel supply chain is undergoing a rapid, government-backed revitalization.
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Crypto Podcasts

June 11, 2025

How RLUSD Will Join USDT & USDC

Empire

Crypto
Key Takeaways:
  1. **RLUSD Rising:** Ripple's ambition is clear: make RLUSD a top 3-4 stablecoin by leveraging strategic acquisitions for mass distribution, potentially issuing billions through platforms like Hidden Road.
  2. **Acquisition = Distribution:** Ripple is effectively purchasing its market share by acquiring businesses like Hidden Road and Metaco, creating an embedded network to push RLUSD adoption.
  3. **Stablecoin Selects:** The future stablecoin landscape will likely feature 5-7 major players, not just two, and Ripple is aggressively positioning RLUSD to be one of them.
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June 11, 2025

Crypto's Next Era: TradFi IPOs or Hyperliquid, PumpFun & Solana?

Bankless

Crypto
Key Takeaways:
  1. TradFi Wants In: The success of Circle's IPO demonstrates a massive, untapped demand from traditional markets for regulated crypto exposure, potentially paving the way for a wave of crypto IPOs.
  2. ETH's Dilemma: While Ethereum is the undisputed settlement layer for stablecoins and RWAs, the direct translation of this utility to ETH asset appreciation remains a critical question, hinging on increased on-chain economic velocity.
  3. Apps are Eating: Solana's ecosystem, with stars like Hyperliquid and Pump.fun, shows that "fat applications" can generate enormous revenue and user engagement, potentially capturing more value than the underlying L1s.
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June 11, 2025

What Is Flipcash? | Ted Livingston

Lightspeed

Crypto
Key Takeaways:
  1. Digital Cash, Real Utility: Flipcash aims to make digital money feel like physical cash—instant, easy, and universally acceptable, starting with a seamless USDC experience.
  2. Solana Speed is Key: The app's core "wow" factor of instant transactions relies heavily on Solana's performance, underscoring the blockchain's capability for consumer-facing applications.
  3. Onboarding Solved?: Requiring a small purchase for an account, immediately offset by a USDC bonus, tackles the "empty wallet" problem, driving immediate engagement and demonstrating value.
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June 11, 2025

Former Fed Official & Stablecoin Expert On The Future Of Money | Robert Bench

Forward Guidance

Crypto
Key Takeaways:
  1. **Card Networks Disrupted**: Stablecoins are poised to dismantle the high-fee "tax" imposed by traditional card payment systems, with innovators like Stripe leading the charge.
  2. **Internet Re-Incentivized**: Ultra-efficient stablecoin networks (like Radius's vision) could replace the ad-driven "attention economy" with a new model of direct value exchange for digital services, driven by AI agents.
  3. **Currency Cold War Heats Up**: The race for digital currency dominance is on, with USD stablecoins, China's e-CNY, and potentially Bitcoin vying to be the backbone of the next-gen global economy, likely leading to fewer, more standardized global currencies.
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June 10, 2025

Wall Street Loves Circle, Crypto's Next Bullish Catalyst?

1000x Podcast

Crypto
Key Takeaways:
  1. Appetite is Insatiable: Investor demand for any crypto-related exposure is immense, capable of pumping stocks like Circle's despite questionable financials.
  2. Fundamentals Still (Should) Matter: Circle's low margins, high costs, and interest rate sensitivity paint a precarious picture, a "terrible company" according to one host, even if its stock moons.
  3. Hype Cycle Peaks & Troughs: The current frenzy across crypto-linked stocks (Circle, potential Ripple IPO, Coinbase, MSTR) signals significant hype, which historically precedes market corrections.
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June 10, 2025

Crypto's Fastest Payments App, Only Possible On Solana | Ted Livingston

Lightspeed

Crypto
Key Takeaways:
  1. Flipcash is betting that a hyper-fast, intuitive "digital cash" experience, leveraging Solana's speed and a novel L2, can carve out a unique niche in the crowded payments landscape.
  2. The shift to USDC and a clever onboarding mechanism (pay for account, get instant credit) aims to overcome common crypto adoption hurdles related to volatility and empty wallets.
  3. Solana's Speed is a Moat: Flipcash's core "instant cash" UX is explicitly tied to Solana's performance, highlighting the chain's capability for consumer-facing applications demanding high speed.
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