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AI Podcasts

December 17, 2025

Rethinking Pre-Training for Agentic AI [Aakanksha Chowdhery] - 759

The TWIML AI Podcast with Sam Charrington

AI
Key Takeaways:
  1. Pre-Training is the New Frontier: The next leap in AI capabilities, particularly for agentic systems, will come from fundamental advancements in pre-training, not just post-training tweaks.
  2. Builders & Investors: Focus on teams rethinking loss objectives, curating high-quality reasoning data, and developing dynamic benchmarks for agentic capabilities. Be wary of "agentic" claims that lack foundational pre-training innovation.
  3. The "So What?": Over the next 6-12 months, expect a push for new benchmarks and data strategies that explicitly train models for multi-step planning, long-form reasoning, and error recovery, moving beyond simple next-token prediction.
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December 16, 2025

What We Learned Deploying AI within Bloomberg’s Engineering Organization – Lei Zhang, Bloomberg

AI Engineer

AI
Key Takeaways:
  1. Strategic Implication: AI fundamentally changes the economics of software development. Organizations must re-evaluate what constitutes "high-quality" engineering and adapt their processes.
  2. Builder/Investor Note: Prioritize platforms that provide guardrails and guidance for AI tool usage, focusing on deterministic verification and robust testing. Uncontrolled AI deployment risks technical debt.
  3. The "So What?": The next 6-12 months will see a bifurcation: companies that strategically integrate AI into their engineering culture and platforms will gain significant efficiency, while those that don't will struggle with quality and adoption.
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December 16, 2025

Your Support Team Should Ship Code – Lisa Orr, Zapier

AI Engineer

AI
Key Takeaways:
  1. Workflow Automation is the New Frontier: The real value of AI in developer tools comes from orchestrating entire workflows, not just individual point solutions.
  2. Embed for Adoption: Tools must integrate seamlessly into existing workflows and IDEs (like Cursor) to achieve high usage.
  3. Support as a Code-Shipping Powerhouse: Empowering non-traditional roles with AI-driven code generation leverages their unique, real-time context, creating significant operational leverage.
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December 17, 2025

Code World Model: Building World Models for Computation – Jacob Kahn, FAIR Meta

AI Engineer

AI
Key Takeaways:
  1. Semantic Shift: The future of AI in code moves from text generation to deep semantic understanding and execution simulation.
  2. Builder Opportunity: Develop next-generation debugging tools and code agents that leverage internal simulation for faster, more efficient development cycles.
  3. Investor Focus: Prioritize models and platforms that demonstrate explicit execution modeling, as this capability will redefine software development and create new market leaders.
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December 17, 2025

AI Kernel Generation: What's working, what's not, what's next – Natalie Serrino, Gimlet Labs

AI Engineer

AI
Key Takeaways:
  1. Infrastructure Shift: AI-driven kernel optimization addresses a critical bottleneck in scaling AI compute, enabling more efficient use of diverse hardware.
  2. Builder/Investor Note: Focus on solutions with robust, hardware-verified performance metrics and a clear human-in-the-loop strategy. AI is a powerful tool for automating optimization, not a magic bullet for novel algorithmic breakthroughs.
  3. The "So What?": This technology frees expert engineers from tedious optimization, allowing them to focus on higher-level research and truly innovative algorithmic design, accelerating the pace of AI development in the next 6-12 months.
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December 16, 2025

Finding The 1% of Stocks That Matter | Henry Ellenbogen Interview

Invest Like The Best

AI
Key Takeaways:
  1. Strategic Implication: The era of "free money" inflated the number of perceived compounders; a return to positive real rates demands a sharper focus on businesses demonstrating genuine financial discipline and competitive advantage.
  2. Builder/Investor Note: Seek out "Act 2" entrepreneurs and companies that can leverage AI to transform existing physical or IP-based advantages, not just create new AI products. Be prepared to buy more when market sentiment turns negative on strong businesses.
  3. The "So What?": The next 6-12 months will differentiate companies that merely adopt AI from those that strategically integrate it to build durable, uncatchable cost and distribution advantages.
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December 17, 2025

“How We Can Eliminate Crime” | Ben Horowitz and Garrett Langley

a16z

AI
Key Takeaways:
  1. The Future of Policing is Intelligent: Integrating AI, drones, and smart cameras creates a precise, accountable, and safer policing model for both officers and communities.
  2. Invest in the "How": Builders and investors should focus on technologies that enhance certainty of capture, streamline judicial processes, and support public-private partnerships to modernize urban safety infrastructure.
  3. Safety Fuels Mobility: Eliminating crime is not just about law enforcement; it's about restoring the fundamental safety required for economic mobility and a functional society.
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December 18, 2025

Two Futures | Runtime 2025

a16z

AI
Key Takeaways:
  1. Strategic Implication: The next decade's value will accrue to those building foundational AI infrastructure and the "invisible layers" that connect intelligent systems.
  2. Builder/Investor Note: Focus capital and talent on core AI models, specialized domain intelligence, and the underlying computational fabric. Superficial applications risk rapid commoditization.
  3. The So What?: This is the defining period for the architecture of global intelligence. Participation now determines future influence and relevance.
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December 16, 2025

⚡️Jailbreaking AGI: Pliny the Liberator & John V on Red Teaming, BT6, and the Future of AI Security

Latent Space

AI
Key Takeaways:
  1. Strategic Shift: AI security must move beyond superficial guardrails to a full-stack, offensive red-teaming approach that accounts for the expanding attack surface of AI agents and their tool access.
  2. Builder/Investor Note: Builders should prioritize integrating offensive security early in development. Investors should be wary of "security theater" and favor solutions that embrace open-source collaboration and address the entire AI application stack.
  3. The "So What?": The accelerating pace of AI development means static security solutions will quickly become obsolete. Proactive, community-driven, and full-stack security research is essential for navigating the next 6-12 months of AI evolution.
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Crypto Podcasts

February 2, 2026

Gavin Zaentz & Pranav Ramesh: Leadpoet, Lead Generation, Intent-Driven Sales Automation | Ep. 79

Ventura Labs

Crypto
Key Takeaways:
  1. The shift from centralized, static data aggregation to decentralized, real-time, incentivized intelligence networks is fundamentally changing how data-intensive industries operate.
  2. Investigate subnet opportunities where incumbent data quality is low and validation is a core challenge.
  3. The future of sales is not just about more leads, but smarter, fresher, and more relevant ones.
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February 3, 2026

Gold Crashes, Bitcoin Slides, and the Fed Shock Markets

Unchained

Crypto
Key Takeaways:
  1. The Macro Shift: As trust erodes in traditional financial systems and geopolitical risks rise, capital is flowing towards more efficient, permissionless DeFi markets. This is forcing traditional finance to adapt or lose market share.
  2. The Tactical Edge: Evaluate DATs trading below NAV for potential M&A or activist plays, as these discounts often reflect management misalignment rather than fundamental asset weakness.
  3. The Bottom Line: The current market volatility, Fed policy shifts, and the rise of DeFi are not just noise; they are reshaping capital allocation. Investors and builders must understand these structural changes to position for the next cycle of institutional adoption.
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February 2, 2026

Metals Crash & Bitcoin Breaks $80k

1000x Podcast

Crypto
Key Takeaways:
  1. Global economic uncertainty and tariff threats are triggering a broad risk-off sentiment, creating dislocations where fundamentally strong assets are sold indiscriminately.
  2. Reallocate capital from speculative metals positions into Bitcoin at current levels and high-conviction, revenue-producing crypto platforms like Hyperliquid.
  3. The current market turbulence is separating the signal from the noise. Focus on assets with strong fundamentals and organic usage, as they are poised for significant gains once the broader market stabilizes.
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February 3, 2026

Is BTC A Buy, Metals Crash, Hyperliquid RWAs, New Fed Chair

1000x Podcast

Crypto
Key Takeaways:
  1. Global market indigestion is creating a flight to quality and a re-evaluation of speculative assets. This environment favors fundamentally strong assets and platforms with clear utility over pure FOMO plays.
  2. Consider tax-loss harvesting Bitcoin positions that are out of the money and reallocate to high-conviction, revenue-producing crypto assets like Hyperliquid.
  3. The "crypto portfolio" concept is evolving; focus on individual assets with strong organic usage and mega-trend tailwinds. This strategic shift will differentiate winners from losers in the coming market cycles.
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February 2, 2026

Why BitGo Went Public | Mike Belshe

Empire

Crypto
Key Takeaways:
  1. Regulatory clarity and institutional demand are converging, driving a fundamental re-architecture of financial market infrastructure. This shift will see traditional finance increasingly rely on regulated crypto-native service providers.
  2. Builders and investors should prioritize infrastructure providers that offer robust regulatory compliance and fiduciary protection, as these are the non-negotiable requirements for the next wave of institutional capital.
  3. The digital asset industry is poised for massive growth, driven by Wall Street's entry. Companies like BitGo, by building transparent, regulated infrastructure, are not just participating in this growth; they are actively shaping the future of finance, making now the time to understand these foundational shifts.
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February 2, 2026

Curated Credit: How Maple and Morpho Approach DeFi Lending | Sid Powell & Merlin Egalite

0xResearch

Crypto
Key Takeaways:
  1. Institutional capital is eyeing DeFi, pushing for tokenized real-world assets like private credit and bonds to diversify yield sources beyond crypto-backed loans. This requires robust risk isolation at the smart contract level and a new generation of independent risk assessors to bridge TradFi and DeFi.
  2. Prioritize protocols that offer explicit risk profiles and transparent fee structures, especially those building towards intent-based lending. For builders, focus on creating infrastructure that supports isolated risk and attracts independent rating agencies.
  3. The future of DeFi lending hinges on transparency and sophisticated risk management. As institutions enter, the demand for clear, independently verified risk assessments will intensify, making protocols that embrace these principles the winners in the next market cycle.
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