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AI Podcasts

November 17, 2025

Hash Rate - Ep 145 - TAO Subnets Templar (3), Basilica (39), Grail (81)

Hash Rate pod - Bittensor $TAO & Subnets

AI
Key Takeaways:
  1. **A New Market is Born:** Templar isn't just cheaper; it enables something that was previously impossible for 99% of the world. Democratizing pre-training means anyone can build a truly custom, sovereign AI.
  2. **Productization is Underway:** Covenant is no longer just a research project. With enterprise sales in motion, the focus is now on revenue. The team has committed that 100% of fees from custom training will be used to buy back its tokens.
  3. **Economics are Being Rewritten:** Basilica’s incentive mechanism is a direct critique of unsustainable models on other compute subnets. Its focus on profitability and positive TAO flow sets a new standard for economic design on Bittensor.
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November 17, 2025

Bryan Johnson: Don’t Die, Beating Entropy, AI Alignment & The Two-Species Future

Bankless

AI
Key Takeaways:
  1. AI Forces a Moral Reboot. The emergence of superintelligence renders our current societal goals dangerously obsolete. Survival must become the new prime directive.
  2. Existence is a Team Sport. The "Don't Die" philosophy is a collective mission ("we don't die") to ensure species-wide survival, not a selfish quest for individual immortality.
  3. Prepare for the Biological Sandbox. Humanity is moving from manipulating physical atoms and digital bits to programming our own biology—a frontier with both unimaginable potential and catastrophic risk.
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November 17, 2025

Emmett Shear on Building AI That Actually Cares: Beyond Control and Steering

a16z

AI
Key Takeaways:
  1. Stop Trying to “Steer” AGI. The control paradigm is a dead end. The goal isn’t a more obedient tool; it’s a trustworthy teammate. We must shift from engineering control to cultivating care.
  2. Alignment is a Process, Not a Product. True alignment isn't a fixed set of rules. It’s a dynamic process of moral learning, akin to raising a child. AIs that only follow rules are brittle and dangerous.
  3. Build for Cooperation, Not Command. The technical path forward involves training AIs in rich, multi-agent environments where they must learn cooperation and theory of mind—the foundational skills for becoming a good member of a group.
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November 16, 2025

Rawson Haverty presents "US & China AI: Lessons from Across the Pacific" | dAGI Summit 2025

Delphi Digital

AI
Key Takeaways:
  1. US Leads in Capital-Intensive Frontier AI; China Excels at Industrial Diffusion. The US leverages deep capital markets for its massive compute buildout and AGI research, while China uses state direction to embed AI into its vast industrial base via open-source models and hardware.
  2. Market Structure Dictates AI Strategy. The US "efficient oligopoly" model prioritizes global dominance and profit reinvestment by a few players. China's "subjugated swarm" model creates intense domestic competition, driving down prices and accelerating adoption at the cost of profitability.
  3. Geopolitical Tension May Be a Necessary Stabilizer. The competition between the US's freedom-oriented, frontier-pushing approach and China's stability-focused, diffusion-driven model creates a complementary tension that could be essential for navigating the "narrow corridor" between AI-driven totalitarianism and uncontrollable chaos.
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November 13, 2025

How Will AI Change Gaming Development? (A Dev’s Take)

The DCo Podcast

AI
Key Takeaways:
  1. Development timelines are collapsing from months to days. AI allows developers to swap entire asset libraries or generate new game concepts at unprecedented speed, turning a two-month art project into a day's work.
  2. The lifespan of any single game is shrinking. Prepare for a world of disposable entertainment. As AI floods the market with content, the strategy will pivot from creating one long-lasting hit to deploying a rapid succession of engaging experiences.
  3. Games are the next evolution of the attention economy. Just as memes became a core tool for community-building around tokens, easily created games will be the next engine for capturing and directing user attention in a hyper-competitive digital world.
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November 11, 2025

AI Nerves, Crypto Realism, Privacy Coins, & Lessons From Trading

1000x Podcast

AI
Key Takeaways:
  1. Adopt a Stock Picker's Mentality. The crypto market is no longer a monolith where a rising tide lifts all boats. Focus on assets with real products, user growth, and cash flow, as the gap between winners and losers will only widen.
  2. Shorting is a Tactical Assault, Not a Siege. Don't "invest" in a short. The only viable short strategies are tactical, targeting specific events like VC unlocks or news-driven spikes. Otherwise, even "total scams" can 5x against you.
  3. Cultivate a Goldfish's Memory. The most critical trading skill is learning how to change your mind. Cut losing trades, forget the loss (but remember the lesson), and redeploy capital without emotional baggage. Stubbornness is a portfolio killer.
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November 11, 2025

Grant Lee: Building Gamma’s AI Presentation Company to 100 Million Users

a16z

AI
Key Takeaways:
  1. Word-of-mouth isn't a feature; it's the engine. Before spending a dime on marketing, obsess over the first 30 seconds of the user experience until people can't help but share it.
  2. Being different is better than being better. Don't build incrementally better slideware. Redefine the core primitives of your category, as Gamma did by moving beyond the 16x9 slide.
  3. Hire painfully slowly to protect your DNA. Resisting the temptation to scale headcount with user growth is a superpower. The goal isn't to hit a hiring target; it's to hire the best people.
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November 7, 2025

Amjad Masad & Adam D’Angelo: How Far Are We From AGI?

a16z

AI
Key Takeaways:
  1. AGI Is a Definitional Debate. Progress toward an AI that can replace a remote worker is happening fast. However, achieving "true" human-like learning efficiency may require an entirely new paradigm beyond scaling current LLMs.
  2. The New Creator Economy Is Code. AI is turning software development into a mainstream creative pursuit, empowering a new class of solo entrepreneurs who can build what previously required entire teams.
  3. Incumbents Learned Their Lesson. Unlike past tech shifts, today's giants are aggressively adopting AI, making it both a sustaining *and* disruptive force. The market is large enough for both incumbents and startups to create massive value.
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November 6, 2025

Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease

a16z

AI
Key Takeaways:
  1. Build the Tools, Not Just the House: CZI’s greatest leverage comes from creating open-source tools and datasets. By building the fundamental infrastructure, they empower the entire scientific community—from academic labs to startups—to accelerate discovery.
  2. Data Is the New Microscope: The future of biology hinges on a tight feedback loop between generating novel, purpose-built datasets and training domain-specific AI models on them. This synergy is unlocking insights that were previously impossible.
  3. Virtual Biology Is the Next Frontier: Simulating biology computationally with "virtual cells" will become the new standard for research, enabling scientists to test riskier hypotheses faster and cheaper, dramatically compressing the timeline for major breakthroughs.
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Crypto Podcasts

May 9, 2025

Coinbase Buys Deribit, Stripe’s Stablecoin Launch, and Ethereum’s Pectra Upgrade | Weekly Roundup

Empire

Crypto
Key Takeaways:
  1. The crypto space is witnessing an intense period of building and institutional adoption, fundamentally reshaping financial infrastructure.
  2. Real-World Integration Accelerates: Major players like Coinbase and Stripe are not just dipping toes but diving headfirst, embedding crypto into mainstream finance and global commerce.
  3. Stablecoins are the New Global Rails: With Stripe's expansion and the US Treasury's bullish $2T forecast, stablecoins are becoming indispensable for borderless, efficient payments.
  4. On-Chain Capital Markets Are Here: The tokenization of real-world assets, particularly equities via platforms like Superstate, is paving the way for more liquid, accessible, and programmable financial markets.
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May 9, 2025

Can Ethereum Scale The L1? | Weekly Roundup

Lightspeed

Crypto
Key Takeaways:
  1. Efficiency ≠ Centralization: Coordinated, rapid bug fixes are signs of an active, aligned ecosystem, not inherent centralization.
  2. L1 Utility is Paramount: Both Ethereum and Solana ecosystems depend on their base layers being genuinely useful and economically viable to support L2s and broader application development.
  3. Performance Drives Decentralization: Contrary to the traditional trilemma, the most performant L1 (attracting the most activity and thus revenue for validators) will likely become the most decentralized due to stronger economic incentives for participation.
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May 6, 2025

Ex Jane Street Veteran's Journey To Crypto | Thomas Uhm

Lightspeed

Crypto
Key Takeaways:
  1. JitoSol's Institutional Edge: JitoSol’s design—autonomy, yield-bearing, and reduced counterparty risk—positions it as attractive institutional-grade collateral and a scalable yield product on Solana.
  2. Sustainable Systems Over Subsidies: Long-term value in crypto infrastructure and services like market making will come from robust, economically sound systems, not short-term, unsustainable incentives.
  3. Solana's Determinism Drive: Solana's push for greater network determinism (predictable transaction outcomes) directly addresses a core institutional need, potentially unlocking further capital allocation.
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May 6, 2025

Bits + Bips LIVE - May 5th, 2025

Unchained

Crypto
Key Takeaways:
  1. Tariff Turmoil Persists: Despite calming rhetoric, the haphazard US tariff rollout creates ongoing uncertainty, with potential for significant market impact if key sectors like AI chips are targeted.
  2. ETH's Uphill Battle: Ethereum faces significant headwinds in sentiment and relative performance; its path to renewed relevance depends on attracting major institutional adoption.
  3. Momentum is King in Crypto: Crypto markets, including assets like XRP (viewed as a short-term trade) and even Doge (noted for technicals), are primarily driven by attention and momentum, not traditional valuation metrics.
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May 5, 2025

Is Saylor Destined to Blow Up?

1000x Podcast

Crypto
Key Takeaways:
  1. **Saylor's Gambit is Bitcoin's Sword of Damocles:** MicroStrategy's leveraged Bitcoin accumulation is a major systemic risk; a blow-up could trigger a severe market downturn.
  2. **Trade Fundamentals, Not Just Narratives:** Focus on assets showing real usage or fitting strong themes (RWA, AI, DeFi yield) as the market gets selective. ETH remains fundamentally challenged despite price bounces.
  3. **Choppy Waters Ahead, Cash is King (Again):** Expect market consolidation. Reduce leverage, hold some cash, and look for dips in strong assets (like Tao) or opportunities to short weak ones (like ETH) – but avoid shorting in euphoric breakouts.
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May 5, 2025

Alex Tapscott: How I Predicted Crypto's Rise (And What's Coming Next)

The Rollup

Crypto
Key Takeaways:
  1. Institutional Bitcoin Demand is Real: Major players are accumulating Bitcoin via direct purchases and ETFs, creating sustained buying pressure.
  2. RWAs & AI are Next: Focus on the tokenization of traditional assets and the infrastructure enabling AI agents to transact autonomously on-chain.
  3. Bet on Platforms for AI: Consider exposure to high-throughput Layer 1s likely to become hubs for AI-driven activity as a proxy for the AI/crypto theme's growth.
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