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AI Podcasts

May 30, 2025

SN17 - 404GEN :: Decentralized AI generated 3D assets

Opentensor Foundation

AI
Key Takeaways:
  1. Unlocking Creative Potential: 404GEN radically lowers barriers to 3D content creation, enabling faster iteration and new forms of interactive media previously unfeasible for smaller teams or individuals.
  2. Gaussian Splats are Ascendant: This representation is emerging as a powerful alternative for 3D AI, and 404GEN is at the forefront of its practical application and tooling.
  3. BitTensor's Competitive Edge Shines: The subnet's rapid quality improvement and the innovative ELO validation system highlight BitTensor's power to incentivize and coordinate decentralized intelligence towards state-of-the-art results.
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May 30, 2025

Hey Tech, Come to Healthcare

a16z

AI
Key Takeaways:
  1. **Build for Behavior Change:** The biggest wins will come from engaging consumers and enabling sustainable health behaviors, an area where tech excels.
  2. **AI is the Leapfrog:** Healthcare can jump directly to AI-driven solutions, bypassing clunky legacy software, especially for service-oriented tasks.
  3. **The Trillion-Dollar Prize is Real:** Whether through full-stack "payvider" models or horizontal platforms, the path to becoming the world's largest company runs through transforming the consumer healthcare experience.
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May 29, 2025

Building a DePIN-powered Shazam for Media with Rumi | Niko Cunningham and Mateusz Poreda

Proof of Coverage Media

AI
Key Takeaways:
  1. **Decentralized Analytics:** Rumi’s DePIN model democratizes media intelligence, offering far richer and more granular data than traditional players like Nielsen.
  2. **Context is King:** The "Shazam for media" capability will fuel a new generation of AI agents and interactive experiences, making media deeply engaging.
  3. **Investor Signal:** The $5M pre-seed (EV3, A16Z CSX) and early traction with industry players like Tivision validate Rumi's approach and market potential.
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May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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May 26, 2025

Chatbot platforms might replace social media

Machine Learning Street Talk

AI
Key Takeaways:
  1. AI Companionship is Exploding: Millions are already deeply engaged with AI for emotional connection, and this is just the beginning as technology like GPT-4o normalizes it.
  2. Lean Engineering Can Win: Chai's success with a tiny, hyper-talented team and innovative techniques like model blending proves that massive VC-backed operations aren't the only path to scale in AI.
  3. The Next Social Platform Might Be AI: As AI offers more active, personalized, and consequence-free social interaction, it could very well become the dominant way people connect, potentially supplanting traditional social media.
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Crypto Podcasts

January 2, 2026

Crypto Only Has 2 Real Business Models | Ejaaz Ahamadeen

The DCo Podcast

Crypto
Key Takeaways:
  1. Value is migrating from raw infrastructure to the model layer. As compute becomes a commodity, the economic winner is the entity that owns the weights and the inference interface.
  2. Audit your portfolio for projects with Visa-style fee structures. Prioritize protocols that generate revenue from external usage rather than internal token circularity.
  3. Sustainable crypto AI requires moving past speculative emissions toward actual service fees. The next year will separate apps that use AI to solve problems from protocols that use AI to sell tokens.
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January 2, 2026

Bittensor Brief #16: Bitsec Subnet 60

Hash Rate Podcast

Crypto
Key Takeaways:
  1. Security is moving from a periodic human service to a continuous machine-verified state.
  2. Stress-test your current security stack by running it against historical exploit benchmarks.
  3. If you are not using AI to defend your code, you are already losing to the AI trying to break it.
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January 2, 2026

Silver Is Going Parabolic, Bitcoin's Quantum Threat, & ETH’s 2026 Setup

Bankless

Crypto
Key Takeaways:
  1. The Macro Move: Capital is rotating from speculative "early" bets into "fundamental" infrastructure as crypto integrates with global finance.
  2. The Tactical Edge: Audit your portfolio for "equity-heavy" protocols and favor "unified" models like Uniswap that prioritize token-holder value.
  3. The Bottom Line: The next year belongs to the builders who can navigate the transition from "underground" experiment to "boring" global backbone.
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January 1, 2026

What's Next For Solana In 2026?

Lightspeed

Crypto
Key Takeaways:
  1. The "Fat Protocol" thesis is being replaced by "Fat Applications" as front-ends capture the spread between network costs and user willingness to pay.
  2. Build or invest in "Super Terminals" like Fuse that abstract gas fees and integrate banking features natively.
  3. In 2026, the winner isn't the fastest chain, but the app that makes the chain invisible. Front-ends are the new sovereign entities of the crypto economy.
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January 1, 2026

Aave Civil War + Flow Hack + Coinbase Everything Exchange - The Chopping Block

Unchained

Crypto
Key Takeaways:
  1. The Macro Movement: Infrastructure costs are creating a natural monopoly for dominant chains. Capital is migrating away from ghost chains that cannot support the $20 million annual integration tax.
  2. The Tactical Edge: Audit the IP structure of your protocol holdings. Prioritize projects where the foundation or DAO owns the primary domain to avoid "stealth privatization" risks.
  3. The Bottom Line: The next year belongs to platforms that own the user relationship and the underlying pipes. Expect a brutal consolidation where only the most integrated apps survive.
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December 31, 2025

The Type of Blockchain Banks Actually Want | Canton Network

The DCo Podcast

Crypto
Key Takeaways:
  1. The Macro Transition: Privacy-First Infrastructure. As the novelty of public ledgers fades, the market is moving toward selective transparency where institutions control data visibility.
  2. The Tactical Edge: Audit Canton. Builders should evaluate the Canton Network for any application involving sensitive corporate data or institutional capital flows.
  3. The Bottom Line: Institutional adoption won't happen on public chains as they exist today. The next phase of growth belongs to networks that treat privacy as a foundational requirement for compliance and scale.
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