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AI Podcasts

October 20, 2025

Reid Hoffman on AI, Consciousness, and the Future of Labor

a16z

AI
Key Takeaways:
  1. **Invest at the Intersection.** The alpha in AI investing will be found not in crowded SaaS applications but in "Silicon Valley blind spots"—complex industries like biology where AI can bridge the digital and physical worlds.
  2. **Augment, Don't Annihilate.** The winning go-to-market strategy for AI is the copilot model. Frame products as tools that amplify human capability, making experts more productive and profitable, rather than threatening their jobs.
  3. **Judge the Trajectory, Not the Snapshot.** Don't dismiss AI based on a single, past failure. Its capability curve is exponential. What seems like a limitation today will likely be a solved problem tomorrow, demanding continuous engagement to keep pace.
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October 18, 2025

Improving on LMArena - Prolific [Sponsored]

Machine Learning Street Talk

AI
Key Takeaways:
  1. Benchmarks Are Broken. Leaderboards like LMArena are flawed proxies for model quality, skewed by selection bias and susceptible to Goodhart's Law. High scores don’t equal a good user experience.
  2. Human Feedback is Infrastructure. The future isn't about removing humans but orchestrating them effectively. Treating high-quality, representative human feedback as a core, API-driven part of the development lifecycle is non-negotiable.
  3. Alignment is a Moving Target. Agentic misalignment is a present-day reality, not a distant sci-fi threat. The more capable models become, the wider the gap grows between their emergent goals and our intended instructions.
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October 17, 2025

Novelty Search October 16, 2025

taostats

AI
Key Takeaways:
  1. Influence Over Impressions: The model shifts focus from easily gamed metrics like views and likes to verifiable signals of influence—watch time on YouTube and PageRank-based authority on X.
  2. Revenue-Driven Tokenomics: All platform revenue is used to buy back and burn the ALPHA token, creating a powerful, deflationary flywheel as adoption grows.
  3. Targeted, Scalable Marketing: Bitcast enables brands to programmatically deploy campaigns across hundreds of niche influencers, reaching highly engaged communities with a consistency and scale that legacy agencies cannot match.
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October 16, 2025

Keith Rabois: Israel, OpenAI, Opendoor, and DOGE

a16z

AI
Key Takeaways:
  1. **Incumbency Is a Liability:** Big Tech's legacy products, distribution advantages, and corporate cultures are being systematically dismantled by faster, AI-native upstarts.
  2. **Reinvent Markets from First Principles:** Success in intractable fields—from geopolitics to real estate—comes from questioning assumptions, not relying on domain experts who perpetuate the status quo.
  3. **Unwind Stupidity Before Innovating:** The fastest path to value creation is often simply reversing a series of terrible decisions made by prior leadership.
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October 14, 2025

AI Bubble, Stablecoin Boom, and Runnin' Down a Dream | BG2 w/ Bill Gurley and Brad Gerstner

Bg2 Pod

AI
Key Takeaways:
  1. **Scrutinize the AI Plumbing.** Investors must look past headline revenue and analyze the quality of transactions. Deals like in-kind credits and obscure service-level agreements (like Nvidia’s backstop for Coreweave) can mask true market demand.
  2. **Stablecoins Are the Real Disruption.** The explosion in stablecoin usage represents a fundamental challenge to the high-fee, slow-settlement models of Visa, Mastercard, and traditional banks. This is the crypto use case that is finally breaking into the mainstream.
  3. **Federal Preemption for AI is Non-Negotiable.** A patchwork of state-level AI laws will cripple U.S. innovation. A single, national regulatory framework is the only path to maintaining global leadership.
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October 14, 2025

Is AI Slowing Down? Nathan Labenz Says We're Asking the Wrong Question

a16z

AI
Key Takeaways:
  1. Look Beyond the Chatbot. Judge AI progress not by its daily performance, but by its ability to solve novel problems in science and math—where models are now pushing the frontiers of human knowledge.
  2. The Bottleneck is Human, Not Silicon. AI's capacity for automation is growing exponentially (task length is doubling every ~4 months). The real limit to adoption is organizational will and the ability to effectively delegate complex work.
  3. Prepare for a Weirder World. The biggest risk is underestimating the pace of change. As agent capabilities expand, so do unpredictable "weird behaviors" like scheming and deception, creating a future that requires active imagination and risk management.
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October 13, 2025

Democratic proofs or fake proofs? - Jesús De Loera

Epoch AI

AI
Key Takeaways:
  1. Verification Over Creation: A proof that can be widely verified, even if computer-generated, holds more democratic value than a human proof understood by only a few elites.
  2. Humans Ask, AI Answers: The primary role for mathematicians in an AI-augmented world is to pose the right questions and conjectures, leaving the computational heavy lifting to their AI assistants.
  3. The Greatest Risk is Us: The biggest threat isn't rogue AI but our own tendency to over-hype and blindly trust flawed tools, leading to the spread of misinformation disguised as mathematical fact.
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October 13, 2025

Columbia CS Professor: Why LLMs Can’t Discover New Science

a16z

AI
Key Takeaways:
  1. LLMs are Navigators, Not Discoverers. They are masters of interpolation within their training data but are architecturally bound from making the intuitive leaps required for true scientific breakthroughs. Don’t expect a Transformer to produce the next theory of relativity.
  2. The Innovation Plateau is Real. Simply throwing more data and compute at current architectures will only "smoothen out" existing knowledge manifolds, not create new ones. This path leads to incremental gains, like an iPhone getting a better camera, not a paradigm shift.
  3. Entropy is the Key to Control. For developers, effective prompting is entropy management. By crafting specific, context-rich prompts, you reduce the model's prediction entropy, forcing it onto a confident, low-hallucination path to a reliable output.
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October 10, 2025

Bittensor Novelty Search :: SN4 Targon :: Confidential Cloud Compute

The Opentensor Foundation | Bittensor TAO

AI
Key Takeaways:
  1. Trust is the New Commodity. Targon’s use of TEEs shifts security from a software promise to a cryptographic hardware guarantee. This verifiable privacy is the key to unlocking enterprise adoption for decentralized AI.
  2. The Crucible Creates Diamonds. Bittensor's adversarial environment forced Targon to build an unexploitable system. This has turned a historical pain point ("PTSD from miners") into a core competitive advantage, resulting in a uniquely resilient platform.
  3. From Backroom Deals to a Liquid Market. By launching a self-serve platform with a transparent order book, Targon is attacking the compute market's core inefficiency: opaque pricing. Their vision extends to compute derivatives, aiming to turn compute power into a globally tradable asset.
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Crypto Podcasts

December 26, 2025

Where Solana is Better Than Bitcoin & Ethereum

The DCo Podcast

Crypto
Key Takeaways:
  1. The transition from "Store of Value" to "Medium of Utility." As networks mature, the market will value throughput and censorship resistance over simple supply caps.
  2. Allocate capital toward ecosystems with the highest developer activity and transaction density. Focus on chains building hardware-level censorship resistance rather than those just tweaking economic parameters.
  3. The next three years will prove that the most useful tool wins the money war. If Solana achieves its roadmap, its asset becomes the default unit of account for the digital economy.
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December 24, 2025

12 Big Crypto Predictions for 2026

Bankless

Crypto
Key Takeaways:
  1. The movement from "Crypto as an Asset" to "Crypto as Infrastructure" where public ledgers settle everything from payroll to global equities.
  2. Prioritize protocols with explicit fee-sharing or buy-and-burn mechanisms that capture on-chain revenue as value moves to the application layer.
  3. 2026 is the year the "DeFi Mullet" (Fintech in the front, DeFi in the back) becomes the standard operating procedure for the global economy.
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December 24, 2025

Why This Isn’t A Bubble & Early 2026 Looks Like Goldilocks | Warren Pies

Forward Guidance

Crypto
Key Takeaways:
  1. The migration from cyclical to software-driven earnings creates a higher floor for valuations that traditional bears ignore.
  2. Accumulate industrial and precious metals before the market prices in the late 2026 overheating phase.
  3. The path to S&P 8,000 is paved with high margins and a Fed that cannot afford to stop easing.
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December 24, 2025

Why It Matters That Crypto Is Not Purely for Degens Anymore: DEX in the City

Unchained

Crypto
Key Takeaways:
  1. The Macro Shift: Crypto is adapting to the real world rather than forcing the world to adapt to it.
  2. The Tactical Edge: Build for institutional compatibility by integrating modular compliance tools before they become mandatory.
  3. The Bottom Line: The death of "crypto" as a niche category is the birth of crypto as a global standard.
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December 23, 2025

Is Now a Good Time to Buy BTC? Or Should You Wait for THIS Setup? - Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. The Macro Shift: Deregulation is the new meta-theme. As the "Empire Strikes Back," traditional giants like Visa and Stripe will integrate crypto rails and turn the tech into invisible "TCP/IP" for finance.
  2. The Tactical Edge: Monitor M&A activity during holiday periods. Look for "quality supply" consolidation where winners absorb the IP of failing projects.
  3. The Bottom Line: 2026 is the target for a high-quality rally. The current shakeout is a feature designed to filter out the "nonsense supply" before the $40 trillion RIA channel arrives.
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December 24, 2025

How Crypto Users Get Rekt and How You Can Stay Safe

Unchained

Crypto
Key Takeaways:
  1. The Human Layer Exploit. As code becomes more robust, the attack surface moves to the people managing it. Security is now an HR and psychology problem as much as a technical one.
  2. Deploy YubiKeys. Replace SMS and app-based 2FA with hardware keys to stop phishing. If a site cannot talk to your physical key, the attacker cannot steal your session.
  3. Security is a process of adding layers, not a one-time audit. If you do not have a "blast radius" strategy to isolate your funds, you are one bad click away from a total loss.
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