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AI Podcasts

August 22, 2025

ONESHOTTED

Trillion Agents

AI
Key Takeaways:
  1. Execution is a Commodity; Ideation is the Moat. The value is rapidly shifting from those who can execute a plan to those who can generate the novel plan in the first place.
  2. Your Org Chart is Now a Repo. Forward-thinking teams are treating their entire operational knowledge base as a single, AI-readable context, turning their company's history and philosophy into a prompt.
  3. Beware the Conflict Resolution Engine. A centralized AI risks becoming an echo chamber that smooths over disagreements. Actively engineer processes (like human-led PR reviews) to preserve essential conflict and challenge groupthink.
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August 22, 2025

The State of AI: Growth, Fragmentation, and the Next Wave

a16z

AI
Key Takeaways:
  1. Zero-Sum is a Losing Bet. The market isn't a monolith. Value is fragmenting across specialized applications in code, image, and vertical workflows. The "winner-take-all" thesis is dead.
  2. Moats are Made, Not Inherent. AI’s magic solves the "bootstrap problem" of user acquisition, but long-term defensibility requires building traditional software moats like brand, workflow integration, and network effects.
  3. Be on the Field, but Pick Your Spot. This is not a market to sit out, but indiscriminate investing is a death sentence. Back exceptional, proven teams, understand that conflicts can lock you out of the best deals, and never confuse market heat with genuine momentum.
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August 21, 2025

Can AI Fix Housing and Healthcare Affordability?

a16z

AI
Key Takeaways:
  1. AI is the deflationary force for stagnant sectors. While software ate the world, it skipped housing and healthcare. AI is finally tackling the operational drag that has caused costs to balloon for decades.
  2. To solve the housing crisis, make it profitable. The path to more housing supply runs through better returns. By making property operations radically more efficient, AI attracts the capital required to build.
  3. The future of work is human + AI. Automation won't eliminate jobs; it will transform them. As AI handles the administrative grind, human roles will shift to higher-value work like community engagement and complex problem-solving.
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August 19, 2025

Hash Rate - Ep 129 - Macrocosmos IOTA (sn9) and DataUniverse (sn13)

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

AI
Key Takeaways:
  1. DTO Means Business: Dynamic TAO has forced a Darwinian shift. Subnets must now achieve product-market fit and generate real revenue to survive, transforming from research projects into self-sustaining businesses.
  2. IOTA’s Grand Ambition: IOTA (SN9) isn't just another model trainer; its architecture aims to train trillion-parameter models on decentralized, consumer-grade hardware, directly challenging the dominance of centralized AI labs.
  3. Time to Garden: The protocol's long-term health hinges on active governance. A strong sentiment is emerging to prune low-effort or malicious subnets to focus emissions on projects capable of creating real, lasting value.
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August 19, 2025

Hash Rate - Ep 128 - Ridges ($TAO Subnet 62)

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

AI
Key Takeaways:
  1. AI Is Moving from Copilot to Pilot. Ridges is betting that the future isn't AI assisting humans, but AI replacing them for specific tasks. Their goal is to make hiring a software engineer as simple as subscribing to a service.
  2. Decentralized Economics Are a Moat. By leveraging Bittensor's incentive layer, Ridges outsources a $15M/year R&D budget to a global pool of competing developers, achieving a cost structure and innovation velocity that centralized players cannot match.
  3. The Breakout Subnet Is Coming. Ridges showcases how a Bittensor subnet can solve real-world business problems—privacy, cost, and quality degradation—to build a product that is not just cheaper, but fundamentally better than its centralized counterparts.
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August 18, 2025

Dylan Patel on GPT-5’s Router Moment, GPUs vs TPUs, Monetization

a16z

AI
Key Takeaways:
  1. From Performance to Profit: The AI industry is pivoting from a war of benchmarks to a game of unit economics. Features like GPT-5’s router signal that cost management and monetization are now as important as model capabilities.
  2. Hardware is a Supply Chain Game: Nvidia’s true moat is its end-to-end control of the supply chain. Competitors aren't just fighting a chip architecture; they're fighting a logistical behemoth that consistently out-executes on everything from memory procurement to time-to-market.
  3. The Grid is the Limit: The biggest check on AI’s expansion is the physical world. The speed at which new power infrastructure and data centers can be built will dictate the pace of AI deployment in the US, creating a major advantage for those who can build faster.
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August 18, 2025

Subnet 56 :: Gradients :: Bittensor End-to-end AI Model Training Suite

Opentensor Foundation

AI
Key Takeaways:
  1. Performance is Proven, Not Promised. Gradients isn't just making claims; it’s delivering benchmark-crushing results, consistently outperforming centralized incumbents and producing state-of-the-art models.
  2. Open Source Unlocks the Enterprise. The shift to verifiable, open-source training scripts is a direct solution to customer data privacy concerns, turning a critical vulnerability into a competitive advantage.
  3. The AutoML Flywheel is Spinning. The network's competitive, tournament-style mechanism creates a self-optimizing system that continuously aggregates the best training techniques, ensuring it remains at the cutting edge.
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August 16, 2025

Google DeepMind Lead Researchers on Genie 3 & the Future of World-Building

a16z

AI
Key Takeaways:
  1. **World Models Are a New Modality.** Genie 3 is not just better video; it's an interactive environment generator. This divergence from passive, cinematic models like Veo signals a new frontier focused on agency and simulation, creating a distinct discipline within generative AI.
  2. **Simulation Is the Key to Embodied AI.** The biggest hurdle for robotics is the lack of realistic training environments. Genie 3 tackles this "sim-to-real" gap head-on, providing a scalable way to train agents on infinite experiences before they ever touch physical hardware.
  3. **Emergent Properties Will Drive the Future.** Key features like spatial memory and nuanced physics weren't explicitly coded but emerged from scaling. The next breakthroughs in world models will come from discovering these unexpected capabilities, not just refining existing ones.
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August 15, 2025

Greg Brockman on OpenAI's Road to AGI

Latent Space

AI
Key Takeaways:
  1. AGI is a Compute Game. The primary bottleneck is compute. The process is one of "crystallizing" energy into compute, then into the potential energy of a trained model. More compute means more intelligence.
  2. The Future is a "Manager of Models." AGI won't be a single entity. It will be an orchestrator that delegates tasks to a fleet of specialized models, from fast local agents to powerful cloud reasoners.
  3. Build for Your AI Coworker. To maximize leverage, structure codebases for AI. This means self-contained modules, robust unit tests, and clear documentation—treating the AI as a team member, not just a tool.
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Crypto Podcasts

April 25, 2025

Is Zora Crypto's Breakout SocialFi Moment? | Weekly Roundup

Lightspeed

Crypto
Key Takeaways:
  1. Transparency is Non-Negotiable: Zora's chaotic token launch proves clear communication and transparent mechanics are crucial for project legitimacy and user safety.
  2. Tokenomics Matter: Launching "for fun" tokens while allocating heavily to insiders erodes trust in an already skeptical market; utility or clear value propositions are needed.
  3. Fix The Game: Rampant bot sniping on launchpads like Pump.fun undermines fairness; innovations like Zora's Doppler AMM are vital experiments to level the playing field.
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April 25, 2025

Are Ethereum stakers getting screwed?

The Gwart Show

Crypto
Key Takeaways:
  1. ETH Stakers Win: Despite mild network inflation, ETH stakers benefit from a net deflationary effect, increasing their network ownership over time.
  2. Stake or Dilute: Holding ETH without staking means passively transferring economic value to those who do stake.
  3. Not All Staking is Equal: Different blockchains have vastly different inflation dynamics for stakers (e.g., Ethereum vs. Solana).
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April 24, 2025

Is there a way to value L1 tokens?

The Gwart Show

Crypto
Key Takeaways:
  1. **No Magic Number:** Accept that L1 valuation isn't solved; it's a dynamic mix of utility demand, network cash flows (via fees/staking), and speculative monetary use.
  2. **Three-Lens Analysis:** Evaluate L1s by considering their token's role as a consumable commodity, its claim on network revenue (equity-like), and its potential as ecosystem money.
  3. **Monitor Monetary Evolution:** Keep an eye on the nascent monetary use cases (NFTs, memecoins); while small now, their cyclical growth suggests potential future value drivers.
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April 23, 2025

The System Is Too Levered To Take Real Pain | Arthur Hayes

Forward Guidance

Crypto
Key Takeaways:
  1. The Treasury is the New Fed: Forget obsessing over Powell; watch Treasury Secretary Bessent's moves (buybacks, SLR) for the real liquidity signals.
  2. Bitcoin Wins the Liquidity Game: Persistent global money printing, driven by systemic necessity, provides a structural tailwind for Bitcoin, potentially decoupling it from traditional risk assets like US tech.
  3. Gold Shines Amidst De-Dollarization: Central banks are diversifying reserves into gold, recognizing US Treasuries are no longer truly "risk-free" due to geopolitical weaponization, a trend reinforcing gold's value.
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April 23, 2025

"There is a Meaningful Vibe Change" - Ethereum's Pivot Has Begun & Community Reactions

Bankless

Crypto
Key Takeaways:
  1. Ethereum leadership and community acknowledge the need to strengthen the L1, viewing it as essential for long-term value accrual and ecosystem health.
  2. Focus is moving from finding the perfect "ETH asset" narrative to demonstrating value through "Ethereum the product" – a robust, scalable L1 attracting users and developers.
  3. As the L1 potentially becomes more competitive, L2s will need stronger, unique value propositions beyond simply being cheaper/faster alternatives.
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April 23, 2025

How To Avoid Regulatory Capture In Crypto | Miller Whitehouse-Levine

Lightspeed

Crypto
Key Takeaways:
  1. Capture Kills Innovation: Regulations creating excessive costs or complexity, even if providing "certainty," are failures if they price out new entrants and smaller players.
  2. Demand Tech-Neutrality: The only sustainable path for crypto regulation involves creating technology-agnostic rules that ensure a fair, level playing field for all participants.
  3. Focus on Macro Impact: Evaluate regulations not just on specifics but on their overall effect on market entry, competition, and innovation – avoid accidentally building impenetrable fortresses for incumbents.
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