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AI Podcasts

December 17, 2025

Rethinking Pre-Training for Agentic AI [Aakanksha Chowdhery] - 759

The TWIML AI Podcast with Sam Charrington

AI
Key Takeaways:
  1. Pre-Training is the New Frontier: The next leap in AI capabilities, particularly for agentic systems, will come from fundamental advancements in pre-training, not just post-training tweaks.
  2. Builders & Investors: Focus on teams rethinking loss objectives, curating high-quality reasoning data, and developing dynamic benchmarks for agentic capabilities. Be wary of "agentic" claims that lack foundational pre-training innovation.
  3. The "So What?": Over the next 6-12 months, expect a push for new benchmarks and data strategies that explicitly train models for multi-step planning, long-form reasoning, and error recovery, moving beyond simple next-token prediction.
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December 16, 2025

What We Learned Deploying AI within Bloomberg’s Engineering Organization – Lei Zhang, Bloomberg

AI Engineer

AI
Key Takeaways:
  1. Strategic Implication: AI fundamentally changes the economics of software development. Organizations must re-evaluate what constitutes "high-quality" engineering and adapt their processes.
  2. Builder/Investor Note: Prioritize platforms that provide guardrails and guidance for AI tool usage, focusing on deterministic verification and robust testing. Uncontrolled AI deployment risks technical debt.
  3. The "So What?": The next 6-12 months will see a bifurcation: companies that strategically integrate AI into their engineering culture and platforms will gain significant efficiency, while those that don't will struggle with quality and adoption.
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December 16, 2025

Your Support Team Should Ship Code – Lisa Orr, Zapier

AI Engineer

AI
Key Takeaways:
  1. Workflow Automation is the New Frontier: The real value of AI in developer tools comes from orchestrating entire workflows, not just individual point solutions.
  2. Embed for Adoption: Tools must integrate seamlessly into existing workflows and IDEs (like Cursor) to achieve high usage.
  3. Support as a Code-Shipping Powerhouse: Empowering non-traditional roles with AI-driven code generation leverages their unique, real-time context, creating significant operational leverage.
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December 17, 2025

Code World Model: Building World Models for Computation – Jacob Kahn, FAIR Meta

AI Engineer

AI
Key Takeaways:
  1. Semantic Shift: The future of AI in code moves from text generation to deep semantic understanding and execution simulation.
  2. Builder Opportunity: Develop next-generation debugging tools and code agents that leverage internal simulation for faster, more efficient development cycles.
  3. Investor Focus: Prioritize models and platforms that demonstrate explicit execution modeling, as this capability will redefine software development and create new market leaders.
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December 17, 2025

AI Kernel Generation: What's working, what's not, what's next – Natalie Serrino, Gimlet Labs

AI Engineer

AI
Key Takeaways:
  1. Infrastructure Shift: AI-driven kernel optimization addresses a critical bottleneck in scaling AI compute, enabling more efficient use of diverse hardware.
  2. Builder/Investor Note: Focus on solutions with robust, hardware-verified performance metrics and a clear human-in-the-loop strategy. AI is a powerful tool for automating optimization, not a magic bullet for novel algorithmic breakthroughs.
  3. The "So What?": This technology frees expert engineers from tedious optimization, allowing them to focus on higher-level research and truly innovative algorithmic design, accelerating the pace of AI development in the next 6-12 months.
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December 16, 2025

Finding The 1% of Stocks That Matter | Henry Ellenbogen Interview

Invest Like The Best

AI
Key Takeaways:
  1. Strategic Implication: The era of "free money" inflated the number of perceived compounders; a return to positive real rates demands a sharper focus on businesses demonstrating genuine financial discipline and competitive advantage.
  2. Builder/Investor Note: Seek out "Act 2" entrepreneurs and companies that can leverage AI to transform existing physical or IP-based advantages, not just create new AI products. Be prepared to buy more when market sentiment turns negative on strong businesses.
  3. The "So What?": The next 6-12 months will differentiate companies that merely adopt AI from those that strategically integrate it to build durable, uncatchable cost and distribution advantages.
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December 17, 2025

“How We Can Eliminate Crime” | Ben Horowitz and Garrett Langley

a16z

AI
Key Takeaways:
  1. The Future of Policing is Intelligent: Integrating AI, drones, and smart cameras creates a precise, accountable, and safer policing model for both officers and communities.
  2. Invest in the "How": Builders and investors should focus on technologies that enhance certainty of capture, streamline judicial processes, and support public-private partnerships to modernize urban safety infrastructure.
  3. Safety Fuels Mobility: Eliminating crime is not just about law enforcement; it's about restoring the fundamental safety required for economic mobility and a functional society.
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December 18, 2025

Two Futures | Runtime 2025

a16z

AI
Key Takeaways:
  1. Strategic Implication: The next decade's value will accrue to those building foundational AI infrastructure and the "invisible layers" that connect intelligent systems.
  2. Builder/Investor Note: Focus capital and talent on core AI models, specialized domain intelligence, and the underlying computational fabric. Superficial applications risk rapid commoditization.
  3. The So What?: This is the defining period for the architecture of global intelligence. Participation now determines future influence and relevance.
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December 16, 2025

⚡️Jailbreaking AGI: Pliny the Liberator & John V on Red Teaming, BT6, and the Future of AI Security

Latent Space

AI
Key Takeaways:
  1. Strategic Shift: AI security must move beyond superficial guardrails to a full-stack, offensive red-teaming approach that accounts for the expanding attack surface of AI agents and their tool access.
  2. Builder/Investor Note: Builders should prioritize integrating offensive security early in development. Investors should be wary of "security theater" and favor solutions that embrace open-source collaboration and address the entire AI application stack.
  3. The "So What?": The accelerating pace of AI development means static security solutions will quickly become obsolete. Proactive, community-driven, and full-stack security research is essential for navigating the next 6-12 months of AI evolution.
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Crypto Podcasts

July 1, 2025

a16z's Crypto Thesis With Ali Yahya

Lightspeed

Crypto
Key Takeaways:
  1. Financials First, Consumer Later: Bet on financial primitives like stablecoins and DeFi today. They are most likely to gain traction first, paving the way for consumer apps once crypto's brand is repaired.
  2. Solana's Mandate is Stablecoins: Solana’s technical achievements are a means to an end. Its success now hinges on aggressively capturing the stablecoin market to anchor its ecosystem and drive network effects.
  3. Proof of Humanity is the AI Counterweight: In an internet flooded with AI, decentralized identity solutions like Worldcoin become critical infrastructure, representing a powerful synergy between crypto and AI.
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July 1, 2025

Bits + Bips LIVE - June 30th, 2025

Unchained

Crypto
Key Takeaways:
  1. The Super App War is On. Robinhood and Coinbase aren't just adding crypto; they're building all-in-one platforms to own the entire user financial journey. The winner will be whoever provides the most seamless, abstracted experience.
  2. Perps Are Coming to TradFi. The purely financial, leverage-on-demand nature of perpetual futures is a killer product. While regulatory and mechanical hurdles remain, expect them to become a staple outside of crypto.
  3. Staking is the Next ETF Battleground. The real game is integrating staking yield into ETFs. The winner will be determined not just by the SEC, but by the IRS, with Liquid Staking Tokens positioned as the most elegant technical solution.
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June 30, 2025

The Stablecoin Future, Macro Moves & Big Tech Embracing Crypto | Permissionless IV Recap

Forward Guidance

Crypto
Key Takeaways:
  1. Bitcoin Treasury Companies Are The New Altcoins. They offer BTC beta through traditional stock markets, tapping into massive distribution and bypassing crypto-native hurdles. This is not a fad; it’s a structural shift.
  2. Stablecoins Are A Geopolitical Tool. Amidst soaring global debt, stablecoins provide a crucial, captive audience for US T-bills, making issuers like Circle exceptionally profitable as they absorb all the yield.
  3. DeFi's UX Is Its Achilles' Heel. As firms like Robinhood enter the fray with superior user experience, DeFi protocols must prove their value beyond regulatory arbitrage or risk being consumed by the centralized players using their own open-source tech.
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June 30, 2025

Macro Updates, Industry Narratives & Big Tech Coming For Crypto | Permissionless IV Recap

0xResearch

Crypto
Key Takeaways
  1. TradFi Rails are the New On-Ramp: The hottest trade is no longer an altcoin but a stock that buys Bitcoin. Corporate treasury vehicles are the "new tokens," leveraging global equity markets for unparalleled distribution.
  2. DeFi's UX Reckoning: Crypto’s open-source ethos inadvertently built the tools for Big Tech to create a superior user experience. Native protocols must now prove decentralization offers a real advantage or risk being out-competed by centralized giants.
  3. Macro Liquidity Isn't a Cure-All: Don't bet on fiscal deficits to lift all boats. Current capital flows are pumping equities, not on-chain altcoins, creating a significant headwind for the long tail of the crypto market.
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June 30, 2025

Macro Updates, Industry Narratives & Big Tech Coming For Crypto | Permissionless IV Recap

Bell Curve

Crypto
Key Takeaways:
  1. The New "Tokens" Are Stocks: The hottest play isn't an L1 token; it's publicly traded companies buying Bitcoin. These "treasury companies" offer crypto exposure through traditional brokerage accounts, tapping into the world's largest distribution networks.
  2. DeFi's Lunch Is on the Menu: Big Tech is no longer just marketing. Firms like Robin Hood are coming for DeFi's profit pools, armed with superior UX and massive user bases. Native crypto apps must now prove they offer more than just a regulatory loophole.
  3. Don't Fight the Flows: Rising government deficits are fueling asset inflation, but the money isn't flowing into altcoins. It's being channeled into equities and Bitcoin ETFs. Betting on a broad altcoin rally based on macro liquidity is a losing trade for now.
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June 30, 2025

Macro Updates, Industry Narratives & Big Tech Coming For Crypto | PERMISSIONLESS IV Recap Bonus Ep.

Empire

Crypto
Key Takeaways:
  1. Equity is the new token. The most potent way to gain crypto exposure is shifting from on-chain tokens to owning the stock of companies that hold crypto, using TradFi rails for unmatched distribution.
  2. DeFi's moat is evaporating. Native crypto protocols must now compete on user experience and genuine utility as Big Tech co-opts their open-source technology, backed by massive user bases and regulatory know-how.
  3. Don't count on the money printer for your altcoins. Macro-level liquidity is not mechanically flowing down the risk curve into on-chain assets. The capital flows from fiscal expansion are primarily benefiting traditional equities, creating a major headwind for the broader altcoin market.
See full notes