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AI Podcasts

December 17, 2025

AI Kernel Generation: What's working, what's not, what's next – Natalie Serrino, Gimlet Labs

AI Engineer

AI
Key Takeaways:
  1. Infrastructure Shift: AI-driven kernel optimization addresses a critical bottleneck in scaling AI compute, enabling more efficient use of diverse hardware.
  2. Builder/Investor Note: Focus on solutions with robust, hardware-verified performance metrics and a clear human-in-the-loop strategy. AI is a powerful tool for automating optimization, not a magic bullet for novel algorithmic breakthroughs.
  3. The "So What?": This technology frees expert engineers from tedious optimization, allowing them to focus on higher-level research and truly innovative algorithmic design, accelerating the pace of AI development in the next 6-12 months.
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December 16, 2025

Finding The 1% of Stocks That Matter | Henry Ellenbogen Interview

Invest Like The Best

AI
Key Takeaways:
  1. Strategic Implication: The era of "free money" inflated the number of perceived compounders; a return to positive real rates demands a sharper focus on businesses demonstrating genuine financial discipline and competitive advantage.
  2. Builder/Investor Note: Seek out "Act 2" entrepreneurs and companies that can leverage AI to transform existing physical or IP-based advantages, not just create new AI products. Be prepared to buy more when market sentiment turns negative on strong businesses.
  3. The "So What?": The next 6-12 months will differentiate companies that merely adopt AI from those that strategically integrate it to build durable, uncatchable cost and distribution advantages.
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December 17, 2025

“How We Can Eliminate Crime” | Ben Horowitz and Garrett Langley

a16z

AI
Key Takeaways:
  1. The Future of Policing is Intelligent: Integrating AI, drones, and smart cameras creates a precise, accountable, and safer policing model for both officers and communities.
  2. Invest in the "How": Builders and investors should focus on technologies that enhance certainty of capture, streamline judicial processes, and support public-private partnerships to modernize urban safety infrastructure.
  3. Safety Fuels Mobility: Eliminating crime is not just about law enforcement; it's about restoring the fundamental safety required for economic mobility and a functional society.
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December 18, 2025

Two Futures | Runtime 2025

a16z

AI
Key Takeaways:
  1. Strategic Implication: The next decade's value will accrue to those building foundational AI infrastructure and the "invisible layers" that connect intelligent systems.
  2. Builder/Investor Note: Focus capital and talent on core AI models, specialized domain intelligence, and the underlying computational fabric. Superficial applications risk rapid commoditization.
  3. The So What?: This is the defining period for the architecture of global intelligence. Participation now determines future influence and relevance.
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December 16, 2025

⚡️Jailbreaking AGI: Pliny the Liberator & John V on Red Teaming, BT6, and the Future of AI Security

Latent Space

AI
Key Takeaways:
  1. Strategic Shift: AI security must move beyond superficial guardrails to a full-stack, offensive red-teaming approach that accounts for the expanding attack surface of AI agents and their tool access.
  2. Builder/Investor Note: Builders should prioritize integrating offensive security early in development. Investors should be wary of "security theater" and favor solutions that embrace open-source collaboration and address the entire AI application stack.
  3. The "So What?": The accelerating pace of AI development means static security solutions will quickly become obsolete. Proactive, community-driven, and full-stack security research is essential for navigating the next 6-12 months of AI evolution.
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December 16, 2025

Why Physical AI Needs a new Data Set | Rerun CEO

Weights & Biases

AI
Key Takeaways:
  1. Data Infrastructure is the Next Bottleneck: The physical AI sector's growth hinges on specialized data tooling that can handle multimodal, multi-rate, episodic data, moving beyond traditional tabular models.
  2. Builders, Prioritize Robustness: Focus on building systems that handle real-world variability and simplify data pipelines. Leverage open-source tools and consider combining imitation and reinforcement learning.
  3. The "So What?": The next 6-12 months will see significant improvements in robot robustness and the ability to perform longer, more complex tasks. This progress will be driven by better data management, making the gap between lab demos and deployable products narrower.
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December 16, 2025

Build reliable AI agents using W&B Training

Weights & Biases

AI
Key Takeaways:
  1. The democratization of RL for LLMs will accelerate the deployment of more reliable and sophisticated AI agents across industries.
  2. Builders should move beyond basic prompt engineering and RAG. RL fine-tuning, now accessible via W&B Serverless RL, is a critical next step for high-stakes agentic applications.
  3. For the next 6-12 months, expect a surge in production-grade AI agents, with open-source models increasingly closing the performance gap with proprietary alternatives through advanced fine-tuning.
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December 15, 2025

Coding Evals: From Code Snippets to Codebases – Naman Jain, Cursor

AI Engineer

AI
Key Takeaways:
  1. Dynamic Evaluation is Non-Negotiable: Static benchmarks are dead. Future AI development demands continuously updated, contamination-resistant evaluation sets.
  2. AI Needs AI to Judge AI: As models grow more sophisticated, LLM-driven "hack detectors" become essential for ensuring code quality and preventing adversarial exploitation of evaluation systems.
  3. User Experience Drives Adoption: For interactive AI coding tools, prioritize low latency and human-centric design; technical prowess alone will not guarantee real-world usage.
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December 15, 2025

Building in the Gemini Era – Kat Kampf & Ammaar Reshi, Google DeepMind

AI Engineer

AI
Key Takeaways:
  1. Strategic Implication: The value in software development shifts from manual coding to high-level architectural design and prompt engineering.
  2. Builder/Investor Note: Experiment with AI Studio's agentic and design capabilities. Focus on describing desired functionality rather than low-level code.
  3. The "So What?": The next 6-12 months will see a surge in AI-powered, full-stack applications built by a broader range of creators, disrupting traditional development paradigms.
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Crypto Podcasts

April 25, 2025

Is Zora Crypto's Breakout SocialFi Moment? | Weekly Roundup

Lightspeed

Crypto
Key Takeaways:
  1. Transparency is Non-Negotiable: Zora's chaotic token launch proves clear communication and transparent mechanics are crucial for project legitimacy and user safety.
  2. Tokenomics Matter: Launching "for fun" tokens while allocating heavily to insiders erodes trust in an already skeptical market; utility or clear value propositions are needed.
  3. Fix The Game: Rampant bot sniping on launchpads like Pump.fun undermines fairness; innovations like Zora's Doppler AMM are vital experiments to level the playing field.
See full notes
April 25, 2025

Are Ethereum stakers getting screwed?

The Gwart Show

Crypto
Key Takeaways:
  1. ETH Stakers Win: Despite mild network inflation, ETH stakers benefit from a net deflationary effect, increasing their network ownership over time.
  2. Stake or Dilute: Holding ETH without staking means passively transferring economic value to those who do stake.
  3. Not All Staking is Equal: Different blockchains have vastly different inflation dynamics for stakers (e.g., Ethereum vs. Solana).
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April 24, 2025

Is there a way to value L1 tokens?

The Gwart Show

Crypto
Key Takeaways:
  1. **No Magic Number:** Accept that L1 valuation isn't solved; it's a dynamic mix of utility demand, network cash flows (via fees/staking), and speculative monetary use.
  2. **Three-Lens Analysis:** Evaluate L1s by considering their token's role as a consumable commodity, its claim on network revenue (equity-like), and its potential as ecosystem money.
  3. **Monitor Monetary Evolution:** Keep an eye on the nascent monetary use cases (NFTs, memecoins); while small now, their cyclical growth suggests potential future value drivers.
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April 23, 2025

The System Is Too Levered To Take Real Pain | Arthur Hayes

Forward Guidance

Crypto
Key Takeaways:
  1. The Treasury is the New Fed: Forget obsessing over Powell; watch Treasury Secretary Bessent's moves (buybacks, SLR) for the real liquidity signals.
  2. Bitcoin Wins the Liquidity Game: Persistent global money printing, driven by systemic necessity, provides a structural tailwind for Bitcoin, potentially decoupling it from traditional risk assets like US tech.
  3. Gold Shines Amidst De-Dollarization: Central banks are diversifying reserves into gold, recognizing US Treasuries are no longer truly "risk-free" due to geopolitical weaponization, a trend reinforcing gold's value.
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April 23, 2025

"There is a Meaningful Vibe Change" - Ethereum's Pivot Has Begun & Community Reactions

Bankless

Crypto
Key Takeaways:
  1. Ethereum leadership and community acknowledge the need to strengthen the L1, viewing it as essential for long-term value accrual and ecosystem health.
  2. Focus is moving from finding the perfect "ETH asset" narrative to demonstrating value through "Ethereum the product" – a robust, scalable L1 attracting users and developers.
  3. As the L1 potentially becomes more competitive, L2s will need stronger, unique value propositions beyond simply being cheaper/faster alternatives.
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April 23, 2025

How To Avoid Regulatory Capture In Crypto | Miller Whitehouse-Levine

Lightspeed

Crypto
Key Takeaways:
  1. Capture Kills Innovation: Regulations creating excessive costs or complexity, even if providing "certainty," are failures if they price out new entrants and smaller players.
  2. Demand Tech-Neutrality: The only sustainable path for crypto regulation involves creating technology-agnostic rules that ensure a fair, level playing field for all participants.
  3. Focus on Macro Impact: Evaluate regulations not just on specifics but on their overall effect on market entry, competition, and innovation – avoid accidentally building impenetrable fortresses for incumbents.
See full notes