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AI Podcasts

November 17, 2025

Hash Rate - Ep 145 - TAO Subnets Templar (3), Basilica (39), Grail (81)

Hash Rate pod - Bittensor $TAO & Subnets

AI
Key Takeaways:
  1. **A New Market is Born:** Templar isn't just cheaper; it enables something that was previously impossible for 99% of the world. Democratizing pre-training means anyone can build a truly custom, sovereign AI.
  2. **Productization is Underway:** Covenant is no longer just a research project. With enterprise sales in motion, the focus is now on revenue. The team has committed that 100% of fees from custom training will be used to buy back its tokens.
  3. **Economics are Being Rewritten:** Basilica’s incentive mechanism is a direct critique of unsustainable models on other compute subnets. Its focus on profitability and positive TAO flow sets a new standard for economic design on Bittensor.
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November 17, 2025

Bryan Johnson: Don’t Die, Beating Entropy, AI Alignment & The Two-Species Future

Bankless

AI
Key Takeaways:
  1. AI Forces a Moral Reboot. The emergence of superintelligence renders our current societal goals dangerously obsolete. Survival must become the new prime directive.
  2. Existence is a Team Sport. The "Don't Die" philosophy is a collective mission ("we don't die") to ensure species-wide survival, not a selfish quest for individual immortality.
  3. Prepare for the Biological Sandbox. Humanity is moving from manipulating physical atoms and digital bits to programming our own biology—a frontier with both unimaginable potential and catastrophic risk.
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November 17, 2025

Emmett Shear on Building AI That Actually Cares: Beyond Control and Steering

a16z

AI
Key Takeaways:
  1. Stop Trying to “Steer” AGI. The control paradigm is a dead end. The goal isn’t a more obedient tool; it’s a trustworthy teammate. We must shift from engineering control to cultivating care.
  2. Alignment is a Process, Not a Product. True alignment isn't a fixed set of rules. It’s a dynamic process of moral learning, akin to raising a child. AIs that only follow rules are brittle and dangerous.
  3. Build for Cooperation, Not Command. The technical path forward involves training AIs in rich, multi-agent environments where they must learn cooperation and theory of mind—the foundational skills for becoming a good member of a group.
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November 16, 2025

Rawson Haverty presents "US & China AI: Lessons from Across the Pacific" | dAGI Summit 2025

Delphi Digital

AI
Key Takeaways:
  1. US Leads in Capital-Intensive Frontier AI; China Excels at Industrial Diffusion. The US leverages deep capital markets for its massive compute buildout and AGI research, while China uses state direction to embed AI into its vast industrial base via open-source models and hardware.
  2. Market Structure Dictates AI Strategy. The US "efficient oligopoly" model prioritizes global dominance and profit reinvestment by a few players. China's "subjugated swarm" model creates intense domestic competition, driving down prices and accelerating adoption at the cost of profitability.
  3. Geopolitical Tension May Be a Necessary Stabilizer. The competition between the US's freedom-oriented, frontier-pushing approach and China's stability-focused, diffusion-driven model creates a complementary tension that could be essential for navigating the "narrow corridor" between AI-driven totalitarianism and uncontrollable chaos.
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November 13, 2025

How Will AI Change Gaming Development? (A Dev’s Take)

The DCo Podcast

AI
Key Takeaways:
  1. Development timelines are collapsing from months to days. AI allows developers to swap entire asset libraries or generate new game concepts at unprecedented speed, turning a two-month art project into a day's work.
  2. The lifespan of any single game is shrinking. Prepare for a world of disposable entertainment. As AI floods the market with content, the strategy will pivot from creating one long-lasting hit to deploying a rapid succession of engaging experiences.
  3. Games are the next evolution of the attention economy. Just as memes became a core tool for community-building around tokens, easily created games will be the next engine for capturing and directing user attention in a hyper-competitive digital world.
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November 11, 2025

AI Nerves, Crypto Realism, Privacy Coins, & Lessons From Trading

1000x Podcast

AI
Key Takeaways:
  1. Adopt a Stock Picker's Mentality. The crypto market is no longer a monolith where a rising tide lifts all boats. Focus on assets with real products, user growth, and cash flow, as the gap between winners and losers will only widen.
  2. Shorting is a Tactical Assault, Not a Siege. Don't "invest" in a short. The only viable short strategies are tactical, targeting specific events like VC unlocks or news-driven spikes. Otherwise, even "total scams" can 5x against you.
  3. Cultivate a Goldfish's Memory. The most critical trading skill is learning how to change your mind. Cut losing trades, forget the loss (but remember the lesson), and redeploy capital without emotional baggage. Stubbornness is a portfolio killer.
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November 11, 2025

Grant Lee: Building Gamma’s AI Presentation Company to 100 Million Users

a16z

AI
Key Takeaways:
  1. Word-of-mouth isn't a feature; it's the engine. Before spending a dime on marketing, obsess over the first 30 seconds of the user experience until people can't help but share it.
  2. Being different is better than being better. Don't build incrementally better slideware. Redefine the core primitives of your category, as Gamma did by moving beyond the 16x9 slide.
  3. Hire painfully slowly to protect your DNA. Resisting the temptation to scale headcount with user growth is a superpower. The goal isn't to hit a hiring target; it's to hire the best people.
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November 7, 2025

Amjad Masad & Adam D’Angelo: How Far Are We From AGI?

a16z

AI
Key Takeaways:
  1. AGI Is a Definitional Debate. Progress toward an AI that can replace a remote worker is happening fast. However, achieving "true" human-like learning efficiency may require an entirely new paradigm beyond scaling current LLMs.
  2. The New Creator Economy Is Code. AI is turning software development into a mainstream creative pursuit, empowering a new class of solo entrepreneurs who can build what previously required entire teams.
  3. Incumbents Learned Their Lesson. Unlike past tech shifts, today's giants are aggressively adopting AI, making it both a sustaining *and* disruptive force. The market is large enough for both incumbents and startups to create massive value.
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November 6, 2025

Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease

a16z

AI
Key Takeaways:
  1. Build the Tools, Not Just the House: CZI’s greatest leverage comes from creating open-source tools and datasets. By building the fundamental infrastructure, they empower the entire scientific community—from academic labs to startups—to accelerate discovery.
  2. Data Is the New Microscope: The future of biology hinges on a tight feedback loop between generating novel, purpose-built datasets and training domain-specific AI models on them. This synergy is unlocking insights that were previously impossible.
  3. Virtual Biology Is the Next Frontier: Simulating biology computationally with "virtual cells" will become the new standard for research, enabling scientists to test riskier hypotheses faster and cheaper, dramatically compressing the timeline for major breakthroughs.
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Crypto Podcasts

December 17, 2025

Lighter vs Hyperliquid: Fees, Fairness, and ADLs - The Chopping Block

Unchained

Crypto
Key Takeaways:
  1. Predictable Risk Management is Paramount: DeFi's long-term success hinges on building transparent, predictable, and fair risk management systems that demonstrably outperform TradFi, especially for institutional players.
  2. Incentive Alignment is Critical: Investors and builders must scrutinize the relationship between DevCo equity and protocol tokens. Misaligned incentives can lead to value destruction for token holders during M&A or other strategic shifts.
  3. The "So What?": The next 6-12 months will see continued innovation in DEX fee models (Lighter's zero-fee tier for retail), RWA derivatives (FX, fixed income), and composability (Lighter's ZKVM sidecar). However, the underlying tension between decentralization ideals and market realities will persist, demanding robust solutions for ADL, governance, and value accrual.
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December 16, 2025

How Hylo Is Accelerating Solana DeFi In 2026 | Plish

Lightspeed

Crypto
Key Takeaways:
  1. Productive Stablecoins are Key: The transition from unproductive to productive stablecoins like hUSD is a significant catalyst for Solana DeFi growth, attracting capital by offering intrinsic yield.
  2. Builders, Simplify Leverage: Hylo's success with xSOL demonstrates the demand for simplified, liquidation-proof leverage products. Builders should focus on making complex DeFi primitives accessible through intuitive design.
  3. The X-Asset Frontier: Hylo's move into XBTC and other X-assets signals a broader trend: tokenizing leverage for diverse crypto assets will be a major growth driver for DeFi in the next 6-12 months.
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December 16, 2025

JPMorgan Goes Onchain as the Fed Cuts & Why Bitcoin Can’t Break Out - Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. Institutional Inevitability: Major financial institutions will continue tokenizing traditional assets, creating a clear, low-risk entry point for TradFi into crypto.
  2. Builder Focus: Build infrastructure that bridges TradFi and crypto, or specialize in high-throughput retail solutions. Regulatory compliance and education are paramount.
  3. Market Patience: Expect continued pressure on high-beta crypto assets until a clear market shift occurs, likely requiring high-beta assets to become oversold and the "value" rally to top out.
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December 16, 2025

Visa Stablecoin Strategy, N3on Crashout, AXL Acquisition, JPMorgan MMF on Ethereum & Nexus x Rialo

The Rollup

Crypto
Key Takeaways:
  1. Strategic Implication: The future of crypto is increasingly defined by institutional adoption, driven by the need for verifiable, private, and compliant digital assets and systems.
  2. Builder/Investor Note: Focus on foundational technologies like ZK proofs and secure interoperability. Avoid speculative retail trends that lack long-term utility.
  3. The "So What?": The convergence of AI and blockchain will redefine trust. Builders who integrate ZKPs to authenticate AI outputs and ensure agent accountability will capture significant value in the next 6-12 months.
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December 16, 2025

10 Crypto Predictions for 2026: $1M BTC, Wall Street Onchain & ETF Takeover

Bankless

Crypto
Key Takeaways:
  1. Strategic Implication: Crypto is transitioning from a niche, retail-driven asset class to a mainstream, institutionally-backed financial infrastructure. This shift will drive sustained growth, reduced volatility, and lower correlation with traditional assets.
  2. Builder/Investor Note: Re-evaluate crypto allocations, recognizing the shift from retail-driven cycles to institutional adoption. Explore diversified exposure beyond Bitcoin, including ETH, Solana, and high-quality DeFi tokens as their economic capture improves. The rise of on-chain vaults indicates demand for professional, diversified asset management strategies on-chain.
  3. The "So What?": The market is vastly underestimating the fundamental progress and institutional acceptance of crypto. The "suit coiners" are bullish for a reason, and their capital will reshape the landscape in 2026 and beyond.
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December 15, 2025

When Do We Buy, Global M2, Does Crypto Need A Catalyst, & Owning Your L’s

1000x Podcast

Crypto
Key Takeaways:
  1. Strategic Implication: The crypto market is maturing. Expect smaller percentage returns and less volatile swings, but a stronger foundation for assets with real value.
  2. Builder/Investor Note: Focus on Bitcoin accumulation in the identified value zone. Avoid speculative altcoin bets unless they demonstrate clear utility and sustainable economics.
  3. The "So What?": The market is in a temporary lull due to year-end flows and M2 divergence. Position for a potential rebound in January, driven by fresh capital and anticipated Western stimulus.
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