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AI Podcasts

February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The Macro Shift: AI is collapsing the time horizon for technological deployment and market dominance, shifting the competitive advantage from pure innovation to a combination of innovation, capital, and rapid infrastructure deployment.
  2. The Tactical Edge: Invest in companies that are not just building AI, but are fundamentally rethinking existing industries with AI-first principles, recognizing that traditional software moats are eroding.
  3. The Bottom Line: The next 12-24 months will see AI's broad impact kick in, creating unprecedented opportunities for those who understand its new "laws of physics" and the critical role of policy in shaping its trajectory.
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February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The healthcare system is moving from reactive, acute care to proactive, preventative interventions, driven by the unsustainable costs of chronic disease and a growing understanding of environmental health.
  2. Build infrastructure that financially incentivizes lifestyle interventions, such as TrueMed's HSA/FSA payment rails for health-promoting products and services.
  3. The next decade will see hundreds of billions of dollars redirected towards preventative health. Companies that bridge the gap between lifestyle choices and healthcare financing will capture significant market share.
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February 3, 2026

SpaceX Engineer Explains America's Biggest Energy Mistake | Scott Nolan, CEO of General Matter

The Generalist

AI
Key Takeaways:
  1. The Macro Shift: Global energy demand, driven by AI, forces a strategic re-evaluation of nuclear power. This creates a window for nations to re-shore critical energy infrastructure, moving from reliance on adversaries to domestic, cost-competitive solutions.
  2. The Tactical Edge: Investigate companies addressing foundational supply chain gaps in critical industries like energy. Look for teams with a "first principles" engineering approach and a track record of commercializing hard tech.
  3. The Bottom Line: America's energy independence and its ability to power future technological growth, like AI, hinge on rebuilding domestic nuclear fuel enrichment. This is not just an industrial opportunity; it is a national security imperative.
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February 4, 2026

The Economic Singularity Will Make Today’s Economy Unrecognizable w/ Dr. Alexander Wissner-Gross

Milk Road AI

AI
Key Takeaways:
  1. The Macro Shift: AI-driven hyperdeflation is colliding with the technical reality of autonomous AI agents creating their own crypto-backed economies, threatening a decoupling from human fiat systems.
  2. The Tactical Edge: Investigate and build infrastructure that bridges human and AI economies, focusing on fiat-to-crypto rails that can accommodate agent-driven transactions to prevent a complete split.
  3. The Bottom Line: The next 5-10 years will see an unprecedented economic transformation. Understanding AI's deflationary power and the emerging AI agent economy is critical for navigating a world where traditional economic models may no longer apply.
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February 3, 2026

OpenClaw Makes AI Agents and CPUs Get Real

Semi Doped

AI
Key Takeaways:
  1. The time of practical AI agents is here, moving compute demand beyond pure GPU inference to a significant reliance on CPUs for coordination, data handling, and security.
  2. Evaluate your agent deployment strategy now, prioritizing sandboxed environments (VPS, dedicated local servers) and exploring cost-optimized model routing to manage API expenses.
  3. Prepare for a future where AI agents become integral to workflows, but recognize the hidden infrastructure costs and security implications, particularly the growing importance of CPU capacity and robust access controls.
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February 4, 2026

⚡️ Context graphs: AI’s trillion-dollar opportunity — Jaya Gupta, Ashu Garg, Foundation Capital

Latent Space

AI
Key Takeaways:
  1. The shift from "how" to "why" in AI agent capabilities creates a new, multi-trillion-dollar market for companies that can capture institutional decision logic.
  2. Invest in or build agentic systems that are in the "right path" of business processes, actively capturing decision traces from unstructured data.
  3. Hundreds of context graphs will be in production at scale within a year, defining a new "context graph stack." The winning companies will be those that master this flywheel, extracting value to accelerate automation and build deep, defensible moats.
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February 2, 2026

We Entered an Era Where No One Knows What Comes Next

Turing Post

AI
Key Takeaways:
  1. The shift from linear, bottleneck-driven technological progress to a multi-layered, interconnected advancement model in AI has rendered traditional forecasting obsolete, forcing a re-evaluation of what "singularity" truly represents.
  2. Prioritize adaptability: Invest in modular, composable AI infrastructure and tools that thrive in multi-layered, unpredictable environments, rather than betting on single-bottleneck solutions.
  3. The inability to narrate AI's future means traditional roadmaps are obsolete; success hinges on navigating simultaneous, interconnected advancements and embracing the emergent.
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February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The era of infrastructure-heavy tech deployment is over; AI's internet-native nature means immediate, widespread application. This shifts the competitive advantage from capital-intensive builds to rapid iteration and data leverage.
  2. Invest in companies that are not just using AI, but are fundamentally rethinking their business models around AI's ability to collapse traditional cost structures and accelerate product development.
  3. AI is a force multiplier for both individual opportunity and national power. Understanding its immediate deployability and the new rules of company building is crucial for investors and builders aiming to lead in the next wave of innovation over the next 12-24 months.
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February 2, 2026

Ben Horowitz and David Solomon: The Sweetest Macro Spot in 40 Years

a16z

AI
Key Takeaways:
  1. Unprecedented fiscal and monetary stimulus, coupled with a deregulatory environment, creates a powerful tailwind for financial assets and tech, driving a capital investment super cycle.
  2. Investors should prioritize companies with proprietary data and GPU access, as these are the new moats in an AI-driven world where traditional software leads are eroding.
  3. The convergence of a stimulative macro environment and AI's disruptive force means capital will flow to those who can scale, innovate, and navigate complex policy landscapes, making strategic positioning now critical for future relevance.
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Crypto Podcasts

January 10, 2026

LIVE: Aerodrome and Metadex03 | 0xResearch

0xResearch

Crypto
Key Takeaways:
  1. The Macro Trend: The transition from fragmented L2 liquidity to unified cross-chain execution.
  2. The Tactical Edge: Monitor Arrow’s Q2 launch on Mainnet to capitalize on the initial liquidity migration.
  3. The Bottom Line: Arrow is building the operating system for Ethereum liquidity. If they capture even a fraction of Mainnet the economic model moves from inflationary to net-positive.
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January 10, 2026

Jordi Alexander on Market Outlook, Token Buybacks, and Neo Finance

The Rollup

Crypto
Key Takeaways:
  1. The move from "fugazi decentralization" to "Neo Finance" means capital will flee empty L1s for protocols with verifiable revenue.
  2. Accumulate Bitcoin as a macro hedge while building a basket of revenue-generating alts like Meteora or Hyperliquid during price dips.
  3. Survival in 2026 requires moving past the "infra thesis" to find projects that treat their token as a real financial instrument.
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January 10, 2026

Zcash drama, stablecoin adoption, reinsurance markets & onchain reputation with Iron, Re, and Fluent

The Rollup

Crypto
Key Takeaways:
  1. The Macro Shift: The Unification. Legacy finance is unbundling into onchain modules where yield is derived from real-world economic activity rather than token emissions.
  2. The Tactical Edge: Audit your yield. Move capital toward protocols like RE that bridge to non-self-referential markets.
  3. The Bottom Line: The next 12 months belong to "Neo-Finance" players who dominate the boring work of regulatory compliance and fiat integration.
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January 9, 2026

Lighter’s Token Launch, Erebor Raises $350M & Walmart's Crypto Strategy

Empire

Crypto
Key Takeaways:
  1. The market is bifurcating into protocols with real product market fit and a long tail of zombie assets.
  2. Monitor the "One Pay" app ecosystem for integration opportunities.
  3. 2026 is the year stablecoins move from treasury management to domestic retail reality.
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January 9, 2026

Aerodrome’s Big Upgrade | Alexander Cutler

0xResearch

Crypto
Key Takeaways:
  1. The Macro Transition: Vertical Liquidity. Exchanges are evolving from passive pools into active revenue collectors that capture MEV and launch fees to subsidize liquidity.
  2. The Tactical Edge: Monitor Aero. Watch the Metadex03 launch in Q2 to see if liquidity migrates from Uniswap to the higher-yield Aero pools on Ethereum Mainnet.
  3. The Bottom Line: Aero is betting that better economics for liquidity providers will always win the war for volume. If they successfully export their Base dominance to Mainnet, the decentralized exchange hierarchy will be permanently altered over the next 12 months.
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January 9, 2026

Nic Carter: Quantum Threatens $600B of Bitcoin

Delphi Digital

Crypto
Key Takeaways:
  1. The transition from classical to quantum computing turns static digital gold into a melting ice cube.
  2. Audit your cold storage to ensure you aren't reusing addresses or holding funds in P2PK formats.
  3. Bitcoin’s survival depends on the community’s ability to prioritize insurance over ideological purity before 2030.
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