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AI Podcasts

August 21, 2025

Can AI Fix Housing and Healthcare Affordability?

a16z

AI
Key Takeaways:
  1. AI is the deflationary force for stagnant sectors. While software ate the world, it skipped housing and healthcare. AI is finally tackling the operational drag that has caused costs to balloon for decades.
  2. To solve the housing crisis, make it profitable. The path to more housing supply runs through better returns. By making property operations radically more efficient, AI attracts the capital required to build.
  3. The future of work is human + AI. Automation won't eliminate jobs; it will transform them. As AI handles the administrative grind, human roles will shift to higher-value work like community engagement and complex problem-solving.
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August 19, 2025

Hash Rate - Ep 129 - Macrocosmos IOTA (sn9) and DataUniverse (sn13)

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

AI
Key Takeaways:
  1. DTO Means Business: Dynamic TAO has forced a Darwinian shift. Subnets must now achieve product-market fit and generate real revenue to survive, transforming from research projects into self-sustaining businesses.
  2. IOTA’s Grand Ambition: IOTA (SN9) isn't just another model trainer; its architecture aims to train trillion-parameter models on decentralized, consumer-grade hardware, directly challenging the dominance of centralized AI labs.
  3. Time to Garden: The protocol's long-term health hinges on active governance. A strong sentiment is emerging to prune low-effort or malicious subnets to focus emissions on projects capable of creating real, lasting value.
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August 19, 2025

Hash Rate - Ep 128 - Ridges ($TAO Subnet 62)

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

AI
Key Takeaways:
  1. AI Is Moving from Copilot to Pilot. Ridges is betting that the future isn't AI assisting humans, but AI replacing them for specific tasks. Their goal is to make hiring a software engineer as simple as subscribing to a service.
  2. Decentralized Economics Are a Moat. By leveraging Bittensor's incentive layer, Ridges outsources a $15M/year R&D budget to a global pool of competing developers, achieving a cost structure and innovation velocity that centralized players cannot match.
  3. The Breakout Subnet Is Coming. Ridges showcases how a Bittensor subnet can solve real-world business problems—privacy, cost, and quality degradation—to build a product that is not just cheaper, but fundamentally better than its centralized counterparts.
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August 18, 2025

Dylan Patel on GPT-5’s Router Moment, GPUs vs TPUs, Monetization

a16z

AI
Key Takeaways:
  1. From Performance to Profit: The AI industry is pivoting from a war of benchmarks to a game of unit economics. Features like GPT-5’s router signal that cost management and monetization are now as important as model capabilities.
  2. Hardware is a Supply Chain Game: Nvidia’s true moat is its end-to-end control of the supply chain. Competitors aren't just fighting a chip architecture; they're fighting a logistical behemoth that consistently out-executes on everything from memory procurement to time-to-market.
  3. The Grid is the Limit: The biggest check on AI’s expansion is the physical world. The speed at which new power infrastructure and data centers can be built will dictate the pace of AI deployment in the US, creating a major advantage for those who can build faster.
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August 18, 2025

Subnet 56 :: Gradients :: Bittensor End-to-end AI Model Training Suite

Opentensor Foundation

AI
Key Takeaways:
  1. Performance is Proven, Not Promised. Gradients isn't just making claims; it’s delivering benchmark-crushing results, consistently outperforming centralized incumbents and producing state-of-the-art models.
  2. Open Source Unlocks the Enterprise. The shift to verifiable, open-source training scripts is a direct solution to customer data privacy concerns, turning a critical vulnerability into a competitive advantage.
  3. The AutoML Flywheel is Spinning. The network's competitive, tournament-style mechanism creates a self-optimizing system that continuously aggregates the best training techniques, ensuring it remains at the cutting edge.
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August 16, 2025

Google DeepMind Lead Researchers on Genie 3 & the Future of World-Building

a16z

AI
Key Takeaways:
  1. **World Models Are a New Modality.** Genie 3 is not just better video; it's an interactive environment generator. This divergence from passive, cinematic models like Veo signals a new frontier focused on agency and simulation, creating a distinct discipline within generative AI.
  2. **Simulation Is the Key to Embodied AI.** The biggest hurdle for robotics is the lack of realistic training environments. Genie 3 tackles this "sim-to-real" gap head-on, providing a scalable way to train agents on infinite experiences before they ever touch physical hardware.
  3. **Emergent Properties Will Drive the Future.** Key features like spatial memory and nuanced physics weren't explicitly coded but emerged from scaling. The next breakthroughs in world models will come from discovering these unexpected capabilities, not just refining existing ones.
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August 15, 2025

Greg Brockman on OpenAI's Road to AGI

Latent Space

AI
Key Takeaways:
  1. AGI is a Compute Game. The primary bottleneck is compute. The process is one of "crystallizing" energy into compute, then into the potential energy of a trained model. More compute means more intelligence.
  2. The Future is a "Manager of Models." AGI won't be a single entity. It will be an orchestrator that delegates tasks to a fleet of specialized models, from fast local agents to powerful cloud reasoners.
  3. Build for Your AI Coworker. To maximize leverage, structure codebases for AI. This means self-contained modules, robust unit tests, and clear documentation—treating the AI as a team member, not just a tool.
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August 15, 2025

The Current Reality of American AI Policy: From ‘Pause AI’ to ‘Build’

a16z

AI
Key Takeaways:
  1. Geopolitics Is the New OS: The AI discourse is no longer an intellectual parlor game about existential risk. It is a strategic mandate driven by fierce competition with adversaries like China.
  2. Open Source Is the Ultimate Moat: The winning strategy isn't to hoard IP but to build an ecosystem. Open source has emerged as the most powerful tool for establishing American models and infrastructure as the global standard.
  3. The Cost of Inaction Exceeds the Risk of Action: The "what's the rush?" argument is dead. The opportunity cost of delaying progress—from curing diseases to solving scientific challenges—is now viewed as a more tangible threat than the theoretical dangers of AI.
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August 15, 2025

Subnet 56 :: Gradients :: Bittensor End-to-end AI Model Training Suite

Opentensor Foundation

AI
Key Takeaways:
  1. **Training is a Solved Problem.** For users and developers, the message is clear: stop building custom training loops. Gradients offers superior performance out-of-the-box, turning the complex art of model training into a simple API call.
  2. **Open Source is the Ultimate Competitive Moat.** By making top training scripts public, Gradients accelerates its own innovation flywheel, creating a continuously compounding advantage that closed-source competitors cannot replicate.
  3. **The Best 8B Model is Now from Bittensor.** Gradients has moved beyond theoretical benchmarks to produce a state-of-the-art model that beats a leading industry player. This is a powerful proof-of-concept for the entire Bittensor ecosystem.
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Crypto Podcasts

October 22, 2025

Institutional Demand for Crypto is Accelerating | Matt Hougan

Forward Guidance

Crypto
Key Takeaways:
  1. **Allocations Are Multiplying:** The standard institutional crypto allocation is moving from a timid 1% to a more confident 3-5%, driven by crypto's declining volatility and the fading fear of a "go-to-zero" event.
  2. **The ETF Universe is Exploding:** New SEC guidelines will unleash a wave of crypto ETFs, from single assets to index funds. This will reshape market structure and provide traditional investors with simple on-ramps to the entire ecosystem.
  3. **Stablecoins are the Real Trojan Horse:** Beyond Bitcoin, institutional demand for stablecoins is immense. They aren't just an asset; they are recognized as the critical settlement layer for a tokenized, 24/7 global market.
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October 21, 2025

Inside Coinbase’s $375m Acquisition of Echo | Shan Aggarwal

Empire

Crypto
Key Takeaways:
  1. Becoming the Capital Stack: Coinbase's endgame is not just being a crypto exchange but providing the full, end-to-end infrastructure for any company—crypto or traditional—to issue, manage, and raise capital on-chain.
  2. Acquire Missionaries, Not Mercenaries: Their M&A success hinges on a proactive, culture-first approach. They identify strategic needs, hunt for the best teams, and integrate them deeply, ensuring founders stay long after their earnouts expire.
  3. Prediction Markets are the Next Trojan Horse: Coinbase is betting big on prediction markets to onboard the next wave of mainstream users, using familiar activities like sports betting as an accessible entry point into the crypto ecosystem.
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October 21, 2025

What's Happening to Crypto Markets? The Onchain Data That Explains Everything

Bankless

Crypto
Key Takeaways:
  1. Leverage Overload, Fundamental Weakness. Record leverage created a "house of cards" structure. Without strong underlying spot volume and new buyers, the market became highly susceptible to cascading liquidations.
  2. The Profits Are In. Long-term Bitcoin holders have already cashed out nearly twice the profit they did last cycle ($900B vs. $500B), indicating the "wealth distribution" phase is well underway.
  3. The Line in the Sand. The key level to watch is Bitcoin's 50-week moving average (around $102k). As long as Bitcoin holds above it, the bull market structure remains intact; two weekly closes below it would be a strong confirmation that the cycle is over.
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October 20, 2025

Sol Strategies: What Meme Coins Revealed About Solana

The DCo Podcast

Crypto
Key Takeaways:
  1. **Volume is the Best Validation**: Meme coins proved Solana isn't just fast in theory; it can handle transactional loads that surpass major centralized exchanges, making it a credible platform for serious financial assets.
  2. **Simplicity Wins**: Solana’s killer feature is its seamless user experience. By eliminating the bridging and multi-chain complexities of rivals, it has created a low-friction environment that attracts both developers and mainstream users.
  3. **The Next Frontier is Tokenization**: The meme coin craze was the chaotic opening act. The main event is the tokenization of real-world assets, and Solana’s proven performance has positioned it as the frontrunner to become the settlement layer for this new market.
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October 20, 2025

Welcome to Forward Guidance

Forward Guidance

Crypto
Key Takeaways:
  1. Stop Reacting, Start Anticipating: The market’s direction is a better economic predictor than official data. Focus on forward guidance, not rearview-mirror analysis.
  2. Bitcoin Is a Macro Asset: The primary thesis for assets like Bitcoin stems from the structural debasement of fiat currencies. Analyze it through the lens of global liquidity and monetary policy.
  3. Trust the Market, Not the Fed: The bond market can and will reject central bank policy. When market signals contradict official narratives, pay attention—the market is often right.
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October 20, 2025

How Futarchy Ends the Rug Pull Era

Bankless

Crypto
Key Takeaways:
  1. From Voting to Value: Futarchy transforms governance from a popularity contest into a pure value-maximization engine, where the only thing that matters is whether a decision increases the token's price.
  2. Investor Protection on-Chain: By locking funds in a market-governed treasury, Futarchy offers automated, code-enforced investor protections that mimic—and may even surpass—traditional shareholder rights.
  3. The End of the Rug Pull Era: Platforms like MetaDAO create a new asset class of "ownership coins" where the incentive to rug is eliminated, signaling a potential turning point for the quality and reliability of crypto investments.
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