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AI Podcasts

December 20, 2025

Are AI Benchmarks Telling The Full Story? [SPONSORED]

Machine Learning Street Talk

AI
Key Takeaways:
  1. Strategic Shift: The market will increasingly demand AI models evaluated on human-centric metrics, not just technical benchmarks. Companies prioritizing user experience and safety will gain a competitive edge.
  2. Builder/Investor Note: Investigate companies developing or utilizing advanced, demographically representative human evaluation frameworks. These are crucial for building defensible, user-aligned AI products.
  3. The "So What?": Over the next 6-12 months, expect a growing focus on AI safety, ethical alignment, and nuanced human preference data. The "Wild West" of AI evaluation is ending, paving the way for more robust, trustworthy systems.
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December 17, 2025

Rethinking Pre-Training for Agentic AI [Aakanksha Chowdhery] - 759

The TWIML AI Podcast with Sam Charrington

AI
Key Takeaways:
  1. Strategic Implication: The next frontier in AI is agentic, and progress hinges on fundamental pre-training innovation, not just post-training optimizations.
  2. Builder/Investor Note: Focus on teams with deep experience in scaling and debugging large models, as this is a high-capital, high-risk endeavor. Builders should prioritize developing new benchmarks for agentic capabilities.
  3. The "So What?": The industry needs to move beyond next-token prediction and static benchmarks to unlock truly capable, self-correcting AI agents in the next 6-12 months.
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December 17, 2025

Code World Model: Building World Models for Computation – Jacob Kahn, FAIR Meta

AI Engineer

AI
Key Takeaways:
  1. Shift in AI Development: The focus moves from syntax-aware code generation to execution-aware reasoning, enabling more robust and intelligent code agents.
  2. Builder/Investor Note: Prioritize tools and platforms that support explicit execution modeling and highly asynchronous, high-throughput RL training for agentic systems.
  3. The "So What?": AI that can simulate complex systems internally will drastically reduce development and testing costs, accelerating innovation in software and distributed systems over the next 6-12 months.
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December 17, 2025

AI Kernel Generation: What's working, what's not, what's next – Natalie Serrino, Gimlet Labs

AI Engineer

AI
Key Takeaways:
  1. Strategic Shift: AI-driven kernel generation is not replacing human genius but augmenting it, allowing experts to focus on novel breakthroughs while AI automates the application of known optimizations across a complex hardware landscape.
  2. Builder/Investor Note: Focus on robust validation and hardware-in-the-loop systems. Claims of "AI inventing new algorithms" in this domain are premature. The real value is in automating the "bag of tricks" for heterogeneous compute.
  3. The "So What?": This technology is critical for scaling agentic AI workloads. Expect significant investment in tools that abstract hardware complexity and enable efficient, automated optimization, driving down the cost of AI inference in the next 6-12 months.
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December 18, 2025

AI Consulting in Practice – NLW, Super ai

AI Engineer

AI
Key Takeaways:
  1. The Agent Economy is Here: Enterprises are moving past pilots with AI agents. Builders should focus on orchestration layers and human-agent interaction design.
  2. ROI Measurement is the Next Frontier: Investors should look for solutions that help organizations accurately track and attribute AI value beyond traditional metrics.
  3. Strategic AI, Not Spot Solutions: The biggest wins come from systematic, cross-organizational AI strategies that target new capabilities and revenue growth, not just incremental time savings.
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December 18, 2025

How to build an AI native company (even if your company is 50 years old) – Dan Shipper, Every

AI Engineer

AI
Key Takeaways:
  1. The 100% AI adoption threshold is a step-function change, not incremental. Companies that commit fully will outpace those with partial integration.
  2. Builders should prioritize "compounding engineering" by codifying knowledge into reusable prompts. This builds an organizational memory that accelerates future development exponentially.
  3. Re-evaluate team structures and roles. Single engineers can own complex products, and even technical managers can contribute code, shifting how organizations operate.
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December 17, 2025

“How We Can Eliminate Crime” | Ben Horowitz and Garrett Langley

a16z

AI
Key Takeaways:
  1. Effective crime reduction requires a shift from reactive punishment to proactive, intelligence-driven deterrence, making it highly probable for criminals to be caught.
  2. The market for AI-powered public safety technology, particularly solutions that integrate data for precision and accountability, presents a significant opportunity. Public-private partnerships are a key funding mechanism.
  3. Over the next 6-12 months, expect to see more cities adopt advanced surveillance and AI tools, driven by private funding, as they seek to improve safety and address staffing shortages without resorting to ineffective, broad-stroke policies.
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December 18, 2025

Two Futures | Runtime 2025

a16z

AI
Key Takeaways:
  1. Strategic Implication: The next decade will be defined by who builds the core infrastructure for intelligence. This is where the most significant value and influence will accrue.
  2. Builder/Investor Note: Direct capital and talent towards foundational AI components—chips, models, and interoperable systems. Avoid the temptation to only build at the application layer.
  3. The So What?: The window for shaping the future of intelligence is now. Engage in the deepest, most complex challenges to secure a footprint in this new era.
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December 18, 2025

The EU and the not-so-simple macroeconomics of AI – Luis Garicano

Epoch AI

AI
Key Takeaways:
  1. Strategic Implication: The global AI race is a zero-sum game for foundational models. Europe's best strategy is a "smart second mover" approach, focusing on the implementation layer by ensuring interoperability and data portability.
  2. Builder/Investor Note: Invest in AI that achieves true autonomy and enhances expert productivity. Be wary of markets stifled by over-regulation, which can impede AI adoption and growth.
  3. The "So What?": Europe faces a critical juncture. Without embracing AI-driven growth, its demographic and debt problems will worsen, leading to higher interest rates without the corresponding economic expansion.
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Crypto Podcasts

August 12, 2025

Did ETH Just Trigger An Alt Season?

1000x Podcast

Crypto
Key Takeaways:
  1. Bet on the ETH Ecosystem. The bounce off cycle lows signals the start of an ETH-centric alt season. Look for opportunities within its ecosystem, as rising ETH prices create positive feedback loops for its native DeFi protocols.
  2. Aerodrome is a Top Pick on Base. AERO presents a compelling investment case due to its superior tokenomics, strong product-market fit on Base, lack of VC overhang, and recent technical breakout. It is positioned to capture massive value as Base grows.
  3. On-Chain Adoption Will Come Through CEXs. The most significant long-term catalyst is the seamless integration of on-chain ecosystems into centralized exchanges. This makes Base-native projects the primary beneficiaries of the next wave of retail adoption, driven by Coinbase.
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August 12, 2025

Most Common Founder Questions a16z Crypto Fields

Empire

Crypto
Key Takeaways:
  1. The conversation has shifted from "Can we build this?" to "How do we grow this?" Founders are now focused on shipping products, forging partnerships, and hiring talent, signaling a decisive move from infrastructure to business execution.
  2. Regulation is focusing on code, not conduct. The move to a "control-based" decentralization framework means what matters is how technically neutral your system is, not who is in your Slack channel.
  3. With scaling solved, UX is the new bottleneck. The industry has moved past the gas wars; the next great challenge is creating intuitive user experiences through better wallet design and key management.
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August 12, 2025

Bits + Bips LIVE: Crypto + Macro News & Analysis - August 11, 2025

Unchained

Crypto
Key Takeaways:
  1. Follow the Flows. Ethereum's rally is a direct result of capital firehoses from new treasury companies. This isn't a narrative trade; it's a structural buying pressure that creates its own momentum.
  2. Yield is Widening. As TradFi rates fall, on-chain credit yields are set to expand. The widening spread between traditional and decentralized finance will be a powerful magnet for capital.
  3. The Treasury Gold Rush Has Begun. The explosion of new treasury companies is a land grab for asset accumulation. The real game will be fought on operational efficiency, yield generation, and brand dominance, leading to inevitable consolidation.
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August 11, 2025

Did ETH Just Signal Alt Season?

1000x Podcast

Crypto
Key Takeaways:
  1. ETH is the bellwether for risk. Its current rally is the starting gun for an "ETH alt season." Use ETH's strength as a barometer for when to be aggressive with altcoin allocations.
  2. Buy breakouts, not bottoms. The most profitable strategy is to wait for assets to break their downtrend, then ride the reflexive narrative loop. Aave (AAVE) and Aerodrome (AERO) are prime examples of this setup.
  3. Aerodrome is a conviction play. With superior tokenomics, a dominant position on Base, and a direct pipeline to Coinbase's retail army, Aerodrome has a clear path to becoming a breakout star of this cycle.
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August 11, 2025

Vitalik Buterin: How Ethereum Becomes The World Ledger

Bankless

Crypto
Key Takeaways:
  1. Privacy as a Feature, Not a Product. The next major user-facing push will be to embed privacy tools directly into mainstream wallets, shifting privacy from a niche cypherpunk concern to a default user experience.
  2. Scale L1, Anchor L2s. The roadmap focuses on a strong L1 as the ultimate settlement and asset-issuance layer. This keeps the sprawling L2 ecosystem economically aligned and prevents fragmentation by making the L1 indispensable.
  3. ETH is the Economic Glue. A strong ETH is essential for coordinating incentives across the ecosystem. It is the core economic asset that aligns the Foundation, L2s, DeFi apps, and users, preventing the community from fracturing.
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August 11, 2025

The 10 Year Vision For Solana Mobile

Lightspeed

Crypto
Key Takeaways:
  1. **Platform, Not Phones.** Success for Solana Mobile isn't another phone sale; it's getting another manufacturer to adopt its platform. The end goal is to be the crypto equivalent of Android—a foundational layer for a world of hardware.
  2. **Go Global or Go Home.** The US is a sideshow. The real action is in the wildly diverse international market, where hundreds of device makers are looking for a competitive edge. This is where Solana Mobile plans to win.
  3. **Ecosystem as the Engine.** The strategy hinges on empowering the ecosystem to "go nuts." If the core team has to scale massively, it’s a sign of failure. True success is when hardware builders and dApp developers drive the platform’s growth organically.
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