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AI Podcasts

August 22, 2025

ONESHOTTED

Trillion Agents

AI
Key Takeaways:
  1. Execution is a Commodity; Ideation is the Moat. The value is rapidly shifting from those who can execute a plan to those who can generate the novel plan in the first place.
  2. Your Org Chart is Now a Repo. Forward-thinking teams are treating their entire operational knowledge base as a single, AI-readable context, turning their company's history and philosophy into a prompt.
  3. Beware the Conflict Resolution Engine. A centralized AI risks becoming an echo chamber that smooths over disagreements. Actively engineer processes (like human-led PR reviews) to preserve essential conflict and challenge groupthink.
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August 22, 2025

The State of AI: Growth, Fragmentation, and the Next Wave

a16z

AI
Key Takeaways:
  1. Zero-Sum is a Losing Bet. The market isn't a monolith. Value is fragmenting across specialized applications in code, image, and vertical workflows. The "winner-take-all" thesis is dead.
  2. Moats are Made, Not Inherent. AI’s magic solves the "bootstrap problem" of user acquisition, but long-term defensibility requires building traditional software moats like brand, workflow integration, and network effects.
  3. Be on the Field, but Pick Your Spot. This is not a market to sit out, but indiscriminate investing is a death sentence. Back exceptional, proven teams, understand that conflicts can lock you out of the best deals, and never confuse market heat with genuine momentum.
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August 21, 2025

Can AI Fix Housing and Healthcare Affordability?

a16z

AI
Key Takeaways:
  1. AI is the deflationary force for stagnant sectors. While software ate the world, it skipped housing and healthcare. AI is finally tackling the operational drag that has caused costs to balloon for decades.
  2. To solve the housing crisis, make it profitable. The path to more housing supply runs through better returns. By making property operations radically more efficient, AI attracts the capital required to build.
  3. The future of work is human + AI. Automation won't eliminate jobs; it will transform them. As AI handles the administrative grind, human roles will shift to higher-value work like community engagement and complex problem-solving.
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August 19, 2025

Hash Rate - Ep 129 - Macrocosmos IOTA (sn9) and DataUniverse (sn13)

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

AI
Key Takeaways:
  1. DTO Means Business: Dynamic TAO has forced a Darwinian shift. Subnets must now achieve product-market fit and generate real revenue to survive, transforming from research projects into self-sustaining businesses.
  2. IOTA’s Grand Ambition: IOTA (SN9) isn't just another model trainer; its architecture aims to train trillion-parameter models on decentralized, consumer-grade hardware, directly challenging the dominance of centralized AI labs.
  3. Time to Garden: The protocol's long-term health hinges on active governance. A strong sentiment is emerging to prune low-effort or malicious subnets to focus emissions on projects capable of creating real, lasting value.
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August 19, 2025

Hash Rate - Ep 128 - Ridges ($TAO Subnet 62)

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

AI
Key Takeaways:
  1. AI Is Moving from Copilot to Pilot. Ridges is betting that the future isn't AI assisting humans, but AI replacing them for specific tasks. Their goal is to make hiring a software engineer as simple as subscribing to a service.
  2. Decentralized Economics Are a Moat. By leveraging Bittensor's incentive layer, Ridges outsources a $15M/year R&D budget to a global pool of competing developers, achieving a cost structure and innovation velocity that centralized players cannot match.
  3. The Breakout Subnet Is Coming. Ridges showcases how a Bittensor subnet can solve real-world business problems—privacy, cost, and quality degradation—to build a product that is not just cheaper, but fundamentally better than its centralized counterparts.
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August 18, 2025

Dylan Patel on GPT-5’s Router Moment, GPUs vs TPUs, Monetization

a16z

AI
Key Takeaways:
  1. From Performance to Profit: The AI industry is pivoting from a war of benchmarks to a game of unit economics. Features like GPT-5’s router signal that cost management and monetization are now as important as model capabilities.
  2. Hardware is a Supply Chain Game: Nvidia’s true moat is its end-to-end control of the supply chain. Competitors aren't just fighting a chip architecture; they're fighting a logistical behemoth that consistently out-executes on everything from memory procurement to time-to-market.
  3. The Grid is the Limit: The biggest check on AI’s expansion is the physical world. The speed at which new power infrastructure and data centers can be built will dictate the pace of AI deployment in the US, creating a major advantage for those who can build faster.
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August 18, 2025

Subnet 56 :: Gradients :: Bittensor End-to-end AI Model Training Suite

Opentensor Foundation

AI
Key Takeaways:
  1. Performance is Proven, Not Promised. Gradients isn't just making claims; it’s delivering benchmark-crushing results, consistently outperforming centralized incumbents and producing state-of-the-art models.
  2. Open Source Unlocks the Enterprise. The shift to verifiable, open-source training scripts is a direct solution to customer data privacy concerns, turning a critical vulnerability into a competitive advantage.
  3. The AutoML Flywheel is Spinning. The network's competitive, tournament-style mechanism creates a self-optimizing system that continuously aggregates the best training techniques, ensuring it remains at the cutting edge.
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August 16, 2025

Google DeepMind Lead Researchers on Genie 3 & the Future of World-Building

a16z

AI
Key Takeaways:
  1. **World Models Are a New Modality.** Genie 3 is not just better video; it's an interactive environment generator. This divergence from passive, cinematic models like Veo signals a new frontier focused on agency and simulation, creating a distinct discipline within generative AI.
  2. **Simulation Is the Key to Embodied AI.** The biggest hurdle for robotics is the lack of realistic training environments. Genie 3 tackles this "sim-to-real" gap head-on, providing a scalable way to train agents on infinite experiences before they ever touch physical hardware.
  3. **Emergent Properties Will Drive the Future.** Key features like spatial memory and nuanced physics weren't explicitly coded but emerged from scaling. The next breakthroughs in world models will come from discovering these unexpected capabilities, not just refining existing ones.
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August 15, 2025

Greg Brockman on OpenAI's Road to AGI

Latent Space

AI
Key Takeaways:
  1. AGI is a Compute Game. The primary bottleneck is compute. The process is one of "crystallizing" energy into compute, then into the potential energy of a trained model. More compute means more intelligence.
  2. The Future is a "Manager of Models." AGI won't be a single entity. It will be an orchestrator that delegates tasks to a fleet of specialized models, from fast local agents to powerful cloud reasoners.
  3. Build for Your AI Coworker. To maximize leverage, structure codebases for AI. This means self-contained modules, robust unit tests, and clear documentation—treating the AI as a team member, not just a tool.
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Crypto Podcasts

May 20, 2025

Bits + Bips LIVE - May 19th, 2025

Unchained

Crypto
Key Takeaways:
  1. Tariffs Trump Tranquility: A 10% tariff floor could trigger summer stagflation, disrupting current Goldilocks market pricing.
  2. Stablecoin Bill is Bellwether: The fate of the "Genius Act" will significantly impact the trajectory of broader US crypto regulation and investor confidence.
  3. Institutional Crypto Evolves: Coinbase's S&P 500 nod and the push for diverse crypto ETFs (like Solana) underscore the sector's maturation, even as regulatory hurdles for features like staking persist.
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May 19, 2025

The State of Venture Today | Roundup Clip

Bell Curve

Crypto
Key Takeaways:
  1. LP Scrutiny Intensifies: Expect smaller fundraises for many VCs, especially in crypto, as LPs demand real returns (DPI) and, for crypto, regulatory certainty.
  2. Endowment Exodus Looms: Yale's $6B private equity sale signals a potential LP supply shock as other endowments may follow suit due to tax changes and liquidity needs.
  3. Elite VCs Consolidate Power: Capital will increasingly flow to the top 5-10 VC firms, particularly those with AI expertise, hastening the decline of underperformers.
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May 19, 2025

The Bull Case For Ethereum | Ryan Berckmans & Tom Dunleavy

Empire

Crypto
Key Takeaways:
  1. ETH's Valuation Paradigm Shift: Value ETH based on Total Value Secured (TVS), not diminishing transaction fees, as it aims to secure trillions in global assets.
  2. L1+L2 is the Winning Formula: Ethereum's strategy of scaling L1 alongside a diverse L2 ecosystem (offering political/business model diversity) is designed to onboard the world.
  3. Coordination & BD are Crucial: Renewed focus on cohesive narrative, business development (like Etherealize), and community alignment are vital to executing Ethereum's ambitious roadmap.
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May 19, 2025

The Genius Behind the Biggest Crypto Exchange in the Sonic Ecosystem

blocmates.

Crypto
Key Takeaways:
  1. Performance is Paramount: Sonic's best-in-class EVM performance is a non-negotiable foundation for ambitious DeFi protocols.
  2. Organic Traction Trumps Hype: Sonic's user-driven ecosystem is cultivating genuine DeFi engagement and sustainable innovation.
  3. AI Will Onboard the Masses: Natural language AI interfaces are set to revolutionize crypto accessibility, making it usable for everyone.
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May 19, 2025

Arthur Hayes: Money Printing & The Crypto Bet

Bankless

Crypto
Key Takeaways:
  1. Brace for Capital Controls: The US is likely to implement capital controls over politically unpalatable tariffs to rebalance its economy, fundamentally changing global capital flows.
  2. Money Printing is Non-Negotiable: Regardless of political rhetoric, the US will print money to manage the fallout from capital flight and fund government spending, massively benefiting hard assets.
  3. Bitcoin & Gold are Your Life Rafts: In an era of devaluing fiat and financial repression, Bitcoin and gold are critical for wealth preservation and growth. Ditch long-term bonds.
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May 19, 2025

Logan Allen: Nockchain's Global Competition for Useful ZK Proof of Work Miners Kicks Off

Delphi Digital

Crypto
Key Takeaways:
  1. ZKPoW is a Novel Force: Nockchain's ZK Proof of Work directly builds valuable ZK proving capacity, turning mining into a productive, network-enhancing activity.
  2. Hardware Revolution Looms: The mining competition will drive innovation in ZK-specific hardware (FPGAs, ASICs for polynomial math), creating a new hardware market distinct from Bitcoin's.
  3. Intent-Driven Future: Nockchain's architecture points towards a future of composable "micro-apps" and verifiable services, where on-chain logic focuses on proof verification, potentially enabling new decentralized AI/ML applications and "computational commodities."
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