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AI Podcasts

January 18, 2026

Why Every Brain Metaphor in History Has Been Wrong [SPECIAL EDITION]

Machine Learning Street Talk

AI
Key Takeaways:
  1. The Strategic Pivot: The transition from "Understanding-First" science to "Prediction-First" engineering. We are building artifacts that work perfectly but remain theoretically opaque.
  2. The Tactical Edge: Audit your AI stack for "Leaky Abstractions." Don't assume a model's reasoning capabilities in one domain will hold when the underlying causal structure changes.
  3. AGI isn't just an engineering milestone; it's a philosophical wager. If the brain isn't a computer, we are building a very powerful helicopter, not a synthetic human.
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January 18, 2026

Why Every Brain Metaphor in History Has Been Wrong [SPECIAL EDITION]

Machine Learning Street Talk

AI
Key Takeaways:
  1. The pivot from "Understanding-First" science to "Prediction-First" engineering creates massive technical liability in our models.
  2. Audit your AI implementations for "Leaky Abstractions" where the model fails to account for physical edge cases.
  3. High-performance automation is not the same as sentient reasoning. Builders who recognize this distinction will avoid the cultural illusion of inevitable AGI.
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January 17, 2026

Brex’s AI Hail Mary — With CTO James Reggio

Latent Space

AI
Key Takeaways:
  1. The transition from deterministic software to agentic networks. Companies are moving from rigid workflows to fluid systems that plan and execute autonomously.
  2. Build an internal LLM gateway early. Centralizing model routing and cost monitoring allows you to swap providers as the model horse race changes without refactoring your product.
  3. AI is not just a feature but a fundamental restructuring of the corporate cost center. Efficiency gains allow a static headcount of 300 engineers to support a business growing 5x.
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January 14, 2026

Identity for AI Agents - Patrick Riley & Carlos Galan, Auth0

AI Engineer

AI
Key Takeaways:
  1. The transition from interactive chat to autonomous "task runners" requires a shift from session-based identity to delegated, long-term authorization.
  2. Implement the Token Vault pattern to decouple your agent logic from the mess of OAuth token refreshing.
  3. In the next year, the "Agentic Web" will live or die by trust. If you cannot prove an agent is authorized to act, it is just a fancy toy.
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January 15, 2026

AI and the Future of Warfare with US Under Secretary of War Emil Michael

No Priors: AI, Machine Learning, Tech, & Startups

AI
Key Takeaways:
  1. The Macro Shift: The Great Re-Shoring. National security now depends on domestic production of critical minerals and semiconductors.
  2. The Tactical Edge: Build for Scale. Prioritize manufacturing competence over pure software features to win government contracts.
  3. The Bottom Line: The defense industrial base is being rebuilt from the ground up. The next decade belongs to the builders who can merge Silicon Valley speed with the Pentagon's scale.
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January 15, 2026

Ben & Marc: Why Everything Is About to Get 10x Bigger

a16z

AI
Key Takeaways:
  1. The transition from software eating the world to AI reinventing the computer means every existing market cap is a floor.
  2. Prioritize the non-fungible creator by providing monetization tools that bypass legacy gatekeepers.
  3. We are entering a period of asymmetric payoffs where the art of picking original thinkers matters more than historical data.
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January 13, 2026

Paul Rosolie: Uncontacted Tribes in the Amazon Jungle | Lex Fridman Podcast #489

Lex Fridman

AI
Key Takeaways:
  1. The Macro Trend: Biological Sovereignty. As global systems destabilize, the Amazon remains the most critical piece of biological infrastructure on the planet.
  2. The Tactical Edge: Support Jungle Keepers. Direct capital to organizations that convert loggers into rangers to secure land concessions.
  3. The Amazon is a finite asset under active siege. Protecting it requires a blend of primitive survival skills and high-tech surveillance over the next 18 months.
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January 12, 2026

Jensen Huang says robots will have human capabilities this year! The Robots at CES Had.. Other Plans

Turing Post

AI
Key Takeaways:
  1. The Macro Pivot: As generative AI masters simulation, the physical world becomes a high-fidelity playground for software.
  2. The Tactical Edge: Invest in the "brain" layer rather than the "limb" layer. Software that can generalize across different hardware forms will capture the most value.
  3. The next decade belongs to embodied AI that reasons in real time. If you are waiting for the hardware to look perfect before paying attention, you will miss the moment the software takes over the physical world.
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January 12, 2026

Your MCP Server is Bad (and you should feel bad) - Jeremiah Lowin, Prefect

AI Engineer

AI
Key Takeaways:
  1. The Macro Pivot: Context as Product. We are moving from raw data transport to opinionated context delivery.
  2. The Tactical Edge: Prune your endpoints. Remove any tool that requires more than one step to achieve a business result.
  3. The Bottom Line: The winners of the agentic era will be those who build the best Agentic Interface Guidelines.
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Crypto Podcasts

September 12, 2025

Sanctum Founder: Solana's Liquid Staking Future | FP Lee

Lightspeed

Crypto
Key Takeaways:
  1. LSTs Are a Distribution Play: For protocols, launching an LST is less about staking yield and more about attracting SOL to gain a strategic advantage in securing blockspace and landing transactions.
  2. Infrastructure Follows the User: Sanctum's pivot to transaction services was not a top-down mandate but a direct response to the needs of its largest partners, proving that the most durable infrastructure is built by solving the immediate, pressing problems of your customers.
  3. Aggregation Is King: Just as Jupiter won by aggregating DEXs for users, Sanctum’s Gateway aims to win by aggregating fragmented transaction delivery networks for developers, creating a simpler and more efficient experience.
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September 10, 2025

Still Time To Be Bullish?

1000x Podcast

Crypto
Key Takeaways:
  1. Patience is Your Superpower. This cycle rewards thesis-driven investing over hyperactive trading. Identify assets with strong value, momentum, and fundamentals, and give them time to play out.
  2. Bet on the On-Chain Casino. The gambling economy is real, profitable, and growing. Look for platforms that facilitate high-asymmetry games (memecoins, raffles) as they capture a powerful cultural trend.
  3. Find Alpha in the Illiquid. The next frontier is tokenizing real-world value. Platforms creating liquid markets for previously stuck assets—from collectibles to crime—are building foundational infrastructure for a much larger on-chain world.
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September 10, 2025

Hyperliquid: The Fastest Growing Exchange in Crypto?

Bankless

Crypto
Key Takeaways:
  1. Revenue Accrual is King. Hyperliquid's model of directing nearly all top-line revenue to token buybacks creates an aggressive and constant bid for the HYPE token, a feature most crypto projects can only dream of.
  2. Product-First Beats VC-First. Its explosive growth comes from building a superior product that attracted a loyal user base first, then leveraging that traction to build an L1 ecosystem—a stark contrast to the typical VC-funded playbook.
  3. A Bet on the Middle Ground. Investing in HYPE is a bet that CEX-level performance and on-chain transparency can outweigh significant centralization and regulatory risks. It’s a category-defining play that sits squarely between DeFi and CeFi.
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September 10, 2025

Former Barclays CEO’s Big Bet on Hyperliquid’s Explosive Growth |  Bob Diamond & David Schamis

Forward Guidance

Crypto
Key Takeaways:
  1. Hyperliquid is a Cash Flow Machine. It is a rare crypto asset with quantifiable fundamentals, generating over $1B in annualized free cash flow with an automated, daily 99% buyback mechanism.
  2. Access is the Arbitrage. The NASDAQ-listed vehicle’s core value proposition is providing regulated access to an asset that US investors cannot easily buy, creating a structural opportunity.
  3. Innovation is Now Permissionless. Hyperliquid’s open architecture allows anyone to build on its rails, enabling new markets like pre-IPO equity trading and accelerating growth without traditional gatekeepers.
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September 9, 2025

Hash Rate - Ep 132 - Real Quantum Computers on Bittensor $TAO (sn63 & sn48)

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

Crypto
Key Takeaways:
  1. **Quantum for the Masses.** Subnet 48 is set to offer free public access to quantum computers, a service that costs thousands per hour, by leveraging Bittensor's tokenomics to subsidize the cost.
  2. **The Crypto Abstraction Playbook.** The Open Quantum platform provides a blueprint for onboarding mainstream users by hiding the blockchain behind a simple web interface with fiat payments, while still rewarding TAO stakers with platform credits.
  3. **The Bitcoin Countdown.** The threat of quantum computing cracking Bitcoin is a tangible, medium-term risk. The migration to quantum-safe encryption is a complex challenge that the industry must begin preparing for now.
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September 9, 2025

SEC Commissioner: A New Era For Crypto In The U.S | Hester Peirce

Lightspeed

Crypto
Key Takeaways:
  1. **Regulation by Enforcement is Over.** The SEC has abandoned its strategy of using lawsuits to create policy. The new focus is on providing clear guidance *before* bringing the hammer down, creating a more predictable environment for builders.
  2. **Liquid Staking Gets the Green Light.** In a major win for DeFi, the SEC has confirmed liquid staking tokens are not securities. This clears the path for protocols like Jito and could accelerate the approval of staked ETFs.
  3. **Build Now or Regret It Later.** Commissioner Peirce delivered a clear ultimatum to the industry: use this favorable regulatory window to build legitimate products. The long-term survival of crypto in the US depends on proving its utility *now*.
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