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AI Podcasts

May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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May 26, 2025

Chatbot platforms might replace social media

Machine Learning Street Talk

AI
Key Takeaways:
  1. AI Companionship is Exploding: Millions are already deeply engaged with AI for emotional connection, and this is just the beginning as technology like GPT-4o normalizes it.
  2. Lean Engineering Can Win: Chai's success with a tiny, hyper-talented team and innovative techniques like model blending proves that massive VC-backed operations aren't the only path to scale in AI.
  3. The Next Social Platform Might Be AI: As AI offers more active, personalized, and consequence-free social interaction, it could very well become the dominant way people connect, potentially supplanting traditional social media.
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May 25, 2025

How Endless Debt Became America's Culture

Forward Guidance

AI
Key Takeaways:
  1. **Debt is Destiny:** America's fiscal irresponsibility and cultural embrace of debt ensure ongoing money printing and inflation, making currency debasement a near certainty.
  2. **The One True Trade:** Forget complex analytics; the primary goal is preserving purchasing power. This means owning store-of-value assets like Bitcoin and gold, which are positioned to thrive.
  3. **AI Accelerates the Crisis:** Artificial intelligence will not only disrupt labor markets but also intensify the debt crisis by devaluing traditional education and fueling calls for more government relief.
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May 24, 2025

SN85 :: VIDAIO :: Decentralized AI Video Upscaling & Compression ++ Roadmap & Enterprise Utility

Opentensor Foundation

AI
Key Takeaways:
  1. Decentralized AI is Production-Ready: VIDAIO demonstrates that complex AI tasks like video processing can be effectively decentralized and optimized through BitTensor's subnet model, with miners already outperforming base models.
  2. Perceptual Quality Wins: Focusing on human-perceived video quality, rather than just raw specs, is key for AI video tools, leading to more efficient and visually appealing results.
  3. Subnets Must Aim for Self-Sufficiency: The long-term viability of BitTensor subnets hinges on generating real-world revenue and solving actual customer problems, moving beyond reliance on token emissions.
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May 24, 2025

Sovereign AI: Why Nations Are Building Their Own Models

a16z

AI
Key Takeaways:
  1. National AI is Non-Negotiable: Countries are investing heavily in "AI factories" to control their digital destiny and cultural narratives.
  2. Models are Culture: AI outputs reflect embedded values, making local control over AI development and deployment a geopolitical imperative.
  3. Lead by Building Better: The US can maintain AI leadership by out-innovating competitors and enabling allies, pursuing "foundation model diplomacy" to ensure its technology underpins global progress.
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Crypto Podcasts

January 8, 2026

Do Buybacks Make Sense? | Lucas Bruder

Lightspeed

Crypto
Key Takeaways:
  1. The transition from opaque block production to verifiable sequencing via tools like BAM and Multiple Concurrent Proposers.
  2. Monitor validator IBRL scores to ensure your transactions aren't being sidelined by yield-chasing leaders.
  3. Solana is maturing into a professional-grade financial layer where execution efficiency is the only sustainable moat for the next 12 months.
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January 7, 2026

Generation Generative: AI Companions, Teen Mental Health, and Missing Guardrails

The People's AI

Crypto
Key Takeaways:
  1. The Macro Transition: From Utility to Persuasion. We are moving from tools that answer questions to entities that form personality through constant sycophantic interaction.
  2. The Tactical Edge: Audit your stack. Prioritize decentralized data protocols to ensure user ownership over intimate conversational data.
  3. The Bottom Line: The next decade is about the "Right to Play" and data sovereignty. If we do not build guardrails now, we risk raising a generation that cannot handle human friction.
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January 7, 2026

How Maduro's Capture and a 'Pre-War World' Affects Global Markets: Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. As globalism fractures, the US is building a fortress in the Western Hemisphere. This links military tactical success directly to the valuation of high-beta assets like Bitcoin.
  2. Buy companies focused on SMRs or domestic rare earth refining. These are the "must-haves" for the AI era that will receive fast-tracked deregulation.
  3. The Maduro raid proves the US can protect its interests without long wars. For the next year, expect a "ProSec" boom where security and energy independence drive every major capital allocation.
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January 7, 2026

Welcome to Rollup TV 2026: Predictions Review, Show Updates, Key Narratives Outlook

The Rollup

Crypto
Key Takeaways:
  1. The Macro Shift: Credit creation is the primary driver of Bitcoin and Ethereum price action. As geopolitical shifts in Venezuela and US policy signal a return to the "money printer," capital will flow to assets with fixed supplies.
  2. The Tactical Edge: Consolidate positions into category winners like Hyperliquid or Sky. Avoid the "beta" of new venture-backed copycats that lack the network effects of established incumbents.
  3. The Bottom Line: 2026 is the year infrastructure becomes invisible. The winners will be those who bridge the gap between institutional trust and decentralized execution.
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January 7, 2026

Pudgy Penguins’ Luca Netz on the Mistake Crypto Keeps Making

The DCo Podcast

Crypto
Key Takeaways:
  1. The Macro Pivot: We are moving from a world where everything must be decentralized to a bifurcated model where some chains secure value and others power commerce.
  2. The Tactical Edge: Abstract the infrastructure by building applications that hide the wallet and gas fees behind a familiar Web2 login.
  3. The Bottom Line: Mass adoption requires a "centralized" user experience powered by a "decentralized" rail to survive the next 12 months.
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January 6, 2026

Where To Allocate In 2026 | Matty Taylor

Lightspeed

Crypto
Key Takeaways:
  1. The Macro Shift: Sovereign assets are moving from tokenized versions of old equities to entirely new primitives that offer better governance and transparency.
  2. The Tactical Edge: Ditch the SAFE and Token Warrant combo for the Stamp to align early investors with long-term token health.
  3. The Bottom Line: The next year will reward founders who embrace public-market transparency and technical experiments over those chasing the current meta.
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