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AI Podcasts

August 4, 2025

Dwarkesh Patel and Noah Smith on AGI and the Economy

a16z

AI
Key Takeaways:
  1. Redefine AGI from Consciousness to Commerce. Forget Turing tests. The real benchmark for AGI is its ability to automate ~95% of white-collar work. The biggest missing piece isn't reasoning, but the capacity for continuous, on-the-job learning.
  2. Prepare for an Economic Singularity. Post-AGI growth won't be an incremental bump; it will be an explosive shift to 20%+ annual growth, driven by infinitely scalable AI labor. The bottleneck won't be human demand but the ambitions of the agents controlling the AI.
  3. The AGI Race Is More Industrial Revolution than Cold War. AGI is not a single bomb but a transformative process. The key risk isn't one nation nuking another, but advanced AIs playing nations against each other, much like the East India Company did in India.
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August 4, 2025

Micaela Bazo & Pedro Penna: AI, Drug Discovery, Decentralized Science, Behavioral Medicine | Ep 55

Ventura Labs

AI
Key Takeaways:
  1. Decentralize R&D for Efficiency. Using token-incentivized networks like Bittensor radically cuts costs and accelerates the initial drug discovery phase by tapping a competitive, global talent pool.
  2. Go Upstream for Bigger Wins. Targeting root "behavioral" causes of disease instead of just symptoms creates drugs with multi-condition applications, unlocking massive, previously unseen market potential.
  3. Innovate on Existing Rails. The fastest path to impact is by building on proven systems. Focusing on small molecules and using industry-standard validation partners creates a practical bridge between the worlds of crypto and traditional pharma.
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August 1, 2025

Will Market Euphoria Cool Off In August? | Weekly Round-Up

Forward Guidance

AI
Key Takeaways:
  1. Stagflation is Here: The Fed is poised to cut rates into rising inflation, an unorthodox move that signals how boxed-in monetary policy has become.
  2. The Two-Tiered Economy is Real: Capital is flowing to the "productive frontiers" of AI and tech, while legacy industries and the un-invested class get crushed. Policy is exacerbating this divide.
  3. Be Tactical, but Bet on the Ponzi: Expect a choppy August as euphoria cools. The long-term game, however, remains the same: bet on the assets that benefit from a global flight out of failing fiat and into productive, scarce technologies.
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August 1, 2025

MCP vs Browser Agents and Moving Beyond Crypto in the AI Space

Trillion Agents

AI
Key Takeaways:
  1. Crypto Is a Niche, Not a Foundation. AI builders are actively scrubbing crypto references from their branding to close enterprise deals. The market has decided: for now, crypto’s role is a payment rail, not the core agent stack.
  2. Bet on Native Protocols, Not Browsers. Browser-based agents are a dead end. The future belongs to agent-native protocols like MCP that enable efficient, bidirectional communication, mirroring the shift from mobile web to native apps.
  3. The AI Race Is a Power Race. The real bottleneck for AGI isn't just chips; it's energy. China's massive infrastructure build-out poses a strategic challenge to the West, which is betting on innovation in nuclear to keep pace. The future of AI may be decided by who can build power plants the fastest.
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July 31, 2025

How Distributed Compute Could Solve AI's Energy Crisis, w/ the CEO of Akash

The People's AI

AI
Key Takeaways:
  1. Energy is the New Scarcity. The race for AI supremacy is a race for power. Platforms like Akash that efficiently harness distributed, underutilized energy offer the only scalable alternative to the centralized model's impending energy crisis.
  2. The Tech is Maturing Rapidly. Asynchronous training and ZK-proofs (championed by projects like Jensen) are making permissionless global compute networks a reality. The performance gap with centralized systems is closing fast.
  3. The Mainstream is Buying In. A confluence of academic acceptance (at conferences like ICML) and favorable government policy (the White House's pro-open-source stance) is creating powerful tailwinds. The narrative has shifted from if decentralized AI is possible to how it will be implemented.
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July 31, 2025

The RLVR Revolution — with Nathan Lambert (AI2, Interconnects.ai)

Latent Space

AI
Key Takeaways:
  1. RLVR is the New SOTA for Solvable Problems: For tasks with clear right answers (code, math), RLVR is the state-of-the-art training method. The community is focused on scaling it, while RLHF remains the domain of fuzzy, human-preference problems.
  2. The Future is Search-Driven: GPT-4o’s heavy reliance on search is not a bug; it’s a feature. The hardest problem is no longer giving models tools, but training them to learn when to use them.
  3. Agents Need More Than Skills: The next leap in AI requires training for strategy, abstraction, and calibration. The goal is an AI that doesn’t just answer questions but efficiently plans its own work without wasting compute.
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July 31, 2025

China Open-Source, Compute Arms Race, Reordering Global Trade | BG2 w/ Bill Gurley and Brad Gerstner

Bg2 Pod

AI
Key Takeaways:
  1. China's Open-Source Models are Winning on Price & Performance. Chinese models offer ~90% of the intelligence of top US proprietary models for a fraction of the cost, driving massive global adoption and threatening to commoditize the model layer. An American open-source champion is desperately needed to compete.
  2. The "Cost is No Object" Compute Buildout is Reshaping the Market. A handful of private companies are spending at a loss to capture market share, fueled by VC. This creates a "sport of kings" dynamic that public companies can't match and makes pick-and-shovel players like Nvidia the biggest winners.
  3. The US Tariff Strategy is Working. Contrary to consensus, the administration's tariff gambit has secured favorable trade deals with the EU and Japan, generating hundreds of billions in revenue without causing significant consumer inflation, and setting the stage for a major renegotiation with China.
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July 31, 2025

Health Tech Founders: The Future of Care Is Personalized, Proactive—and AI-Powered

a16z

AI
Key Takeaways:
  1. Biology is the ultimate API for AI. The most impactful AI will be fed not just digital data but real-world biological signals. Companies are building the infrastructure to bring a user's biology online, turning abstract health data into a constant, actionable feed.
  2. Engagement metrics are being rewritten. Forget Daily Active Users. The new model is "intense, intentional engagement" during periods of need. Growth is a function of trust and real-world impact, where the best champions are users who have been genuinely helped.
  3. AI's role is augmentation, not automation. The goal isn't to replace doctors or therapists but to empower them. By translating noise into signal, AI lets human experts skip the data-sifting and focus on what they do best: solving problems.
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July 30, 2025

AI Content and the War for Your Attention

a16z

AI
Key Takeaways:
  1. AI is an attention-polluting machine. The primary challenge for social platforms will soon be managing the tidal wave of AI-generated "slop" designed to hijack algorithms, which risks alienating users entirely.
  2. The future of social is private. The psychological burden of being a micro-celebrity in a digital panopticon is pushing users away from public feeds and into smaller, trusted, and often monetized group chats.
  3. Attention mining’s endgame is total immersion. With phones saturated, the commercial logic of adtech demands new frontiers. VR is the path to monetizing waking hours, and Neuralink is the one to monetize dreams.
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Crypto Podcasts

November 5, 2025

Why the Crypto Markets Seem Down Bad as Bitcoin Dips Below $100K

Unchained

Crypto
Key Takeaways:
  1. Despite the brutal sentiment, both speakers remain bullish, predicting a sharp reversal and a new all-time high for Bitcoin by the end of the year once macro clarity emerges.
  2. Macro is King. Bitcoin's fate is now tied to the broader economy. Forget four-year cycles; the key catalyst is a resolution to the government shutdown, which could unlock pent-up energy in the market.
  3. The Treasury Trade is Toast. The era of companies boosting their stock by simply buying Bitcoin is over. Expect a painful shakeout as the market demands real utility and revenue, leading to more forced selling.
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November 5, 2025

Play to Earn Crypto Games: $65B Opportunity | Open Game Protocol & Zynga Founder

The DCo Podcast

Crypto
Key Takeaways:
  1. Distribution is the prize, not payments. The real money in gaming isn't in payment rails, which are being competed down to zero. The scarcest and most valuable asset is user attention, and Open Game Protocol is designed to monetize distribution.
  2. Decouple to survive. Tying a single game to a single token creates a fatal dependency. A flexible, many-to-many protocol allows ecosystems to thrive by spreading risk and aligning incentives across multiple games and communities.
  3. Content abundance requires new discovery. As AI makes game creation cheap and fast, the bottleneck shifts from production to discovery. Integrating games directly into high-intent surfaces like crypto wallets creates a powerful, non-advertising-based discovery channel.
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November 4, 2025

Bits + Bips LIVE

Unchained

Crypto
Key Takeaways:
  1. **Follow the Suits, Not the Shouts.** The market’s real signal is the massive disconnect between gloomy retail sentiment on social media and the unprecedented optimism from financial advisors and institutional platforms.
  2. **Distribution is the New Kingmaker.** From Ripple buying prime brokerages to Tether leveraging its global south dominance, the primary battle is for distribution channels. The technical "best" solution is irrelevant if it can't reach users.
  3. **Regulation Will Be a Slow Grind, Not a Big Bang.** Comprehensive crypto legislation is politically gridlocked. The industry’s integration into legacy finance will continue brick-by-brick through regulated products like ETFs, not sweeping bills from Congress.
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November 4, 2025

LIVE: BOCCACCIO EXPLAINING TO HIS WIFE THAT THEY LOST IT ALL | 0xResearch

0xResearch

Crypto
Key Takeaways:
  1. Tokenized Funds Are a Real-World Unlock. Unlike many crypto narratives, bringing funds on-chain solves a tangible, expensive problem in traditional finance, creating massive operational efficiencies and new financial primitives.
  2. The Bitcoin Holder Base Is Shifting. The ongoing "Bitcoin IPO" via ETFs means the asset is moving from the hands of early adopters to institutional portfolios. This structural shift will define its future trajectory.
  3. Cash Is Your Best Hedge. In a market with fewer winners, holding cash is a strategic imperative. It prevents forced liquidation and provides the dry powder needed to seize high-conviction opportunities as they arise.
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November 3, 2025

War Stories From a Crypto Founder | Kain Warwick

Empire

Crypto
Key Takeaways:
  1. Airdrops Are Now Protection Money: Stop viewing airdrops as a tool for buying loyalty. The modern meta is about paying the community to prevent negative campaigns. Consider models that require financial commitment, not just clicks.
  2. Decentralization is a Journey, Not a Destination: The path to unseating CEXs is paved with compromises. Prioritize a seamless user experience, even if it means starting with a more centralized architecture, and iterate towards permissionlessness over time.
  3. Surviving is the Ultimate Edge: In a space where most participants wash out after one cycle, consistency is a superpower. The founders and investors who can endure the brutal bear markets and avoid personal burnout are the ones who ultimately win.
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November 3, 2025

“The Debasement Trade” - Luke Gromen on Gold, Bitcoin & The 100 Year Reset

Bankless

Crypto
Key Takeaways:
  1. The Debasement is Permanent. The US fiscal position makes currency debasement a permanent feature, not a bug. The winning strategy is to treat hard assets like gold and Bitcoin as long-term holdings, buying on dips rather than timing a temporary "trade."
  2. Watch Central Banks, Not Pundits. The most significant signal is that foreign central banks are systemically divesting from US Treasuries into gold. This is not market noise; it's a structural realignment of the global financial order.
  3. Own the Physical Asset. Paper gold (like ETFs) carries a critical tail risk. In a true crisis, governments could seize the underlying physical gold and cash-settle ETF holders at a pre-crisis price. If you don't hold it, you don't own it.
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