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AI Podcasts

October 21, 2025

Google Researcher Proves Life Emerges From Code

Machine Learning Street Talk

AI
Key Takeaways:
  1. Life Isn't *Like* Code; It *Is* Code. The emergence of self-replicating systems is a predictable outcome of computation and thermodynamics, giving rise to function and purpose from a random, purposeless state.
  2. Complexity is Built by Merging. Evolution’s primary driver isn't random mutation but symbiogenesis—the composition of existing parts into more sophisticated wholes.
  3. Stop Othering AI. View artificial intelligence not as an alien invader but as a new layer in humanity’s own collective intelligence, built from and integrated with our own cognitive outputs.
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October 21, 2025

How Kong Was Born: APIs, Hustle, and the Future of AI Infrastructure

a16z

AI
Key Takeaways:
  1. Survive to See the Next Wave. Kong's seven years of struggle weren't a failure but a prerequisite. They stayed alive long enough for the market (microservices, cloud) to catch up to their vision, proving that resilience buys you shots on goal.
  2. Infrastructure Follows a Pattern. The abstraction of common logic to a central gateway, which happened with microservices, is happening again with LLMs. Enterprises won't manage security and routing for hundreds of models individually; they'll centralize it.
  3. AI's Native Language Is the API. The paradigm shift to AI is fundamentally a shift from human-UI interaction to machine-API interaction. The companies building the picks and shovels for this programmatic, agent-driven economy are positioned to capture immense value.
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October 21, 2025

Bittensor Brief #12: Synth - Subnet 50

Hash Rate pod - Bittensor $TAO & Subnets

AI
Key Takeaways:
  1. Democratized Alpha. Synth puts institutional-grade predictive power, once the exclusive domain of Wall Street, into the hands of any on-chain user, from individual traders to AI agents.
  2. A Proven Edge. The model isn't speculative. A live test on Polymarket generated a 110% return, demonstrating a quantifiable, real-world advantage.
  3. Intelligent and Improving. The network’s competitive design ensures it gets smarter over time, proven by a 33% reduction in error rates since January.
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October 20, 2025

Reid Hoffman on AI, Consciousness, and the Future of Labor

a16z

AI
Key Takeaways:
  1. **Invest at the Intersection.** The alpha in AI investing will be found not in crowded SaaS applications but in "Silicon Valley blind spots"—complex industries like biology where AI can bridge the digital and physical worlds.
  2. **Augment, Don't Annihilate.** The winning go-to-market strategy for AI is the copilot model. Frame products as tools that amplify human capability, making experts more productive and profitable, rather than threatening their jobs.
  3. **Judge the Trajectory, Not the Snapshot.** Don't dismiss AI based on a single, past failure. Its capability curve is exponential. What seems like a limitation today will likely be a solved problem tomorrow, demanding continuous engagement to keep pace.
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October 18, 2025

Improving on LMArena - Prolific [Sponsored]

Machine Learning Street Talk

AI
Key Takeaways:
  1. Benchmarks Are Broken. Leaderboards like LMArena are flawed proxies for model quality, skewed by selection bias and susceptible to Goodhart's Law. High scores don’t equal a good user experience.
  2. Human Feedback is Infrastructure. The future isn't about removing humans but orchestrating them effectively. Treating high-quality, representative human feedback as a core, API-driven part of the development lifecycle is non-negotiable.
  3. Alignment is a Moving Target. Agentic misalignment is a present-day reality, not a distant sci-fi threat. The more capable models become, the wider the gap grows between their emergent goals and our intended instructions.
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October 17, 2025

Novelty Search October 16, 2025

taostats

AI
Key Takeaways:
  1. Influence Over Impressions: The model shifts focus from easily gamed metrics like views and likes to verifiable signals of influence—watch time on YouTube and PageRank-based authority on X.
  2. Revenue-Driven Tokenomics: All platform revenue is used to buy back and burn the ALPHA token, creating a powerful, deflationary flywheel as adoption grows.
  3. Targeted, Scalable Marketing: Bitcast enables brands to programmatically deploy campaigns across hundreds of niche influencers, reaching highly engaged communities with a consistency and scale that legacy agencies cannot match.
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October 16, 2025

Keith Rabois: Israel, OpenAI, Opendoor, and DOGE

a16z

AI
Key Takeaways:
  1. **Incumbency Is a Liability:** Big Tech's legacy products, distribution advantages, and corporate cultures are being systematically dismantled by faster, AI-native upstarts.
  2. **Reinvent Markets from First Principles:** Success in intractable fields—from geopolitics to real estate—comes from questioning assumptions, not relying on domain experts who perpetuate the status quo.
  3. **Unwind Stupidity Before Innovating:** The fastest path to value creation is often simply reversing a series of terrible decisions made by prior leadership.
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October 14, 2025

AI Bubble, Stablecoin Boom, and Runnin' Down a Dream | BG2 w/ Bill Gurley and Brad Gerstner

Bg2 Pod

AI
Key Takeaways:
  1. **Scrutinize the AI Plumbing.** Investors must look past headline revenue and analyze the quality of transactions. Deals like in-kind credits and obscure service-level agreements (like Nvidia’s backstop for Coreweave) can mask true market demand.
  2. **Stablecoins Are the Real Disruption.** The explosion in stablecoin usage represents a fundamental challenge to the high-fee, slow-settlement models of Visa, Mastercard, and traditional banks. This is the crypto use case that is finally breaking into the mainstream.
  3. **Federal Preemption for AI is Non-Negotiable.** A patchwork of state-level AI laws will cripple U.S. innovation. A single, national regulatory framework is the only path to maintaining global leadership.
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October 14, 2025

Is AI Slowing Down? Nathan Labenz Says We're Asking the Wrong Question

a16z

AI
Key Takeaways:
  1. Look Beyond the Chatbot. Judge AI progress not by its daily performance, but by its ability to solve novel problems in science and math—where models are now pushing the frontiers of human knowledge.
  2. The Bottleneck is Human, Not Silicon. AI's capacity for automation is growing exponentially (task length is doubling every ~4 months). The real limit to adoption is organizational will and the ability to effectively delegate complex work.
  3. Prepare for a Weirder World. The biggest risk is underestimating the pace of change. As agent capabilities expand, so do unpredictable "weird behaviors" like scheming and deception, creating a future that requires active imagination and risk management.
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Crypto Podcasts

December 31, 2025

Steady Lads 100th Episode Year End Spectacular w/ Special Guests

Steady Lads Podcast

Crypto
Key Takeaways:
  1. The Macro Pivot: Fiscal dominance is replacing monetary policy as the primary market driver.
  2. The Tactical Edge: Accumulate Bitcoin dominance while shorting legacy "dino" alts that lack cash flow.
  3. The 2026 roadmap favors protocols that act as the plumbing for the AI economy.
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December 31, 2025

27 Crypto Predictions for 2026 (Ethereum Renaissance, BlackRock Chain & More)

Bankless

Crypto
Key Takeaways:
  1. The Macro Transition: Institutional Convergence. Crypto is shedding its speculative skin to become a fundamental asset class. This transition mirrors the 2002 post-bubble internet era where utility replaced hype.
  2. The Tactical Edge: Identify the Compounders. Focus on protocols with durable income and deep moats. Avoid the "L1 rotation" and prioritize DeFi entities integrating with real-world credit markets.
  3. The Bottom Line: 2026 is about survival and positioning. The winners will be those who build sustainable equity value rather than chasing the next speculative token flip.
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December 31, 2025

2026 Crypto Predictions with Haseeb Qureshi

The Rollup

Crypto
Key Takeaways:
  1. Capital is migrating from "AI slop" back to crypto-native fundamentals as interest rates drop and fiscal stimulus kicks in.
  2. Prioritize stablecoin distribution plays and equity perpetuals that utilize RFQ models to minimize funding rate volatility.
  3. 2026 is the year crypto grows up. The winners will be those building functional products that solve the last-mile problem for global finance.
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December 31, 2025

The Rollup 2025 Awards Ceremony & 2026 Market Predictions

The Rollup

Crypto
Key Takeaways:
  1. The merger of institutional distribution and decentralized settlement creates a Neo Finance layer that renders the TradFi versus DeFi debate obsolete.
  2. Prioritize the last mile by integrating stablecoin payment cards or yield bearing assets into existing fintech wrappers.
  3. 2026 belongs to protocols with verified revenue and institutional partnerships. The era of vibe-based valuation is dead.
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December 31, 2025

2026 Predictions: BTC & ETH Hit Record Highs, TradFi Uses Solana: Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. Capital is migrating from offshore exchanges to regulated US derivatives markets as the CME faces competition from Coinbase.
  2. Prioritize stablecoins with transparent reserve locations to avoid contagion where a bank failure triggers a crypto de-peg.
  3. Success depends on building utility-first infrastructure rather than chasing the ghost of 2021-style token launches.
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December 30, 2025

How Canton Network Was Built for Institutional Use in Crypto

The DCo Podcast

Crypto
Key Takeaways:
  1. The transition from speculation to utility. Capital is moving from crypto native games to real world efficiency gains.
  2. Prioritize infrastructure. Build or invest in protocols that prioritize liquidity and institutional compliance over short term retail hype.
  3. The next year will see the crypto casino fade as institutional rails like Canton Network enable the migration of trillions in traditional assets.
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