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AI Podcasts

May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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May 26, 2025

Chatbot platforms might replace social media

Machine Learning Street Talk

AI
Key Takeaways:
  1. AI Companionship is Exploding: Millions are already deeply engaged with AI for emotional connection, and this is just the beginning as technology like GPT-4o normalizes it.
  2. Lean Engineering Can Win: Chai's success with a tiny, hyper-talented team and innovative techniques like model blending proves that massive VC-backed operations aren't the only path to scale in AI.
  3. The Next Social Platform Might Be AI: As AI offers more active, personalized, and consequence-free social interaction, it could very well become the dominant way people connect, potentially supplanting traditional social media.
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May 25, 2025

How Endless Debt Became America's Culture

Forward Guidance

AI
Key Takeaways:
  1. **Debt is Destiny:** America's fiscal irresponsibility and cultural embrace of debt ensure ongoing money printing and inflation, making currency debasement a near certainty.
  2. **The One True Trade:** Forget complex analytics; the primary goal is preserving purchasing power. This means owning store-of-value assets like Bitcoin and gold, which are positioned to thrive.
  3. **AI Accelerates the Crisis:** Artificial intelligence will not only disrupt labor markets but also intensify the debt crisis by devaluing traditional education and fueling calls for more government relief.
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May 24, 2025

SN85 :: VIDAIO :: Decentralized AI Video Upscaling & Compression ++ Roadmap & Enterprise Utility

Opentensor Foundation

AI
Key Takeaways:
  1. Decentralized AI is Production-Ready: VIDAIO demonstrates that complex AI tasks like video processing can be effectively decentralized and optimized through BitTensor's subnet model, with miners already outperforming base models.
  2. Perceptual Quality Wins: Focusing on human-perceived video quality, rather than just raw specs, is key for AI video tools, leading to more efficient and visually appealing results.
  3. Subnets Must Aim for Self-Sufficiency: The long-term viability of BitTensor subnets hinges on generating real-world revenue and solving actual customer problems, moving beyond reliance on token emissions.
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May 24, 2025

Sovereign AI: Why Nations Are Building Their Own Models

a16z

AI
Key Takeaways:
  1. National AI is Non-Negotiable: Countries are investing heavily in "AI factories" to control their digital destiny and cultural narratives.
  2. Models are Culture: AI outputs reflect embedded values, making local control over AI development and deployment a geopolitical imperative.
  3. Lead by Building Better: The US can maintain AI leadership by out-innovating competitors and enabling allies, pursuing "foundation model diplomacy" to ensure its technology underpins global progress.
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Crypto Podcasts

January 12, 2026

Claude Opus 4.5’s Breakout Moment & Investing in 2026 with Qiao Wang

Empire

Crypto
Key Takeaways:
  1. The Macro Pivot: Proprietary data and enterprise switching costs are the only walls left standing as AI commoditizes the act of writing code.
  2. The Tactical Edge: Build internal tools using natural language agents to automate specific, low-volume workflows that third-party vendors ignore.
  3. The Bottom Line: The billion-dollar company with a single employee is no longer a fantasy; it is a mathematical certainty for those who master the prompt over the next twelve months.
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January 13, 2026

How Claude Code is Changing the World with Nick Emmons

The Rollup

Crypto
Key Takeaways:
  1. The migration from human-centric interfaces to agent-first protocols where software is a temporary utility rather than a permanent product.
  2. Use Git and MCP servers to give your agents a persistent memory and toolset, allowing them to work autonomously through complex loops.
  3. Software is no longer the prize; it is the commodity. Your value in the next year depends on how well you direct the agents that build it.
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January 12, 2026

HIP-3 Market Design and Felix’s Role | Charlie, Felix Protocol

0xResearch

Crypto
Key Takeaways:
  1. The Macro Strategic Pivot: Vertical Consolidation. Protocols are moving away from modularity toward integrated stacks to capture maximum fee revenue.
  2. The Tactical Edge: Monitor BLP Rates. Watch the spread between Felix and Hyperliquid’s native lending rates. Capital will migrate to the platform offering the lowest borrow cost for margin trading.
  3. The Bottom Line: Hyperliquid is winning by becoming a DeFi Super App rather than just a perp engine. Its success over the next year depends on its ability to manage UI fragmentation while keeping all revenue inside the Hype ecosystem.
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January 12, 2026

Is Canton a Real Blockchain? | Canton Founder Yuval Rooz

Bankless

Crypto
Key Takeaways:
  1. The Macro Transition: We are seeing a split between "Pure Crypto" for sovereignty and "Institutional Rails" for global capital markets.
  2. The Tactical Edge: Monitor Broadridge volume to gauge the actual velocity of institutional on-chain adoption.
  3. The Bottom Line: The next decade is not about crypto replacing banks. It is about banks adopting crypto's efficiency while keeping their legal moats.
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January 12, 2026

Who Actually Owns the Aave Brand -- the DAO or Labs? Uneasy Money

Unchained

Crypto
Key Takeaways:
  1. The "Fat App" thesis is evolving into the "Sovereign Brand" thesis where the front-end is the ultimate moat.
  2. Audit your protocol's meatspace dependencies—domains, trademarks, and front-ends—before they become points of failure.
  3. Decentralization isn't just about smart contracts; it is about ensuring the front door to your protocol cannot be locked by a single executive.
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January 10, 2026

Why Crypto Still Struggles to Capture the Value It Creates | Roundup

Bell Curve

Crypto
Key Takeaways:
  1. The transition from "Software as a Service" to "Software as a Network" where value flows to the protocol layer.
  2. Prioritize infrastructure that owns the end-user relationship or provides essential stability for open stacks.
  3. AI models will migrate to crypto rails to solve the monetization gap that has hindered open-source development for forty years.
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